GREMLIN Database
YIEE - Uncharacterized protein YieE
UniProt: P0ADM8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11722
Length: 249 (193)
Sequences: 1190 (1015)
Seq/√Len: 73.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_S98_E4.1301.00
124_S167_Q3.4641.00
69_K79_S3.2641.00
147_L168_L3.2241.00
92_A99_C3.1971.00
90_G101_L3.0191.00
90_G195_W2.8891.00
24_C43_R2.7851.00
39_F43_R2.5521.00
181_N188_D2.4231.00
152_L163_P2.2861.00
63_V71_V2.2381.00
152_L157_D2.0731.00
49_L93_L2.0661.00
60_P72_F2.0421.00
92_A197_V2.0361.00
150_S198_A2.0211.00
181_N185_A2.0201.00
50_M80_F2.0001.00
85_A104_E1.9761.00
181_N187_C1.9681.00
35_R38_R1.9421.00
28_A39_F1.9401.00
24_C39_F1.9111.00
123_F166_L1.9081.00
31_I35_R1.8771.00
126_N167_Q1.8571.00
119_D128_S1.8061.00
69_K98_E1.7561.00
154_L181_N1.7491.00
51_F60_P1.7231.00
140_A144_L1.6971.00
45_L89_V1.6921.00
104_E146_T1.6861.00
127_E148_R1.6761.00
152_L159_L1.6461.00
134_Q137_P1.6401.00
51_F58_E1.6230.99
28_A40_L1.6210.99
162_D166_L1.4960.99
24_C47_A1.4890.99
54_Y60_P1.4850.99
119_D122_T1.4660.99
147_L185_A1.4560.99
147_L196_S1.4450.99
42_S89_V1.4300.99
146_T196_S1.4280.99
17_S29_R1.4200.99
120_N128_S1.4090.99
49_L91_V1.3980.98
183_V186_L1.3940.98
88_M190_E1.3890.98
145_I158_V1.3850.98
152_L161_D1.3750.98
24_C51_F1.3590.98
118_P152_L1.3540.98
26_Q30_N1.3420.98
92_A101_L1.3410.98
34_H38_R1.3370.98
38_R87_N1.3340.98
190_E193_L1.3100.98
35_R89_V1.2890.97
21_P47_A1.2780.97
82_I91_V1.2680.97
45_L91_V1.2550.97
152_L166_L1.2330.97
122_T163_P1.2140.96
131_I144_L1.1990.96
56_I60_P1.1970.96
20_L39_F1.1970.96
130_W140_A1.1940.96
27_E39_F1.1850.96
83_S90_G1.1820.96
43_R82_I1.1790.96
38_R86_G1.1760.95
144_L147_L1.1720.95
161_D165_D1.1620.95
94_T99_C1.1490.95
138_N142_A1.1180.94
47_A51_F1.1170.94
41_A89_V1.1110.94
130_W144_L1.1050.94
118_P141_R1.1040.94
106_Q142_A1.1030.94
159_L163_P1.0990.93
47_A58_E1.0800.93
185_A188_D1.0730.93
63_V73_S1.0410.92
107_R142_A1.0360.91
86_G105_L1.0250.91
159_L162_D1.0230.91
54_Y72_F1.0210.91
21_P43_R1.0200.91
118_P123_F1.0160.90
103_M193_L1.0130.90
17_S25_H1.0080.90
51_F54_Y1.0050.90
20_L24_C0.9950.90
143_Q194_V0.9780.89
119_D131_I0.9720.88
106_Q194_V0.9710.88
103_M133_K0.9660.88
61_E73_S0.9640.88
46_L82_I0.9630.88
123_F163_P0.9630.88
35_R86_G0.9620.88
28_A31_I0.9590.88
32_P35_R0.9490.87
104_E119_D0.9340.86
145_I149_R0.9340.86
47_A60_P0.9320.86
120_N132_S0.9190.85
53_L78_P0.9140.85
69_K80_F0.9110.85
45_L90_G0.8970.84
183_V188_D0.8970.84
43_R64_T0.8960.84
38_R85_A0.8890.84
181_N186_L0.8830.83
113_H137_P0.8830.83
46_L89_V0.8820.83
122_T166_L0.8760.83
102_D149_R0.8740.82
111_G117_A0.8650.82
22_S25_H0.8560.81
30_N81_S0.8510.81
24_C58_E0.8450.80
17_S28_A0.8450.80
98_E200_T0.8450.80
140_A143_Q0.8440.80
28_A150_S0.8410.80
81_S101_L0.8370.80
152_L162_D0.8370.80
16_I40_L0.8260.79
27_E64_T0.8230.79
151_V155_T0.8210.78
147_L183_V0.8200.78
129_L133_K0.8160.78
141_R145_I0.8160.78
143_Q185_A0.8120.78
78_P87_N0.8100.77
124_S177_C0.8070.77
22_S26_Q0.7960.76
50_M93_L0.7940.76
147_L151_V0.7920.76
72_F196_S0.7910.76
43_R46_L0.7870.75
131_I140_A0.7790.75
46_L80_F0.7770.74
24_C199_V0.7770.74
144_L168_L0.7730.74
161_D166_L0.7730.74
20_L40_L0.7660.73
