IMDH - ECOLI - GREMLIN Contacts

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IMDH - Inosine-5'-monophosphate dehydrogenase

UniProt:	P0ADG7	Sequences: MLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGYPVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVEKALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKESPNYRLGS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10421
Length:	488 (472)
Sequences:	2854 (1080)
Seq/√Len:	49.7

ECOLI - IMDH GUAC
BACSU - IMDH GUAC
HALSA - IMDH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
69_F	221_G	6.512	1.00
37_T	272_Q	4.724	1.00
76_I	236_A	4.287	1.00
449_T	452_E	4.116	1.00
187_D	191_H	4.101	1.00
7_E	461_R	3.703	1.00
100_V	123_V	3.652	1.00
348_A	441_C	3.617	1.00
211_C	219_R	3.301	1.00
285_R	289_E	3.247	1.00
356_S	454_R	3.167	1.00
53_T	68_G	3.155	1.00
31_S	39_R	3.043	1.00
33_Q	39_R	3.019	1.00
327_A	330_G	2.929	1.00
255_E	259_Q	2.926	1.00
351_I	438_L	2.892	1.00
162_V	185_V	2.846	1.00
22_T	255_E	2.758	1.00
235_D	239_A	2.705	1.00
285_R	327_A	2.676	1.00
69_F	244_V	2.675	1.00
452_E	456_K	2.670	1.00
265_R	273_I	2.618	1.00
278_V	284_A	2.610	1.00
238_V	271_L	2.582	1.00
234_V	264_T	2.572	1.00
20_H	286_A	2.490	1.00
20_H	255_E	2.461	1.00
342_R	467_I	2.449	1.00
448_G	452_E	2.440	1.00
282_A	458_E	2.420	1.00
450_I	454_R	2.376	1.00
44_M	431_I	2.373	1.00
284_A	324_A	2.371	1.00
283_G	324_A	2.358	1.00
104_T	108_E	2.326	1.00
278_V	283_G	2.311	1.00
82_E	85_R	2.309	1.00
75_S	78_R	2.297	1.00
288_A	328_L	2.291	1.00
35_T	272_Q	2.280	1.00
284_A	288_A	2.273	1.00
221_G	244_V	2.254	1.00
265_R	293_S	2.246	1.00
30_L	435_M	2.228	1.00
278_V	324_A	2.226	1.00
224_V	234_V	2.219	1.00
360_V	364_L	2.213	1.00
147_Q	151_V	2.211	1.00
245_L	271_L	2.172	1.00
142_V	147_Q	2.165	1.00
34_L	244_V	2.134	1.00
167_A	170_V	2.117	1.00
33_Q	332_G	2.116	1.00
123_V	149_V	2.094	1.00
234_V	245_L	2.067	1.00
107_R	111_E	2.042	1.00
360_V	363_M	2.030	1.00
259_Q	262_R	1.981	0.99
57_L	427_L	1.962	0.99
34_L	274_I	1.959	0.99
55_A	82_E	1.951	0.99
230_N	260_R	1.946	0.99
67_I	244_V	1.934	0.99
451_D	455_T	1.933	0.99
100_V	149_V	1.929	0.99
107_R	146_N	1.916	0.99
100_V	109_V	1.907	0.99
417_I	475_V	1.901	0.99
347_I	358_V	1.898	0.99
451_D	454_R	1.893	0.99
286_A	289_E	1.880	0.99
101_L	104_T	1.879	0.99
348_A	453_L	1.859	0.99
264_T	273_I	1.841	0.99
392_G	418_E	1.832	0.99
163_R	188_D	1.801	0.99
328_L	335_V	1.796	0.99
284_A	335_V	1.778	0.99
235_D	268_Y	1.770	0.99
155_P	158_R	1.733	0.99
261_I	275_G	1.721	0.99
