GREMLIN Database
VIAA - Protein ViaA
UniProt: P0ADN0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11730
Length: 483 (447)
Sequences: 334 (236)
Seq/√Len: 11.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_S292_T5.4121.00
396_A428_P4.3811.00
406_L444_H3.4890.98
406_L416_A3.1170.96
61_L76_C2.8810.93
448_A463_F2.8220.93
407_Q434_K2.7720.92
406_L409_R2.7530.92
398_C416_A2.7240.91
321_P414_A2.7230.91
293_Y398_C2.6540.90
404_E434_K2.6020.89
420_S467_W2.5880.89
395_L418_V2.5700.88
422_F463_F2.5680.88
255_L289_Q2.5310.88
271_T284_R2.4710.86
254_G325_C2.3960.84
132_W422_F2.3200.82
384_F394_D2.3170.82
277_L337_E2.3140.82
264_L288_K2.2850.81
348_M364_S2.2840.81
216_A347_L2.2760.81
281_F361_M2.2710.81
337_E384_F2.2440.80
415_D421_D2.2220.80
396_A449_V2.1750.78
326_V384_F2.1150.76
136_L398_C2.0690.74
416_A444_H2.0520.74
341_K345_L2.0470.73
340_A384_F1.9770.71
163_M189_G1.9730.71
385_L388_Q1.9630.70
159_V404_E1.9500.70
431_V435_V1.9350.69
411_W469_F1.9080.68
395_L422_F1.8760.67
416_A446_F1.8730.66
260_D399_F1.8700.66
327_D331_S1.8430.65
220_G331_S1.8430.65
220_G327_D1.8430.65
320_G331_S1.8430.65
220_G320_G1.8430.65
320_G327_D1.8430.65
137_I364_S1.8160.64
254_G332_M1.7890.63
216_A350_I1.7810.62
403_M438_L1.7710.62
73_E277_L1.7620.61
339_C417_V1.7230.60
182_R445_R1.6680.57
429_D432_T1.6620.57
328_T345_L1.6540.56
281_F285_L1.6540.56
258_S361_M1.6520.56
181_G185_D1.6500.56
94_Q168_Q1.6440.56
211_E214_R1.6230.55
320_G329_S1.6220.55
220_G329_S1.6220.55
285_L353_A1.6210.55
291_L372_L1.6170.55
132_W446_F1.6140.54
169_L322_F1.6110.54
402_I416_A1.6020.54
269_L296_H1.5920.53
102_L215_L1.5880.53
327_D415_D1.5520.51
331_S415_D1.5520.51
327_D421_D1.5520.51
331_S421_D1.5520.51
320_G421_D1.5520.51
220_G415_D1.5520.51
320_G415_D1.5520.51
220_G421_D1.5520.51
344_C402_I1.5500.51
385_L389_F1.5450.51
127_L136_L1.5370.51
341_K385_L1.5270.50
342_A345_L1.5170.50
439_Q449_V1.5100.49
423_I463_F1.5070.49
293_Y297_G1.5060.49
259_D353_A1.4950.49
422_F467_W1.4930.49
364_S384_F1.4780.48
323_I405_R1.4750.48
252_V361_M1.4700.48
221_R294_R1.4630.47
148_L252_V1.4600.47
106_W132_W1.4570.47
212_L347_L1.4560.47
297_G347_L1.4490.46
393_T399_F1.4490.46
391_G415_D1.4370.46
391_G421_D1.4370.46
323_I440_R1.4340.46
176_N261_I1.4310.46
214_R419_I1.4290.46
401_A404_E1.4250.45
235_M238_F1.4050.44
132_W463_F1.4050.44
28_A58_R1.4040.44
349_R411_W1.4010.44
385_L467_W1.3990.44
322_F460_M1.3910.44
266_P330_G1.3900.44
139_Q206_L1.3880.44
161_E285_L1.3810.43
264_L269_L1.3740.43
210_P371_E1.3630.42
321_P356_R1.3610.42
332_M340_A1.3520.42
262_L269_L1.3480.42
263_R293_Y1.3460.42
332_M384_F1.3450.42
418_V423_I1.3430.41
258_S261_I1.3410.41
176_N419_I1.3390.41
184_W346_A1.3370.41
329_S421_D1.3300.41
329_S415_D1.3300.41
206_L297_G1.3290.41
328_T332_M1.3290.41
249_P280_E1.3280.41
42_L63_D1.3240.41
320_G356_R1.3240.41
