GREMLIN Database
YECD - Isochorismatase family protein YecD
UniProt: P0ADI7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12378
Length: 188 (166)
Sequences: 10066 (6951)
Seq/√Len: 539.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_E117_R3.3631.00
113_E147_F2.7431.00
55_R100_I2.7351.00
105_G141_N2.7331.00
123_T148_N2.7041.00
44_F49_Q2.5011.00
9_T123_T2.4671.00
37_A127_C2.3351.00
113_E145_L2.2651.00
16_L37_A2.2601.00
123_T150_V2.2531.00
40_L152_A2.2491.00
161_A165_N2.2271.00
126_L139_A2.2071.00
19_G83_W2.0801.00
8_T122_D2.0041.00
171_I176_A1.9511.00
111_D115_Q1.9201.00
10_A121_I1.8751.00
136_E140_R1.8191.00
142_A149_L1.7771.00
36_R39_K1.7601.00
99_I115_Q1.7591.00
36_R181_V1.7581.00
36_R155_A1.7401.00
106_A138_T1.7311.00
153_E178_V1.6941.00
43_K47_S1.6911.00
52_F115_Q1.6911.00
131_T164_H1.6771.00
153_E180_S1.6401.00
18_E88_A1.6331.00
9_T125_V1.5891.00
45_R96_D1.5841.00
21_L87_P1.5511.00
13_V41_A1.5151.00
154_D181_V1.4891.00
44_F125_V1.4721.00
97_I115_Q1.4691.00
124_I142_A1.4661.00
54_V106_A1.4641.00
125_V152_A1.4391.00
39_K182_E1.4281.00
13_V127_C1.4171.00
132_N158_A1.3751.00
126_L138_T1.3661.00
131_T156_C1.3521.00
38_G42_A1.3341.00
12_V126_L1.3301.00
29_T32_E1.3291.00
50_P119_R1.3291.00
135_V151_I1.3191.00
158_A164_H1.3161.00
136_E170_H1.3141.00
162_E165_N1.3071.00
131_T168_I1.3031.00
38_G89_A1.2871.00
115_Q119_R1.2471.00
42_A46_A1.2451.00
57_G84_W1.2401.00
165_N169_N1.2351.00
13_V16_L1.2301.00
14_I134_G1.2081.00
33_V37_A1.2051.00
117_R147_F1.2041.00
55_R86_H1.1931.00
151_I156_C1.1871.00
11_L44_F1.1841.00
114_L118_R1.1801.00
155_A181_V1.1761.00
35_N89_A1.1741.00
153_E168_I1.1731.00
13_V37_A1.1691.00
136_E167_S1.1591.00
141_N145_L1.1561.00
80_P100_I1.1311.00
156_C164_H1.0781.00
41_A45_R1.0751.00
36_R154_D1.0511.00
40_L155_A1.0431.00
57_G100_I1.0341.00
124_I149_L1.0291.00
111_D114_L1.0121.00
18_E85_Q1.0091.00
55_R98_E1.0091.00
125_V150_V1.0071.00
139_A151_I0.9901.00
148_N177_R0.9851.00
41_A53_L0.9781.00
79_L82_N0.9631.00
86_H98_E0.9601.00
137_S140_R0.9481.00
131_T158_A0.9451.00
85_Q91_G0.9451.00
18_E22_P0.9361.00
10_A52_F0.9321.00
139_A171_I0.9291.00
15_D101_K0.9271.00
43_K46_A0.9181.00
93_T96_D0.9141.00
9_T49_Q0.9141.00
38_G92_A0.9091.00
160_S163_Q0.9091.00
150_V177_R0.8941.00
162_E166_N0.8921.00
16_L129_I0.8871.00
164_H168_I0.8841.00
152_A179_R0.8721.00
53_L92_A0.8701.00
10_A116_L0.8681.00
108_Y145_L0.8621.00
39_K43_K0.8571.00
168_I178_V0.8531.00
122_D148_N0.8511.00
162_E169_N0.8501.00
115_Q118_R0.8501.00
107_F142_A0.8491.00
57_G80_P0.8481.00
39_K42_A0.8461.00
103_Q146_G0.8381.00
53_L86_H0.8331.00
150_V179_R0.8331.00
152_A155_A0.8281.00
59_S80_P0.8151.00
50_P121_I0.8121.00
12_V112_L0.8081.00
33_V157_S0.8051.00
40_L127_C0.8051.00
34_V38_G0.8051.00
8_T123_T0.8021.00