109_V	134_I	1.704	0.98
83_V	242_V	1.695	0.98
103_T	148_P	1.687	0.98
102_P	131_V	1.683	0.98
61_L	431_I	1.682	0.98
100_V	104_T	1.657	0.98
249_S	257_V	1.655	0.98
42_I	435_M	1.648	0.98
148_P	151_V	1.646	0.98
244_V	274_I	1.624	0.98
173_A	177_E	1.621	0.98
44_M	360_V	1.609	0.98
281_A	327_A	1.607	0.98
45_L	357_A	1.597	0.98
247_I	261_I	1.595	0.98
285_R	330_G	1.591	0.98
35_T	294_A	1.589	0.98
297_V	335_V	1.589	0.98
235_D	267_K	1.586	0.98
351_I	450_I	1.570	0.97
250_S	444_L	1.564	0.97
36_K	334_P	1.557	0.97
129_E	191_H	1.553	0.97
288_A	333_I	1.546	0.97
363_M	434_Q	1.544	0.97
229_G	232_E	1.531	0.97
69_F	246_L	1.525	0.97
163_R	166_E	1.502	0.97
31_S	41_N	1.487	0.96
111_E	115_R	1.483	0.96
364_L	427_L	1.474	0.96
34_L	221_G	1.462	0.96
78_R	82_E	1.461	0.96
289_E	331_T	1.460	0.96
273_I	292_C	1.459	0.96
284_A	328_L	1.452	0.96
164_E	193_I	1.450	0.96
44_M	364_L	1.442	0.96
441_C	453_L	1.442	0.96
329_E	454_R	1.432	0.95
447_C	457_A	1.406	0.95
412_L	440_S	1.399	0.95
46_S	53_T	1.393	0.95
103_T	150_S	1.381	0.94
322_A	326_E	1.370	0.94
170_V	173_A	1.360	0.94
34_L	357_A	1.355	0.94
285_R	331_T	1.354	0.94
134_I	152_Y	1.349	0.94
281_A	326_E	1.343	0.94
247_I	275_G	1.340	0.93
279_A	315_V	1.340	0.93
258_L	262_R	1.336	0.93
45_L	274_I	1.333	0.93
288_A	331_T	1.329	0.93
109_V	113_T	1.313	0.93
368_E	426_R	1.309	0.93
351_I	454_R	1.307	0.93
162_V	166_E	1.306	0.93
22_T	448_G	1.304	0.93
275_G	292_C	1.300	0.92
374_I	381_S	1.300	0.92
242_V	271_L	1.276	0.92
83_V	222_A	1.268	0.91
36_K	293_S	1.261	0.91
37_T	270_D	1.260	0.91
321_V	337_A	1.258	0.91
234_V	268_Y	1.250	0.91
328_L	331_T	1.249	0.91
368_E	423_Y	1.240	0.90
34_L	45_L	1.240	0.90
176_H	179_R	1.220	0.90
294_A	357_A	1.217	0.90
325_V	335_V	1.212	0.89
334_P	356_S	1.209	0.89
309_I	467_I	1.208	0.89
34_L	294_A	1.203	0.89
24_L	256_G	1.197	0.89
72_K	256_G	1.195	0.89
417_I	481_S	1.190	0.89
101_L	131_V	1.186	0.88
46_S	68_G	1.178	0.88
447_C	452_E	1.173	0.88
442_M	450_I	1.173	0.88
37_T	214_E	1.161	0.87
281_A	285_R	1.161	0.87
118_F	121_Y	1.159	0.87
46_S	61_L	1.155	0.87
57_L	364_L	1.152	0.87
351_I	453_L	1.137	0.86
30_L	439_R	1.131	0.86
108_E	111_E	1.127	0.86
105_T	148_P	1.126	0.86
453_L	457_A	1.124	0.86
232_E	235_D	1.123	0.86
247_I	264_T	1.116	0.85
231_E	263_E	1.110	0.85
36_K	333_I	1.108	0.85
353_A	459_F	1.106	0.85
214_E	219_R	1.105	0.85
106_L	142_V	1.098	0.84
27_T	448_G	1.098	0.84
29_D	39_R	1.096	0.84
284_A	327_A	1.095	0.84
98_Q	123_V	1.087	0.84
263_E	267_K	1.085	0.83
32_T	42_I	1.076	0.83
35_T	244_V	1.075	0.83
