GREMLIN Database
YIDH - Inner membrane protein YidH
UniProt: P0ADM0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11696
Length: 115 (107)
Sequences: 538 (396)
Seq/√Len: 38.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_A86_D3.9091.00
36_G60_C3.7971.00
12_Y81_M2.7581.00
12_Y41_Q2.6871.00
7_G78_E2.6241.00
10_P82_R2.4241.00
8_E84_K2.3711.00
35_A100_L2.3481.00
6_L83_L2.0980.99
62_F99_I2.0220.99
32_F62_F1.9880.99
50_V54_L1.8950.98
33_L63_S1.8800.98
31_G70_G1.8050.97
39_L43_A1.7350.97
69_Y73_R1.6190.95
80_A88_P1.5950.95
12_Y90_T1.5790.94
40_D56_A1.5550.94
64_G104_A1.5550.94
38_G62_F1.5390.94
84_K98_L1.5210.93
7_G10_P1.4480.91
68_M98_L1.4350.91
15_S73_R1.4330.91
98_L108_M1.3650.89
42_L54_L1.3630.89
24_A27_R1.3380.88
75_L79_K1.3340.87
70_G81_M1.3290.87
6_L53_E1.3110.87
55_L110_L1.2850.85
9_A87_L1.2700.85
71_Y93_L1.2690.85
53_E57_L1.2420.83
12_Y93_L1.2330.83
10_P18_N1.2050.81
15_S69_Y1.1990.81
35_A105_V1.1930.81
77_N81_M1.1720.80
31_G63_S1.1710.80
54_L85_E1.1650.79
9_A82_R1.1270.77
90_T93_L1.1170.76
29_A48_T1.0970.75
90_T99_I1.0820.74
38_G100_L1.0790.74
22_F52_R1.0650.73
8_E76_R1.0640.73
78_E82_R1.0610.72
7_G70_G1.0490.72
73_R77_N1.0400.71
58_L99_I1.0100.69
45_D110_L0.9900.67
36_G67_A0.9850.67
18_N82_R0.9650.65
70_G92_S0.9570.64
72_L76_R0.9450.63
56_A94_L0.9250.62
51_I108_M0.9100.60
43_A46_F0.9100.60
55_L95_I0.9090.60
48_T103_V0.9070.60
18_N22_F0.9010.60
37_V67_A0.9010.60
58_L97_S0.8980.59
12_Y77_N0.8890.59
100_L103_V0.8760.58
45_D111_V0.8710.57
49_P80_A0.8550.56
34_A63_S0.8500.55
9_A105_V0.8490.55
57_L62_F0.8490.55
38_G52_R0.8480.55
41_Q44_P0.8390.54
43_A108_M0.8360.54
34_A37_V0.8290.53
18_N87_L0.8220.53
97_S104_A0.8210.53
30_L73_R0.8190.52
69_Y92_S0.8180.52
41_Q81_M0.8030.51
38_G79_K0.7960.50
62_F91_N0.7950.50
81_M90_T0.7920.50
42_L107_V0.7860.49
15_S30_L0.7840.49
66_L92_S0.7480.46
42_L96_I0.7440.46
10_P78_E0.7280.44
27_R34_A0.7260.44
70_G99_I0.7250.44
32_F43_A0.7170.43
15_S93_L0.7170.43
44_P91_N0.7130.43
15_S75_L0.7080.43
55_L107_V0.7070.42
8_E95_I0.7040.42
36_G56_A0.6910.41
77_N93_L0.6890.41
6_L54_L0.6880.41
95_I112_L0.6810.40
61_L98_L0.6790.40
38_G45_D0.6740.40
58_L108_M0.6710.39
31_G78_E0.6700.39
15_S63_S0.6670.39
79_K99_I0.6620.39
53_E61_L0.6570.38
36_G94_L0.6550.38
35_A62_F0.6530.38
41_Q78_E0.6520.38
15_S47_A0.6460.37
41_Q56_A0.6460.37
44_P110_L0.6400.37
40_D71_Y0.6390.37
57_L96_I0.6380.37
50_V103_V0.6370.36
60_C111_V0.6370.36
6_L33_L0.6350.36
39_L62_F0.6340.36
12_Y18_N0.6300.36
72_L111_V0.6270.36
38_G97_S0.6260.36
18_N81_M0.6160.35
64_G67_A0.6110.34
87_L111_V0.6090.34
11_D74_W0.6080.34
65_G112_L0.6070.34
72_L91_N0.6050.34
7_G83_L0.6010.34
15_S77_N0.6000.33
40_D93_L0.5990.33
6_L105_V0.5970.33
39_L110_L0.5960.33
37_V47_A0.5950.33
72_L106_I0.5940.33
12_Y43_A0.5930.33
101_M112_L0.5900.33
44_P90_T0.5870.32
45_D81_M0.5830.32
18_N78_E0.5830.32
50_V106_I0.5780.32
57_L95_I0.5780.32
66_L96_I0.5760.32
59_L107_V0.5750.32
33_L73_R0.5700.31
33_L55_L0.5670.31
15_S78_E0.5660.31
42_L47_A0.5640.31
44_P106_I0.5590.30
47_A109_G0.5530.30
11_D18_N0.5470.29
102_V105_V0.5460.29
83_L105_V0.5390.29
12_Y47_A0.5310.28
40_D78_E0.5190.27
57_L103_V0.5090.27
6_L100_L0.5010.26
13_R17_A0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1zP 8 0.9739 8.2 0.945 Contact Map
3h90A 3 0.9565 5 0.95 Contact Map
2w3zA 1 0 4.9 0.95 Contact Map
3v6tA 1 0.3391 4.5 0.951 Contact Map
2wdqC 1 0.2783 3.5 0.954 Contact Map
2m20A 2 0.4435 3.3 0.954 Contact Map
1x6vB 2 0.313 2.6 0.957 Contact Map
1ee8A 2 0.3391 2.5 0.957 Contact Map
4p02B 1 0.4696 2.4 0.958 Contact Map
2mkvA 1 0.3826 2.4 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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