GREMLIN Database
YHHN - Uncharacterized membrane protein YhhN
UniProt: P0ADI9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12214
Length: 208 (193)
Sequences: 1236 (958)
Seq/√Len: 68.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_S86_S7.8941.00
90_Y199_H4.7621.00
143_V169_F4.4531.00
84_F138_M4.0151.00
175_W191_A2.9521.00
69_T79_A2.8711.00
55_V93_Y2.5921.00
167_L197_A2.5751.00
32_P70_L2.5731.00
68_L82_A2.5701.00
34_T196_F2.4201.00
80_I84_F2.3891.00
64_L82_A2.2751.00
161_A205_S2.2131.00
174_V190_I2.2001.00
61_A85_L2.1431.00
142_M165_A2.0471.00
15_S30_F2.0241.00
51_I205_S1.9981.00
139_T165_A1.9881.00
51_I93_Y1.9741.00
87_H175_W1.9651.00
35_L38_L1.9541.00
164_G202_I1.9471.00
32_P67_A1.8961.00
31_K69_T1.8551.00
194_C198_G1.8511.00
7_A37_L1.7841.00
80_I180_Y1.7511.00
88_L92_I1.7391.00
85_L89_L1.6801.00
79_A172_N1.6160.99
39_L63_L1.6130.99
54_L92_I1.5850.99
31_K79_A1.5710.99
57_A89_L1.5550.99
200_F204_R1.5440.99
34_T192_A1.5330.99
170_I194_C1.5250.99
95_A145_L1.4870.99
28_W70_L1.4550.99
80_I132_I1.4450.98
15_S192_A1.4380.98
12_A196_F1.4340.98
12_A15_S1.4200.98
87_H91_T1.3950.98
65_G82_A1.3890.98
87_H138_M1.3770.98
38_L191_A1.3740.98
191_A194_C1.3650.98
118_L133_C1.3420.98
135_F168_L1.3260.97
68_L78_Y1.3040.97
135_F172_N1.2830.97
113_L173_F1.2700.97
110_L143_V1.2660.96
58_G93_Y1.2320.96
136_I139_T1.2300.96
36_L196_F1.2270.96
8_V38_L1.2270.96
160_S204_R1.2210.96
114_G140_L1.2210.96
34_T63_L1.2150.96
62_S87_H1.2030.95
83_F135_F1.2030.95
94_F142_M1.1960.95
36_L63_L1.1960.95
8_V12_A1.1940.95
117_L173_F1.1940.95
91_T141_V1.1880.95
143_V165_A1.1630.94
35_L192_A1.1470.94
11_S30_F1.1420.94
11_S34_T1.1230.93
62_S199_H1.1180.93
38_L203_V1.1020.93
178_S183_R1.0910.92
139_T142_M1.0710.91
15_S19_S1.0690.91
118_L122_W1.0690.91
127_E131_P1.0600.91
8_V15_S1.0590.91
76_L80_I1.0310.90
80_I131_P1.0240.89
69_T76_L1.0230.89
79_A171_S1.0170.89
122_W125_L1.0140.89
65_G83_F1.0080.89
168_L172_N1.0050.89
110_L140_L0.9930.88
8_V192_A0.9930.88
192_A196_F0.9910.88
140_L143_V0.9760.87
60_C64_L0.9710.87
144_W205_S0.9700.87
30_F34_T0.9670.87
92_I96_S0.9540.86
16_V196_F0.9520.86
35_L196_F0.9490.86
79_A135_F0.9490.86
35_L203_V0.9490.86
147_G162_F0.9410.85
87_H172_N0.9380.85
61_A64_L0.9370.85
83_F195_Y0.9310.84
202_I205_S0.9220.84
61_A65_G0.9160.84
175_W180_Y0.9110.83
146_A165_A0.9080.83
11_S15_S0.9050.83
35_L199_H0.9040.83
38_L205_S0.9000.82
139_T176_L0.8960.82
69_T87_H0.8880.82
178_S187_D0.8840.81
35_L63_L0.8830.81
58_G90_Y0.8830.81
161_A202_I0.8820.81
69_T172_N0.8790.81
8_V34_T0.8720.80
9_C13_W0.8630.80
77_M129_R0.8620.80
69_T82_A0.8610.80
55_V58_G0.8580.79
76_L176_L0.8570.79
83_F172_N0.8530.79
178_S184_F0.8480.78
55_V202_I0.8430.78
61_A89_L0.8400.78
15_S27_R0.8290.77
58_G202_I0.8140.76
7_A14_L0.8110.75
54_L93_Y0.8030.75
196_F205_S0.8010.74
61_A82_A0.7980.74
39_L56_L0.7980.74
175_W186_A0.7970.74
128_Y132_I0.7940.74
35_L90_Y0.7940.74
145_L148_E0.7920.74
187_D191_A0.7890.73
27_R32_P0.7790.72
80_I176_L0.7770.72
58_G89_L0.7760.72
76_L179_H0.7740.72
76_L139_T0.7680.71
122_W129_R0.7660.71
195_Y199_H0.7600.70
38_L42_A0.7580.70
87_H139_T0.7580.70
128_Y131_P0.7570.70
135_F195_Y0.7550.70
