GREMLIN Database
YIAW - Inner membrane protein YiaW
UniProt: P0ADK4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12291
Length: 107 (101)
Sequences: 134 (67)
Seq/√Len: 6.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_H44_I3.5790.91
97_Q102_K3.3820.89
46_V67_T3.3290.88
90_R95_E3.0880.84
13_F17_V3.0830.83
2_F6_F2.9320.80
4_D31_L2.3520.63
86_Q89_Q2.1010.54
46_V69_Y2.0630.52
37_N57_V2.0460.52
19_F68_L1.8740.45
37_N71_P1.7760.42
69_Y84_V1.7760.42
70_R73_R1.7380.40
61_F64_I1.7140.39
13_F77_M1.6190.36
3_L8_L1.5240.33
83_S88_Q1.5240.33
90_R101_I1.4250.30
82_S93_G1.4130.29
13_F61_F1.4110.29
31_L72_E1.3950.29
11_L70_R1.3690.28
95_E99_A1.3610.28
11_L72_E1.3360.27
90_R102_K1.3100.26
86_Q101_I1.2830.25
7_A54_T1.2780.25
25_L56_H1.2640.25
98_L101_I1.2520.25
87_L98_L1.2260.24
23_I45_H1.1990.23
57_V100_D1.1940.23
24_I95_E1.1890.23
15_F96_K1.1510.22
95_E101_I1.1500.22
12_I96_K1.1210.21
10_V24_I1.1190.21
19_F54_T1.1180.21
21_G87_L1.1120.21
87_L90_R1.1070.21
45_H68_L1.1030.21
79_S99_A1.0680.20
69_Y80_H1.0640.20
95_E102_K1.0530.20
58_I91_I1.0500.19
46_V50_V1.0190.19
54_T74_G1.0100.19
71_P77_M1.0100.19
6_F9_G1.0050.18
71_P85_M1.0040.18
7_A74_G0.9990.18
31_L45_H0.9850.18
82_S89_Q0.9340.17
97_Q100_D0.9330.17
15_F77_M0.9280.17
37_N68_L0.9280.17
41_A77_M0.9160.16
81_D85_M0.9150.16
80_H84_V0.9040.16
50_V58_I0.8980.16
69_Y88_Q0.8920.16
91_I94_L0.8850.16
40_H50_V0.8780.16
81_D88_Q0.8730.16
10_V17_V0.8660.15
9_G80_H0.8580.15
18_I23_I0.8570.15
14_V28_I0.8550.15
42_D74_G0.8530.15
11_L73_R0.8430.15
22_I97_Q0.8390.15
19_F23_I0.8360.15
26_H48_G0.8230.15
27_D48_G0.8230.15
46_V83_S0.8190.15
69_Y83_S0.8130.14
53_F57_V0.8120.14
15_F25_L0.8080.14
78_Q91_I0.8060.14
81_D90_R0.8010.14
34_K67_T0.8010.14
79_S89_Q0.7970.14
41_A57_V0.7790.14
22_I54_T0.7780.14
84_V87_L0.7780.14
15_F41_A0.7710.14
14_V34_K0.7630.14
6_F10_V0.7620.14
50_V72_E0.7480.13
19_F74_G0.7350.13
54_T73_R0.7290.13
83_S89_Q0.7270.13
90_R97_Q0.7190.13
42_D67_T0.7180.13
46_V82_S0.7150.13
93_G102_K0.7120.13
58_I99_A0.7090.13
22_I74_G0.7030.13
73_R76_G0.6880.12
10_V96_K0.6870.12
96_K100_D0.6860.12
24_I41_A0.6820.12
46_V80_H0.6810.12
31_L68_L0.6790.12
23_I28_I0.6780.12
40_H79_S0.6760.12
81_D93_G0.6740.12
57_V90_R0.6650.12
30_Y63_W0.6640.12
81_D86_Q0.6550.12
32_I42_D0.6530.12
58_I72_E0.6510.12
61_F69_Y0.6450.12
14_V62_L0.6420.12
19_F67_T0.6410.12
69_Y89_Q0.6400.12
84_V88_Q0.6390.12
15_F58_I0.6290.11
16_L90_R0.6240.11
6_F22_I0.6200.11
2_F13_F0.6170.11
84_V101_I0.6090.11
54_T68_L0.6060.11
25_L79_S0.6060.11
17_V100_D0.6040.11
23_I48_G0.5990.11
86_Q99_A0.5970.11
40_H71_P0.5880.11
57_V81_D0.5820.11
10_V15_F0.5810.11
10_V13_F0.5690.11
4_D15_F0.5650.10
28_I45_H0.5630.10
4_D41_A0.5570.10
93_G98_L0.5560.10
27_D56_H0.5500.10
26_H56_H0.5500.10
31_L71_P0.5430.10
6_F83_S0.5420.10
99_A102_K0.5390.10
58_I64_I0.5380.10
78_Q83_S0.5340.10
40_H83_S0.5300.10
26_H45_H0.5250.10
27_D45_H0.5250.10
17_V77_M0.5130.10
57_V78_Q0.5100.10
94_L98_L0.5080.10
15_F35_K0.5010.10
18_I81_D0.5000.10
24_I99_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kd8A 1 0.2336 46.9 0.94 Contact Map
2akfA 3 0.2897 42.9 0.941 Contact Map
3w92A 3 0.2897 41.3 0.941 Contact Map
4dznA 3 0.243 40.2 0.942 Contact Map
1kd8B 1 0.2336 34.8 0.944 Contact Map
3viqB 1 0.3084 34.7 0.944 Contact Map
2wq1A 3 0.2336 30.1 0.946 Contact Map
2pnvA 5 0.2804 29.3 0.946 Contact Map
3rvyA 3 0.2523 28.5 0.946 Contact Map
3cveA 4 0.2804 28.1 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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