GREMLIN Database
ENTB - Isochorismatase
UniProt: P0ADI4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10260
Length: 285 (231)
Sequences: 7172 (6580)
Seq/√Len: 432.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_D266_M3.1191.00
137_M141_S3.0861.00
237_N240_D2.5941.00
214_S281_S2.3601.00
213_A216_A2.3161.00
148_I173_M2.3131.00
218_L255_W2.2241.00
235_D274_D2.2241.00
164_A168_D2.1981.00
132_S166_M2.1621.00
132_S136_Q2.1271.00
74_V78_A2.0551.00
143_R147_I2.0281.00
237_N271_P2.0191.00
221_V251_L2.0141.00
95_W98_G2.0061.00
115_D118_D2.0041.00
219_R273_I2.0011.00
256_R261_D1.9881.00
270_N279_L1.9691.00
149_T189_S1.9251.00
111_R115_D1.8631.00
224_P254_R1.8371.00
234_D273_I1.8291.00
70_H73_P1.8011.00
55_Q59_N1.7971.00
199_R202_M1.7941.00
119_T127_S1.7911.00
107_K111_R1.7851.00
131_R166_M1.7631.00
272_T275_A1.7621.00
50_C54_E1.7511.00
49_N52_M1.7321.00
222_I273_I1.7141.00
211_I234_D1.7051.00
119_T122_V1.7011.00
143_R169_I1.6531.00
108_V112_L1.6251.00
186_H189_S1.6161.00
217_A258_V1.5971.00
92_N95_W1.5901.00
73_P77_T1.5801.00
109_V112_L1.5601.00
163_D168_D1.5591.00
188_M192_Y1.5581.00
88_R91_L1.5461.00
265_V269_K1.5351.00
217_A220_E1.5351.00
175_A186_H1.5271.00
163_D167_R1.5261.00
229_S232_P1.5091.00
163_D166_M1.4951.00
122_V127_S1.4891.00
164_A167_R1.4821.00
91_L94_M1.4591.00
74_V77_T1.4581.00
212_P234_D1.4521.00
216_A220_E1.4411.00
134_L163_D1.4351.00
123_K157_C1.4281.00
90_L93_D1.3951.00
220_E258_V1.3891.00
199_R203_T1.3801.00
244_D247_R1.3691.00
266_M279_L1.3671.00
270_N275_A1.3591.00
61_A65_D1.3581.00
123_K126_Y1.3501.00
212_P216_A1.3441.00
90_L94_M1.3441.00
89_A93_D1.3411.00
211_I278_K1.3301.00
221_V255_W1.3281.00
211_I215_K1.3221.00
187_L191_K1.3141.00
215_K234_D1.2991.00
81_K85_D1.2951.00
172_F175_A1.2901.00
147_I169_I1.2881.00
111_R114_P1.2831.00
238_L243_L1.2761.00
222_I243_L1.2731.00
251_L267_L1.2651.00
185_E189_S1.2451.00
266_M269_K1.2341.00
88_R92_N1.2081.00
221_V254_R1.2031.00
77_T81_K1.1961.00
102_S110_D1.1891.00
219_R234_D1.1581.00
89_A92_N1.1581.00
189_S192_Y1.1571.00
134_L161_A1.1441.00
144_N147_I1.1431.00
126_Y130_H1.1351.00
109_V131_R1.1131.00
137_M140_E1.1081.00
84_S87_D1.1051.00
102_S106_Q1.0961.00
214_S217_A1.0921.00
108_V111_R1.0891.00
92_N96_G1.0881.00
249_M253_A1.0881.00
103_P106_Q1.0791.00
163_D169_I1.0711.00
134_L137_M1.0671.00
104_E107_K1.0651.00
94_M98_G1.0601.00
202_M206_L1.0581.00
211_I274_D1.0541.00
156_G160_T1.0451.00
177_A180_D1.0451.00
193_V196_R1.0351.00
228_E232_P1.0351.00
214_S280_L1.0291.00
176_D179_A1.0281.00