144_D	147_Q	1.071	0.83
352_A	457_A	1.071	0.83
11_F	321_V	1.071	0.83
166_E	170_V	1.069	0.83
16_L	445_T	1.069	0.83
247_I	257_V	1.068	0.82
143_T	173_A	1.068	0.82
295_V	328_L	1.065	0.82
164_E	188_D	1.062	0.82
347_I	434_Q	1.058	0.82
472_V	475_V	1.048	0.81
288_A	330_G	1.034	0.80
262_R	266_A	1.028	0.80
175_M	183_A	1.028	0.80
48_A	296_K	1.027	0.80
8_A	460_V	1.026	0.80
364_L	466_G	1.020	0.79
44_M	435_M	1.017	0.79
281_A	323_D	1.017	0.79
288_A	327_A	1.017	0.79
121_Y	149_V	1.015	0.79
327_A	331_T	1.015	0.79
265_R	292_C	1.010	0.79
168_R	172_L	1.007	0.79
138_D	184_L	1.007	0.79
234_V	271_L	1.005	0.78
294_A	334_P	1.005	0.78
9_L	461_R	0.999	0.78
356_S	451_D	0.999	0.78
63_Q	89_H	0.998	0.78
261_I	292_C	0.998	0.78
229_G	260_R	0.995	0.78
55_A	85_R	0.995	0.78
364_L	431_I	0.994	0.78
284_A	295_V	0.993	0.78
186_V	190_F	0.990	0.77
19_A	458_E	0.983	0.77
9_L	318_I	0.979	0.77
171_V	183_A	0.977	0.76
245_L	249_S	0.967	0.76
19_A	456_K	0.966	0.76
93_V	185_V	0.957	0.75
124_V	128_N	0.953	0.75
309_I	472_V	0.953	0.75
360_V	434_Q	0.950	0.74
367_T	427_L	0.949	0.74
329_E	455_T	0.948	0.74
38_I	219_R	0.948	0.74
224_V	245_L	0.945	0.74
262_R	289_E	0.936	0.73
400_D	403_F	0.934	0.73
45_L	67_I	0.932	0.73
202_Q	206_R	0.932	0.73
171_V	184_L	0.924	0.72
103_T	126_E	0.923	0.72
105_T	108_E	0.921	0.72
447_C	472_V	0.919	0.72
110_K	145_L	0.918	0.72
258_L	286_A	0.917	0.72
261_I	273_I	0.915	0.72
102_P	134_I	0.912	0.71
324_A	327_A	0.912	0.71
222_A	242_V	0.910	0.71
81_E	84_R	0.906	0.71
271_L	293_S	0.904	0.71
326_E	330_G	0.903	0.71
100_V	108_E	0.901	0.70
102_P	150_S	0.898	0.70
358_V	364_L	0.898	0.70
318_I	457_A	0.897	0.70
127_E	191_H	0.895	0.70
78_R	81_E	0.895	0.70
279_A	299_I	0.893	0.70
163_R	170_V	0.891	0.70
234_V	238_V	0.890	0.69
142_V	145_L	0.889	0.69
98_Q	118_F	0.887	0.69
329_E	356_S	0.887	0.69
36_K	272_Q	0.885	0.69
33_Q	36_K	0.884	0.69
101_L	126_E	0.884	0.69
253_H	286_A	0.884	0.69
117_G	136_G	0.884	0.69
64_E	428_K	0.882	0.69
351_I	457_A	0.878	0.68
224_V	230_N	0.878	0.68
19_A	447_C	0.877	0.68
21_S	251_H	0.875	0.68
72_K	397_G	0.874	0.68
328_L	356_S	0.871	0.68
321_V	335_V	0.869	0.68
278_V	295_V	0.869	0.68
272_Q	294_A	0.862	0.67
261_I	283_G	0.861	0.67
160_V	178_K	0.860	0.67
102_P	124_V	0.855	0.66
162_V	184_L	0.854	0.66
265_R	269_P	0.852	0.66
162_V	174_K	0.848	0.66
440_S	443_G	0.846	0.66
462_I	467_I	0.845	0.65
17_V	21_S	0.845	0.65
57_L	61_L	0.843	0.65
412_L	432_H	0.843	0.65
106_L	147_Q	0.840	0.65
44_M	61_L	0.839	0.65
360_V	427_L	0.835	0.65
