GREMLIN Database
YIGB - Flavin mononucleotide phosphatase YigB
UniProt: P0ADP0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11202
Length: 238 (200)
Sequences: 26232 (20853)
Seq/√Len: 1474.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_S182_E4.2631.00
171_L175_K2.9571.00
142_E147_G2.8471.00
161_R165_F2.8241.00
197_A204_A2.6811.00
12_A178_V2.5981.00
119_H123_K2.5011.00
123_K149_Y2.4451.00
130_P151_E2.3921.00
10_I203_Q2.3821.00
187_G193_D2.3411.00
173_A183_I2.2391.00
171_L174_E2.2371.00
161_R167_D2.2211.00
132_V152_F2.2121.00
134_I168_M2.1571.00
38_F100_A2.1261.00
139_A158_P2.1011.00
198_I225_H2.0851.00
152_F175_K2.0651.00
229_S233_S1.9921.00
194_V204_A1.9571.00
13_L129_W1.9431.00
34_E104_N1.9291.00
15_F131_L1.9191.00
195_G199_R1.9131.00
203_Q225_H1.8681.00
126_A151_E1.8241.00
184_L205_C1.7901.00
173_A202_M1.7841.00
14_T185_H1.7551.00
179_P182_E1.7501.00
185_H197_A1.7111.00
124_Q128_K1.6971.00
14_T134_I1.6961.00
126_A149_Y1.6941.00
10_I184_L1.6511.00
12_A176_L1.6491.00
118_T231_L1.6181.00
178_V183_I1.6051.00
14_T172_A1.5831.00
173_A180_I1.5801.00
131_L150_F1.5361.00
13_L186_V1.5161.00
208_R229_S1.5031.00
132_V176_L1.4661.00
115_P209_P1.4451.00
39_V100_A1.4341.00
13_L125_L1.4211.00
205_C228_I1.4141.00
20_T186_V1.3641.00
17_L22_Y1.3631.00
205_C226_L1.3351.00
74_R78_R1.3301.00
78_R81_E1.2961.00
21_L118_T1.2941.00
208_R227_E1.2931.00
104_N107_K1.2771.00
121_T231_L1.2771.00
17_L133_A1.2751.00
230_R233_S1.2691.00
96_A100_A1.2681.00
124_Q127_K1.2641.00
100_A104_N1.2511.00
38_F104_N1.2491.00
166_S170_F1.2351.00
154_L175_K1.2311.00
117_Q120_D1.2301.00
154_L172_A1.2301.00
34_E38_F1.2241.00
169_Y196_G1.2231.00
169_Y185_H1.2011.00
98_A102_M1.1921.00
183_I202_M1.1801.00
30_R108_W1.1691.00
53_D56_R1.1571.00
14_T183_I1.1561.00
100_A103_I1.1301.00
169_Y202_M1.1221.00
35_A39_V1.1211.00
134_I172_A1.1191.00
167_D171_L1.1151.00
37_T43_H1.1141.00
114_V146_L1.1111.00
126_A131_L1.1071.00
12_A183_I1.0971.00
99_H103_I1.0951.00
12_A130_P1.0931.00
120_D232_A1.0891.00
139_A155_R1.0761.00
78_R82_Q1.0751.00
104_N108_W1.0481.00
145_G148_D1.0451.00
34_E37_T1.0441.00
170_F200_S1.0431.00
17_L137_G1.0391.00
194_V224_P1.0381.00
75_W79_S1.0251.00
123_K127_K1.0191.00
198_I204_A1.0191.00
18_D24_N1.0061.00
30_R34_E1.0021.00
170_F174_E0.9901.00
119_H149_Y0.9891.00
167_D170_F0.9881.00
18_D137_G0.9861.00
135_T155_R0.9841.00
34_E108_W0.9721.00
185_H202_M0.9621.00
170_F180_I0.9601.00
172_A176_L0.9591.00
122_L150_F0.9541.00
114_V119_H0.9461.00
33_R37_T0.9371.00
154_L171_L0.9361.00
101_A105_F0.9301.00
203_Q226_L0.9291.00
103_I107_K0.9281.00
117_Q230_R0.9261.00
71_D74_R0.9211.00
169_Y187_G0.9161.00
30_R33_R0.9051.00
12_A132_V0.9031.00
139_A157_G0.9011.00
71_D75_W0.9001.00
93_E96_A0.8981.00
95_S99_H0.8981.00
14_T176_L0.8881.00
133_A150_F0.8861.00
30_R111_R0.8851.00
54_L57_L0.8831.00
125_L129_W0.8821.00
155_R158_P0.8801.00
36_L41_N0.8751.00
180_I202_M0.8681.00
192_T195_G0.8671.00
120_D123_K0.8631.00
115_P207_I0.8601.00
152_F176_L0.8581.00
123_K148_D0.8571.00
98_A101_A0.8521.00
160_G167_D0.8501.00
97_G101_A0.8501.00
178_V182_E0.8421.00
198_I223_L0.8411.00
75_W78_R0.8411.00
18_D135_T0.8401.00
29_L33_R0.8391.00
186_V205_C0.8331.00
184_L203_Q0.8281.00
228_I234_L0.8241.00
14_T202_M0.8211.00
205_C234_L0.8041.00
81_E85_L0.8041.00
189_D192_T0.8041.00
