GREMLIN Database
FIME - Type 1 fimbriae regulatory protein FimE
UniProt: P0ADH7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10312
Length: 198 (175)
Sequences: 28719 (22054)
Seq/√Len: 1667.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_G160_L4.6571.00
71_T161_G3.0471.00
50_Y87_T2.9811.00
142_C159_Y2.6831.00
134_H137_M2.6751.00
35_A135_P2.2651.00
35_A45_L2.2041.00
61_N72_V2.1831.00
49_H101_A2.1481.00
39_G142_C2.1161.00
42_I136_H2.0901.00
58_G80_R2.0881.00
49_H110_R2.0831.00
154_R157_Q2.0161.00
140_H173_A1.9231.00
37_R76_R1.8661.00
59_R72_V1.8521.00
66_K69_F1.8131.00
80_R84_E1.8131.00
12_V36_Y1.8031.00
30_C86_W1.7971.00
33_L82_A1.7201.00
147_A156_I1.7191.00
152_D155_L1.7081.00
69_F163_R1.6931.00
146_L151_A1.6901.00
162_H168_T1.6591.00
75_L80_R1.6471.00
28_D119_I1.6231.00
160_L168_T1.6201.00
154_R158_D1.6101.00
148_E178_R1.5911.00
54_D57_E1.5471.00
74_P159_Y1.5171.00
43_S47_D1.4861.00
44_E71_T1.4771.00
19_V123_A1.4601.00
8_T11_E1.4551.00
42_I113_R1.4451.00
40_M62_I1.4361.00
42_I46_L1.4181.00
20_C29_Y1.4041.00
29_Y33_L1.3841.00
9_G145_E1.3751.00
12_V145_E1.3711.00
31_L116_A1.3701.00
49_H52_D1.3661.00
157_Q165_I1.3421.00
124_G133_T1.3401.00
40_M45_L1.3401.00
36_Y145_E1.3391.00
147_A172_T1.3081.00
146_L156_I1.2981.00
54_D59_R1.2871.00
167_H170_R1.2731.00
113_R117_Y1.2731.00
55_L84_E1.2651.00
119_I122_D1.2431.00
101_A110_R1.2401.00
142_C146_L1.2331.00
144_Y173_A1.2331.00
148_E175_N1.2241.00
63_R70_S1.2231.00
52_D63_R1.2221.00
37_R79_E1.2041.00
18_A126_E1.2021.00
115_Q118_R1.1991.00
49_H100_D1.1981.00
7_L141_A1.1811.00
51_Q100_D1.1801.00
36_Y138_L1.1801.00
166_R169_V1.1751.00
7_L133_T1.1641.00
9_G149_R1.1591.00
30_C82_A1.1541.00
153_T169_V1.1461.00
7_L15_M1.1421.00
50_Y102_I1.1361.00
31_L45_L1.1351.00
36_Y141_A1.1321.00
165_I169_V1.1151.00
48_L60_I1.1031.00
16_M33_L1.0991.00
120_I124_G1.0891.00
11_E14_A1.0881.00
114_Q117_Y1.0851.00
29_Y82_A1.0851.00
155_L182_L1.0791.00
145_E148_E1.0721.00
31_L103_F1.0611.00
18_A127_A1.0481.00
112_S115_Q1.0461.00
61_N70_S1.0461.00
37_R78_D1.0361.00
158_D179_F1.0351.00
58_G77_F1.0201.00
141_A145_E1.0071.00
42_I117_Y1.0051.00
42_I116_A1.0001.00
14_A18_A0.9991.00
50_Y90_R0.9981.00
117_Y121_R0.9901.00
30_C85_R0.9881.00
101_A104_I0.9881.00
19_V32_I0.9791.00
55_L80_R0.9701.00
51_Q99_T0.9651.00
121_R132_Q0.9591.00
26_A89_E0.9571.00
46_L116_A0.9481.00
13_Q17_Q0.9391.00
30_C103_F0.9281.00
76_R79_E0.9271.00
178_R181_G0.9181.00
6_Y141_A0.9051.00
117_Y135_P0.9031.00
86_W90_R0.8991.00
77_F81_E0.8981.00
34_L103_F0.8961.00
164_N167_H0.8951.00
123_A126_E0.8951.00
181_G185_R0.8931.00
157_Q168_T0.8931.00
38_H73_H0.8901.00
63_R68_G0.8901.00
105_S109_S0.8871.00
15_M32_I0.8761.00
122_D126_E0.8651.00
159_Y179_F0.8651.00
154_R169_V0.8631.00
9_G13_Q0.8551.00
120_I138_L0.8511.00
180_A184_E0.8461.00
33_L78_D0.8401.00
90_R104_I0.8401.00
142_C160_L0.8331.00
41_R136_H0.8241.00
79_E82_A0.8201.00
