GREMLIN Database
PINR - Putative DNA-invertase from lambdoid prophage Rac
UniProt: P0ADI0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13372
Length: 196 (177)
Sequences: 9691 (7193)
Seq/√Len: 540.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_G55_R3.2141.00
37_I59_R2.9731.00
163_R176_E2.7221.00
56_L66_L2.5541.00
39_E52_G2.5041.00
159_V180_S2.4201.00
8_C21_R2.3021.00
21_R25_E2.2231.00
6_A24_I2.1581.00
111_K126_D2.1521.00
159_V163_R2.1241.00
124_E131_R2.1051.00
21_R38_E1.9931.00
44_S125_R1.9551.00
138_R142_A1.9481.00
168_V176_E1.9321.00
79_M86_E1.8961.00
163_R168_V1.8621.00
171_S175_R1.8431.00
139_A144_K1.8351.00
78_A115_Q1.7991.00
22_R26_S1.7891.00
21_R36_I1.7481.00
176_E180_S1.7321.00
115_Q119_A1.7291.00
129_L133_H1.7041.00
112_M123_F1.6831.00
79_M83_K1.6611.00
82_R115_Q1.6541.00
81_I118_S1.6311.00
88_L93_I1.6301.00
122_E126_D1.6161.00
168_V172_A1.5911.00
164_I173_I1.5691.00
87_Q91_T1.5581.00
179_T184_I1.5541.00
89_T111_K1.5471.00
111_K122_E1.5181.00
85_V114_M1.5121.00
5_F59_R1.4961.00
107_S110_G1.4811.00
97_C101_G1.4451.00
60_L66_L1.4341.00
53_F84_T1.4041.00
125_R128_L1.3971.00
60_L93_I1.3931.00
6_A36_I1.3901.00
5_F56_L1.3561.00
35_Q55_R1.3551.00
169_S172_A1.3461.00
112_M119_A1.3381.00
72_D121_A1.3231.00
132_T136_I1.3181.00
49_E54_N1.3171.00
125_R129_L1.2991.00
75_G81_I1.2961.00
137_V141_G1.2811.00
68_V97_C1.2771.00
78_A82_R1.2551.00
68_V95_V1.2401.00
12_T15_Q1.2331.00
174_A184_I1.2311.00
161_F165_K1.2291.00
65_Q96_H1.2181.00
25_E36_I1.2111.00
159_V176_E1.2071.00
163_R173_I1.1911.00
138_R141_G1.1841.00
171_S181_R1.1831.00
78_A118_S1.1581.00
160_V173_I1.1461.00
162_E166_S1.1371.00
22_R138_R1.1311.00
35_Q59_R1.1181.00
164_I170_I1.1151.00
55_R59_R1.1051.00
86_E90_E1.0981.00
28_G33_P1.0891.00
41_I47_T1.0761.00
135_G139_A1.0731.00
41_I51_P1.0681.00
85_V95_V1.0581.00
69_T134_S1.0571.00
159_V162_E1.0511.00
6_A33_P1.0501.00
124_E128_L1.0471.00
25_E29_F1.0431.00
10_I40_H1.0371.00
136_I146_F1.0311.00
179_T183_T1.0291.00
170_I185_L1.0271.00
23_E69_T1.0261.00
53_F56_L1.0261.00
19_N69_T1.0231.00
37_I52_G1.0081.00
181_R185_L1.0031.00
8_C36_I1.0021.00
8_C17_T1.0001.00
24_I67_I0.9981.00
94_R106_T0.9621.00
136_I140_R0.9621.00
65_Q94_R0.9581.00
69_T99_A0.9451.00
57_L84_T0.9441.00
72_D131_R0.9411.00
8_C38_E0.9411.00
163_R166_S0.9311.00
181_R184_I0.9291.00
57_L87_Q0.9271.00
43_G76_C0.9251.00
37_I56_L0.9231.00
133_H136_I0.9231.00
61_K87_Q0.9221.00
112_M120_V0.9181.00
71_L121_A0.9101.00
179_T182_Q0.9031.00
68_V74_L0.9021.00
160_V184_I0.8971.00
74_L84_T0.8971.00
158_Q162_E0.8931.00
127_L131_R0.8931.00
116_V119_A0.8881.00
128_L132_T0.8861.00
83_K87_Q0.8821.00
123_F127_L0.8811.00
4_I65_Q0.8771.00
8_C24_I0.8751.00
140_R146_F0.8731.00
153_N156_Q0.8691.00
43_G75_G0.8671.00
23_E26_S0.8591.00
172_A175_R0.8501.00
108_P130_E0.8451.00
62_C92_G0.8411.00
27_A67_I0.8391.00
176_E179_T0.8371.00
17_T38_E0.8341.00
137_V140_R0.8331.00
80_D83_K0.8281.00
56_L60_L0.8211.00
