EDD - ECOLI - GREMLIN Contacts

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EDD - Phosphogluconate dehydratase

UniProt:	P0ADF6	Sequences: MNPQLLRVTNRIIERSRETRSAYLARIEQAKTSTVHRSQLACGNLAHGFAACQPEDKASLKSMLRNNIAIITSYNDMLSAHQPYEHYPEIIRKALHEANAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAVGLSHNMFDGALFLGVCDKIVPGLTMAALSFGHLPAVFVPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQLPGSSFVHPDSPLRDALTAAAARQVTRMTGNGNEWMPIGKMIDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGIQINWDDFSDLSDVVPLMARLYPNGPADINHFQAAGGVPVLVRELLKAGLLHEDVNTVAGFGLSRYTLEPWLNNGELDWREGAEKSLDSNVIASFEQPFSHHGGTKVLSGNLGRAVMKTSAVPVENQVIEAPAVVFESQHDVMPAFEAGLLDRDCVVVVRHQGPKANGMPELHKLMPPLGVLLDRCFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDIIRVNGQTGELTLLVDEAELAAREPHIPDLSASRVGTGRELFSALREKLSGAEQGATCITF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10257
Length:	603 (540)
Sequences:	4834 (1952)
Seq/√Len:	84.0

ECOLI - EDD YAGF YJHG ILVD
BACSU - ILVD
SULSO - ILVD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
445_E	545_R	4.488	1.00
537_K	566_E	4.341	1.00
282_I	287_V	3.870	1.00
285_K	367_H	3.705	1.00
545_R	556_L	3.619	1.00
537_K	562_L	3.584	1.00
445_E	556_L	3.569	1.00
288_V	367_H	3.392	1.00
468_R	503_K	3.291	1.00
445_E	543_I	3.244	1.00
277_P	280_K	3.242	1.00
539_R	568_H	3.211	1.00
547_N	550_T	3.153	1.00
147_G	269_T	3.048	1.00
368_E	379_S	2.901	1.00
538_V	555_L	2.861	1.00
361_L	368_E	2.841	1.00
203_D	206_A	2.801	1.00
170_H	279_G	2.701	1.00
170_H	280_K	2.684	1.00
543_I	556_L	2.657	1.00
272_G	277_P	2.616	1.00
408_A	412_Q	2.597	1.00
68_I	147_G	2.571	1.00
449_V	470_C	2.547	1.00
545_R	554_T	2.543	1.00
282_I	286_V	2.450	1.00
449_V	540_D	2.443	1.00
374_A	381_Y	2.432	1.00
447_P	543_I	2.423	1.00
166_L	282_I	2.415	1.00
480_K	531_D	2.406	1.00
539_R	561_E	2.383	1.00
321_D	424_S	2.366	1.00
558_D	561_E	2.359	1.00
239_M	282_I	2.340	1.00
561_E	564_A	2.331	1.00
264_Q	267_R	2.309	1.00
176_V	261_A	2.309	1.00
293_A	357_V	2.303	1.00
162_T	239_M	2.298	1.00
453_S	456_D	2.253	1.00
292_V	329_V	2.223	1.00
194_R	515_A	2.213	1.00
426_N	554_T	2.201	1.00
324_S	328_D	2.200	1.00
174_V	265_V	2.187	1.00
285_K	369_D	2.151	1.00
430_A	553_L	2.140	1.00
246_F	344_I	2.133	1.00
507_V	525_V	2.131	1.00
443_V	547_N	2.103	1.00
72_T	104_V	2.095	1.00
376_F	380_R	2.094	1.00
291_I	323_F	2.085	1.00
162_T	310_M	2.084	1.00
452_E	475_R	2.076	1.00
292_V	330_V	2.064	1.00
559_E	563_A	2.055	1.00
54_P	212_A	2.049	1.00
54_P	60_L	2.047	1.00
295_L	326_L	2.001	1.00
271_N	276_M	1.998	1.00
370_V	378_L	1.995	1.00