34_L60_I0.8181.00
26_A85_R0.8121.00
148_E177_A0.8081.00
75_L79_E0.8001.00
85_R89_E0.7911.00
7_L11_E0.7811.00
5_R137_M0.7781.00
119_I123_A0.7721.00
115_Q119_I0.7711.00
9_G148_E0.7711.00
19_V29_Y0.7671.00
35_A138_L0.7661.00
120_I135_P0.7631.00
18_A123_A0.7611.00
82_A85_R0.7591.00
157_Q169_V0.7581.00
74_P180_A0.7511.00
30_C79_E0.7481.00
6_Y173_A0.7471.00
153_T165_I0.7411.00
151_A155_L0.7401.00
54_D61_N0.7331.00
33_L37_R0.7301.00
34_L79_E0.7221.00
78_D81_E0.7211.00
34_L40_M0.7171.00
176_A179_F0.7171.00
12_V16_M0.7111.00
33_L79_E0.7101.00
183_W186_N0.7051.00
121_R125_I0.7001.00
42_I135_P0.6941.00
143_G156_I0.6851.00
47_D110_R0.6821.00
40_M60_I0.6801.00
151_A182_L0.6781.00
116_A135_P0.6781.00
46_L113_R0.6761.00
133_T137_M0.6751.00
147_A175_N0.6691.00
137_M140_H0.6631.00
182_L185_R0.6611.00
34_L45_L0.6601.00
175_N178_R0.6591.00
27_R111_L0.6591.00
30_C34_L0.6591.00
143_G172_T0.6521.00
118_R122_D0.6521.00
53_L102_I0.6501.00
54_D58_G0.6481.00
177_A181_G0.6481.00
32_I138_L0.6471.00
28_D123_A0.6461.00
30_C83_V0.6461.00
10_K14_A0.6401.00
32_I120_I0.6291.00
87_T90_R0.6281.00
151_A156_I0.6261.00
55_L58_G0.6251.00
26_A30_C0.6241.00
144_Y172_T0.6221.00
59_R180_A0.6221.00
121_R124_G0.6211.00
27_R86_W0.6151.00
86_W89_E0.6151.00
27_R119_I0.6131.00
87_T91_A0.6111.00
114_Q121_R0.6081.00
35_A42_I0.6061.00
16_M29_Y0.6041.00
155_L159_Y0.6041.00
112_S118_R0.6021.00
6_Y144_Y0.5951.00
84_E88_Q0.5951.00
39_G160_L0.5911.00
140_H170_R0.5891.00
38_H76_R0.5881.00
7_L12_V0.5841.00
163_R167_H0.5821.00
16_M19_V0.5811.00
50_Y91_A0.5801.00
115_Q122_D0.5761.00
77_F184_E0.5751.00
34_L83_V0.5751.00
14_A127_A0.5741.00
55_L75_L0.5731.00
181_G184_E0.5701.00
24_T106_R0.5681.00
64_R71_T0.5661.00
83_V102_I0.5661.00
154_R172_T0.5611.00
120_I133_T0.5601.00
44_E64_R0.5601.00
15_M124_G0.5551.00
40_M44_E0.5541.00
156_I172_T0.5531.00
151_A185_R0.5531.00
143_G162_H0.5511.00
165_I168_T0.5501.00
147_A174_S0.5491.00
27_R30_C0.5481.00
117_Y134_H0.5451.00
143_G168_T0.5431.00
152_D182_L0.5431.00
14_A17_Q0.5381.00
7_L137_M0.5371.00
64_R161_G0.5361.00
26_A29_Y0.5331.00
105_S115_Q0.5311.00
81_E85_R0.5301.00
4_R140_H0.5231.00
144_Y174_S0.5191.00
14_A129_T0.5181.00
147_A152_D0.5131.00
124_G134_H0.5111.00
114_Q118_R0.5101.00
157_Q167_H0.5101.00
104_I108_G0.5091.00
164_N168_T0.5071.00
55_L102_I0.5051.00
85_R88_Q0.5041.00
5_R132_Q0.5031.00
28_D31_L0.5021.00
52_D64_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nkhA 2 0.9697 100 0.226 Contact Map
2a3vA 3 0.9293 100 0.235 Contact Map
1a0pA 1 0.8939 100 0.268 Contact Map
4a8eA 2 0.8737 100 0.272 Contact Map
1z19A 3 0.9091 100 0.29 Contact Map
1z1bA 3 0.8939 100 0.29 Contact Map
1xo0A 3 0.9343 100 0.3 Contact Map
1ae9A 4 0.8384 100 0.303 Contact Map
1aihA 2 0.8485 100 0.362 Contact Map
3vcfA 1 0.7929 99.9 0.439 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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