92_A96_D0.8021.00
106_A112_L0.7971.00
22_P25_G0.7771.00
20_I134_G0.7751.00
14_I126_L0.7701.00
116_L147_F0.7701.00
76_A79_L0.7661.00
127_C155_A0.7641.00
22_P31_D0.7631.00
40_L181_V0.7561.00
18_E87_P0.7521.00
78_V81_E0.7471.00
126_L135_V0.7431.00
53_L95_S0.7361.00
32_E35_N0.7341.00
97_I119_R0.7241.00
35_N39_K0.7231.00
129_I157_S0.7221.00
163_Q166_N0.7191.00
139_A176_A0.7131.00
169_N172_Y0.7131.00
50_P115_Q0.7121.00
34_V87_P0.7111.00
88_A91_G0.7101.00
41_A51_V0.7091.00
132_N170_H0.7051.00
52_F97_I0.7051.00
53_L96_D0.7021.00
53_L90_L0.6971.00
141_N144_E0.6951.00
42_A91_G0.6951.00
39_K181_V0.6941.00
16_L87_P0.6941.00
126_L149_L0.6921.00
167_S171_I0.6911.00
143_W176_A0.6881.00
52_F119_R0.6861.00
38_G91_G0.6801.00
78_V82_N0.6771.00
132_N159_A0.6731.00
132_N163_Q0.6721.00
33_V129_I0.6701.00
103_Q109_G0.6631.00
114_L117_R0.6601.00
130_S133_I0.6581.00
156_C168_I0.6521.00
137_S175_I0.6501.00
13_V53_L0.6491.00
166_N170_H0.6481.00
21_L34_V0.6471.00
37_A155_A0.6421.00
109_G114_L0.6281.00
42_A93_T0.6251.00
45_R51_V0.6241.00
87_P90_L0.6211.00
139_A149_L0.6191.00
11_L40_L0.6171.00
130_S158_A0.6171.00
28_H32_E0.6171.00
166_N169_N0.6161.00
45_R95_S0.6151.00
30_A129_I0.6151.00
35_N38_G0.6141.00
151_I168_I0.6131.00
45_R93_T0.6131.00
19_G78_V0.6091.00
169_N173_P0.6071.00
44_F50_P0.6061.00
92_A98_E0.6031.00
11_L51_V0.6021.00
52_F99_I0.6011.00
75_P78_V0.6011.00
11_L127_C0.5991.00
19_G25_G0.5991.00
55_R84_W0.5941.00
81_E85_Q0.5870.99
40_L125_V0.5830.99
28_H157_S0.5790.99
55_R85_Q0.5780.99
45_R53_L0.5770.99
108_Y144_E0.5760.99
149_L152_A0.5680.99
163_Q169_N0.5650.99
8_T120_G0.5640.99
59_S62_Y0.5640.99
34_V90_L0.5630.99
153_E164_H0.5630.99
16_L33_V0.5620.99
151_I171_I0.5600.99
105_G144_E0.5600.99
31_D89_A0.5580.99
104_W138_T0.5560.99
11_L41_A0.5540.99
41_A44_F0.5540.99
74_S104_W0.5520.99
53_L98_E0.5520.99
99_I111_D0.5440.99
21_L30_A0.5430.99
60_A76_A0.5420.99
72_A76_A0.5420.99
153_E172_Y0.5340.99
86_H92_A0.5310.99
72_A75_P0.5300.99
101_K134_G0.5290.99
41_A96_D0.5280.99
104_W144_E0.5240.99
135_V156_C0.5230.99
107_F110_T0.5230.99
27_P30_A0.5220.99
50_P96_D0.5190.99
130_S159_A0.5150.99
16_L90_L0.5140.99
40_L44_F0.5130.99
168_I172_Y0.5110.99
26_G31_D0.5090.99
108_Y141_N0.5070.99
140_R174_R0.5050.98
34_V89_A0.5010.98
17_Q54_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j2rA 4 0.9947 100 0.139 Contact Map
3txyA 2 0.9947 100 0.152 Contact Map
3kl2A 4 1 100 0.17 Contact Map
3hb7A 3 0.9574 100 0.171 Contact Map
2fq1A 2 0.9894 100 0.173 Contact Map
3irvA 2 0.9894 100 0.175 Contact Map
1nbaA 4 0.9947 100 0.185 Contact Map
4l07A 4 1 100 0.185 Contact Map
1nf9A 2 0.9734 100 0.186 Contact Map
3ot4A 4 1 100 0.187 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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