GREMLIN Database
IMDH - Inosine-5'-monophosphate dehydrogenase
UniProt: P0ADG7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10421
Length: 488 (472)
Sequences: 2854 (1080)
Seq/√Len: 49.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_F221_G6.5121.00
37_T272_Q4.7241.00
76_I236_A4.2871.00
449_T452_E4.1161.00
187_D191_H4.1011.00
7_E461_R3.7031.00
100_V123_V3.6521.00
348_A441_C3.6171.00
211_C219_R3.3011.00
285_R289_E3.2471.00
356_S454_R3.1671.00
53_T68_G3.1551.00
31_S39_R3.0431.00
33_Q39_R3.0191.00
327_A330_G2.9291.00
255_E259_Q2.9261.00
351_I438_L2.8921.00
162_V185_V2.8461.00
22_T255_E2.7581.00
235_D239_A2.7051.00
285_R327_A2.6761.00
69_F244_V2.6751.00
452_E456_K2.6701.00
265_R273_I2.6181.00
278_V284_A2.6101.00
238_V271_L2.5821.00
234_V264_T2.5721.00
20_H286_A2.4901.00
20_H255_E2.4611.00
342_R467_I2.4491.00
448_G452_E2.4401.00
282_A458_E2.4201.00
450_I454_R2.3761.00
44_M431_I2.3731.00
284_A324_A2.3711.00
283_G324_A2.3581.00
104_T108_E2.3261.00
278_V283_G2.3111.00
82_E85_R2.3091.00
75_S78_R2.2971.00
288_A328_L2.2911.00
35_T272_Q2.2801.00
284_A288_A2.2731.00
221_G244_V2.2541.00
265_R293_S2.2461.00
30_L435_M2.2281.00
278_V324_A2.2261.00
224_V234_V2.2191.00
360_V364_L2.2131.00
147_Q151_V2.2111.00
245_L271_L2.1721.00
142_V147_Q2.1651.00
34_L244_V2.1341.00
167_A170_V2.1171.00
33_Q332_G2.1161.00
123_V149_V2.0941.00
234_V245_L2.0671.00
107_R111_E2.0421.00
360_V363_M2.0301.00
259_Q262_R1.9810.99
57_L427_L1.9620.99
34_L274_I1.9590.99
55_A82_E1.9510.99
230_N260_R1.9460.99
67_I244_V1.9340.99
451_D455_T1.9330.99
100_V149_V1.9290.99
107_R146_N1.9160.99
100_V109_V1.9070.99
417_I475_V1.9010.99
347_I358_V1.8980.99
451_D454_R1.8930.99
286_A289_E1.8800.99
101_L104_T1.8790.99
348_A453_L1.8590.99
264_T273_I1.8410.99
392_G418_E1.8320.99
163_R188_D1.8010.99
328_L335_V1.7960.99
284_A335_V1.7780.99
235_D268_Y1.7700.99
155_P158_R1.7330.99
261_I275_G1.7210.99
109_V134_I1.7040.98
83_V242_V1.6950.98
103_T148_P1.6870.98
102_P131_V1.6830.98
61_L431_I1.6820.98
100_V104_T1.6570.98
249_S257_V1.6550.98
42_I435_M1.6480.98
148_P151_V1.6460.98
244_V274_I1.6240.98
173_A177_E1.6210.98
44_M360_V1.6090.98
281_A327_A1.6070.98
45_L357_A1.5970.98
247_I261_I1.5950.98
285_R330_G1.5910.98
35_T294_A1.5890.98
297_V335_V1.5890.98
235_D267_K1.5860.98
351_I450_I1.5700.97
250_S444_L1.5640.97
36_K334_P1.5570.97
129_E191_H1.5530.97
288_A333_I1.5460.97
363_M434_Q1.5440.97
229_G232_E1.5310.97
69_F246_L1.5250.97
163_R166_E1.5020.97
31_S41_N1.4870.96