220_G356_R1.3240.41
331_S356_R1.3240.41
327_D356_R1.3240.41
218_Q326_V1.3220.40
219_L447_H1.3220.40
278_E282_Y1.3080.40
268_E363_F1.2990.39
274_I284_R1.2980.39
278_E463_F1.2970.39
196_Y200_V1.2950.39
220_G268_E1.2910.39
268_E327_D1.2910.39
268_E320_G1.2910.39
268_E331_S1.2910.39
291_L297_G1.2890.39
448_A467_W1.2820.39
348_M399_F1.2650.38
265_L321_P1.2620.38
293_Y424_A1.2590.38
293_Y395_L1.2570.37
94_Q265_L1.2540.37
266_P332_M1.2530.37
108_E215_L1.2480.37
290_L337_E1.2460.37
216_A346_A1.2430.37
287_E345_L1.2420.37
334_G389_F1.2420.37
270_A427_L1.2340.36
185_D385_L1.2300.36
326_V445_R1.2280.36
128_F136_L1.2270.36
281_F467_W1.2230.36
61_L92_L1.2190.36
400_R434_K1.2160.36
132_W420_S1.2090.35
334_G337_E1.2080.35
216_A276_E1.1990.35
114_V404_E1.1990.35
281_F347_L1.1950.35
254_G384_F1.1930.35
284_R345_L1.1920.35
321_P334_G1.1900.34
396_A439_Q1.1870.34
79_Q430_D1.1860.34
351_A420_S1.1860.34
354_E449_V1.1810.34
199_I384_F1.1730.34
290_L328_T1.1700.34
394_D403_M1.1690.34
256_Q289_Q1.1650.33
446_F463_F1.1620.33
358_C385_L1.1580.33
203_G346_A1.1510.33
319_R350_I1.1450.33
422_F448_A1.1440.32
281_F331_S1.1430.32
220_G281_F1.1430.32
281_F320_G1.1430.32
281_F327_D1.1430.32
106_W215_L1.1420.32
272_L337_E1.1400.32
35_F411_W1.1390.32
360_I396_A1.1250.32
239_R312_K1.1250.32
328_T384_F1.1220.32
46_I435_V1.1210.32
62_K71_T1.1190.31
112_Q153_E1.1180.31
100_H146_Q1.1170.31
398_C451_M1.1080.31
252_V422_F1.1020.31
130_Q273_G1.1020.31
195_D286_V1.1000.31
235_M307_R1.0940.30
329_S356_R1.0900.30
206_L344_C1.0900.30
295_L342_A1.0900.30
339_C451_M1.0850.30
196_Y406_L1.0820.30
336_N343_F1.0820.30
398_C420_S1.0780.30
118_S255_L1.0760.30
271_T277_L1.0710.29
315_D438_L1.0690.29
356_R414_A1.0680.29
263_R398_C1.0660.29
429_D433_S1.0610.29
324_V398_C1.0530.29
268_E329_S1.0510.29
320_G332_M1.0490.29
327_D332_M1.0490.29
220_G332_M1.0490.29
385_L420_S1.0490.29
203_G361_M1.0470.29
290_L334_G1.0440.28
289_Q359_Y1.0420.28
56_A80_S1.0410.28
245_P251_Q1.0410.28
341_K392_G1.0390.28
202_Y398_C1.0380.28
260_D449_V1.0350.28
331_S363_F1.0340.28
320_G363_F1.0340.28
327_D363_F1.0340.28
220_G363_F1.0340.28
356_R415_D1.0330.28
356_R421_D1.0330.28
52_R453_A1.0280.28
163_M412_F1.0210.28
221_R445_R1.0150.27
21_E24_I1.0090.27
283_R466_I1.0050.27
157_S451_M1.0050.27
264_L292_T1.0030.27
297_G392_G1.0030.27
216_A444_H1.0000.27
268_E421_D1.0000.27
268_E415_D1.0000.27
113_L380_Q0.9980.27
204_E403_M0.9870.26
30_P34_V0.9840.26
183_L467_W0.9840.26
255_L412_F0.9830.26
135_S382_I0.9830.26
336_N411_W0.9810.26
213_K416_A0.9790.26
202_Y346_A0.9740.26
248_V364_S0.9710.26
341_K389_F0.9650.25
306_E312_K0.9640.25
199_I349_R0.9560.25
423_I452_S0.9520.25
199_I385_L0.9510.25
360_I364_S0.9490.25
295_L298_E0.9400.24
132_W358_C0.9390.24
321_P358_C0.9360.24
35_F38_K0.9360.24
221_R347_L0.9350.24
223_R439_Q0.9350.24
30_P36_F0.9300.24
