GREMLIN Database
YGFZ - tRNA-modifying protein YgfZ
UniProt: P0ADE8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12685
Length: 326 (309)
Sequences: 8083 (5445)
Seq/√Len: 309.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_Q127_A3.7331.00
31_T81_G3.3581.00
264_D275_R3.3131.00
210_I238_A3.1041.00
19_L128_A3.0911.00
237_R241_R2.8521.00
265_L294_V2.6831.00
13_A17_L2.5921.00
33_T81_G2.5681.00
18_P124_Q2.5481.00
36_D39_K2.5451.00
251_L292_V2.5161.00
116_V170_A2.4661.00
309_R312_A2.3791.00
305_I314_T2.3291.00
42_Q48_D2.2801.00
252_A316_H2.2321.00
20_T184_N2.2091.00
15_A20_T2.1891.00
254_S316_H2.1751.00
262_G278_T2.0501.00
203_A261_A2.0421.00
54_E77_R2.0321.00
305_I316_H1.9991.00
307_R314_T1.9961.00
232_Q236_A1.9821.00
30_A95_L1.9801.00
44_Q98_L1.9771.00
31_T110_A1.9701.00
14_S18_P1.9601.00
38_E82_F1.9321.00
285_L288_G1.9151.00
228_C232_Q1.8731.00
267_L274_R1.8701.00
169_T172_M1.8141.00
38_E77_R1.8041.00
166_D169_T1.7991.00
279_V292_V1.7831.00
233_E236_A1.7721.00
14_S182_E1.7421.00
306_F315_L1.7211.00
116_V167_E1.7051.00
33_T110_A1.6981.00
131_N180_E1.6951.00
171_N175_D1.6881.00
276_T300_M1.6781.00
61_A69_M1.6731.00
95_L99_K1.6691.00
174_T183_L1.6581.00
13_A287_D1.6561.00
35_A106_K1.6541.00
97_E101_Y1.6531.00
274_R297_N1.6481.00
96_T100_K1.6431.00
267_L272_N1.6321.00
57_H74_R1.6121.00
251_L294_V1.6051.00
165_T173_L1.5821.00
38_E50_S1.5791.00
36_D106_K1.5771.00
91_R111_P1.5751.00
176_K179_G1.5621.00
264_D309_R1.5441.00
228_C233_E1.5371.00
141_K148_A1.5331.00
21_L178_R1.5331.00
78_D81_G1.5321.00
143_V148_A1.5261.00
266_E275_R1.5171.00
64_D207_G1.4811.00
12_T191_A1.4801.00
46_T63_C1.4791.00
21_L118_L1.4751.00
49_V75_L1.4711.00
61_A221_G1.4551.00
218_A221_G1.4471.00
33_T108_T1.4401.00
249_W296_M1.4341.00
266_E309_R1.4301.00
45_V60_A1.4271.00
128_A181_A1.4111.00
301_E304_S1.4011.00
45_V75_L1.4001.00
30_A86_E1.3991.00
44_Q101_Y1.3981.00
10_Q182_E1.3981.00
145_K176_K1.3901.00
194_I283_V1.3571.00
147_G169_T1.3541.00
284_K289_Q1.3471.00
32_I84_W1.3441.00
9_R13_A1.3441.00
28_A91_R1.3421.00
18_P182_E1.3361.00
61_A216_L1.3351.00
102_A109_I1.3301.00
293_Q320_L1.3281.00
47_A60_A1.3281.00
297_N300_M1.3181.00
37_S82_F1.3071.00
213_A246_R1.2991.00
56_Q138_S1.2821.00
252_A318_E1.2781.00
48_D51_Q1.2741.00
84_W98_L1.2621.00
233_E237_R1.2541.00
110_A114_E1.2541.00
212_Q235_V1.2541.00
93_P207_G1.2401.00
212_Q224_F1.2351.00
144_V149_T1.2311.00
42_Q50_S1.2281.00
266_E273_W1.2251.00
127_A130_A1.2231.00