111_E115_R1.4830.96
364_L427_L1.4740.96
34_L221_G1.4620.96
78_R82_E1.4610.96
289_E331_T1.4600.96
273_I292_C1.4590.96
284_A328_L1.4520.96
164_E193_I1.4500.96
44_M364_L1.4420.96
441_C453_L1.4420.96
329_E454_R1.4320.95
447_C457_A1.4060.95
412_L440_S1.3990.95
46_S53_T1.3930.95
103_T150_S1.3810.94
322_A326_E1.3700.94
170_V173_A1.3600.94
34_L357_A1.3550.94
285_R331_T1.3540.94
134_I152_Y1.3490.94
281_A326_E1.3430.94
247_I275_G1.3400.93
279_A315_V1.3400.93
258_L262_R1.3360.93
45_L274_I1.3330.93
288_A331_T1.3290.93
109_V113_T1.3130.93
368_E426_R1.3090.93
351_I454_R1.3070.93
162_V166_E1.3060.93
22_T448_G1.3040.93
275_G292_C1.3000.92
374_I381_S1.3000.92
242_V271_L1.2760.92
83_V222_A1.2680.91
36_K293_S1.2610.91
37_T270_D1.2600.91
321_V337_A1.2580.91
234_V268_Y1.2500.91
328_L331_T1.2490.91
368_E423_Y1.2400.90
34_L45_L1.2400.90
176_H179_R1.2200.90
294_A357_A1.2170.90
325_V335_V1.2120.89
334_P356_S1.2090.89
309_I467_I1.2080.89
34_L294_A1.2030.89
24_L256_G1.1970.89
72_K256_G1.1950.89
417_I481_S1.1900.89
101_L131_V1.1860.88
46_S68_G1.1780.88
447_C452_E1.1730.88
442_M450_I1.1730.88
37_T214_E1.1610.87
281_A285_R1.1610.87
118_F121_Y1.1590.87
46_S61_L1.1550.87
57_L364_L1.1520.87
351_I453_L1.1370.86
30_L439_R1.1310.86
108_E111_E1.1270.86
105_T148_P1.1260.86
453_L457_A1.1240.86
232_E235_D1.1230.86
247_I264_T1.1160.85
231_E263_E1.1100.85
36_K333_I1.1080.85
353_A459_F1.1060.85
214_E219_R1.1050.85
106_L142_V1.0980.84
27_T448_G1.0980.84
29_D39_R1.0960.84
284_A327_A1.0950.84
98_Q123_V1.0870.84
263_E267_K1.0850.83
32_T42_I1.0760.83
35_T244_V1.0750.83
144_D147_Q1.0710.83
352_A457_A1.0710.83
11_F321_V1.0710.83
166_E170_V1.0690.83
16_L445_T1.0690.83
247_I257_V1.0680.82
143_T173_A1.0680.82
295_V328_L1.0650.82
164_E188_D1.0620.82
347_I434_Q1.0580.82
472_V475_V1.0480.81
288_A330_G1.0340.80
262_R266_A1.0280.80
175_M183_A1.0280.80
48_A296_K1.0270.80
8_A460_V1.0260.80
364_L466_G1.0200.79
44_M435_M1.0170.79
281_A323_D1.0170.79
288_A327_A1.0170.79
121_Y149_V1.0150.79
327_A331_T1.0150.79
265_R292_C1.0100.79
168_R172_L1.0070.79
138_D184_L1.0070.79
234_V271_L1.0050.78
294_A334_P1.0050.78
9_L461_R0.9990.78
356_S451_D0.9990.78
63_Q89_H0.9980.78
261_I292_C0.9980.78
229_G260_R0.9950.78
55_A85_R0.9950.78
364_L431_I0.9940.78
284_A295_V0.9930.78
186_V190_F0.9900.77
19_A458_E0.9830.77
9_L318_I0.9790.77
171_V183_A0.9770.76
245_L249_S0.9670.76
19_A456_K0.9660.76
93_V185_V0.9570.75
124_V128_N0.9530.75
309_I472_V0.9530.75
360_V434_Q0.9500.74