212_P281_S1.0221.00
189_S193_V1.0221.00
207_L210_P1.0211.00
78_A82_E1.0171.00
255_W260_G1.0121.00
78_A81_K1.0071.00
52_M55_Q0.9951.00
186_H192_Y0.9941.00
225_L251_L0.9931.00
89_A94_M0.9841.00
162_T166_M0.9831.00
73_P78_A0.9821.00
94_M97_P0.9811.00
121_L157_C0.9801.00
244_D264_F0.9761.00
185_E193_V0.9761.00
156_G159_T0.9731.00
60_I67_C0.9711.00
75_Y78_A0.9691.00
182_S185_E0.9681.00
104_E112_L0.9661.00
135_E138_L0.9651.00
223_L232_P0.9611.00
93_D96_G0.9611.00
252_A256_R0.9601.00
56_V59_N0.9581.00
185_E188_M0.9571.00
106_Q110_D0.9541.00
221_V258_V0.9531.00
54_E58_A0.9411.00
192_Y195_G0.9411.00
219_R233_F0.9401.00
91_L95_W0.9401.00
73_P76_Y0.9331.00
172_F176_D0.9321.00
188_M191_K0.9201.00
202_M210_P0.9191.00
72_I76_Y0.9181.00
106_Q109_V0.9171.00
218_L273_I0.9151.00
255_W262_I0.9141.00
76_Y80_P0.9111.00
157_C161_A0.9081.00
105_Q109_V0.9061.00
197_S202_M0.9031.00
247_R250_A0.9001.00
125_R129_F0.8931.00
83_Q87_D0.8931.00
193_V197_S0.8871.00
55_Q58_A0.8861.00
102_S107_K0.8791.00
175_A179_A0.8761.00
105_Q112_L0.8751.00
110_D114_P0.8741.00
254_R258_V0.8731.00
67_C78_A0.8701.00
158_M161_A0.8701.00
60_I64_R0.8681.00
95_W99_L0.8681.00
107_K112_L0.8671.00
164_A169_I0.8621.00
165_F168_D0.8601.00
218_L277_W0.8501.00
190_L193_V0.8471.00
249_M264_F0.8341.00
121_L160_T0.8341.00
255_W280_L0.8341.00
128_A157_C0.8281.00
266_M270_N0.8241.00
256_R260_G0.8171.00
188_M193_V0.8171.00
79_Q86_E0.8131.00
252_A267_L0.8131.00
250_A254_R0.8121.00
197_S200_V0.8111.00
56_V60_I0.8111.00
133_P137_M0.8091.00
162_T165_F0.8091.00
246_V249_M0.8081.00
251_L276_W0.8081.00
53_M56_V0.7971.00
136_Q139_K0.7951.00
192_Y196_R0.7931.00
68_K71_N0.7881.00
91_L96_G0.7871.00
204_E207_L0.7861.00
90_L95_W0.7751.00
202_M205_E0.7721.00
248_M264_F0.7701.00
104_E109_V0.7681.00
125_R130_H0.7681.00
179_A182_S0.7681.00
58_A62_A0.7661.00
234_D274_D0.7631.00
74_V79_Q0.7611.00
275_A278_K0.7521.00
126_Y157_C0.7511.00
189_S194_A0.7461.00
102_S105_Q0.7421.00
52_M59_N0.7421.00
72_I75_Y0.7401.00
218_L276_W0.7401.00
221_V224_P0.7321.00
248_M267_L0.7301.00
180_D183_R0.7251.00
176_D180_D0.7241.00
127_S130_H0.7221.00
184_D187_L0.7211.00
248_M252_A0.7191.00
203_T206_L0.7191.00
132_S139_K0.7161.00
57_I63_L0.7141.00
133_P136_Q0.7141.00
170_K174_V0.7101.00
62_A65_D0.7051.00
185_E195_G0.7021.00
244_D249_M0.7001.00
62_A66_Y0.6991.00
222_I276_W0.6981.00
170_K175_A0.6951.00
185_E194_A0.6951.00
145_Q170_K0.6931.00
244_D248_M0.6921.00
214_S277_W0.6911.00
119_T123_K0.6901.00
128_A161_A0.6851.00
239_I243_L0.6821.00
202_M207_L0.6821.00
