GREMLIN Database
SUHB - Inositol-1-monophosphatase
UniProt: P0ADG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10983
Length: 267 (246)
Sequences: 10203 (7201)
Seq/√Len: 459.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
220_V225_G3.9421.00
117_Y124_L3.5271.00
79_V107_I3.3341.00
78_D108_K3.1091.00
128_T131_Q3.0871.00
228_S250_V3.0831.00
217_E221_R2.8461.00
132_G222_E2.7381.00
118_D121_R2.6721.00
11_A54_T2.6491.00
14_K54_T2.5261.00
154_A200_V2.4161.00
18_L50_V2.4001.00
110_R129_R2.2531.00
16_G117_Y2.2401.00
229_D233_G2.2041.00
79_V105_V2.1651.00
80_Q106_R2.1201.00
202_G253_M2.1101.00
99_F120_M2.1101.00
42_N46_A2.0601.00
126_T134_Q1.9851.00
49_A53_D1.9721.00
22_N43_V1.9291.00
19_I47_A1.9031.00
107_I112_E1.8901.00
48_E66_T1.8871.00
54_T57_K1.8831.00
59_Y62_H1.8761.00
82_V106_R1.8581.00
134_Q139_R1.8081.00
32_S45_K1.8051.00
52_I56_R1.7901.00
62_H79_V1.7821.00
125_F197_A1.7751.00
106_R111_T1.7661.00
114_A218_L1.7431.00
135_L197_A1.7251.00
52_I64_I1.7071.00
20_A120_M1.6821.00
12_A103_I1.6811.00
127_A222_E1.6701.00
50_V54_T1.6391.00
116_V193_A1.6131.00
218_L222_E1.6021.00
7_I59_Y1.6011.00
8_A81_W1.5981.00
123_E135_L1.5921.00
118_D190_L1.5691.00
7_I58_S1.5621.00
100_A189_A1.5601.00
7_I11_A1.5591.00
9_V126_T1.5341.00
193_A219_L1.5211.00
147_D150_G1.4831.00
31_A34_K1.4791.00
123_E199_R1.4771.00
104_A214_A1.4571.00
78_D107_I1.4521.00
19_I86_L1.4481.00
102_S189_A1.4411.00
62_H81_W1.4381.00
10_R58_S1.4381.00
18_L21_K1.4351.00
41_T93_I1.4241.00
170_N173_G1.4181.00
23_Y99_F1.4111.00
133_A140_L1.3951.00
110_R221_R1.3951.00
12_A115_V1.3941.00
123_E197_A1.3911.00
130_G222_E1.3801.00
245_G250_V1.3511.00
129_R221_R1.3411.00
51_I83_I1.3401.00
13_R124_L1.3191.00
192_L244_A1.3061.00
81_W105_V1.3041.00
83_I103_I1.3041.00
54_T58_S1.2971.00
53_D57_K1.2871.00
20_A99_F1.2761.00
51_I103_I1.2741.00
9_V13_R1.2731.00
5_L126_T1.2621.00
19_I99_F1.2591.00
192_L216_G1.2571.00
49_A69_S1.2431.00
55_I62_H1.2361.00
9_V124_L1.2331.00
129_R222_E1.2271.00
52_I66_T1.2061.00
10_R14_K1.2031.00
46_A49_A1.1911.00
48_E69_S1.1881.00
194_Y199_R1.1821.00
39_F93_I1.1791.00
153_L202_G1.1691.00
169_I173_G1.1661.00
14_K50_V1.1641.00
226_I251_K1.1641.00
39_F90_T1.1611.00
48_E52_I1.1591.00
127_A218_L1.1361.00
112_E129_R1.1341.00
221_R234_H1.1221.00
18_L46_A1.1191.00
52_I69_S1.1131.00
217_E227_V1.1121.00
117_Y122_N1.1061.00
220_V244_A1.1041.00
170_N174_K1.1021.00
96_L185_T1.0991.00
251_K255_A1.0881.00
151_T249_V1.0831.00
45_K49_A1.0721.00
19_I43_V1.0701.00
143_S201_D1.0561.00
104_A111_T1.0561.00
82_V214_A1.0531.00
105_V113_V1.0461.00
252_A255_A1.0431.00
65_I82_V1.0361.00
11_A51_I1.0311.00
