GREMLIN Database
FIMB - Type 1 fimbriae regulatory protein FimB
UniProt: P0ADH5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10309
Length: 200 (178)
Sequences: 29832 (22782)
Seq/√Len: 1707.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_G165_L4.8731.00
56_I93_L3.0141.00
77_T166_G2.9401.00
147_C164_Y2.7111.00
139_H142_M2.6881.00
41_C140_P2.3401.00
67_Y78_T2.3071.00
45_G147_C2.2311.00
41_C51_I2.1921.00
64_K86_V2.1911.00
55_R106_W2.1761.00
159_R162_Q2.0791.00
48_A141_H2.0701.00
65_C78_T2.0231.00
43_I82_L1.9901.00
55_R115_P1.9731.00
36_C92_W1.9051.00
145_H178_A1.8751.00
86_V90_K1.8751.00
18_I42_F1.8571.00
39_L88_A1.8531.00
14_T17_E1.8011.00
75_F168_R1.7301.00
151_L156_I1.7291.00
34_N124_I1.7281.00
81_L86_V1.6971.00
157_D160_L1.6961.00
167_H173_T1.6581.00
159_R163_D1.6551.00
165_L173_T1.6431.00
153_N183_R1.6341.00
152_A161_I1.6321.00
15_H150_A1.5891.00
49_S53_R1.5571.00
48_A52_C1.5401.00
48_A118_R1.5101.00
35_Y39_L1.4721.00
13_L146_S1.4701.00
18_I150_A1.4681.00
60_D63_A1.4641.00
25_A128_S1.4591.00
80_P164_Y1.4481.00
26_N35_Y1.4461.00
162_Q170_I1.4451.00
50_E77_T1.4241.00
55_R58_D1.4231.00
46_F51_I1.4051.00
152_A177_T1.3721.00
172_H175_W1.3451.00
129_G138_I1.3341.00
58_D69_H1.3191.00
22_L39_L1.3091.00
42_F150_A1.3091.00
151_L161_I1.3081.00
118_R122_Y1.2971.00
124_I127_T1.2901.00
46_F68_I1.2881.00
37_L121_F1.2871.00
60_D65_C1.2841.00
147_C151_L1.2791.00
61_L90_K1.2751.00
70_R76_S1.2591.00
120_Q123_H1.2541.00
42_F143_L1.2391.00
55_R105_E1.2371.00
13_L138_I1.2321.00
153_N180_N1.2231.00
171_R174_V1.2221.00
106_W115_P1.2181.00
149_F178_A1.2091.00
24_A131_N1.2081.00
158_T174_V1.1941.00
15_H154_M1.1851.00
36_C88_A1.1851.00
43_I85_E1.1851.00
170_I174_V1.1521.00
42_F146_S1.1371.00
160_L187_I1.1331.00
43_I84_K1.1221.00
56_I107_V1.1201.00
37_L51_I1.1191.00
35_Y88_A1.1071.00
57_S105_E1.1071.00
36_C91_N1.1061.00
54_L66_I1.0901.00
17_E20_S1.0891.00
117_S120_Q1.0871.00
70_R74_G1.0861.00
150_A153_N1.0831.00
13_L21_L1.0791.00
20_S24_A1.0791.00
24_A132_A1.0661.00
125_I129_G1.0641.00
12_F146_S1.0621.00
122_Y126_S1.0611.00
37_L108_F1.0581.00
119_Q122_Y1.0511.00
146_S150_A1.0081.00
163_D184_F1.0051.00
64_K83_N0.9961.00
48_A122_Y0.9921.00
32_A95_I0.9911.00
67_Y76_S0.9781.00
56_I96_R0.9771.00
48_A121_F0.9691.00
57_S104_S0.9661.00
92_W96_R0.9581.00
25_A38_T0.9511.00
106_W109_L0.9331.00
110_S114_N0.9291.00
82_L85_E0.9231.00
126_S137_E0.9181.00
61_L86_V0.9161.00
11_N142_M0.9131.00
19_E23_K0.9121.00
159_R174_V0.9101.00
15_H19_E0.9061.00
128_S131_N0.9061.00
186_G190_R0.9001.00
162_Q173_T0.8981.00
122_Y140_P0.8961.00
169_N172_H0.8901.00
183_R186_G0.8831.00
36_C108_F0.8801.00
83_N87_Q0.8771.00
185_Y189_D0.8721.00
80_P185_Y0.8671.00
47_R141_H0.8611.00
125_I143_L0.8601.00
39_L84_K0.8591.00
71_L77_T0.8561.00
127_T131_N0.8531.00
32_A91_N0.8521.00
52_C121_F0.8501.00
40_L108_F0.8501.00
147_C165_L0.8431.00
24_A128_S0.8421.00
120_Q124_I0.8351.00
164_Y184_F0.8271.00
44_H79_H0.8221.00