258_L	275_G	0.834	0.64
319_T	323_D	0.832	0.64
292_C	295_V	0.831	0.64
325_V	332_G	0.831	0.64
447_C	456_K	0.827	0.64
311_T	470_S	0.826	0.64
93_V	99_T	0.822	0.63
278_V	335_V	0.820	0.63
108_E	121_Y	0.820	0.63
389_G	402_Y	0.819	0.63
51_T	54_E	0.812	0.62
104_T	121_Y	0.809	0.62
231_E	267_K	0.806	0.62
130_L	182_K	0.804	0.62
168_R	174_K	0.802	0.61
17_V	458_E	0.798	0.61
427_L	431_I	0.798	0.61
100_V	112_L	0.796	0.61
224_V	247_I	0.794	0.61
14_V	353_A	0.794	0.61
110_K	114_E	0.793	0.60
279_A	324_A	0.792	0.60
96_D	192_L	0.792	0.60
377_Y	420_R	0.789	0.60
259_Q	263_E	0.788	0.60
19_A	445_T	0.787	0.60
426_R	429_E	0.786	0.60
219_R	244_V	0.785	0.60
230_N	234_V	0.785	0.60
26_N	405_S	0.785	0.60
39_R	219_R	0.780	0.59
67_I	357_A	0.780	0.59
110_K	134_I	0.777	0.59
28_A	449_T	0.776	0.59
289_E	330_G	0.773	0.59
258_L	283_G	0.771	0.58
324_A	335_V	0.767	0.58
70_I	83_V	0.766	0.58
202_Q	342_R	0.765	0.58
41_N	211_C	0.765	0.58
260_R	263_E	0.763	0.58
447_C	455_T	0.763	0.58
69_F	250_S	0.760	0.57
318_I	353_A	0.756	0.57
80_A	236_A	0.754	0.57
138_D	153_M	0.753	0.57
344_S	434_Q	0.751	0.56
63_Q	429_E	0.751	0.56
172_L	204_A	0.750	0.56
238_V	242_V	0.750	0.56
172_L	179_R	0.749	0.56
164_E	187_D	0.746	0.56
375_E	420_R	0.743	0.56
342_R	397_G	0.742	0.55
226_A	412_L	0.741	0.55
245_L	311_T	0.740	0.55
236_A	239_A	0.739	0.55
57_L	431_I	0.736	0.55
100_V	472_V	0.736	0.55
319_T	322_A	0.732	0.54
466_G	470_S	0.727	0.54
75_S	424_K	0.725	0.54
113_T	118_F	0.723	0.53
328_L	467_I	0.722	0.53
60_A	431_I	0.721	0.53
93_V	98_Q	0.719	0.53
324_A	328_L	0.719	0.53
188_D	191_H	0.719	0.53
17_V	299_I	0.717	0.53
35_T	274_I	0.716	0.53
247_I	284_A	0.713	0.52
113_T	121_Y	0.713	0.52
81_E	115_R	0.712	0.52
80_A	84_R	0.712	0.52
8_A	319_T	0.710	0.52
171_V	196_I	0.710	0.52
95_T	215_Q	0.708	0.52
11_F	299_I	0.707	0.52
88_K	136_G	0.706	0.52
226_A	230_N	0.706	0.52
113_T	183_A	0.706	0.52
17_V	445_T	0.706	0.52
34_L	319_T	0.703	0.51
225_G	229_G	0.702	0.51
47_A	423_Y	0.702	0.51
107_R	145_L	0.702	0.51
91_S	94_V	0.701	0.51
79_Q	242_V	0.700	0.51
309_I	460_V	0.700	0.51
47_A	296_K	0.699	0.51
84_R	193_I	0.699	0.51
367_T	430_I	0.698	0.51
171_V	195_M	0.698	0.51
347_I	360_V	0.698	0.51
61_L	67_I	0.697	0.51
106_L	152_Y	0.697	0.51
249_S	283_G	0.696	0.51
227_G	230_N	0.694	0.51
258_L	290_A	0.694	0.51
104_T	149_V	0.694	0.51
463_S	466_G	0.694	0.51
64_E	207_K	0.694	0.51
168_R	201_F	0.692	0.50
88_K	382_Y	0.692	0.50
231_E	234_V	0.691	0.50
190_F	193_I	0.691	0.50
33_Q	356_S	0.691	0.50
61_L	364_L	0.690	0.50
324_A	356_S	0.689	0.50