28_W32_P0.7490.69
65_G180_Y0.7440.69
114_G136_I0.7410.69
6_I13_W0.7400.68
131_P176_L0.7330.68
173_F194_C0.7280.67
44_Q108_L0.7260.67
166_S170_I0.7180.66
169_F198_G0.7180.66
167_L194_C0.7150.66
79_A168_L0.7120.65
18_A70_L0.7120.65
79_A87_H0.7070.65
160_S197_A0.6970.64
19_S27_R0.6970.64
58_G138_M0.6940.63
15_S70_L0.6900.63
5_F8_V0.6900.63
56_L177_G0.6880.63
139_T162_F0.6850.62
164_G205_S0.6810.62
26_Q33_L0.6770.62
52_S203_V0.6770.62
34_T38_L0.6730.61
91_T145_L0.6730.61
164_G198_G0.6680.61
124_R181_R0.6640.60
174_V191_A0.6630.60
6_I9_C0.6550.59
77_M131_P0.6550.59
83_F168_L0.6550.59
12_A19_S0.6540.59
42_A55_V0.6540.59
108_L163_V0.6520.59
39_L49_D0.6500.58
104_W107_P0.6500.58
62_S90_Y0.6490.58
18_A29_V0.6480.58
105_P109_V0.6470.58
47_M56_L0.6370.57
37_L40_L0.6370.57
66_D168_L0.6360.57
59_L90_Y0.6350.57
84_F131_P0.6350.57
121_I131_P0.6350.57
37_L191_A0.6340.57
58_G86_S0.6310.56
51_I206_L0.6310.56
148_E202_I0.6290.56
6_I10_L0.6260.56
79_A83_F0.6250.55
11_S37_L0.6230.55
92_I109_V0.6180.55
81_G115_A0.6180.55
31_K135_F0.6110.54
127_E134_T0.6100.54
83_F171_S0.6060.53
111_L170_I0.6050.53
69_T135_F0.6040.53
5_F13_W0.6030.53
62_S139_T0.6020.53
32_P63_L0.6000.53
130_W133_C0.6000.53
44_Q88_L0.6000.53
80_I139_T0.5990.52
35_L191_A0.5980.52
183_R187_D0.5980.52
14_L30_F0.5970.52
86_S138_M0.5960.52
30_F35_L0.5940.52
5_F14_L0.5930.52
15_S196_F0.5930.52
65_G69_T0.5910.51
11_S43_W0.5910.51
108_L115_A0.5900.51
144_W161_A0.5880.51
63_L196_F0.5860.51
185_R189_A0.5850.51
65_G199_H0.5830.50
15_S34_T0.5820.50
140_L173_F0.5810.50
103_F108_L0.5800.50
176_L180_Y0.5790.50
137_G141_V0.5780.50
179_H191_A0.5780.50
8_V13_W0.5760.50
42_A86_S0.5750.49
54_L89_L0.5700.49
43_W56_L0.5680.49
31_K172_N0.5670.49
66_D195_Y0.5660.48
34_T144_W0.5650.48
76_L142_M0.5650.48
51_I58_G0.5620.48
80_I87_H0.5610.48
169_F174_V0.5600.48
8_V205_S0.5570.47
61_A161_A0.5570.47
43_W46_P0.5470.46
15_S88_L0.5440.46
7_A22_G0.5440.46
81_G186_A0.5430.46
9_C18_A0.5430.46
109_V116_L0.5390.45
14_L159_L0.5380.45
132_I180_Y0.5380.45
30_F192_A0.5370.45
87_H174_V0.5350.45
91_T162_F0.5350.45
54_L58_G0.5340.45
90_Y176_L0.5320.44
84_F134_T0.5310.44
108_L117_L0.5300.44
34_T42_A0.5300.44
8_V196_F0.5280.44
76_L172_N0.5270.44
19_S193_A0.5210.43
58_G91_T0.5180.43
13_W96_S0.5170.43
87_H168_L0.5170.43
6_I115_A0.5170.43
45_A167_L0.5170.43
42_A192_A0.5170.43
92_I112_V0.5150.42
172_N199_H0.5140.42
62_S171_S0.5140.42
128_Y178_S0.5130.42
43_W53_Y0.5100.42
109_V118_L0.5100.42
44_Q106_L0.5100.42
105_P185_R0.5080.42
176_L198_G0.5060.41
70_L84_F0.5060.41
43_W116_L0.5060.41
198_G202_I0.5050.41
80_I179_H0.5030.41
57_A60_C0.5020.41
40_L54_L0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.3558 1.4 0.962 Contact Map
3m73A 3 0.5288 0.9 0.966 Contact Map
4tphA 2 0.7067 0.9 0.966 Contact Map
4jq6A 3 0.2596 0.9 0.966 Contact Map
4i7zE 1 0.1346 0.9 0.966 Contact Map
4q65A 1 0.7163 0.8 0.967 Contact Map
2l6wA 2 0.125 0.8 0.968 Contact Map
2a65A 2 0.2692 0.8 0.968 Contact Map
4knfA 3 0.2885 0.7 0.969 Contact Map
3b5dA 2 0.4567 0.7 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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