77_N86_E0.8201.00
33_P36_I0.8191.00
66_L88_L0.8191.00
172_A176_E0.8171.00
19_N134_S0.8131.00
129_L132_T0.8111.00
23_E134_S0.8101.00
123_F126_D0.8071.00
19_N138_R0.7971.00
112_M116_V0.7951.00
96_H104_D0.7931.00
116_V120_V0.7911.00
5_F37_I0.7881.00
173_I177_F0.7861.00
161_F164_I0.7861.00
61_K91_T0.7791.00
18_E22_R0.7771.00
78_A122_E0.7631.00
170_I174_A0.7591.00
10_I15_Q0.7561.00
115_Q126_D0.7541.00
23_E99_A0.7541.00
7_Y39_E0.7521.00
26_S29_F0.7511.00
130_E134_S0.7471.00
27_A98_L0.7461.00
19_N23_E0.7421.00
44_S47_T0.7411.00
22_R25_E0.7391.00
113_M117_I0.7391.00
27_A96_H0.7391.00
4_I28_G0.7311.00
55_R58_A0.7301.00
127_L130_E0.7261.00
19_N70_K0.7261.00
56_L59_R0.7241.00
25_E33_P0.7211.00
182_Q185_L0.7181.00
162_E165_K0.7151.00
44_S129_L0.7131.00
17_T40_H0.7111.00
84_T88_L0.7081.00
120_V123_F0.7041.00
168_V173_I0.7021.00
38_E52_G0.7011.00
53_F74_L0.6991.00
70_K99_A0.6981.00
148_R151_V0.6891.00
71_L97_C0.6881.00
24_I28_G0.6871.00
128_L135_G0.6861.00
136_I139_A0.6821.00
158_Q161_F0.6811.00
180_S184_I0.6771.00
124_E127_L0.6741.00
81_I114_M0.6731.00
160_V177_F0.6721.00
28_G67_I0.6721.00
132_T135_G0.6691.00
109_T112_M0.6671.00
133_H137_V0.6621.00
48_S80_D0.6581.00
178_K184_I0.6571.00
47_T54_N0.6541.00
112_M115_Q0.6541.00
167_G173_I0.6431.00
170_I181_R0.6371.00
117_I120_V0.6341.00
109_T123_F0.6331.00
113_M120_V0.6291.00
75_G84_T0.6281.00
94_R104_D0.6281.00
113_M116_V0.6271.00
139_A146_F0.6241.00
154_E158_Q0.6181.00
170_I184_I0.6171.00
87_Q90_E0.6151.00
58_A62_C0.6081.00
71_L114_M0.6051.00
67_I98_L0.6021.00
83_K86_E0.6021.00
70_K127_L0.6001.00
47_T53_F0.5981.00
16_T40_H0.5901.00
151_V154_E0.5891.00
60_L88_L0.5860.99
54_N58_A0.5850.99
79_M82_R0.5780.99
29_F33_P0.5780.99
53_F57_L0.5780.99
70_K131_R0.5760.99
153_N157_K0.5760.99
129_L136_I0.5760.99
77_N80_D0.5710.99
169_S175_R0.5680.99
154_E157_K0.5630.99
6_A28_G0.5630.99
24_I98_L0.5600.99
78_A119_A0.5600.99
145_R150_P0.5590.99
22_R141_G0.5580.99
173_I176_E0.5570.99
134_S137_V0.5560.99
131_R134_S0.5550.99
164_I169_S0.5500.99
175_R179_T0.5500.99
180_S185_L0.5490.99
174_A178_K0.5490.99
154_E161_F0.5440.99
173_I184_I0.5420.99
37_I55_R0.5390.99
163_R180_S0.5320.99
96_H102_G0.5270.99
4_I67_I0.5230.99
163_R167_G0.5190.99
115_Q122_E0.5190.99
43_G80_D0.5150.99
126_D129_L0.5130.99
180_S183_T0.5110.99
108_P111_K0.5100.99
174_A177_F0.5100.99
169_S173_I0.5070.99
59_R62_C0.5060.99
152_L156_Q0.5060.99
134_S138_R0.5010.98
115_Q118_S0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r0qC 3 0.9031 100 0.194 Contact Map
3uj3X 2 0.6327 100 0.196 Contact Map
1gdtA 2 0.9337 100 0.199 Contact Map
4bqqA 2 0.9286 100 0.229 Contact Map
3g13A 2 0.7449 100 0.31 Contact Map
3guvA 2 0.7041 100 0.323 Contact Map
2gm5A 4 0.6327 100 0.391 Contact Map
3lhkA 2 0.7143 100 0.435 Contact Map
3ilxA 2 0.6633 100 0.445 Contact Map
3bvpA 4 0.6378 100 0.459 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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