442_Q	549_Q	1.974	1.00
557_V	562_L	1.968	1.00
182_A	250_D	1.959	1.00
68_I	269_T	1.955	1.00
284_E	288_V	1.947	1.00
319_N	322_D	1.897	1.00
576_R	580_G	1.875	1.00
324_S	551_G	1.874	1.00
427_L	538_V	1.866	1.00
260_A	263_R	1.851	1.00
564_A	567_P	1.847	1.00
267_R	270_G	1.842	1.00
538_V	544_I	1.828	1.00
150_F	173_A	1.827	1.00
569_I	572_L	1.822	1.00
555_L	562_L	1.814	1.00
377_G	380_R	1.787	1.00
234_V	240_Q	1.784	1.00
100_A	266_T	1.771	1.00
564_A	568_H	1.753	1.00
253_L	348_Q	1.746	1.00
538_V	557_V	1.745	1.00
174_V	264_Q	1.744	1.00
357_V	378_L	1.740	1.00
166_L	314_A	1.733	1.00
288_V	325_D	1.732	1.00
452_E	456_D	1.729	1.00
421_K	551_G	1.728	1.00
267_R	271_N	1.705	1.00
562_L	566_E	1.691	1.00
443_V	549_Q	1.688	1.00
97_E	263_R	1.685	1.00
585_S	589_E	1.657	1.00
165_A	173_A	1.637	1.00
147_G	265_V	1.634	1.00
240_Q	244_S	1.630	1.00
357_V	383_L	1.626	1.00
563_A	567_P	1.624	1.00
174_V	373_V	1.620	1.00
291_I	318_I	1.616	1.00
196_L	201_K	1.614	1.00
534_L	562_L	1.607	1.00
183_S	345_N	1.603	1.00
459_P	463_A	1.600	1.00
95_L	100_A	1.594	1.00
429_R	433_K	1.593	1.00
292_V	326_L	1.588	1.00
202_V	206_A	1.578	1.00
229_T	299_G	1.577	1.00
86_H	255_D	1.573	1.00
444_I	447_P	1.565	1.00
140_L	148_A	1.559	1.00
452_E	476_H	1.555	1.00
70_I	95_L	1.548	1.00
38_S	42_C	1.530	1.00
268_M	276_M	1.530	1.00
443_V	545_R	1.519	1.00
447_P	470_C	1.511	0.99
526_T	595_E	1.509	0.99
236_F	293_A	1.503	0.99
450_V	538_V	1.496	0.99
289_N	370_V	1.476	0.99
448_A	544_I	1.468	0.99
328_D	417_H	1.467	0.99
96_H	102_G	1.463	0.99
244_S	257_L	1.463	0.99
78_L	110_A	1.452	0.99
325_D	329_V	1.443	0.99
359_E	362_K	1.439	0.99
90_I	259_A	1.434	0.99
554_T	559_E	1.427	0.99
451_F	460_A	1.425	0.99
451_F	465_L	1.425	0.99
536_A	569_I	1.421	0.99
284_E	322_D	1.420	0.99
322_D	325_D	1.406	0.99
460_A	466_L	1.393	0.99
186_P	206_A	1.393	0.99
89_E	93_K	1.382	0.99
342_A	405_N	1.382	0.99
563_A	566_E	1.374	0.99
312_R	596_Q	1.367	0.99
60_L	208_L	1.365	0.99
376_F	381_Y	1.365	0.99
448_A	538_V	1.362	0.99
557_V	561_E	1.361	0.99
71_I	139_G	1.360	0.99
88_P	151_L	1.358	0.99
163_M	313_A	1.355	0.99
62_S	65_R	1.352	0.99
239_M	278_I	1.352	0.99
91_I	149_L	1.349	0.99
285_K	288_V	1.341	0.99
464_G	500_R	1.340	0.99
430_A	433_K	1.335	0.99
335_R	341_P	1.334	0.99
282_I	314_A	1.330	0.99
321_D	325_D	1.323	0.99
164_A	278_I	1.322	0.99
431_V	435_S	1.322	0.99
229_T	303_H	1.312	0.99
307_L	318_I	1.304	0.98
84_Y	153_V	1.303	0.98
304_T	308_V	1.295	0.98
363_A	410_F	1.290	0.98
93_K	96_H	1.290	0.98
456_D	459_P	1.279	0.98
76_D	92_R	1.278	0.98
347_F	356_L	1.267	0.98
90_I	255_D	1.253	0.98