295_L360_I0.9290.24
109_Q412_F0.9280.24
257_Q361_M0.9270.24
366_E412_F0.9260.24
393_T415_D0.9250.24
393_T421_D0.9250.24
276_E322_F0.9250.24
324_V344_C0.9220.24
173_L383_R0.9160.24
250_E297_G0.9160.24
126_T199_I0.9130.24
394_D420_S0.9110.23
164_T264_L0.9070.23
337_E389_F0.9060.23
139_Q204_E0.9040.23
156_L420_S0.9040.23
424_A452_S0.9030.23
182_R326_V0.9030.23
260_D353_A0.9020.23
96_L348_M0.9010.23
119_T433_S0.9000.23
378_I465_H0.9000.23
422_F446_F0.9000.23
389_F469_F0.9000.23
105_P112_Q0.8990.23
399_F418_V0.8980.23
251_Q425_Q0.8930.23
326_V344_C0.8920.23
205_F444_H0.8890.23
261_I291_L0.8870.23
30_P40_P0.8870.23
326_V371_E0.8870.23
342_A372_L0.8850.23
337_E341_K0.8840.23
159_V221_R0.8830.23
342_A459_I0.8830.23
422_F450_A0.8800.22
153_E325_C0.8770.22
263_R295_L0.8770.22
217_E383_R0.8760.22
282_Y362_L0.8750.22
203_G445_R0.8730.22
420_S471_T0.8700.22
201_K407_Q0.8680.22
281_F329_S0.8660.22
179_A273_G0.8650.22
296_H439_Q0.8580.22
227_S347_L0.8550.22
101_R223_R0.8510.21
278_E423_I0.8490.21
270_A288_K0.8480.21
27_L32_L0.8460.21
235_M311_H0.8450.21
249_P284_R0.8440.21
221_R424_A0.8430.21
418_V422_F0.8410.21
83_L89_I0.8390.21
215_L225_A0.8390.21
193_R207_N0.8390.21
48_D52_R0.8380.21
58_R61_L0.8380.21
261_I290_L0.8370.21
254_G364_S0.8360.21
36_F261_I0.8320.21
136_L464_D0.8310.21
49_D382_I0.8300.21
392_G421_D0.8290.21
392_G415_D0.8290.21
242_V315_D0.8290.21
259_D262_L0.8280.21
109_Q204_E0.8280.21
104_S117_N0.8250.21
290_L389_F0.8240.21
288_K360_I0.8240.21
418_V463_F0.8200.20
288_K438_L0.8200.20
110_A113_L0.8190.20
148_L265_L0.8190.20
327_D391_G0.8150.20
331_S391_G0.8150.20
320_G391_G0.8150.20
220_G391_G0.8150.20
204_E382_I0.8140.20
230_R349_R0.8140.20
254_G323_I0.8110.20
128_F322_F0.8110.20
94_Q100_H0.8110.20
152_R422_F0.8100.20
305_I376_Q0.8090.20
194_G372_L0.8070.20
339_C424_A0.8060.20
23_I270_A0.8050.20
212_L221_R0.8050.20
260_D466_I0.8020.20
255_L330_G0.8020.20
281_F415_D0.8010.20
281_F421_D0.8010.20
150_E400_R0.8010.20
218_Q270_A0.8010.20
239_R275_T0.7990.20
325_C347_L0.7970.20
98_L451_M0.7960.20
329_S332_M0.7950.20
254_G337_E0.7940.20
262_L398_C0.7910.20
324_V343_F0.7910.20
163_M231_N0.7880.19
403_M434_K0.7870.19
408_S430_D0.7870.19
75_M404_E0.7850.19
326_V419_I0.7840.19
329_S363_F0.7840.19
324_V375_P0.7820.19
398_C422_F0.7820.19
326_V335_F0.7820.19
277_L384_F0.7800.19
389_F394_D0.7800.19
284_R349_R0.7790.19
347_L351_A0.7790.19
347_L361_M0.7770.19
269_L298_E0.7720.19
72_E153_E0.7700.19
161_E264_L0.7690.19
361_M367_I0.7690.19
213_K360_I0.7660.19
22_M37_E0.7640.19
396_A417_V0.7630.19
237_T310_V0.7610.19
108_E112_Q0.7600.19
92_L96_L0.7600.19
446_F467_W0.7600.19
395_L424_A0.7590.19
87_Q436_K0.7590.19
120_I124_L0.7590.19
266_P451_M0.7560.19
381_A384_F0.7560.19
332_M415_D0.7550.18
332_M421_D0.7550.18
38_K212_L0.7530.18
358_C371_E0.7500.18
322_F346_A0.7490.18