17_N21_K1.0271.00
22_N46_A1.0241.00
111_T218_L1.0221.00
10_R54_T1.0161.00
21_K25_T1.0111.00
11_A50_V1.0021.00
18_L22_N0.9961.00
190_L194_Y0.9851.00
47_A51_I0.9821.00
14_K17_N0.9731.00
7_I55_I0.9661.00
111_T217_E0.9631.00
44_D68_E0.9601.00
23_Y120_M0.9531.00
192_L220_V0.9461.00
226_I250_V0.9431.00
229_D232_G0.9421.00
140_L197_A0.9211.00
22_N42_N0.9181.00
226_I247_P0.9181.00
35_G38_D0.9171.00
175_L253_M0.9161.00
79_V112_E0.9131.00
65_I80_Q0.9121.00
23_Y95_R0.9101.00
246_N249_V0.9101.00
188_A208_L0.9061.00
30_E33_Q0.9061.00
41_T89_T0.9061.00
91_N183_R0.9061.00
13_R122_N0.9031.00
8_A115_V0.9021.00
172_V176_F0.8961.00
116_V219_L0.8881.00
250_V254_L0.8861.00
55_I59_Y0.8821.00
98_H194_Y0.8761.00
47_A86_L0.8731.00
105_V112_E0.8721.00
133_A222_E0.8711.00
113_V128_T0.8561.00
133_A219_L0.8531.00
168_Y171_I0.8511.00
65_I211_W0.8471.00
135_L138_Y0.8441.00
5_L128_T0.8401.00
116_V216_G0.8361.00
13_R117_Y0.8331.00
66_T69_S0.8261.00
6_N9_V0.8241.00
6_N10_R0.8231.00
125_F193_A0.8171.00
68_E89_T0.8171.00
20_A122_N0.8091.00
146_R248_R0.8081.00
63_T80_Q0.7931.00
18_L47_A0.7891.00
67_E89_T0.7801.00
102_S215_A0.7781.00
102_S116_V0.7781.00
151_T201_D0.7761.00
100_A187_S0.7731.00
13_R17_N0.7721.00
44_D89_T0.7681.00
19_I92_F0.7671.00
148_L151_T0.7671.00
173_G177_N0.7641.00
9_V115_V0.7641.00
5_L115_V0.7581.00
129_R218_L0.7561.00
147_D252_A0.7561.00
10_R13_R0.7561.00
152_I181_D0.7551.00
15_A50_V0.7531.00
110_R234_H0.7501.00
104_A218_L0.7451.00
47_A101_V0.7441.00
5_L113_V0.7411.00
55_I105_V0.7411.00
59_Y81_W0.7401.00
48_E70_G0.7361.00
243_V254_L0.7361.00
73_E77_Q0.7321.00
12_A101_V0.7321.00
34_K38_D0.7281.00
192_L227_V0.7191.00
157_F160_K0.7171.00
104_A114_A0.7161.00
220_V227_V0.7141.00
145_A151_T0.7121.00
143_S146_R0.7101.00
142_G225_G0.7061.00
102_S216_G0.7031.00
15_A47_A0.7031.00
127_A133_A0.7021.00
132_G139_R0.7001.00
42_N45_K0.7001.00
43_V47_A0.6961.00
29_V34_K0.6951.00
15_A101_V0.6941.00
107_I110_R0.6941.00
216_G219_L0.6941.00
171_I174_K0.6921.00
106_R214_A0.6911.00
195_V200_V0.6891.00
100_A190_L0.6871.00
187_S190_L0.6861.00
127_A219_L0.6841.00
142_G223_A0.6821.00
245_G249_V0.6821.00
44_D67_E0.6811.00
84_D89_T0.6781.00
232_G254_L0.6781.00
43_V92_F0.6761.00
154_A191_D0.6761.00
52_I70_G0.6761.00
217_E237_M0.6731.00
152_I156_G0.6731.00
46_A50_V0.6721.00
22_N25_T0.6721.00
8_A62_H0.6701.00
123_E136_N0.6691.00
100_A118_D0.6681.00
129_R132_G0.6681.00
188_A205_E0.6671.00
63_T77_Q0.6671.00
128_T222_E0.6661.00
183_R186_G0.6661.00
221_R226_I0.6651.00
118_D125_F0.6641.00
44_D84_D0.6621.00
168_Y172_V0.6601.00
50_V53_D0.6571.00
13_R16_G0.6551.00
126_T137_G0.6501.00
196_A219_L0.6451.00