92_E96_T1.2231.00
209_F295_V1.2171.00
227_G232_Q1.2121.00
212_Q244_N1.2111.00
194_I281_A1.2111.00
132_L177_L1.2101.00
251_L315_L1.2091.00
40_Y98_L1.2081.00
308_V315_L1.1981.00
165_T170_A1.1961.00
60_A73_L1.1931.00
267_L300_M1.1861.00
266_E307_R1.1771.00
10_Q13_A1.1711.00
142_Q151_L1.1691.00
40_Y107_V1.1691.00
53_A56_Q1.1651.00
7_P10_Q1.1511.00
214_T295_V1.1391.00
43_G105_S1.1381.00
95_L109_I1.1251.00
75_L84_W1.1241.00
120_V129_L1.1201.00
304_S317_I1.1191.00
76_F139_K1.1101.00
172_M176_K1.1061.00
31_T83_A1.1041.00
43_G230_T1.0941.00
75_L82_F1.0931.00
254_S314_T1.0921.00
236_A240_F1.0911.00
193_N281_A1.0881.00
36_D105_S1.0881.00
265_L308_V1.0871.00
234_M238_A1.0861.00
206_S209_F1.0801.00
217_Q239_K1.0741.00
32_I98_L1.0731.00
77_R82_F1.0731.00
101_Y230_T1.0711.00
13_A289_Q1.0701.00
32_I37_S1.0651.00
147_G172_M1.0621.00
97_E230_T1.0611.00
38_E49_V1.0591.00
213_A238_A1.0541.00
306_F317_I1.0501.00
303_D316_H1.0491.00
99_K102_A1.0481.00
224_F239_K1.0481.00
238_A244_N1.0401.00
126_R159_E1.0391.00
239_K242_G1.0371.00
296_M306_F1.0311.00
90_V93_P1.0151.00
19_L181_A1.0151.00
253_G315_L1.0111.00
310_D313_N0.9991.00
275_R278_T0.9941.00
54_E79_G0.9901.00
300_M304_S0.9741.00
260_E263_E0.9721.00
35_A80_D0.9691.00
32_I109_I0.9681.00
267_L276_T0.9661.00
302_P319_P0.9581.00
126_R161_F0.9501.00
210_I213_A0.9441.00
46_T61_A0.9431.00
276_T306_F0.9431.00
21_L174_T0.9431.00
26_D186_S0.9411.00
62_H98_L0.9331.00
8_P187_Q0.9321.00
309_R313_N0.9251.00
27_W85_I0.9251.00
250_L322_Y0.9211.00
224_F229_Y0.9191.00
29_L117_L0.9131.00
128_A180_E0.9081.00
199_P205_N0.9071.00
118_L174_T0.9061.00
102_A105_S0.9021.00
247_A298_N0.9001.00
62_H73_L0.8961.00
41_M82_F0.8951.00
45_V62_H0.8951.00
185_N188_Q0.8901.00
29_L115_R0.8881.00
254_S305_I0.8861.00
59_L72_N0.8791.00
46_T222_I0.8781.00
117_L164_V0.8751.00
121_A160_R0.8741.00
43_G104_F0.8731.00
65_A230_T0.8731.00
267_L307_R0.8721.00
244_N298_N0.8711.00
175_D179_G0.8711.00
224_F236_A0.8631.00
69_M214_T0.8631.00
147_G173_L0.8621.00
24_L119_G0.8571.00
165_T169_T0.8551.00
42_Q226_K0.8541.00
212_Q217_Q0.8541.00
97_E100_K0.8511.00
255_A314_T0.8501.00
245_K298_N0.8481.00
64_D70_W0.8471.00
60_A75_L0.8461.00
213_A245_K0.8421.00
251_L308_V0.8411.00
285_L291_V0.8381.00
212_Q222_I0.8371.00
69_M205_N0.8371.00
134_S143_V0.8351.00
259_P263_E0.8351.00
176_K180_E0.8331.00
259_P308_V0.8311.00
264_D278_T0.8271.00
70_W93_P0.8221.00
28_A111_P0.8211.00
48_D223_S0.8191.00
184_N188_Q0.8171.00