91_N95_I0.8161.00
96_R109_L0.8131.00
21_L38_T0.8081.00
162_Q174_V0.8041.00
41_C143_L0.8031.00
153_N182_G0.8031.00
158_T170_I0.8001.00
60_D67_Y0.7951.00
13_L17_E0.7901.00
85_E88_A0.7881.00
88_A91_N0.7791.00
40_L85_E0.7771.00
124_I128_S0.7751.00
39_L43_I0.7651.00
81_L85_E0.7651.00
148_G161_I0.7621.00
125_I140_P0.7621.00
40_L66_I0.7531.00
156_I160_L0.7501.00
84_K87_Q0.7461.00
25_A35_Y0.7381.00
48_A140_P0.7271.00
12_F178_A0.7161.00
126_S130_G0.7121.00
181_A184_F0.7061.00
121_F140_P0.7031.00
38_T143_L0.6981.00
52_C118_R0.6941.00
180_N183_R0.6931.00
36_C85_E0.6841.00
18_I22_L0.6831.00
148_G177_T0.6801.00
15_H153_N0.6801.00
12_F149_F0.6781.00
67_Y70_R0.6781.00
40_L46_F0.6761.00
187_I190_R0.6761.00
156_I187_I0.6731.00
13_L18_I0.6731.00
123_H127_T0.6711.00
138_I142_M0.6691.00
65_C185_Y0.6581.00
16_S20_S0.6561.00
92_W95_I0.6501.00
32_A36_C0.6481.00
33_R92_W0.6411.00
38_T125_I0.6391.00
39_L85_E0.6281.00
40_L51_I0.6281.00
53_R115_P0.6281.00
36_C40_L0.6271.00
34_N128_S0.6211.00
33_R116_L0.6211.00
59_I107_V0.6201.00
93_L96_R0.6201.00
182_G186_G0.6191.00
126_S129_G0.6161.00
24_A27_T0.6161.00
27_T31_A0.6141.00
117_S123_H0.6071.00
46_F66_I0.6061.00
149_F177_T0.6061.00
148_G173_T0.6031.00
40_L89_L0.5951.00
33_R124_I0.5931.00
36_C89_L0.5891.00
148_G167_H0.5881.00
44_H82_L0.5881.00
60_D64_K0.5871.00
45_G165_L0.5851.00
33_R36_C0.5811.00
56_I97_T0.5811.00
142_M145_H0.5801.00
152_A157_D0.5791.00
30_H111_R0.5791.00
156_I190_R0.5781.00
61_L64_K0.5761.00
157_D187_I0.5761.00
152_A180_N0.5751.00
50_E71_L0.5701.00
93_L97_T0.5691.00
161_I177_T0.5681.00
119_Q126_S0.5681.00
20_S23_K0.5661.00
21_L129_G0.5661.00
152_A179_S0.5661.00
49_S71_L0.5611.00
46_F50_E0.5571.00
125_I138_I0.5551.00
32_A35_Y0.5541.00
89_L107_V0.5491.00
87_Q91_N0.5441.00
90_K94_S0.5441.00
13_L142_M0.5421.00
22_L35_Y0.5371.00
41_C48_A0.5371.00
145_H175_W0.5361.00
159_R170_I0.5361.00
159_R177_T0.5351.00
61_L81_L0.5341.00
58_D70_R0.5321.00
9_K76_S0.5271.00
50_E166_G0.5261.00
168_R172_H0.5261.00
53_R70_R0.5251.00
160_L183_R0.5251.00
151_L164_Y0.5251.00
160_L164_Y0.5231.00
93_L107_V0.5221.00
61_L107_V0.5201.00
156_I161_I0.5181.00
119_Q123_H0.5181.00
55_R104_S0.5181.00
83_N189_D0.5171.00
20_S134_L0.5171.00
20_S132_A0.5151.00
184_F188_W0.5111.00
22_L25_A0.5111.00
120_Q127_T0.5081.00
186_G189_D0.5081.00
7_N175_W0.5061.00
59_I66_I0.5051.00
152_A158_T0.5041.00
90_K93_L0.5031.00
162_Q172_H0.5021.00
10_R145_H0.5011.00
91_N94_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nkhA 2 0.955 100 0.218 Contact Map
2a3vA 3 0.945 100 0.22 Contact Map
1a0pA 1 0.88 100 0.254 Contact Map
4a8eA 2 0.895 100 0.263 Contact Map
1z1bA 3 0.915 100 0.273 Contact Map
1z19A 3 0.925 100 0.279 Contact Map
1xo0A 3 0.955 100 0.284 Contact Map
1ae9A 4 0.825 100 0.301 Contact Map
1aihA 2 0.84 100 0.352 Contact Map
3vcfA 1 0.785 99.9 0.444 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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