184_R191_D0.6431.00
18_L43_V0.6421.00
213_F235_N0.6381.00
68_E84_D0.6381.00
131_Q222_E0.6340.99
103_I115_V0.6320.99
141_R144_T0.6310.99
249_V252_A0.6300.99
30_E42_N0.6270.99
123_E194_Y0.6260.99
21_K24_E0.6220.99
94_K180_A0.6220.99
82_V104_A0.6200.99
11_A15_A0.6180.99
90_T94_K0.6170.99
247_P251_K0.6170.99
156_G159_F0.6170.99
118_D123_E0.6150.99
55_I81_W0.6150.99
11_A58_S0.6150.99
236_Y239_T0.6130.99
67_E212_D0.6100.99
128_T132_G0.6090.99
8_A113_V0.6090.99
26_P29_V0.6040.99
243_V253_M0.6030.99
15_A19_I0.6000.99
208_L213_F0.6000.99
169_I175_L0.6000.99
106_R109_G0.6000.99
155_T158_P0.6000.99
81_W113_V0.5990.99
135_L199_R0.5990.99
67_E84_D0.5980.99
247_P250_V0.5950.99
148_L252_A0.5900.99
144_T248_R0.5890.99
17_N20_A0.5870.99
22_N86_L0.5840.99
5_L9_V0.5840.99
90_T152_I0.5820.99
47_A50_V0.5820.99
106_R210_P0.5810.99
12_A117_Y0.5790.99
139_R222_E0.5770.99
16_G124_L0.5760.99
213_F217_E0.5730.99
56_R72_L0.5730.99
65_I71_E0.5710.99
13_R136_N0.5700.99
8_A12_A0.5690.99
69_S72_L0.5680.99
82_V111_T0.5670.99
127_A132_G0.5660.99
64_I83_I0.5660.99
192_L195_V0.5650.99
140_L223_A0.5640.99
80_Q109_G0.5610.99
20_A119_P0.5610.99
16_G20_A0.5600.99
187_S191_D0.5550.99
29_V42_N0.5550.99
44_D212_D0.5540.99
221_R227_V0.5540.99
116_V215_A0.5530.99
68_E212_D0.5530.99
210_P238_L0.5520.99
98_H185_T0.5510.99
85_P89_T0.5490.99
98_H190_L0.5480.98
91_N186_G0.5470.98
30_E34_K0.5450.98
167_T171_I0.5450.98
7_I54_T0.5430.98
22_N92_F0.5430.98
97_P121_R0.5420.98
87_D212_D0.5410.98
25_T42_N0.5380.98
228_S232_G0.5370.98
145_A201_D0.5340.98
227_V244_A0.5330.98
14_K18_L0.5300.98
67_E85_P0.5300.98
44_D85_P0.5280.98
126_T136_N0.5270.98
191_D203_F0.5270.98
101_V115_V0.5250.98
45_K69_S0.5250.98
68_E85_P0.5240.98
115_V124_L0.5240.98
11_A14_K0.5240.98
133_A223_A0.5240.98
19_I101_V0.5230.98
40_V45_K0.5210.98
245_G253_M0.5210.98
191_D200_V0.5160.98
40_V48_E0.5130.98
172_V175_L0.5110.98
185_T191_D0.5100.98
171_I175_L0.5090.98
153_L156_G0.5090.98
171_I204_F0.5070.98
219_L223_A0.5060.97
245_G248_R0.5060.97
66_T72_L0.5030.97
34_K41_T0.5020.97
155_T184_R0.5020.97
167_T170_N0.5000.97
100_A116_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qflA 1 0.9813 100 0.086 Contact Map
3lv0A 2 0.9663 100 0.098 Contact Map
4n81A 2 0.9288 100 0.103 Contact Map
2pcrA 3 0.8989 100 0.106 Contact Map
2fvzA 2 0.8951 100 0.129 Contact Map
2p3nA 4 0.9551 100 0.129 Contact Map
4i3yA 2 0.9625 100 0.132 Contact Map
2q74A 2 0.8764 100 0.134 Contact Map
2bjiA 2 0.9813 100 0.139 Contact Map
3t0jA 3 0.9588 100 0.14 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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