96_T99_K0.8091.00
47_A223_S0.8041.00
43_G228_C0.8041.00
47_A58_L0.8041.00
135_E140_E0.8031.00
259_P290_V0.8011.00
130_A135_E0.8001.00
63_C235_V0.7941.00
151_L161_F0.7941.00
39_K105_S0.7941.00
36_D104_F0.7901.00
41_M49_V0.7881.00
95_L111_P0.7861.00
12_T192_L0.7861.00
14_S184_N0.7841.00
120_V163_I0.7841.00
215_N247_A0.7780.99
52_M56_Q0.7770.99
45_V49_V0.7740.99
224_F232_Q0.7740.99
120_V128_A0.7720.99
115_R166_D0.7720.99
127_A131_N0.7720.99
209_F246_R0.7700.99
86_E94_Q0.7690.99
51_Q58_L0.7640.99
76_F152_L0.7610.99
211_P235_V0.7570.99
172_M175_D0.7570.99
303_D317_I0.7550.99
41_M45_V0.7510.99
201_I205_N0.7500.99
237_R240_F0.7490.99
29_L164_V0.7470.99
210_I234_M0.7470.99
44_Q97_E0.7460.99
253_G290_V0.7370.99
229_Y236_A0.7310.99
112_D115_R0.7290.99
85_I162_L0.7260.99
38_E42_Q0.7260.99
30_A98_L0.7190.99
22_M184_N0.7160.99
52_M58_L0.7110.99
197_G320_L0.7090.99
12_T287_D0.7090.99
251_L279_V0.7060.99
141_K150_T0.7060.99
143_V146_E0.7050.99
284_K290_V0.7010.99
70_W207_G0.6990.99
235_V238_A0.6970.99
229_Y235_V0.6950.99
39_K43_G0.6930.99
153_W161_F0.6930.99
191_A283_V0.6900.99
21_L120_V0.6880.99
65_A101_Y0.6860.99
83_A115_R0.6860.99
129_L161_F0.6840.99
139_K142_Q0.6820.99
45_V73_L0.6790.99
246_R297_N0.6790.99
33_T80_D0.6750.99
16_R195_E0.6740.99
73_L84_W0.6700.98
178_R183_L0.6700.98
139_K150_T0.6670.98
98_L109_I0.6660.98
57_H76_F0.6650.98
125_A159_E0.6640.98
156_H160_R0.6640.98
116_V165_T0.6630.98
120_V181_A0.6630.98
70_W97_E0.6610.98
32_I41_M0.6610.98
91_R113_D0.6610.98
241_R245_K0.6590.98
213_A244_N0.6540.98
57_H152_L0.6510.98
163_I177_L0.6500.98
102_A107_V0.6480.98
32_I40_Y0.6480.98
28_A112_D0.6440.98
279_V282_A0.6430.98
54_E78_D0.6420.98
63_C69_M0.6400.98
28_A86_E0.6400.98
136_L140_E0.6390.98
191_A285_L0.6380.98
130_A134_S0.6380.98
40_Y43_G0.6380.98
149_T165_T0.6370.98
66_K208_Q0.6350.98
178_R181_A0.6340.98
153_W159_E0.6340.98
265_L306_F0.6320.98
248_L293_Q0.6310.98
252_A291_V0.6280.98
11_P185_N0.6280.98
194_I291_V0.6280.98
46_T221_G0.6270.98
40_Y102_A0.6270.98
66_K207_G0.6260.98
64_D68_K0.6260.98
72_N216_L0.6260.98
251_L306_F0.6240.98
259_P315_L0.6230.98
212_Q239_K0.6220.98
145_K172_M0.6190.97
81_G141_K0.6190.97
29_L112_D0.6180.97
238_A242_G0.6150.97
45_V58_L0.6110.97
133_F144_V0.6080.97
234_M237_R0.6070.97
209_F214_T0.6060.97
267_L304_S0.6040.97
236_A239_K0.6020.97
62_H97_E0.6020.97
318_E322_Y0.5980.97
137_P140_E0.5950.97
206_S278_T0.5930.97
39_K50_S0.5920.97
246_R278_T0.5920.97