367_T427_L0.9490.74
329_E455_T0.9480.74
38_I219_R0.9480.74
224_V245_L0.9450.74
262_R289_E0.9360.73
400_D403_F0.9340.73
45_L67_I0.9320.73
202_Q206_R0.9320.73
171_V184_L0.9240.72
103_T126_E0.9230.72
105_T108_E0.9210.72
447_C472_V0.9190.72
110_K145_L0.9180.72
258_L286_A0.9170.72
261_I273_I0.9150.72
102_P134_I0.9120.71
324_A327_A0.9120.71
222_A242_V0.9100.71
81_E84_R0.9060.71
271_L293_S0.9040.71
326_E330_G0.9030.71
100_V108_E0.9010.70
102_P150_S0.8980.70
358_V364_L0.8980.70
318_I457_A0.8970.70
127_E191_H0.8950.70
78_R81_E0.8950.70
279_A299_I0.8930.70
163_R170_V0.8910.70
234_V238_V0.8900.69
142_V145_L0.8890.69
98_Q118_F0.8870.69
329_E356_S0.8870.69
36_K272_Q0.8850.69
33_Q36_K0.8840.69
101_L126_E0.8840.69
253_H286_A0.8840.69
117_G136_G0.8840.69
64_E428_K0.8820.69
351_I457_A0.8780.68
224_V230_N0.8780.68
19_A447_C0.8770.68
21_S251_H0.8750.68
72_K397_G0.8740.68
328_L356_S0.8710.68
321_V335_V0.8690.68
278_V295_V0.8690.68
272_Q294_A0.8620.67
261_I283_G0.8610.67
160_V178_K0.8600.67
102_P124_V0.8550.66
162_V184_L0.8540.66
265_R269_P0.8520.66
162_V174_K0.8480.66
440_S443_G0.8460.66
462_I467_I0.8450.65
17_V21_S0.8450.65
57_L61_L0.8430.65
412_L432_H0.8430.65
106_L147_Q0.8400.65
44_M61_L0.8390.65
360_V427_L0.8350.65
258_L275_G0.8340.64
319_T323_D0.8320.64
292_C295_V0.8310.64
325_V332_G0.8310.64
447_C456_K0.8270.64
311_T470_S0.8260.64
93_V99_T0.8220.63
278_V335_V0.8200.63
108_E121_Y0.8200.63
389_G402_Y0.8190.63
51_T54_E0.8120.62
104_T121_Y0.8090.62
231_E267_K0.8060.62
130_L182_K0.8040.62
168_R174_K0.8020.61
17_V458_E0.7980.61
427_L431_I0.7980.61
100_V112_L0.7960.61
224_V247_I0.7940.61
14_V353_A0.7940.61
110_K114_E0.7930.60
279_A324_A0.7920.60
96_D192_L0.7920.60
377_Y420_R0.7890.60
259_Q263_E0.7880.60
19_A445_T0.7870.60
426_R429_E0.7860.60
219_R244_V0.7850.60
230_N234_V0.7850.60
26_N405_S0.7850.60
39_R219_R0.7800.59
67_I357_A0.7800.59
110_K134_I0.7770.59
28_A449_T0.7760.59
289_E330_G0.7730.59
258_L283_G0.7710.58
324_A335_V0.7670.58
70_I83_V0.7660.58
202_Q342_R0.7650.58
41_N211_C0.7650.58
260_R263_E0.7630.58
447_C455_T0.7630.58
69_F250_S0.7600.57
318_I353_A0.7560.57
80_A236_A0.7540.57
138_D153_M0.7530.57
344_S434_Q0.7510.56
63_Q429_E0.7510.56
172_L204_A0.7500.56
238_V242_V0.7500.56
172_L179_R0.7490.56
164_E187_D0.7460.56
375_E420_R0.7430.56
342_R397_G0.7420.55
226_A412_L0.7410.55
245_L311_T0.7400.55
236_A239_A0.7390.55
57_L431_I0.7360.55
100_V472_V0.7360.55
319_T322_A0.7320.54
466_G470_S0.7270.54
75_S424_K0.7250.54