447_H465_H0.7490.18
88_F91_Q0.7470.18
204_E207_N0.7450.18
283_R456_K0.7450.18
283_R346_A0.7440.18
281_F363_F0.7430.18
363_F421_D0.7410.18
363_F415_D0.7410.18
216_A362_L0.7410.18
235_M241_M0.7400.18
73_E77_Y0.7400.18
358_C447_H0.7400.18
268_E356_R0.7370.18
362_L398_C0.7350.18
294_R452_S0.7340.18
224_E312_K0.7310.18
185_D372_L0.7310.18
321_P332_M0.7290.18
131_R138_V0.7270.18
326_V412_F0.7260.18
73_E99_L0.7240.18
258_S352_L0.7220.18
263_R274_I0.7180.17
240_T313_D0.7150.17
194_G432_T0.7130.17
420_S444_H0.7120.17
341_K384_F0.7120.17
95_I111_R0.7090.17
266_P328_T0.7050.17
420_S463_F0.7020.17
272_L352_L0.7020.17
217_E439_Q0.7010.17
191_L370_Y0.7000.17
186_M324_V0.7000.17
118_S408_S0.7000.17
283_R411_W0.7000.17
284_R371_E0.6990.17
223_R242_V0.6990.17
196_Y252_V0.6980.17
88_F99_L0.6940.17
259_D360_I0.6930.17
101_R119_T0.6930.17
235_M306_E0.6910.17
70_L73_E0.6910.17
278_E352_L0.6910.17
324_V412_F0.6910.17
238_F313_D0.6910.17
122_S126_T0.6910.17
344_C452_S0.6900.17
67_P73_E0.6890.17
195_D406_L0.6870.17
132_W136_L0.6860.17
328_T337_E0.6850.17
255_L461_R0.6800.16
207_N403_M0.6790.16
360_I394_D0.6780.16
252_V290_L0.6760.16
35_F40_P0.6740.16
119_T122_S0.6740.16
90_V94_Q0.6730.16
47_T72_E0.6710.16
68_P94_Q0.6710.16
238_F243_R0.6700.16
203_G357_R0.6690.16
153_E399_F0.6690.16
228_I276_E0.6690.16
85_T275_T0.6680.16
95_I463_F0.6660.16
325_C358_C0.6650.16
444_H463_F0.6650.16
413_D445_R0.6640.16
203_G299_S0.6630.16
414_A421_D0.6630.16
254_G359_Y0.6630.16
37_E319_R0.6620.16
249_P398_C0.6610.16
251_Q271_T0.6580.16
434_K437_E0.6570.16
213_K330_G0.6570.16
149_E153_E0.6540.16
242_V310_V0.6530.16
298_E338_Q0.6520.16
240_T308_P0.6520.16
94_Q122_S0.6500.16
24_I34_V0.6500.16
398_C446_F0.6500.16
433_S437_E0.6490.16
297_G342_A0.6480.16
56_A68_P0.6470.16
243_R326_V0.6460.16
109_Q232_D0.6450.15
395_L402_I0.6430.15
283_R322_F0.6430.15
172_I260_D0.6420.15
157_S204_E0.6420.15
160_Q261_I0.6410.15
272_L290_L0.6400.15
397_S403_M0.6360.15
83_L267_P0.6350.15
191_L366_E0.6350.15
77_Y128_F0.6330.15
203_G242_V0.6320.15
27_L36_F0.6300.15
151_E439_Q0.6300.15
51_P139_Q0.6300.15
104_S420_S0.6290.15
123_A419_I0.6280.15
120_I449_V0.6280.15
262_L287_E0.6280.15
384_F389_F0.6280.15
449_V458_G0.6270.15
219_L358_C0.6260.15
280_E283_R0.6250.15
39_F46_I0.6250.15
90_V101_R0.6250.15
418_V462_I0.6220.15
219_L463_F0.6220.15
230_R419_I0.6210.15
290_L356_R0.6200.15
256_Q448_A0.6190.15
112_Q117_N0.6190.15
252_V262_L0.6170.15
285_L352_L0.6160.15
114_V417_V0.6160.15
116_A429_D0.6150.15
226_K280_E0.6120.15
206_L457_P0.6120.15
281_F393_T0.6100.15
100_H112_Q0.6090.15
40_P43_K0.6070.15
258_S285_L0.6060.15
297_G365_T0.6060.15
397_S469_F0.6030.14
100_H434_K0.6030.14
293_Y362_L0.5990.14
53_W377_G0.5980.14
289_Q374_G0.5970.14
219_L420_S0.5950.14
137_I145_Q0.5920.14
222_S242_V0.5910.14
199_I394_D0.5900.14
259_D288_K0.5890.14