404_S	412_Q	1.249	0.98
429_R	435_S	1.247	0.98
94_A	262_A	1.246	0.98
359_E	404_S	1.246	0.98
111_M	142_H	1.244	0.98
281_M	286_V	1.242	0.98
68_I	95_L	1.236	0.98
284_E	325_D	1.230	0.98
95_L	262_A	1.226	0.98
85_E	89_E	1.225	0.98
287_V	310_M	1.224	0.98
209_E	213_A	1.217	0.98
162_T	234_V	1.216	0.98
236_F	357_V	1.214	0.98
455_H	459_P	1.214	0.98
473_V	538_V	1.213	0.98
401_S	404_S	1.211	0.98
264_Q	271_N	1.210	0.97
58_A	103_Q	1.207	0.97
577_V	580_G	1.206	0.97
170_H	277_P	1.202	0.97
468_R	499_D	1.195	0.97
149_L	265_V	1.195	0.97
149_L	262_A	1.189	0.97
537_K	557_V	1.187	0.97
473_V	544_I	1.186	0.97
443_V	550_T	1.185	0.97
449_V	467_D	1.183	0.97
191_V	210_S	1.183	0.97
67_N	103_Q	1.178	0.97
77_M	145_F	1.178	0.97
366_L	378_L	1.172	0.97
69_A	140_L	1.168	0.97
592_S	596_Q	1.167	0.97
97_E	259_A	1.159	0.97
166_L	239_M	1.157	0.97
361_L	366_L	1.156	0.97
433_K	436_A	1.155	0.97
526_T	593_G	1.155	0.97
426_N	559_E	1.146	0.97
450_V	540_D	1.142	0.96
69_A	148_A	1.133	0.96
409_S	412_Q	1.126	0.96
317_Q	596_Q	1.121	0.96
361_L	379_S	1.119	0.96
164_A	168_F	1.119	0.96
150_F	175_F	1.118	0.96
90_I	93_K	1.113	0.96
185_L	190_K	1.105	0.96
58_A	101_V	1.104	0.96
74_Y	85_E	1.103	0.96
332_L	415_S	1.094	0.95
537_K	569_I	1.093	0.95
449_V	460_A	1.093	0.95
71_I	148_A	1.091	0.95
187_N	206_A	1.087	0.95
177_P	244_S	1.084	0.95
38_S	41_A	1.078	0.95
470_C	540_D	1.078	0.95
535_L	538_V	1.074	0.95
50_A	211_E	1.074	0.95
136_A	164_A	1.072	0.95
284_E	317_Q	1.071	0.95
455_H	488_H	1.070	0.95
40_L	53_Q	1.070	0.95
432_M	546_V	1.064	0.95
109_P	135_S	1.063	0.95
246_F	348_Q	1.061	0.95
86_H	89_E	1.060	0.95
192_R	343_D	1.055	0.94
358_R	398_A	1.052	0.94
208_L	212_A	1.048	0.94
237_M	287_V	1.046	0.94
377_G	381_Y	1.046	0.94
123_E	488_H	1.044	0.94
152_G	158_V	1.041	0.94
593_G	596_Q	1.040	0.94
505_A	546_V	1.040	0.94
534_L	566_E	1.038	0.94
280_K	371_N	1.035	0.94
447_P	467_D	1.034	0.94
288_V	322_D	1.030	0.94
187_N	209_E	1.029	0.94
452_E	539_R	1.026	0.94
426_N	555_L	1.024	0.94
429_R	436_A	1.023	0.93
182_A	251_S	1.019	0.93
60_L	212_A	1.018	0.93
247_V	251_S	1.013	0.93
94_A	97_E	1.011	0.93
427_L	534_L	1.006	0.93
242_P	381_Y	0.996	0.93
361_L	384_E	0.991	0.92
534_L	555_L	0.985	0.92
572_L	576_R	0.982	0.92
449_V	466_L	0.982	0.92
182_A	217_A	0.976	0.92
361_L	383_L	0.973	0.92
305_M	308_V	0.966	0.91
93_K	259_A	0.966	0.91
264_Q	268_M	0.965	0.91
566_E	569_I	0.962	0.91
363_A	411_E	0.961	0.91
466_L	472_V	0.961	0.91
276_M	371_N	0.959	0.91
217_A	252_P	0.957	0.91
73_S	161_L	0.954	0.91
557_V	566_E	0.953	0.91
294_L	303_H	0.951	0.91
150_F	165_A	0.945	0.90
