GREMLIN Database
ILVM - Acetolactate synthase isozyme 2 small subunit
UniProt: P0ADG1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10501
Length: 87 (78)
Sequences: 161 (106)
Seq/√Len: 12.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_L31_V4.9831.00
22_R26_H4.2751.00
31_V34_M4.0460.99
4_H64_L2.4780.88
38_A47_I2.1440.80
17_L55_R1.8330.68
15_E22_R1.6850.61
7_N74_A1.6770.60
6_V57_V1.6710.60
71_A75_I1.6240.58
5_Q33_S1.5730.55
53_S73_V1.5040.52
15_E26_H1.4990.52
10_A73_V1.4660.50
12_F30_H1.4590.50
6_V24_V1.4570.50
14_P36_M1.4550.49
16_T59_L1.4490.49
52_A57_V1.3490.44
32_C70_V1.3460.44
62_S68_V1.2430.39
20_V31_V1.2360.39
61_F68_V1.2280.38
24_V49_L1.1700.36
34_M64_L1.1110.33
2_M77_Q1.1110.33
2_M75_I1.0870.32
10_A30_H1.0630.31
22_R29_F1.0560.31
33_S50_T1.0460.30
2_M9_S1.0410.30
8_V72_H1.0250.29
9_S49_L1.0090.29
11_R71_A1.0050.28
61_F71_A1.0020.28
37_A68_V0.9990.28
10_A48_E0.9990.28
26_H29_F0.9970.28
15_E55_R0.9860.28
15_E29_F0.9820.28
31_V49_L0.9730.27
5_Q54_P0.9710.27
16_T68_V0.9710.27
62_S71_A0.9700.27
20_V73_V0.9640.27
22_R33_S0.9490.26
8_V20_V0.9420.26
5_Q59_L0.9250.25
12_F48_E0.9240.25
43_Q57_V0.9240.25
12_F50_T0.9010.24
36_M45_I0.8940.24
12_F61_F0.8760.23
16_T36_M0.8750.23
17_L59_L0.8740.23
32_C71_A0.8710.23
45_I61_F0.8640.23
15_E69_D0.8560.23
54_P58_D0.8510.23
56_S73_V0.8490.23
30_H49_L0.8460.22
22_R55_R0.8230.22
26_H33_S0.8210.22
40_S54_P0.8020.21
35_N41_D0.8000.21
37_A45_I0.7990.21
76_C79_T0.7890.20
35_N52_A0.7710.20
26_H50_T0.7450.19
3_Q53_S0.7410.19
6_V56_S0.7360.19
20_V42_A0.7170.18
57_V61_F0.7170.18
39_A57_V0.7050.18
26_H55_R0.6930.18
43_Q62_S0.6900.17
54_P62_S0.6860.17
29_F55_R0.6820.17
13_N24_V0.6790.17
19_R53_S0.6780.17
14_P45_I0.6700.17
46_N72_H0.6620.17
4_H34_M0.6550.16
7_N31_V0.6510.16
36_M55_R0.6500.16
20_V34_M0.6470.16
5_Q75_I0.6360.16
24_V54_P0.6310.16
37_A73_V0.6310.16
65_N72_H0.6290.16
9_S74_A0.6260.16
3_Q32_C0.6110.15
24_V74_A0.6090.15
21_L51_V0.6080.15
31_V75_I0.6000.15
7_N75_I0.5980.15
10_A20_V0.5980.15
4_H71_A0.5900.15
59_L68_V0.5880.15
41_D44_N0.5840.15
5_Q64_L0.5840.15
58_D69_D0.5760.14
32_C48_E0.5520.14
4_H65_N0.5520.14
10_A49_L0.5410.14
8_V79_T0.5390.13
5_Q48_E0.5380.13
22_R38_A0.5260.13
20_V33_S0.5250.13
34_M39_A0.5210.13
4_H75_I0.5210.13
19_R67_L0.5160.13
32_C68_V0.5120.13
47_I56_S0.5080.13
5_Q17_L0.5040.13
62_S70_V0.5000.13
22_R50_T0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f1fA 4 0.9655 98.6 0.717 Contact Map
2pc6A 2 0.977 98.5 0.718 Contact Map
2fgcA 2 0.977 98.3 0.735 Contact Map
2lvwA 2 1 96.5 0.812 Contact Map
1zpvA 3 0.977 95.1 0.831 Contact Map
2ko1A 2 0.9655 93.8 0.841 Contact Map
1y7pA 5 0.9885 93.7 0.842 Contact Map
1u8sA 2 0.931 86 0.867 Contact Map
2nyiA 2 0.9195 83.4 0.871 Contact Map
2jheA 2 0.931 81.6 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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