113_T118_F0.7230.53
328_L467_I0.7220.53
60_A431_I0.7210.53
93_V98_Q0.7190.53
324_A328_L0.7190.53
188_D191_H0.7190.53
17_V299_I0.7170.53
35_T274_I0.7160.53
247_I284_A0.7130.52
113_T121_Y0.7130.52
81_E115_R0.7120.52
80_A84_R0.7120.52
8_A319_T0.7100.52
171_V196_I0.7100.52
95_T215_Q0.7080.52
11_F299_I0.7070.52
88_K136_G0.7060.52
226_A230_N0.7060.52
113_T183_A0.7060.52
17_V445_T0.7060.52
34_L319_T0.7030.51
225_G229_G0.7020.51
47_A423_Y0.7020.51
107_R145_L0.7020.51
91_S94_V0.7010.51
79_Q242_V0.7000.51
309_I460_V0.7000.51
47_A296_K0.6990.51
84_R193_I0.6990.51
367_T430_I0.6980.51
171_V195_M0.6980.51
347_I360_V0.6980.51
61_L67_I0.6970.51
106_L152_Y0.6970.51
249_S283_G0.6960.51
227_G230_N0.6940.51
258_L290_A0.6940.51
104_T149_V0.6940.51
463_S466_G0.6940.51
64_E207_K0.6940.51
168_R201_F0.6920.50
88_K382_Y0.6920.50
231_E234_V0.6910.50
190_F193_I0.6910.50
33_Q356_S0.6910.50
61_L364_L0.6900.50
324_A356_S0.6890.50
110_K139_V0.6890.50
150_S155_P0.6890.50
226_A261_I0.6880.50
445_T457_A0.6880.50
32_T450_I0.6860.50
110_K144_D0.6840.50
230_N249_S0.6820.49
226_A260_R0.6790.49
348_A351_I0.6790.49
30_L42_I0.6780.49
281_A325_V0.6780.49
399_S406_D0.6780.49
162_V198_V0.6770.49
138_D154_T0.6760.49
293_S333_I0.6760.49
227_G410_D0.6740.48
63_Q472_V0.6730.48
384_S432_H0.6720.48
72_K299_I0.6720.48
261_I364_L0.6710.48
301_P306_T0.6700.48
34_L67_I0.6690.48
81_E85_R0.6690.48
104_T150_S0.6690.48
266_A289_E0.6680.48
128_N191_H0.6650.48
80_A240_A0.6640.47
30_L438_L0.6620.47
235_D238_V0.6600.47
256_G259_Q0.6590.47
32_T357_A0.6580.47
173_A273_I0.6570.47
36_K294_A0.6570.47
419_G475_V0.6560.47
23_V28_A0.6560.47
32_T274_I0.6560.47
242_V245_L0.6550.47
64_E209_N0.6540.46
413_V440_S0.6530.46
375_E479_K0.6510.46
130_L186_V0.6490.46
104_T123_V0.6490.46
120_G182_K0.6460.46
109_V149_V0.6460.46
26_N406_D0.6460.46
323_D326_E0.6450.46
166_E183_A0.6450.46
184_L192_L0.6440.45
234_V273_I0.6440.45
93_V375_E0.6430.45
112_L121_Y0.6430.45
34_L40_L0.6430.45
10_T318_I0.6420.45
141_F386_R0.6420.45
108_E149_V0.6420.45
238_V268_Y0.6420.45
285_R288_A0.6410.45
11_F337_A0.6390.45
99_T185_V0.6380.45
38_I244_V0.6360.45
124_V191_H0.6360.45
91_S417_I0.6350.45
255_E262_R0.6300.44
311_T468_Q0.6290.44
250_S311_T0.6280.44
17_V44_M0.6280.44
89_H116_N0.6280.44
101_L150_S0.6270.44
283_G286_A0.6270.44
309_I470_S0.6270.44
163_R193_I0.6270.44
48_A284_A0.6250.44
376_L381_S0.6240.43
91_S212_K0.6240.43
247_I273_I0.6240.43
84_R115_R0.6240.43
219_R357_A0.6230.43
166_E174_K0.6210.43