467_D	470_C	0.944	0.90
284_E	316_I	0.942	0.90
378_L	381_Y	0.941	0.90
358_R	399_E	0.939	0.90
421_K	549_Q	0.938	0.90
43_G	119_Q	0.936	0.90
472_V	497_L	0.935	0.90
247_V	257_L	0.934	0.90
345_N	349_A	0.933	0.90
422_V	431_V	0.931	0.90
431_V	436_A	0.930	0.90
404_S	409_S	0.927	0.90
577_V	585_S	0.924	0.89
119_Q	143_N	0.924	0.89
358_R	362_K	0.923	0.89
358_R	361_L	0.923	0.89
252_P	256_A	0.922	0.89
364_G	410_F	0.920	0.89
473_V	555_L	0.918	0.89
237_M	290_G	0.916	0.89
40_L	144_M	0.914	0.89
266_T	270_G	0.908	0.89
63_M	101_V	0.906	0.89
430_A	435_S	0.905	0.88
432_M	548_G	0.902	0.88
131_V	138_V	0.902	0.88
186_P	210_S	0.900	0.88
578_G	582_E	0.898	0.88
471_V	544_I	0.897	0.88
134_M	586_A	0.894	0.88
132_I	160_G	0.891	0.88
240_Q	261_A	0.891	0.88
522_A	546_V	0.889	0.88
498_L	521_S	0.888	0.88
82_Q	218_P	0.887	0.87
241_L	264_Q	0.887	0.87
131_V	583_L	0.885	0.87
452_E	572_L	0.885	0.87
272_G	278_I	0.885	0.87
333_M	410_F	0.884	0.87
174_V	261_A	0.883	0.87
53_Q	56_D	0.880	0.87
124_L	141_S	0.879	0.87
93_K	97_E	0.877	0.87
297_T	356_L	0.874	0.87
341_P	405_N	0.870	0.86
445_E	554_T	0.869	0.86
55_E	79_S	0.868	0.86
196_L	210_S	0.868	0.86
461_F	493_P	0.867	0.86
286_V	371_N	0.866	0.86
359_E	411_E	0.866	0.86
477_Q	488_H	0.864	0.86
587_L	591_L	0.862	0.86
88_P	104_V	0.860	0.86
92_R	104_V	0.860	0.86
335_R	342_A	0.858	0.86
330_V	365_L	0.856	0.86
276_M	280_K	0.856	0.86
484_M	488_H	0.852	0.85
560_A	564_A	0.849	0.85
474_V	477_Q	0.848	0.85
54_P	63_M	0.846	0.85
441_N	444_I	0.844	0.85
84_Y	178_S	0.843	0.85
178_S	220_T	0.843	0.85
189_E	206_A	0.842	0.85
555_L	558_D	0.839	0.84
71_I	136_A	0.836	0.84
362_K	399_E	0.834	0.84
152_G	175_F	0.834	0.84
256_A	260_A	0.834	0.84
253_L	256_A	0.834	0.84
112_C	116_T	0.832	0.84
532_G	569_I	0.832	0.84
328_D	551_G	0.831	0.84
67_N	101_V	0.831	0.84
491_M	512_L	0.829	0.84
100_A	262_A	0.828	0.84
586_A	590_K	0.826	0.83
190_K	345_N	0.826	0.83
433_K	437_V	0.825	0.83
281_M	371_N	0.825	0.83
83_P	178_S	0.822	0.83
182_A	248_H	0.822	0.83
47_H	196_L	0.821	0.83
239_M	281_M	0.820	0.83
268_M	373_V	0.819	0.83
371_N	376_F	0.818	0.83
350_A	404_S	0.817	0.83
233_V	294_L	0.816	0.83
357_V	366_L	0.816	0.83
466_L	540_D	0.813	0.82
59_S	62_S	0.808	0.82
279_G	315_G	0.804	0.82
264_Q	276_M	0.802	0.82
430_A	436_A	0.801	0.82
362_K	379_S	0.800	0.81
192_R	196_L	0.799	0.81
149_L	176_V	0.798	0.81
262_A	265_V	0.797	0.81
430_A	526_T	0.797	0.81
111_M	138_V	0.795	0.81
384_E	398_A	0.793	0.81
378_L	383_L	0.793	0.81
361_L	364_G	0.792	0.81
572_L	578_G	0.791	0.81
293_A	353_V	0.790	0.81
136_A	161_L	0.790	0.81