110_K	139_V	0.689	0.50
150_S	155_P	0.689	0.50
226_A	261_I	0.688	0.50
445_T	457_A	0.688	0.50
32_T	450_I	0.686	0.50
110_K	144_D	0.684	0.50
230_N	249_S	0.682	0.49
226_A	260_R	0.679	0.49
348_A	351_I	0.679	0.49
30_L	42_I	0.678	0.49
281_A	325_V	0.678	0.49
399_S	406_D	0.678	0.49
162_V	198_V	0.677	0.49
138_D	154_T	0.676	0.49
293_S	333_I	0.676	0.49
227_G	410_D	0.674	0.48
63_Q	472_V	0.673	0.48
384_S	432_H	0.672	0.48
72_K	299_I	0.672	0.48
261_I	364_L	0.671	0.48
301_P	306_T	0.670	0.48
34_L	67_I	0.669	0.48
81_E	85_R	0.669	0.48
104_T	150_S	0.669	0.48
266_A	289_E	0.668	0.48
128_N	191_H	0.665	0.48
80_A	240_A	0.664	0.47
30_L	438_L	0.662	0.47
235_D	238_V	0.660	0.47
256_G	259_Q	0.659	0.47
32_T	357_A	0.658	0.47
173_A	273_I	0.657	0.47
36_K	294_A	0.657	0.47
419_G	475_V	0.656	0.47
23_V	28_A	0.656	0.47
32_T	274_I	0.656	0.47
242_V	245_L	0.655	0.47
64_E	209_N	0.654	0.46
413_V	440_S	0.653	0.46
375_E	479_K	0.651	0.46
130_L	186_V	0.649	0.46
104_T	123_V	0.649	0.46
120_G	182_K	0.646	0.46
109_V	149_V	0.646	0.46
26_N	406_D	0.646	0.46
323_D	326_E	0.645	0.46
166_E	183_A	0.645	0.46
184_L	192_L	0.644	0.45
234_V	273_I	0.644	0.45
93_V	375_E	0.643	0.45
112_L	121_Y	0.643	0.45
34_L	40_L	0.643	0.45
10_T	318_I	0.642	0.45
141_F	386_R	0.642	0.45
108_E	149_V	0.642	0.45
238_V	268_Y	0.642	0.45
285_R	288_A	0.641	0.45
11_F	337_A	0.639	0.45
99_T	185_V	0.638	0.45
38_I	244_V	0.636	0.45
124_V	191_H	0.636	0.45
91_S	417_I	0.635	0.45
255_E	262_R	0.630	0.44
311_T	468_Q	0.629	0.44
250_S	311_T	0.628	0.44
17_V	44_M	0.628	0.44
89_H	116_N	0.628	0.44
101_L	150_S	0.627	0.44
283_G	286_A	0.627	0.44
309_I	470_S	0.627	0.44
163_R	193_I	0.627	0.44
48_A	284_A	0.625	0.44
376_L	381_S	0.624	0.43
91_S	212_K	0.624	0.43
247_I	273_I	0.624	0.43
84_R	115_R	0.624	0.43
219_R	357_A	0.623	0.43
166_E	174_K	0.621	0.43
249_S	256_G	0.621	0.43
171_V	375_E	0.618	0.43
410_D	429_E	0.617	0.43
98_Q	121_Y	0.617	0.43
100_V	162_V	0.617	0.43
137_R	182_K	0.616	0.43
60_A	427_L	0.616	0.43
11_F	119_A	0.615	0.43
273_I	293_S	0.613	0.42
400_D	404_Q	0.612	0.42
135_T	154_T	0.612	0.42
342_R	380_R	0.610	0.42
141_F	176_H	0.609	0.42
279_A	386_R	0.609	0.42
101_L	124_V	0.609	0.42
246_L	250_S	0.609	0.42
232_E	236_A	0.608	0.42
363_M	430_I	0.608	0.42
89_H	207_K	0.608	0.42
38_I	272_Q	0.605	0.42
438_L	442_M	0.604	0.41
32_T	333_I	0.603	0.41
289_E	327_A	0.603	0.41
272_Q	334_P	0.602	0.41
105_T	146_N	0.602	0.41
267_K	270_D	0.602	0.41
73_N	389_G	0.602	0.41
84_R	123_V	0.602	0.41
311_T	462_I	0.599	0.41