249_S256_G0.6210.43
171_V375_E0.6180.43
410_D429_E0.6170.43
98_Q121_Y0.6170.43
100_V162_V0.6170.43
137_R182_K0.6160.43
60_A427_L0.6160.43
11_F119_A0.6150.43
273_I293_S0.6130.42
400_D404_Q0.6120.42
135_T154_T0.6120.42
342_R380_R0.6100.42
141_F176_H0.6090.42
279_A386_R0.6090.42
101_L124_V0.6090.42
246_L250_S0.6090.42
232_E236_A0.6080.42
363_M430_I0.6080.42
89_H207_K0.6080.42
38_I272_Q0.6050.42
438_L442_M0.6040.41
32_T333_I0.6030.41
289_E327_A0.6030.41
272_Q334_P0.6020.41
105_T146_N0.6020.41
267_K270_D0.6020.41
73_N389_G0.6020.41
84_R123_V0.6020.41
311_T462_I0.5990.41
99_T121_Y0.5980.41
228_A232_E0.5980.41
60_A64_E0.5970.41
110_K131_V0.5970.41
347_I438_L0.5960.41
90_E212_K0.5960.41
47_A134_I0.5960.41
67_I272_Q0.5950.41
219_R272_Q0.5930.40
263_E266_A0.5930.40
60_A171_V0.5930.40
190_F447_C0.5920.40
294_A333_I0.5890.40
70_I82_E0.5890.40
222_A237_L0.5880.40
67_I294_A0.5850.40
266_A449_T0.5830.39
311_T444_L0.5830.39
225_G234_V0.5810.39
166_E171_V0.5800.39
135_T138_D0.5800.39
375_E382_Y0.5800.39
265_R294_A0.5790.39
378_Q472_V0.5780.39
84_R116_N0.5780.39
57_L424_K0.5780.39
136_G171_V0.5760.39
17_V323_D0.5760.39
394_M398_S0.5760.39
36_K45_L0.5750.39
46_S52_V0.5750.39
454_R457_A0.5740.38
44_M358_V0.5740.38
34_L69_F0.5740.38
154_T159_L0.5720.38
44_M283_G0.5710.38
113_T171_V0.5700.38
53_T61_L0.5680.38
144_D151_V0.5680.38
9_L14_V0.5680.38
249_S279_A0.5670.38
61_L68_G0.5670.38
25_P73_N0.5660.38
264_T448_G0.5660.38
32_T40_L0.5660.38
115_R262_R0.5660.38
313_V460_V0.5660.38
239_A262_R0.5650.38
94_V174_K0.5640.38
394_M411_K0.5640.38
36_K330_G0.5640.38
169_E172_L0.5630.37
8_A461_R0.5630.37
257_V443_G0.5630.37
229_G399_S0.5630.37
67_I221_G0.5630.37
363_M424_K0.5630.37
17_V460_V0.5620.37
275_G294_A0.5610.37
55_A463_S0.5600.37
122_P192_L0.5590.37
134_I278_V0.5580.37
251_H443_G0.5570.37
60_A297_V0.5570.37
231_E260_R0.5550.37
59_I161_T0.5550.37
163_R189_E0.5550.37
27_T56_R0.5550.37
33_Q334_P0.5550.37
35_T38_I0.5550.37
26_N409_A0.5540.37
172_L216_G0.5530.36
101_L148_P0.5530.36
73_N443_G0.5530.36
207_K370_S0.5520.36
94_V168_R0.5490.36
303_S441_C0.5490.36
374_I424_K0.5490.36
96_D173_A0.5480.36
170_V224_V0.5480.36
391_L463_S0.5480.36
94_V184_L0.5470.36
80_A238_V0.5470.36
226_A256_G0.5470.36
147_Q152_Y0.5460.36
356_S426_R0.5460.36
61_L64_E0.5460.36
295_V335_V0.5450.36
255_E258_L0.5450.36
172_L201_F0.5440.36
74_M396_K0.5440.36
278_V326_E0.5420.35
228_A231_E0.5410.35
214_E288_A0.5410.35
278_V374_I0.5410.35