586_A	600_C	0.790	0.81
65_R	97_E	0.789	0.81
545_R	552_E	0.787	0.80
37_R	40_L	0.781	0.80
94_A	259_A	0.780	0.80
486_E	489_K	0.778	0.80
507_V	538_V	0.777	0.80
461_F	496_V	0.775	0.79
287_V	316_I	0.775	0.79
335_R	408_A	0.775	0.79
168_F	171_L	0.774	0.79
558_D	564_A	0.772	0.79
72_T	84_Y	0.771	0.79
379_S	383_L	0.769	0.79
581_R	585_S	0.769	0.79
192_R	195_Q	0.768	0.79
162_T	282_I	0.767	0.79
444_I	471_V	0.766	0.79
329_V	365_L	0.766	0.79
266_T	269_T	0.765	0.78
324_S	421_K	0.764	0.78
312_R	317_Q	0.763	0.78
138_V	583_L	0.763	0.78
173_A	278_I	0.759	0.78
350_A	401_S	0.758	0.78
70_I	92_R	0.755	0.78
98_A	262_A	0.755	0.78
232_M	245_S	0.755	0.78
232_M	297_T	0.753	0.77
65_R	101_V	0.753	0.77
473_V	525_V	0.751	0.77
110_A	157_I	0.750	0.77
347_F	407_I	0.749	0.77
166_L	287_V	0.748	0.77
95_L	149_L	0.747	0.77
94_A	98_A	0.746	0.77
111_M	125_S	0.746	0.77
371_N	381_Y	0.745	0.77
276_M	381_Y	0.745	0.77
449_V	465_L	0.745	0.77
429_R	534_L	0.744	0.77
334_A	356_L	0.744	0.77
476_H	536_A	0.742	0.76
204_R	208_L	0.741	0.76
36_H	141_S	0.741	0.76
36_H	40_L	0.740	0.76
467_D	502_F	0.740	0.76
243_G	348_Q	0.740	0.76
466_L	470_C	0.739	0.76
80_A	112_C	0.739	0.76
120_D	579_T	0.735	0.76
285_K	370_V	0.735	0.76
522_A	525_V	0.734	0.76
292_V	365_L	0.733	0.75
427_L	475_R	0.732	0.75
525_V	535_L	0.731	0.75
70_I	91_I	0.730	0.75
326_L	329_V	0.729	0.75
283_D	286_V	0.727	0.75
272_G	276_M	0.726	0.75
516_S	521_S	0.726	0.75
152_G	161_L	0.726	0.75
166_L	286_V	0.726	0.75
84_Y	104_V	0.720	0.74
84_Y	88_P	0.713	0.73
70_I	148_A	0.713	0.73
177_P	231_Q	0.712	0.73
423_L	430_A	0.709	0.73
73_S	152_G	0.709	0.73
177_P	254_R	0.709	0.73
224_Y	297_T	0.708	0.73
371_N	374_A	0.707	0.73
286_V	316_I	0.706	0.73
39_Q	144_M	0.706	0.73
66_N	100_A	0.706	0.73
296_A	333_M	0.706	0.73
265_V	269_T	0.705	0.73
76_D	104_V	0.704	0.72
41_A	67_N	0.704	0.72
592_S	599_T	0.704	0.72
547_N	552_E	0.703	0.72
69_A	145_F	0.700	0.72
287_V	318_I	0.698	0.72
186_P	209_E	0.693	0.71
268_M	281_M	0.692	0.71
170_H	278_I	0.692	0.71
148_A	173_A	0.689	0.71
185_L	188_K	0.688	0.71
304_T	323_F	0.688	0.71
190_K	343_D	0.688	0.71
369_D	379_S	0.688	0.71
91_I	151_L	0.683	0.70
365_L	410_F	0.682	0.70
279_G	581_R	0.682	0.70
42_C	64_L	0.681	0.70
368_E	383_L	0.681	0.70
233_V	307_L	0.680	0.70
380_R	384_E	0.679	0.70
69_A	105_A	0.679	0.70
427_L	554_T	0.679	0.70
452_E	540_D	0.679	0.70
291_I	326_L	0.679	0.70
95_L	102_G	0.678	0.70
166_L	278_I	0.677	0.70
258_T	261_A	0.677	0.70
458_M	492_P	0.677	0.70
255_D	259_A	0.675	0.69
291_I	307_L	0.675	0.69
557_V	563_A	0.674	0.69
59_S	63_M	0.674	0.69