99_T	121_Y	0.598	0.41
228_A	232_E	0.598	0.41
60_A	64_E	0.597	0.41
110_K	131_V	0.597	0.41
347_I	438_L	0.596	0.41
90_E	212_K	0.596	0.41
47_A	134_I	0.596	0.41
67_I	272_Q	0.595	0.41
219_R	272_Q	0.593	0.40
263_E	266_A	0.593	0.40
60_A	171_V	0.593	0.40
190_F	447_C	0.592	0.40
294_A	333_I	0.589	0.40
70_I	82_E	0.589	0.40
222_A	237_L	0.588	0.40
67_I	294_A	0.585	0.40
266_A	449_T	0.583	0.39
311_T	444_L	0.583	0.39
225_G	234_V	0.581	0.39
166_E	171_V	0.580	0.39
135_T	138_D	0.580	0.39
375_E	382_Y	0.580	0.39
265_R	294_A	0.579	0.39
378_Q	472_V	0.578	0.39
84_R	116_N	0.578	0.39
57_L	424_K	0.578	0.39
136_G	171_V	0.576	0.39
17_V	323_D	0.576	0.39
394_M	398_S	0.576	0.39
36_K	45_L	0.575	0.39
46_S	52_V	0.575	0.39
454_R	457_A	0.574	0.38
44_M	358_V	0.574	0.38
34_L	69_F	0.574	0.38
154_T	159_L	0.572	0.38
44_M	283_G	0.571	0.38
113_T	171_V	0.570	0.38
53_T	61_L	0.568	0.38
144_D	151_V	0.568	0.38
9_L	14_V	0.568	0.38
249_S	279_A	0.567	0.38
61_L	68_G	0.567	0.38
25_P	73_N	0.566	0.38
264_T	448_G	0.566	0.38
32_T	40_L	0.566	0.38
115_R	262_R	0.566	0.38
313_V	460_V	0.566	0.38
239_A	262_R	0.565	0.38
94_V	174_K	0.564	0.38
394_M	411_K	0.564	0.38
36_K	330_G	0.564	0.38
169_E	172_L	0.563	0.37
8_A	461_R	0.563	0.37
257_V	443_G	0.563	0.37
229_G	399_S	0.563	0.37
67_I	221_G	0.563	0.37
363_M	424_K	0.563	0.37
17_V	460_V	0.562	0.37
275_G	294_A	0.561	0.37
55_A	463_S	0.560	0.37
122_P	192_L	0.559	0.37
134_I	278_V	0.558	0.37
251_H	443_G	0.557	0.37
60_A	297_V	0.557	0.37
231_E	260_R	0.555	0.37
59_I	161_T	0.555	0.37
163_R	189_E	0.555	0.37
27_T	56_R	0.555	0.37
33_Q	334_P	0.555	0.37
35_T	38_I	0.555	0.37
26_N	409_A	0.554	0.37
172_L	216_G	0.553	0.36
101_L	148_P	0.553	0.36
73_N	443_G	0.553	0.36
207_K	370_S	0.552	0.36
94_V	168_R	0.549	0.36
303_S	441_C	0.549	0.36
374_I	424_K	0.549	0.36
96_D	173_A	0.548	0.36
170_V	224_V	0.548	0.36
391_L	463_S	0.548	0.36
94_V	184_L	0.547	0.36
80_A	238_V	0.547	0.36
226_A	256_G	0.547	0.36
147_Q	152_Y	0.546	0.36
356_S	426_R	0.546	0.36
61_L	64_E	0.546	0.36
295_V	335_V	0.545	0.36
255_E	258_L	0.545	0.36
172_L	201_F	0.544	0.36
74_M	396_K	0.544	0.36
278_V	326_E	0.542	0.35
228_A	231_E	0.541	0.35
214_E	288_A	0.541	0.35
278_V	374_I	0.541	0.35
234_V	247_I	0.540	0.35
187_D	193_I	0.540	0.35
321_V	325_V	0.540	0.35
137_R	181_E	0.540	0.35
109_V	204_A	0.539	0.35
477_I	480_E	0.538	0.35
63_Q	370_S	0.537	0.35
129_E	190_F	0.537	0.35
38_I	274_I	0.537	0.35
57_L	60_A	0.536	0.35
261_I	290_A	0.536	0.35
16_L	74_M	0.535	0.35
56_R	456_K	0.535	0.35
319_T	378_Q	0.534	0.35