125_L131_L0.8031.00
10_I129_W0.8001.00
77_F81_E0.7991.00
76_R79_S0.7981.00
72_V75_W0.7971.00
204_A225_H0.7931.00
11_S129_W0.7891.00
159_H171_L0.7881.00
194_V206_W0.7881.00
82_Q85_L0.7841.00
99_H102_M0.7841.00
132_V172_A0.7761.00
117_Q232_A0.7721.00
219_D223_L0.7671.00
168_M172_A0.7611.00
119_H145_G0.7591.00
90_S93_E0.7541.00
75_W80_I0.7531.00
206_W227_E0.7511.00
75_W83_A0.7461.00
84_M87_A0.7451.00
115_P118_T0.7431.00
219_D222_L0.7381.00
136_N162_S0.7341.00
122_L149_Y0.7341.00
209_P231_L0.7321.00
53_D86_D0.7321.00
120_D124_Q0.7291.00
196_G200_S0.7241.00
10_I182_E0.7201.00
130_P178_V0.7201.00
11_S178_V0.7181.00
14_T132_V0.7121.00
169_Y193_D0.7101.00
158_P175_K0.7091.00
28_I32_E0.7081.00
131_L149_Y0.7081.00
19_D25_R0.7021.00
131_L151_E0.6981.00
74_R77_F0.6961.00
33_R44_P0.6941.00
22_Y144_F0.6921.00
195_G198_I0.6881.00
26_P113_D0.6871.00
13_L184_L0.6851.00
73_T77_F0.6761.00
31_T35_A0.6751.00
11_S130_P0.6711.00
218_W221_R0.6701.00
97_G100_A0.6611.00
27_V112_I0.6591.00
136_N192_T0.6561.00
154_L168_M0.6551.00
23_D26_P0.6531.00
80_I83_A0.6531.00
33_R45_A0.6521.00
168_M196_G0.6471.00
121_T186_V0.6461.00
72_V83_A0.6451.00
119_H148_D0.6421.00
22_Y112_I0.6401.00
152_F172_A0.6381.00
185_H193_D0.6371.00
74_R79_S0.6291.00
102_M106_A0.6281.00
150_F153_V0.6261.00
23_D113_D0.6261.00
134_I185_H0.6231.00
118_T122_L0.6231.00
117_Q121_T0.6231.00
73_T79_S0.6211.00
53_D57_L0.6171.00
159_H168_M0.6171.00
186_V234_L0.6141.00
18_D188_D0.6131.00
173_A178_V0.6091.00
96_A99_H0.6061.00
141_P147_G0.6051.00
37_T42_Y0.6041.00
39_V96_A0.6021.00
71_D79_S0.6011.00
228_I231_L0.5991.00
92_E96_A0.5991.00
185_H196_G0.5971.00
20_T207_I0.5971.00
118_T121_T0.5941.00
108_W111_R0.5931.00
180_I183_I0.5931.00
166_S199_R0.5921.00
173_A200_S0.5911.00
152_F155_R0.5901.00
72_V76_R0.5891.00
76_R80_I0.5881.00
82_Q86_D0.5881.00
73_T83_A0.5861.00
43_H46_L0.5831.00
73_T76_R0.5821.00
173_A179_P0.5801.00
192_T196_G0.5791.00
121_T125_L0.5741.00
106_A140_Q0.5721.00
26_P30_R0.5711.00
23_D115_P0.5691.00
28_I137_G0.5691.00
74_R82_Q0.5661.00
35_A100_A0.5641.00
80_I84_M0.5631.00
121_T124_Q0.5621.00
123_K126_A0.5601.00
24_N137_G0.5561.00
31_T104_N0.5551.00
114_V144_F0.5521.00
117_Q209_P0.5511.00
33_R43_H0.5511.00
170_F173_A0.5501.00
17_L135_T0.5481.00
116_Q232_A0.5471.00
126_A148_D0.5471.00
14_T169_Y0.5461.00
101_A104_N0.5451.00
142_E148_D0.5431.00
206_W219_D0.5411.00
28_I101_A0.5401.00
15_F121_T0.5381.00
85_L88_G0.5351.00
169_Y197_A0.5341.00
39_V97_G0.5331.00
21_L133_A0.5311.00
20_T193_D0.5291.00
103_I106_A0.5281.00
13_L131_L0.5271.00
134_I154_L0.5271.00
136_N164_P0.5261.00
121_T228_I0.5231.00
73_T78_R0.5231.00
156_A168_M0.5181.00
10_I13_L0.5171.00
207_I231_L0.5161.00
116_Q230_R0.5161.00
195_G223_L0.5141.00
35_A97_G0.5141.00
122_L131_L0.5071.00
141_P144_F0.5051.00
206_W224_P0.5001.00
89_L92_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vayA 2 0.9496 100 0.313 Contact Map
3ed5A 1 0.9286 100 0.33 Contact Map
4uw9A 1 0.8193 100 0.339 Contact Map
2om6A 2 0.9244 100 0.343 Contact Map
3umbA 2 0.9202 100 0.348 Contact Map
3smvA 1 0.9286 100 0.349 Contact Map
3qnmA 1 0.9286 100 0.351 Contact Map
3l5kA 1 0.8908 100 0.354 Contact Map
3s6jA 2 0.8697 100 0.356 Contact Map
1te2A 2 0.8739 100 0.356 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0083 seconds.