462_E	515_A	0.673	0.69
71_I	105_A	0.673	0.69
558_D	562_L	0.673	0.69
446_A	471_V	0.672	0.69
107_G	161_L	0.672	0.69
288_V	369_D	0.672	0.69
451_F	466_L	0.672	0.69
181_M	215_Y	0.672	0.69
379_S	384_E	0.672	0.69
354_P	381_Y	0.671	0.69
433_K	438_P	0.670	0.69
456_D	460_A	0.668	0.69
549_Q	552_E	0.668	0.69
320_W	595_E	0.668	0.69
429_R	432_M	0.667	0.68
544_I	555_L	0.662	0.68
468_R	502_F	0.659	0.67
531_D	593_G	0.659	0.67
218_P	250_D	0.659	0.67
239_M	283_D	0.658	0.67
580_G	585_S	0.657	0.67
367_H	370_V	0.657	0.67
548_G	551_G	0.656	0.67
281_M	372_T	0.656	0.67
85_E	92_R	0.655	0.67
75_N	139_G	0.655	0.67
447_P	545_R	0.654	0.67
437_V	548_G	0.654	0.67
282_I	318_I	0.653	0.67
191_V	195_Q	0.652	0.67
193_I	197_Y	0.651	0.67
62_S	263_R	0.650	0.66
484_M	594_A	0.649	0.66
328_D	421_K	0.649	0.66
268_M	271_N	0.648	0.66
318_I	323_F	0.648	0.66
447_P	471_V	0.647	0.66
362_K	411_E	0.647	0.66
192_R	515_A	0.647	0.66
437_V	441_N	0.646	0.66
46_A	49_F	0.646	0.66
196_L	214_S	0.646	0.66
476_H	568_H	0.646	0.66
355_V	407_I	0.645	0.66
457_V	472_V	0.645	0.66
292_V	360_L	0.645	0.66
311_A	316_I	0.644	0.66
370_V	377_G	0.644	0.66
73_S	110_A	0.644	0.66
261_A	265_V	0.644	0.66
98_A	266_T	0.643	0.66
421_K	432_M	0.642	0.65
70_I	88_P	0.641	0.65
370_V	379_S	0.641	0.65
236_F	366_L	0.641	0.65
532_G	537_K	0.641	0.65
73_S	107_G	0.640	0.65
312_R	599_T	0.640	0.65
90_I	94_A	0.638	0.65
315_G	581_R	0.637	0.65
95_L	265_V	0.636	0.65
236_F	353_V	0.635	0.65
153_V	178_S	0.635	0.65
286_V	314_A	0.634	0.65
536_A	567_P	0.633	0.64
174_V	268_M	0.633	0.64
239_M	286_V	0.633	0.64
140_L	171_L	0.632	0.64
324_S	327_S	0.632	0.64
304_T	431_V	0.630	0.64
47_H	207_L	0.629	0.64
68_I	265_V	0.629	0.64
283_D	370_V	0.628	0.64
536_A	572_L	0.626	0.64
131_V	135_S	0.623	0.63
279_G	314_A	0.623	0.63
421_K	434_T	0.622	0.63
248_H	348_Q	0.621	0.63
471_V	505_A	0.621	0.63
531_D	569_I	0.620	0.63
530_Y	571_D	0.618	0.63
78_L	139_G	0.618	0.63
77_M	139_G	0.618	0.63
89_E	92_R	0.617	0.62
36_H	39_Q	0.617	0.62
75_N	110_A	0.616	0.62
374_A	377_G	0.615	0.62
233_V	237_M	0.615	0.62
53_Q	58_A	0.613	0.62
576_R	579_T	0.613	0.62
234_V	310_M	0.613	0.62
333_M	359_E	0.613	0.62
333_M	408_A	0.612	0.62
85_E	104_V	0.612	0.62
236_F	370_V	0.612	0.62
342_A	406_V	0.611	0.62
247_V	348_Q	0.611	0.62
183_S	222_T	0.611	0.62
117_Q	223_F	0.611	0.62
186_P	202_V	0.611	0.62
48_G	144_M	0.610	0.62
438_P	441_N	0.609	0.61
539_R	569_I	0.609	0.61
166_L	279_G	0.609	0.61
259_A	263_R	0.608	0.61
510_G	598_A	0.608	0.61
198_A	462_E	0.607	0.61
94_A	263_R	0.607	0.61
530_Y	591_L	0.606	0.61
36_H	43_G	0.603	0.61