234_V247_I0.5400.35
187_D193_I0.5400.35
321_V325_V0.5400.35
137_R181_E0.5400.35
109_V204_A0.5390.35
477_I480_E0.5380.35
63_Q370_S0.5370.35
129_E190_F0.5370.35
38_I274_I0.5370.35
57_L60_A0.5360.35
261_I290_A0.5360.35
16_L74_M0.5350.35
56_R456_K0.5350.35
319_T378_Q0.5340.35
384_S420_R0.5340.35
57_L211_C0.5340.35
329_E332_G0.5340.35
116_N136_G0.5330.35
288_A334_P0.5330.35
67_I219_R0.5330.35
28_A186_V0.5320.34
50_D71_H0.5310.34
447_C453_L0.5300.34
133_I195_M0.5290.34
448_G456_K0.5290.34
25_P443_G0.5290.34
441_C445_T0.5270.34
399_S409_A0.5270.34
63_Q457_A0.5260.34
272_Q357_A0.5240.34
186_V193_I0.5240.34
449_T457_A0.5240.34
395_S399_S0.5240.34
364_L430_I0.5230.34
394_M402_Y0.5230.34
86_V243_D0.5220.34
34_L272_Q0.5220.34
405_S409_A0.5220.34
26_N256_G0.5210.33
374_I429_E0.5210.33
36_K142_V0.5200.33
179_R265_R0.5200.33
31_S128_N0.5190.33
231_E268_Y0.5190.33
324_A351_I0.5190.33
154_T181_E0.5190.33
389_G401_R0.5180.33
28_A447_C0.5180.33
364_L434_Q0.5180.33
136_G195_M0.5180.33
78_R396_K0.5170.33
170_V174_K0.5170.33
301_P308_R0.5160.33
39_R214_E0.5150.33
35_T357_A0.5150.33
69_F271_L0.5140.33
230_N247_I0.5140.33
141_F179_R0.5130.33
28_A45_L0.5130.33
73_N402_Y0.5120.33
36_K332_G0.5120.33
133_I154_T0.5120.33
438_L461_R0.5110.33
84_R88_K0.5110.33
214_E332_G0.5110.33
129_E189_E0.5100.32
121_Y207_K0.5090.32
162_V165_G0.5090.32
90_E93_V0.5090.32
151_V177_E0.5090.32
74_M82_E0.5080.32
106_L146_N0.5070.32
296_K301_P0.5070.32
198_V384_S0.5070.32
9_L207_K0.5070.32
221_G246_L0.5060.32
335_V356_S0.5060.32
100_V378_Q0.5060.32
107_R115_R0.5060.32
352_A476_T0.5060.32
118_F311_T0.5050.32
27_T453_L0.5050.32
328_L342_R0.5050.32
233_R419_G0.5050.32
88_K378_Q0.5050.32
106_L145_L0.5040.32
131_V167_A0.5040.32
301_P346_D0.5040.32
413_V443_G0.5040.32
168_R205_E0.5030.32
326_E458_E0.5020.32
432_H440_S0.5020.32
26_N445_T0.5010.32
224_V264_T0.5010.32
203_K212_K0.5010.32
356_S458_E0.5010.32
28_A257_V0.5010.32
462_I470_S0.5000.32
76_I80_A0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3usbA 4 0.8832 100 0.436 Contact Map
2cu0A 4 0.7234 100 0.465 Contact Map
1vrdA 3 0.6557 100 0.471 Contact Map
4af0A 3 0.7131 100 0.475 Contact Map
1jcnA 6 0.7746 100 0.493 Contact Map
1zfjA 4 0.9652 100 0.504 Contact Map
1me8A 3 0.6988 100 0.529 Contact Map
4fxsA 3 0.9549 100 0.549 Contact Map
5ahnA 3 0.6086 100 0.555 Contact Map
4zqmA 3 0.6619 100 0.629 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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