258_S431_V0.5870.14
324_V330_G0.5870.14
448_A454_H0.5870.14
67_P75_M0.5850.14
53_W422_F0.5830.14
280_E290_L0.5830.14
335_F451_M0.5820.14
114_V117_N0.5820.14
58_R71_T0.5810.14
280_E362_L0.5810.14
37_E404_E0.5810.14
243_R349_R0.5800.14
339_C343_F0.5790.14
463_F467_W0.5790.14
24_I27_L0.5790.14
293_Y447_H0.5780.14
265_L323_I0.5770.14
395_L405_R0.5770.14
288_K403_M0.5760.14
424_A448_A0.5750.14
94_Q404_E0.5750.14
186_M319_R0.5740.14
87_Q433_S0.5730.14
238_F311_H0.5720.14
134_L138_V0.5710.14
184_W202_Y0.5700.14
137_I178_T0.5700.14
306_E310_V0.5700.14
297_G459_I0.5700.14
290_L342_A0.5680.14
329_S391_G0.5670.14
109_Q146_Q0.5660.14
269_L325_C0.5650.14
92_L186_M0.5650.14
118_S406_L0.5640.14
340_A389_F0.5630.14
208_E410_E0.5620.13
357_R390_R0.5620.13
138_V192_K0.5620.13
272_L389_F0.5610.13
257_Q343_F0.5610.13
208_E404_E0.5600.13
166_S417_V0.5600.13
215_L343_F0.5590.13
174_A213_K0.5560.13
106_W276_E0.5560.13
81_Q145_Q0.5560.13
219_L422_F0.5550.13
297_G377_G0.5550.13
286_V451_M0.5520.13
181_G385_L0.5520.13
109_Q239_R0.5510.13
87_Q190_Q0.5510.13
239_R242_V0.5510.13
435_V447_H0.5510.13
157_S214_R0.5510.13
252_V463_F0.5500.13
136_L143_L0.5490.13
62_K65_R0.5490.13
95_I184_W0.5470.13
449_V469_F0.5470.13
169_L403_M0.5450.13
219_L384_F0.5440.13
254_G328_T0.5440.13
59_S63_D0.5420.13
79_Q432_T0.5410.13
62_K199_I0.5400.13
413_D443_Q0.5390.13
104_S128_F0.5380.13
224_E317_Q0.5380.13
225_A416_A0.5380.13
386_S414_A0.5340.13
42_L403_M0.5330.13
25_A461_R0.5310.13
156_L445_R0.5310.13
157_S191_L0.5310.13
97_D306_E0.5300.13
109_Q432_T0.5300.13
281_F356_R0.5290.13
320_G393_T0.5290.13
331_S393_T0.5290.13
220_G393_T0.5290.13
297_G372_L0.5290.13
327_D393_T0.5290.13
103_N115_D0.5280.13
134_L137_I0.5280.13
73_E384_F0.5270.13
203_G206_L0.5260.13
145_Q212_L0.5260.13
201_K440_R0.5250.13
231_N310_V0.5240.13
172_I277_L0.5240.13
306_E442_H0.5230.13
274_I279_Y0.5230.13
287_E389_F0.5220.13
278_E446_F0.5210.13
422_F444_H0.5200.13
394_D467_W0.5180.13
272_L341_K0.5180.13
58_R80_S0.5150.12
282_Y346_A0.5140.12
332_M362_L0.5110.12
148_L335_F0.5100.12
188_A265_L0.5100.12
398_C444_H0.5090.12
236_E294_R0.5070.12
237_T313_D0.5040.12
155_L293_Y0.5040.12
240_T305_I0.5040.12
212_L408_S0.5030.12
37_E75_M0.5030.12
171_P233_A0.5030.12
121_T125_H0.5020.12
452_S456_K0.5020.12
146_Q430_D0.5020.12
76_C350_I0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x31A 2 0.3437 99.7 0.863 Contact Map
1n3yA 1 0.3416 99.6 0.873 Contact Map
1q0pA 1 0.3188 99.6 0.874 Contact Map
1mf7A 1 0.3478 99.6 0.876 Contact Map
4rckA 2 0.3354 99.6 0.876 Contact Map
4jduA 1 0.3271 99.6 0.877 Contact Map
1ijbA 1 0.3644 99.5 0.878 Contact Map
4hqoA 1 0.3727 99.5 0.879 Contact Map
4f1jA 1 0.3478 99.5 0.879 Contact Map
4okrA 1 0.3292 99.5 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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