GREMLIN Database
YIGI - Uncharacterized protein YigI
UniProt: P0ADP2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11467
Length: 155 (125)
Sequences: 3197 (2217)
Seq/√Len: 198.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_E43_A3.4051.00
43_A116_R3.3911.00
102_I130_V3.1981.00
41_Q120_T2.6521.00
72_A135_V2.4761.00
120_T138_H2.3811.00
34_R41_Q2.3341.00
44_F63_V2.3011.00
68_L135_V2.2181.00
34_R39_F2.1801.00
42_L71_A2.1481.00
76_C131_A1.9901.00
39_F122_S1.9791.00
31_E43_A1.9421.00
65_A104_L1.9361.00
122_S134_R1.8921.00
65_A108_Y1.8491.00
38_E78_G1.7991.00
103_D107_D1.7901.00
136_E144_Y1.7851.00
36_E39_F1.7721.00
43_A118_T1.7631.00
134_R147_S1.7271.00
122_S136_E1.7051.00
68_L148_A1.6831.00
39_F120_T1.6301.00
71_A119_A1.6161.00
68_L137_L1.6111.00
33_E41_Q1.5821.00
41_Q118_T1.5101.00
112_G145_I1.5081.00
45_K116_R1.4141.00
124_L147_S1.3901.00
110_R143_L1.3771.00
76_C133_A1.3641.00
79_S126_A1.3631.00
27_A49_M1.3511.00
59_L117_F1.3111.00
115_E140_E1.2911.00
72_A150_A1.2831.00
16_E20_Y1.2691.00
124_L134_R1.2441.00
61_G108_Y1.2421.00
136_E147_S1.2381.00
46_N59_L1.2351.00
139_N143_L1.2171.00
64_I112_G1.1741.00
112_G117_F1.1621.00
125_R130_V1.1561.00
65_A106_V1.1531.00
24_F66_S1.1371.00
47_Q50_M1.1351.00
67_A119_A1.1351.00
120_T142_Q1.1321.00
123_L126_A1.1301.00
107_D132_V1.1281.00
64_I146_A1.1261.00
117_F145_I1.1181.00
45_K50_M1.1161.00
75_V123_L1.0981.00
64_I108_Y1.0961.00
31_E116_R1.0921.00
138_H142_Q1.0911.00
117_F137_L1.0721.00
79_S123_L1.0611.00
24_F63_V1.0321.00
81_L97_S1.0091.00
17_M20_Y1.0061.00
20_Y26_R1.0031.00
138_H144_Y0.9871.00
119_A135_V0.9831.00
31_E45_K0.9780.99
14_V17_M0.9670.99
46_N50_M0.9560.99
69_D101_T0.9490.99
144_Y147_S0.9430.99
50_M63_V0.9230.99
109_L147_S0.9210.99
125_R132_V0.9050.99
72_A152_Y0.8940.99
38_E75_V0.8700.99
109_L125_R0.8580.99
120_T136_E0.8540.99
68_L106_V0.8510.99
15_G19_V0.8480.99
44_F67_A0.8410.98
60_H70_V0.8390.98
37_K79_S0.8330.98
46_N51_V0.8270.98
107_D149_T0.8130.98
132_V151_T0.8120.98
77_V98_R0.8090.98
67_A137_L0.8040.98
30_M44_F0.7940.98
48_P51_V0.7940.98
72_A133_A0.7910.98
72_A148_A0.7830.98
58_I100_G0.7770.97
42_L121_S0.7700.97
69_D73_G0.7660.97
119_A137_L0.7510.97
135_V148_A0.7510.97
104_L108_Y0.7510.97
30_M42_L0.7450.97
50_M59_L0.7170.96
134_R149_T0.7150.96
118_T138_H0.7150.96
109_L144_Y0.7140.96
126_A131_A0.7060.96
129_K153_M0.7030.95
33_E116_R0.6960.95
25_N30_M0.6950.95
59_L112_G0.6930.95
24_F60_H0.6890.95
76_C99_M0.6880.95
40_A75_V0.6810.95
121_S135_V0.6790.94
105_R149_T0.6770.94
118_T142_Q0.6750.94
110_R125_R0.6620.94
75_V121_S0.6600.94
26_R49_M0.6510.93
64_I137_L0.6470.93
123_L133_A0.6470.93
75_V78_G0.6470.93
62_G66_S0.6420.93
101_T150_A0.6390.93
139_N145_I0.6380.92
115_E139_N0.6340.92
73_G152_Y0.6270.92
35_Y78_G0.6200.91
103_D151_T0.6160.91
14_V18_F0.6150.91
123_L131_A0.6030.90
80_T97_S0.6030.90
104_L150_A0.5960.90
121_S133_A0.5920.89
110_R153_M0.5910.89
22_M55_A0.5900.89
116_R140_E0.5880.89
130_V153_M0.5870.89
15_G18_F0.5860.89
16_E31_E0.5850.89
116_R139_N0.5830.89
22_M74_L0.5790.88
32_L42_L0.5770.88
78_G123_L0.5710.88
17_M21_H0.5710.88
23_P51_V0.5710.88
103_D149_T0.5680.87
65_A148_A0.5670.87
68_L104_L0.5620.87
100_G150_A0.5580.86
76_C152_Y0.5560.86
55_A74_L0.5550.86
132_V147_S0.5550.86
52_G56_Q0.5530.86
21_H26_R0.5530.86
29_G49_M0.5520.86
32_L40_A0.5510.86
102_I153_M0.5470.85
76_C126_A0.5440.85
23_P26_R0.5430.85
124_L144_Y0.5420.85
25_N70_V0.5410.85
69_D100_G0.5400.85
109_L130_V0.5390.85
43_A140_E0.5380.84
29_G44_F0.5350.84
135_V150_A0.5340.84
112_G115_E0.5330.84
74_L77_V0.5230.83
107_D130_V0.5210.83
63_V117_F0.5210.83
76_C80_T0.5200.82
46_N114_G0.5190.82
52_G62_G0.5160.82
55_A73_G0.5160.82
14_V19_V0.5150.82
35_Y40_A0.5140.82
46_N117_F0.5130.82
22_M52_G0.5130.82
28_L63_V0.5100.81
30_M119_A0.5090.81
56_Q100_G0.5080.81
61_G127_G0.5070.81
52_G60_H0.5030.80
56_Q99_M0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e8pA 3 0.9806 100 0.362 Contact Map
4rmmA 2 0.8452 99.9 0.385 Contact Map
3f1tA 2 0.871 99.9 0.395 Contact Map
3lmbA 2 0.9097 99.9 0.405 Contact Map
1yocA 4 0.8968 99.9 0.413 Contact Map
3hduA 4 0.9677 99.9 0.418 Contact Map
3gekA 3 0.7677 99.9 0.422 Contact Map
1t82A 2 0.871 99.9 0.423 Contact Map
1sh8A 2 0.8516 99.9 0.424 Contact Map
1vh5A 2 0.8839 99.9 0.433 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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