79_Q85_D0.6821.00
260_G280_L0.6791.00
225_L247_R0.6791.00
148_I152_Y0.6791.00
49_N53_M0.6741.00
199_R208_P0.6731.00
143_R167_R0.6721.00
270_N278_K0.6721.00
75_Y79_Q0.6701.00
92_N98_G0.6671.00
212_P215_K0.6621.00
178_L182_S0.6591.00
218_L251_L0.6591.00
88_R94_M0.6591.00
65_D68_K0.6550.99
200_V203_T0.6540.99
185_E192_Y0.6530.99
198_G202_M0.6520.99
125_R128_A0.6520.99
70_H74_V0.6460.99
174_V177_A0.6440.99
100_T103_P0.6420.99
145_Q172_F0.6420.99
255_W266_M0.6410.99
58_A61_A0.6410.99
103_P109_V0.6370.99
205_E208_P0.6370.99
183_R187_L0.6360.99
60_I68_K0.6350.99
153_A159_T0.6340.99
67_C70_H0.6320.99
81_K86_E0.6320.99
53_M60_I0.6320.99
201_V204_E0.6270.99
183_R186_H0.6260.99
201_V207_L0.6260.99
175_A180_D0.6250.99
198_G201_V0.6240.99
67_C71_N0.6210.99
59_N85_D0.6190.99
239_I268_A0.6170.99
134_L138_L0.6160.99
66_Y69_Q0.6160.99
52_M67_C0.6150.99
77_T80_P0.6150.99
82_E87_D0.6120.99
59_N62_A0.6080.99
78_A85_D0.6070.99
96_G99_L0.6030.99
126_Y129_F0.6020.99
110_D113_T0.5990.99
79_Q83_Q0.5920.99
71_N78_A0.5900.99
79_Q82_E0.5890.99
101_R104_E0.5880.99
135_E163_D0.5850.99
250_A253_A0.5820.99
246_V264_F0.5820.99
252_A262_I0.5810.99
63_L67_C0.5810.99
56_V63_L0.5740.99
249_M265_V0.5700.99
172_F180_D0.5690.99
220_E224_P0.5670.99
103_P107_K0.5670.99
186_H195_G0.5670.99
269_K279_L0.5650.98
266_M276_W0.5650.98
204_E208_P0.5620.98
76_Y79_Q0.5600.98
164_A170_K0.5590.98
197_S201_V0.5580.98
104_E108_V0.5580.98
191_K195_G0.5570.98
172_F177_A0.5550.98
211_I281_S0.5540.98
174_V180_D0.5540.98
239_I267_L0.5520.98
199_R204_E0.5520.98
202_M209_A0.5480.98
94_M99_L0.5470.98
192_Y197_S0.5460.98
82_E85_D0.5450.98
104_E165_F0.5440.98
100_T105_Q0.5430.98
222_I251_L0.5370.98
105_Q108_V0.5320.98
248_M265_V0.5310.98
64_R67_C0.5280.98
213_A217_A0.5280.98
73_P80_P0.5250.98
186_H193_V0.5240.98
228_E233_F0.5230.98
74_V80_P0.5200.97
215_K273_I0.5140.97
88_R93_D0.5130.97
219_R223_L0.5120.97
79_Q84_S0.5110.97
202_M208_P0.5080.97
215_K274_D0.5060.97
109_V166_M0.5030.97
93_D98_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fq1A 2 0.9789 100 0.348 Contact Map
1nf9A 2 0.7228 99.9 0.639 Contact Map
3tg2A 2 0.7193 99.9 0.65 Contact Map
2jgpA 1 0.2842 99.7 0.693 Contact Map
3r2jA 2 0.6596 99.7 0.705 Contact Map
1im5A 1 0.607 99.7 0.707 Contact Map
3irvA 2 0.6947 99.7 0.707 Contact Map
4l07A 4 0.7228 99.7 0.711 Contact Map
3pl1A 1 0.607 99.7 0.712 Contact Map
3hb7A 3 0.6456 99.7 0.716 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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