36_H	144_M	0.602	0.61
543_I	555_L	0.601	0.60
81_H	181_M	0.599	0.60
350_A	407_I	0.599	0.60
449_V	468_R	0.599	0.60
359_E	410_F	0.599	0.60
148_A	168_F	0.598	0.60
243_G	354_P	0.598	0.60
185_L	349_A	0.595	0.60
256_A	259_A	0.595	0.60
460_A	465_L	0.593	0.59
217_A	250_D	0.593	0.59
438_P	442_Q	0.592	0.59
427_L	535_L	0.592	0.59
117_Q	225_G	0.592	0.59
333_M	356_L	0.592	0.59
234_V	239_M	0.592	0.59
222_T	337_Y	0.592	0.59
484_M	489_K	0.590	0.59
324_S	424_S	0.590	0.59
332_L	414_F	0.589	0.59
127_L	583_L	0.588	0.59
171_L	278_I	0.587	0.59
566_E	570_P	0.587	0.59
96_H	101_V	0.587	0.59
81_H	112_C	0.586	0.58
405_N	408_A	0.586	0.58
432_M	437_V	0.586	0.58
267_R	276_M	0.584	0.58
87_Y	151_L	0.584	0.58
450_V	555_L	0.583	0.58
557_V	564_A	0.583	0.58
257_L	261_A	0.583	0.58
264_Q	373_V	0.582	0.58
495_G	515_A	0.581	0.58
199_E	500_R	0.580	0.58
297_T	347_F	0.580	0.58
564_A	570_P	0.579	0.58
260_A	264_Q	0.577	0.57
459_P	465_L	0.577	0.57
87_Y	94_A	0.577	0.57
120_D	141_S	0.577	0.57
301_T	524_H	0.576	0.57
295_L	327_S	0.576	0.57
427_L	555_L	0.575	0.57
571_D	576_R	0.575	0.57
43_G	46_A	0.574	0.57
254_R	257_L	0.574	0.57
332_L	418_G	0.573	0.57
374_A	380_R	0.573	0.57
232_M	344_I	0.573	0.57
531_D	595_E	0.573	0.57
447_P	555_L	0.572	0.57
80_A	157_I	0.572	0.57
113_D	122_M	0.572	0.57
205_M	209_E	0.572	0.57
292_V	367_H	0.572	0.57
491_M	494_L	0.572	0.57
339_N	436_A	0.571	0.57
222_T	343_D	0.570	0.56
336_L	347_F	0.570	0.56
53_Q	63_M	0.570	0.56
193_I	202_V	0.569	0.56
572_L	577_V	0.569	0.56
364_G	368_E	0.569	0.56
432_M	522_A	0.567	0.56
72_T	225_G	0.567	0.56
554_T	557_V	0.566	0.56
304_T	422_V	0.566	0.56
582_E	585_S	0.565	0.56
136_A	150_F	0.565	0.56
324_S	417_H	0.564	0.56
69_A	139_G	0.564	0.56
113_D	121_G	0.563	0.55
251_S	348_Q	0.562	0.55
405_N	412_Q	0.562	0.55
417_H	442_Q	0.561	0.55
426_N	534_L	0.559	0.55
383_L	399_E	0.558	0.55
282_I	310_M	0.558	0.55
165_A	175_F	0.558	0.55
66_N	266_T	0.555	0.54
444_I	505_A	0.554	0.54
505_A	519_V	0.554	0.54
175_F	244_S	0.554	0.54
69_A	104_V	0.553	0.54
152_G	215_Y	0.551	0.54
91_I	265_V	0.551	0.54
71_I	110_A	0.551	0.54
56_D	101_V	0.551	0.54
135_S	139_G	0.551	0.54
460_A	540_D	0.551	0.54
114_G	121_G	0.551	0.54
61_K	260_A	0.550	0.54
441_N	519_V	0.550	0.54
362_K	368_E	0.550	0.54
202_V	210_S	0.549	0.54
355_V	404_S	0.549	0.54
444_I	519_V	0.549	0.54
116_T	119_Q	0.548	0.53
447_P	556_L	0.548	0.53
432_M	436_A	0.548	0.53
141_S	144_M	0.547	0.53
87_Y	90_I	0.546	0.53
432_M	435_S	0.546	0.53
291_I	319_N	0.545	0.53
265_V	268_M	0.545	0.53
546_V	553_L	0.543	0.53
294_L	299_G	0.542	0.53
515_A	521_S	0.542	0.53