384_S	420_R	0.534	0.35
57_L	211_C	0.534	0.35
329_E	332_G	0.534	0.35
116_N	136_G	0.533	0.35
288_A	334_P	0.533	0.35
67_I	219_R	0.533	0.35
28_A	186_V	0.532	0.34
50_D	71_H	0.531	0.34
447_C	453_L	0.530	0.34
133_I	195_M	0.529	0.34
448_G	456_K	0.529	0.34
25_P	443_G	0.529	0.34
441_C	445_T	0.527	0.34
399_S	409_A	0.527	0.34
63_Q	457_A	0.526	0.34
272_Q	357_A	0.524	0.34
186_V	193_I	0.524	0.34
449_T	457_A	0.524	0.34
395_S	399_S	0.524	0.34
364_L	430_I	0.523	0.34
394_M	402_Y	0.523	0.34
86_V	243_D	0.522	0.34
34_L	272_Q	0.522	0.34
405_S	409_A	0.522	0.34
26_N	256_G	0.521	0.33
374_I	429_E	0.521	0.33
36_K	142_V	0.520	0.33
179_R	265_R	0.520	0.33
31_S	128_N	0.519	0.33
231_E	268_Y	0.519	0.33
324_A	351_I	0.519	0.33
154_T	181_E	0.519	0.33
389_G	401_R	0.518	0.33
28_A	447_C	0.518	0.33
364_L	434_Q	0.518	0.33
136_G	195_M	0.518	0.33
78_R	396_K	0.517	0.33
170_V	174_K	0.517	0.33
301_P	308_R	0.516	0.33
39_R	214_E	0.515	0.33
35_T	357_A	0.515	0.33
69_F	271_L	0.514	0.33
230_N	247_I	0.514	0.33
141_F	179_R	0.513	0.33
28_A	45_L	0.513	0.33
73_N	402_Y	0.512	0.33
36_K	332_G	0.512	0.33
133_I	154_T	0.512	0.33
438_L	461_R	0.511	0.33
84_R	88_K	0.511	0.33
214_E	332_G	0.511	0.33
129_E	189_E	0.510	0.32
121_Y	207_K	0.509	0.32
162_V	165_G	0.509	0.32
90_E	93_V	0.509	0.32
151_V	177_E	0.509	0.32
74_M	82_E	0.508	0.32
106_L	146_N	0.507	0.32
296_K	301_P	0.507	0.32
198_V	384_S	0.507	0.32
9_L	207_K	0.507	0.32
221_G	246_L	0.506	0.32
335_V	356_S	0.506	0.32
100_V	378_Q	0.506	0.32
107_R	115_R	0.506	0.32
352_A	476_T	0.506	0.32
118_F	311_T	0.505	0.32
27_T	453_L	0.505	0.32
328_L	342_R	0.505	0.32
233_R	419_G	0.505	0.32
88_K	378_Q	0.505	0.32
106_L	145_L	0.504	0.32
131_V	167_A	0.504	0.32
301_P	346_D	0.504	0.32
413_V	443_G	0.504	0.32
168_R	205_E	0.503	0.32
326_E	458_E	0.502	0.32
432_H	440_S	0.502	0.32
26_N	445_T	0.501	0.32
224_V	264_T	0.501	0.32
203_K	212_K	0.501	0.32
356_S	458_E	0.501	0.32
28_A	257_V	0.501	0.32
462_I	470_S	0.500	0.32
76_I	80_A	0.500	0.32

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3usbA	4	0.8832	100	0.436	Contact Map
2cu0A	4	0.7234	100	0.465	Contact Map
1vrdA	3	0.6557	100	0.471	Contact Map
4af0A	3	0.7131	100	0.475	Contact Map
1jcnA	6	0.7746	100	0.493	Contact Map
1zfjA	4	0.9652	100	0.504	Contact Map
1me8A	3	0.6988	100	0.529	Contact Map
4fxsA	3	0.9549	100	0.549	Contact Map
5ahnA	3	0.6086	100	0.555	Contact Map
4zqmA	3	0.6619	100	0.629	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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