GREMLIN Database
ILVN - Acetolactate synthase isozyme 1 small subunit
UniProt: P0ADF8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10502
Length: 96 (85)
Sequences: 1803 (802)
Seq/√Len: 87.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_N48_D3.1811.00
41_C50_S2.9071.00
17_N50_S2.8291.00
15_V21_V2.7891.00
16_R74_D2.4811.00
22_M39_I2.4131.00
63_E67_S2.2921.00
49_K76_V2.2021.00
37_E57_N2.0951.00
22_M41_C1.9971.00
31_R56_V1.8501.00
16_R76_V1.7381.00
27_G32_R1.7351.00
18_H74_D1.6451.00
67_S70_D1.5561.00
63_E77_K1.5421.00
21_V52_I1.5141.00
70_D77_K1.5131.00
44_I47_S1.5061.00
25_V52_I1.4680.99
8_N88_F1.4590.99
38_G55_L1.4320.99
39_I50_S1.3740.99
23_T30_A1.3650.99
23_T26_C1.3320.99
31_R71_K1.3270.99
22_M36_V1.3210.99
21_V31_R1.3000.99
17_N46_D1.2790.98
15_V25_V1.2640.98
17_N43_P1.2520.98
11_L19_P1.2320.98
15_V52_I1.2300.98
9_V80_R1.2140.98
36_V41_C1.1720.97
40_L52_I1.1280.97
51_H91_I1.1130.96
35_N41_C1.1110.96
25_V72_L1.1000.96
68_Q71_K1.0850.96
27_G30_A1.0640.95
56_V65_M1.0640.95
13_L54_L1.0520.95
8_N37_E1.0170.94
32_R71_K1.0090.94
15_V41_C1.0070.94
10_I88_F0.9620.92
41_C52_I0.9610.92
13_L69_I0.9230.90
66_I70_D0.9000.89
82_Q85_P0.8850.88
27_G31_R0.8800.88
21_V26_C0.8780.88
24_H72_L0.8750.88
21_V50_S0.8750.88
63_E66_I0.8750.88
30_A39_I0.8440.86
45_Q77_K0.8390.85
15_V26_C0.8330.85
24_H50_S0.8270.85
12_E81_N0.8190.84
70_D79_Q0.8140.84
20_G30_A0.8130.84
26_C52_I0.8070.83
10_I20_G0.7900.82
11_L79_Q0.7810.81
9_V73_E0.7740.81
14_T89_N0.7600.79
82_Q86_T0.7570.79
55_L62_L0.7530.79
45_Q51_H0.7510.78
63_E79_Q0.7490.78
64_Q68_Q0.7470.78
43_P47_S0.7310.77
22_M50_S0.7150.75
25_V54_L0.7150.75
11_L66_I0.7140.75
17_N44_I0.7130.75
23_T71_K0.7060.74
28_L34_F0.7030.74
57_N60_Q0.6890.72
66_I80_R0.6780.71
16_R30_A0.6680.70
20_G27_G0.6620.69
45_Q91_I0.6560.69
9_V72_L0.6500.68
23_T27_G0.6480.68
44_I53_W0.6400.67
19_P40_L0.6390.67
69_I80_R0.6350.66
29_F34_F0.6310.66
52_I71_K0.6300.65
25_V70_D0.6210.64
70_D73_E0.6100.63
48_D85_P0.6090.63
19_P72_L0.6080.63
10_I55_L0.6030.62
42_L79_Q0.6020.62
70_D85_P0.5980.61
23_T39_I0.5930.61
28_L64_Q0.5900.60
55_L88_F0.5820.59
11_L86_T0.5780.59
35_N50_S0.5780.59
45_Q92_A0.5770.59
36_V39_I0.5760.59
27_G75_V0.5740.58
36_V71_K0.5660.57
63_E70_D0.5650.57
67_S77_K0.5630.57
37_E43_P0.5600.56
18_H60_Q0.5560.56
59_D92_A0.5490.55
83_S86_T0.5470.55
11_L56_V0.5440.54
43_P65_M0.5430.54
46_D86_T0.5390.54
34_F40_L0.5380.54
16_R48_D0.5360.53
26_C72_L0.5350.53
9_V88_F0.5330.53
32_R72_L0.5250.52
11_L62_L0.5200.51
10_I89_N0.5140.50
88_F92_A0.5090.50
31_R42_L0.5010.49
24_H33_A0.5010.49
58_D62_L0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f1fA 4 0.9271 99.9 0.419 Contact Map
2pc6A 2 0.9375 99.9 0.419 Contact Map
2fgcA 2 0.9375 99.9 0.426 Contact Map
2lvwA 2 1 99.4 0.634 Contact Map
1y7pA 5 0.9479 98.9 0.703 Contact Map
1zpvA 3 0.9167 98.5 0.745 Contact Map
2f06A 4 0.9479 98.3 0.756 Contact Map
2ko1A 2 0.8958 98.3 0.76 Contact Map
1u8sA 2 0.8958 98.2 0.766 Contact Map
3n0vA 4 0.9375 97.9 0.783 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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