GREMLIN Database
YIAA - Inner membrane protein YiaA
UniProt: P0ADJ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11186
Length: 145 (129)
Sequences: 172 (106)
Seq/√Len: 9.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_L82_V4.9181.00
49_V85_I4.9041.00
33_N101_L3.6530.97
22_G112_F3.1950.94
36_M99_L2.5400.82
57_S75_Y2.4050.79
47_V111_F2.3550.77
45_F49_V2.1190.69
53_F79_C1.9880.64
14_I117_G1.9480.62
6_S85_I1.9370.62
50_L55_A1.8730.59
28_L55_A1.8570.58
21_V111_F1.8340.57
12_F120_A1.8280.57
39_N43_Y1.8260.57
7_T125_I1.7950.55
91_M108_G1.5670.45
14_I77_M1.5270.44
46_A50_L1.5090.43
32_W107_Y1.5030.43
114_S117_G1.4780.41
55_A83_F1.4560.41
81_T85_I1.4430.40
68_G72_T1.4430.40
16_S120_A1.4400.40
36_M48_L1.3880.38
109_L113_L1.3750.37
56_A72_T1.3510.36
36_M107_Y1.3190.35
119_V125_I1.3150.35
13_S128_A1.3030.34
19_A72_T1.2840.33
101_L108_G1.2820.33
83_F87_V1.2610.33
55_A73_S1.2610.33
12_F16_S1.2430.32
81_T84_I1.2240.31
43_Y76_Y1.1970.30
58_Y79_C1.1970.30
19_A113_L1.1960.30
20_L121_V1.1890.30
15_V27_Y1.1480.28
26_T109_L1.1470.28
28_L83_F1.1440.28
46_A49_V1.1400.28
47_V87_V1.1340.28
108_G113_L1.1170.27
26_T112_F1.1140.27
36_M74_I1.0990.27
50_L81_T1.0990.27
28_L79_C1.0980.27
58_Y125_I1.0950.26
9_S114_S1.0940.26
8_Y78_T1.0780.26
45_F76_Y1.0720.26
72_T120_A1.0700.26
76_Y125_I1.0580.25
71_T77_M1.0380.25
13_S125_I1.0340.24
41_K97_A1.0230.24
65_K92_V1.0190.24
25_V37_Q1.0160.24
112_F117_G1.0150.24
12_F92_V1.0140.24
73_S86_S1.0070.24
54_S130_I0.9990.23
53_F82_V0.9970.23
50_L78_T0.9910.23
78_T82_V0.9880.23
58_Y83_F0.9730.22
34_A43_Y0.9650.22
33_N109_L0.9500.22
90_L121_V0.9460.22
54_S86_S0.9360.21
8_Y100_L0.9360.21
17_W72_T0.9350.21
58_Y73_S0.9320.21
53_F120_A0.9290.21
8_Y80_L0.9220.21
82_V86_S0.9080.21
13_S71_T0.9080.21
20_L56_A0.9020.20
88_A95_W0.9000.20
56_A90_L0.8960.20
79_C125_I0.8950.20
39_N89_L0.8950.20
36_M57_S0.8880.20
80_L116_F0.8860.20
61_T88_A0.8840.20
65_K101_L0.8800.20
31_L34_A0.8730.20
71_T80_L0.8710.19
55_A82_V0.8610.19
76_Y117_G0.8610.19
8_Y67_E0.8500.19
50_L109_L0.8420.19
38_L89_L0.8380.19
18_I95_W0.8360.19
83_F129_G0.8300.18
8_Y117_G0.8110.18
10_P18_I0.8090.18
84_I99_L0.8060.18
48_L51_G0.8050.18
74_I84_I0.8010.18
12_F17_W0.7980.18
12_F95_W0.7980.18
119_V128_A0.7960.17
10_P14_I0.7960.17
89_L113_L0.7870.17
9_S125_I0.7830.17
81_T125_I0.7750.17
73_S114_S0.7740.17
6_S108_G0.7710.17
18_I22_G0.7580.17
15_V120_A0.7560.16
9_S24_I0.7560.16
21_V88_A0.7470.16
70_P110_A0.7460.16
5_I131_N0.7330.16
78_T112_F0.7280.16
84_I119_V0.7270.16
66_Y110_A0.7210.16
65_K120_A0.7210.16
21_V33_N0.7200.16
27_Y83_F0.7140.15
61_T71_T0.7090.15
98_T108_G0.7080.15
70_P91_M0.7030.15
109_L125_I0.6990.15
65_K85_I0.6980.15
6_S87_V0.6930.15
112_F120_A0.6920.15
61_T65_K0.6850.15
110_A115_L0.6810.15
17_W32_W0.6760.15
110_A130_I0.6690.14
25_V29_L0.6640.14
53_F90_L0.6610.14
16_S27_Y0.6540.14
11_A62_V0.6530.14
25_V28_L0.6520.14
27_Y43_Y0.6520.14
24_I47_V0.6490.14
9_S90_L0.6480.14
91_M132_P0.6470.14
43_Y69_I0.6420.14
41_K100_L0.6320.14
69_I79_C0.6290.14
9_S109_L0.6210.13
88_A91_M0.6160.13
62_V113_L0.6130.13
7_T118_A0.6100.13
32_W45_F0.6080.13
35_E86_S0.5960.13
78_T86_S0.5960.13
87_V91_M0.5920.13
6_S49_V0.5920.13
41_K107_Y0.5920.13
12_F62_V0.5880.13
14_I98_T0.5880.13
20_L107_Y0.5850.13
24_I81_T0.5850.13
31_L107_Y0.5850.13
34_A128_A0.5790.13
61_T81_T0.5780.13
9_S70_P0.5720.12
24_I91_M0.5720.12
76_Y84_I0.5710.12
21_V86_S0.5680.12
39_N118_A0.5630.12
65_K110_A0.5600.12
77_M107_Y0.5590.12
82_V111_F0.5580.12
47_V85_I0.5540.12
33_N114_S0.5480.12
23_G57_S0.5420.12
9_S117_G0.5380.12
56_A100_L0.5370.12
78_T84_I0.5370.12
89_L97_A0.5360.12
35_E129_G0.5350.12
49_V109_L0.5320.12
14_I95_W0.5310.12
50_L88_A0.5280.12
86_S133_P0.5280.12
29_L133_P0.5190.11
65_K73_S0.5170.11
10_P88_A0.5140.11
108_G121_V0.5120.11
9_S130_I0.5110.11
69_I132_P0.5030.11
13_S17_W0.5020.11
44_Y58_Y0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b4rA 2 0.4069 21 0.958 Contact Map
4ikvA 1 0.8621 14.7 0.961 Contact Map
2i68A 2 0.5241 11.4 0.963 Contact Map
3m73A 3 0.8828 6.7 0.967 Contact Map
1x9bA 1 0.1586 6.2 0.967 Contact Map
1d2dA 1 0.2138 4.2 0.97 Contact Map
1jb0X 1 0.2 3.5 0.971 Contact Map
4av3A 2 0.7724 3.5 0.971 Contact Map
4p6vB 1 0.4345 3.4 0.971 Contact Map
2cfqA 1 0.8828 3.4 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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