368_E	384_E	0.542	0.53
359_E	409_S	0.542	0.53
435_S	438_P	0.541	0.53
456_D	465_L	0.541	0.53
75_N	106_G	0.540	0.52
529_A	535_L	0.540	0.52
360_L	364_G	0.540	0.52
91_I	95_L	0.539	0.52
92_R	102_G	0.539	0.52
49_F	118_G	0.538	0.52
585_S	590_K	0.537	0.52
74_Y	88_P	0.536	0.52
372_T	381_Y	0.536	0.52
189_E	341_P	0.536	0.52
577_V	582_E	0.535	0.52
400_K	404_S	0.535	0.52
173_A	239_M	0.534	0.52
239_M	314_A	0.534	0.52
106_G	109_P	0.534	0.52
177_P	240_Q	0.533	0.52
360_L	366_L	0.533	0.52
217_A	251_S	0.531	0.51
231_Q	245_S	0.530	0.51
171_L	473_V	0.530	0.51
458_M	462_E	0.529	0.51
56_D	82_Q	0.529	0.51
128_S	138_V	0.529	0.51
383_L	398_A	0.528	0.51
45_L	198_A	0.527	0.51
140_L	145_F	0.526	0.51
61_K	263_R	0.525	0.50
335_R	405_N	0.524	0.50
421_K	548_G	0.523	0.50
231_Q	254_R	0.523	0.50
268_M	280_K	0.523	0.50
559_E	562_L	0.522	0.50
319_N	325_D	0.521	0.50
167_S	313_A	0.521	0.50
95_L	266_T	0.521	0.50
283_D	316_I	0.521	0.50
196_L	199_E	0.521	0.50
191_V	194_R	0.521	0.50
70_I	104_V	0.520	0.50
318_I	321_D	0.520	0.50
71_I	106_G	0.520	0.50
323_F	422_V	0.520	0.50
56_D	92_R	0.519	0.50
474_V	516_S	0.519	0.50
47_H	50_A	0.518	0.50
206_A	209_E	0.517	0.49
539_R	555_L	0.517	0.49
248_H	345_N	0.516	0.49
362_K	410_F	0.515	0.49
118_G	122_M	0.515	0.49
183_S	346_H	0.514	0.49
319_N	595_E	0.514	0.49
162_T	237_M	0.514	0.49
58_A	63_M	0.513	0.49
243_G	247_V	0.513	0.49
335_R	414_F	0.513	0.49
439_V	442_Q	0.513	0.49
83_P	249_P	0.512	0.49
186_P	191_V	0.512	0.49
71_I	107_G	0.512	0.49
116_T	125_S	0.511	0.49
448_A	471_V	0.511	0.49
451_F	540_D	0.511	0.49
248_H	251_S	0.511	0.49
591_L	598_A	0.510	0.48
285_K	325_D	0.509	0.48
567_P	570_P	0.509	0.48
76_D	82_Q	0.508	0.48
308_V	526_T	0.508	0.48
260_A	267_R	0.508	0.48
106_G	151_L	0.508	0.48
356_L	407_I	0.507	0.48
444_I	503_K	0.506	0.48
476_H	569_I	0.506	0.48
370_V	381_Y	0.503	0.48
244_S	254_R	0.503	0.48
423_L	432_M	0.503	0.48
41_A	119_Q	0.502	0.47
287_V	290_G	0.502	0.47
327_S	419_G	0.501	0.47
333_M	360_L	0.501	0.47
233_V	245_S	0.500	0.47
477_Q	484_M	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2gp4A	2	0.8541	100	0.068	Contact Map
3rfqA	5	0.2189	76.9	0.981	Contact Map
2pcnA	3	0.2338	69.8	0.982	Contact Map
2is8A	3	0.2355	62	0.983	Contact Map
4xcwA	3	0.257	60.3	0.984	Contact Map
2c5qA	3	0.3118	50.9	0.984	Contact Map
1nxjA	3	0.2255	47.4	0.985	Contact Map
2mpuA	1	0.1459	47.3	0.985	Contact Map
4lhbA	4	0.2222	45.8	0.985	Contact Map
1zymA	2	0.3715	44.3	0.985	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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