15_A192_L0.5910.97
302_P317_I0.5890.97
16_R287_D0.5890.97
41_M84_W0.5880.97
217_Q247_A0.5870.97
114_E166_D0.5850.96
121_A156_H0.5840.96
85_I164_V0.5820.96
193_N204_A0.5820.96
15_A184_N0.5780.96
114_E168_A0.5750.96
148_A169_T0.5740.96
136_L141_K0.5730.96
44_Q62_H0.5730.96
205_N209_F0.5730.96
37_S77_R0.5730.96
149_T153_W0.5720.96
133_F145_K0.5720.96
130_A133_F0.5720.96
57_H154_F0.5710.96
122_G125_A0.5710.96
137_P141_K0.5710.96
62_H94_Q0.5700.96
248_L295_V0.5700.96
77_R81_G0.5700.96
282_A290_V0.5680.96
76_F85_I0.5680.96
87_R190_L0.5670.96
250_L291_V0.5670.96
212_Q238_A0.5620.96
66_K234_M0.5610.96
92_E111_P0.5610.96
22_M121_A0.5600.95
135_E142_Q0.5600.95
296_M317_I0.5580.95
149_T163_I0.5580.95
100_K103_V0.5580.95
152_L155_E0.5560.95
59_L221_G0.5550.95
48_D225_K0.5540.95
40_Y105_S0.5530.95
250_L320_L0.5510.95
224_F235_V0.5510.95
30_A109_I0.5500.95
93_P96_T0.5490.95
118_L170_A0.5490.95
302_P320_L0.5490.95
147_G166_D0.5490.95
83_A164_V0.5490.95
249_W317_I0.5470.95
44_Q230_T0.5470.95
103_V106_K0.5470.95
18_P128_A0.5470.95
152_L164_V0.5460.95
16_R192_L0.5440.95
21_L181_A0.5430.95
39_K42_Q0.5430.95
24_L117_L0.5420.95
125_A161_F0.5420.95
69_M204_A0.5400.95
41_M98_L0.5400.95
192_L195_E0.5380.94
190_L281_A0.5380.94
226_K232_Q0.5370.94
32_I82_F0.5370.94
205_N214_T0.5350.94
190_L200_V0.5340.94
144_V173_L0.5330.94
256_S290_V0.5320.94
302_P305_I0.5310.94
258_L290_V0.5300.94
247_A299_D0.5290.94
91_R95_L0.5290.94
197_G250_L0.5290.94
21_L177_L0.5290.94
221_G224_F0.5290.94
242_G298_N0.5280.94
136_L198_F0.5270.94
222_I229_Y0.5240.94
151_L163_I0.5230.94
249_W304_S0.5230.94
36_D107_V0.5220.93
276_T297_N0.5220.93
200_V203_A0.5220.93
78_D150_T0.5200.93
37_S107_V0.5200.93
302_P318_E0.5190.93
27_W117_L0.5170.93
119_G189_W0.5160.93
59_L198_F0.5140.93
125_A128_A0.5130.93
160_R193_N0.5120.93
93_P97_E0.5110.93
25_D116_V0.5060.92
83_A150_T0.5060.92
136_L139_K0.5050.92
238_A241_R0.5050.92
28_A89_S0.5030.92
267_L306_F0.5020.92
222_I226_K0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vlyA 1 0.9908 100 0.144 Contact Map
3girA 1 0.9693 100 0.145 Contact Map
1yx2A 1 0.9724 100 0.148 Contact Map
1wosA 1 0.9724 100 0.151 Contact Map
1v5vA 2 0.9755 100 0.158 Contact Map
2gagA 1 0.9785 100 0.161 Contact Map
3ttgA 1 0.9693 100 0.162 Contact Map
4pabA 1 0.9755 100 0.165 Contact Map
1wsrA 2 0.9755 100 0.168 Contact Map
1vloA 1 0.9785 100 0.168 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0106 seconds.