39_F198_A0.7660.73
20_L36_Q0.7650.73
104_E122_T0.7650.73
12_E16_I0.7620.73
147_L167_Q0.7580.73
147_L150_S0.7480.72
34_H86_G0.7470.72
151_V198_A0.7450.71
117_A121_H0.7450.71
26_Q69_K0.7440.71
186_L195_W0.7240.69
127_E159_L0.7130.68
43_R47_A0.7120.68
79_S94_T0.7110.68
84_Y141_R0.7070.67
50_M60_P0.7070.67
151_V168_L0.7050.67
150_S195_W0.7030.67
53_L181_N0.7020.67
177_C180_V0.7010.67
156_G159_L0.7000.67
142_A194_V0.6990.66
122_T164_R0.6990.66
85_A146_T0.6970.66
16_I45_L0.6970.66
157_D160_N0.6970.66
50_M170_P0.6950.66
99_C106_Q0.6940.66
154_L158_V0.6910.66
46_L91_V0.6880.65
20_L43_R0.6870.65
46_L85_A0.6860.65
14_H17_S0.6860.65
28_A47_A0.6820.65
59_L125_S0.6770.64
147_L195_W0.6750.64
80_F91_V0.6730.63
50_M78_P0.6710.63
11_T164_R0.6700.63
65_L71_V0.6690.63
157_D161_D0.6650.63
94_T199_V0.6650.63
100_G153_K0.6620.62
125_S129_L0.6610.62
78_P136_D0.6580.62
184_E188_D0.6580.62
97_G200_T0.6530.61
72_F101_L0.6500.61
17_S44_G0.6490.61
122_T128_S0.6480.61
125_S164_R0.6430.60
16_I19_R0.6430.60
152_L158_V0.6410.60
139_E194_V0.6400.60
83_S149_R0.6390.59
39_F42_S0.6380.59
173_G176_K0.6370.59
39_F104_E0.6340.59
62_I69_K0.6300.58
80_F141_R0.6280.58
79_S96_E0.6270.58
51_F131_I0.6260.58
123_F141_R0.6260.58
81_S84_Y0.6250.58
128_S132_S0.6170.57
48_E52_M0.6160.57
55_G59_L0.6160.57
101_L195_W0.6140.56
85_A141_R0.6120.56
50_M62_I0.6120.56
69_K81_S0.6050.55
88_M103_M0.6040.55
84_Y102_D0.6040.55
85_A105_L0.6020.55
18_V62_I0.5990.55
136_D139_E0.5980.55
65_L160_N0.5980.55
155_T161_D0.5970.54
141_R149_R0.5940.54
25_H29_R0.5880.53
93_L196_S0.5860.53
123_F151_V0.5820.53
62_I72_F0.5810.52
105_L192_V0.5810.52
81_S142_A0.5770.52
67_K160_N0.5760.52
28_A46_L0.5760.52
57_G73_S0.5760.52
65_L98_E0.5740.52
27_E36_Q0.5740.52
51_F150_S0.5720.51
108_A121_H0.5710.51
40_L45_L0.5670.51
151_V163_P0.5660.51
21_P24_C0.5610.50
79_S97_G0.5600.50
178_A181_N0.5600.50
65_L166_L0.5580.50
133_K179_H0.5560.49
167_Q198_A0.5550.49
47_A50_M0.5530.49
130_W152_L0.5510.49
187_C190_E0.5490.48
142_A163_P0.5490.48
43_R150_S0.5490.48
24_C27_E0.5490.48
119_D123_F0.5470.48
107_R133_K0.5460.48
84_Y149_R0.5440.48
49_L94_T0.5430.48
95_T129_L0.5410.47
75_K196_S0.5380.47
176_K202_T0.5370.47
62_I163_P0.5370.47
149_R158_V0.5350.47
88_M193_L0.5350.47
47_A148_R0.5330.46
78_P165_D0.5310.46
183_V197_V0.5310.46
121_H151_V0.5300.46
35_R159_L0.5290.46
51_F195_W0.5290.46
128_S131_I0.5280.46
46_L104_E0.5280.46
39_F82_I0.5240.45
46_L64_T0.5220.45
42_S46_L0.5200.45
148_R158_V0.5180.45
35_R43_R0.5180.45
168_L183_V0.5180.45
31_I66_P0.5170.45
152_L160_N0.5160.44
141_R163_P0.5090.44
60_P148_R0.5040.43
111_G142_A0.5040.43
123_F128_S0.5030.43
54_Y63_V0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qr0A 2 0.8594 100 0.392 Contact Map
2c43A 1 0.8835 100 0.396 Contact Map
4qvhA 2 0.7671 100 0.532 Contact Map
4qjkA 1 0.7711 100 0.539 Contact Map
4jm7A 3 0.49 99.9 0.664 Contact Map
2wasA 3 0.4096 99.6 0.742 Contact Map
2wdsA 3 0.4257 99.6 0.748 Contact Map
3hykA 3 0.4297 99.6 0.749 Contact Map
3qmnA 4 0.4378 99.6 0.753 Contact Map
1fthA 3 0.4297 99.6 0.753 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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