GREMLIN Database
YGAU - Uncharacterized protein YgaU
UniProt: P0ADE6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12675
Length: 149 (139)
Sequences: 1778 (1306)
Seq/√Len: 110.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_Y105_D6.2651.00
99_Y114_V5.3061.00
127_A147_P3.2771.00
101_V142_Q3.1481.00
11_G18_V3.0391.00
106_T109_A2.7031.00
120_L123_K2.6511.00
125_F136_D2.6381.00
132_L135_P2.4521.00
100_T143_V2.4001.00
123_K127_A2.3811.00
63_S66_A2.1491.00
97_Q114_V2.1411.00
119_N127_A2.1181.00
119_N123_K2.1031.00
52_D80_I1.9581.00
124_I146_I1.9361.00
78_S87_V1.9061.00
108_S118_A1.8951.00
101_V140_P1.8481.00
96_S147_P1.7741.00
34_H38_T1.6931.00
31_V40_I1.6521.00
73_A76_N1.6181.00
108_S121_Y1.6081.00
121_Y124_I1.6021.00
119_N124_I1.5641.00
12_E18_V1.5621.00
125_F135_P1.5461.00
96_S145_R1.5371.00
107_L121_Y1.5271.00
101_V110_I1.4991.00
11_G16_D1.3651.00
102_K113_Q1.3581.00
77_I81_A1.3341.00
98_F143_V1.3331.00
134_S137_K1.3281.00
7_V10_A1.3241.00
34_H37_K1.3241.00
5_N25_D1.2930.99
99_Y102_K1.2850.99
35_L38_T1.2820.99
99_Y110_I1.2760.99
88_K91_T1.2450.99
39_G42_D1.2070.99
110_I144_L1.1990.99
89_T94_T1.1890.99
67_K70_I1.1780.99
4_F25_D1.1720.99
121_Y125_F1.1420.99
32_Q43_A1.1340.98
19_T23_D1.1270.98
89_T93_A1.1190.98
13_K124_I1.1130.98
122_N125_F1.1010.98
135_P138_I1.0900.98
132_L142_Q1.0820.98
5_N23_D1.0670.98
107_L124_I1.0480.97
62_L65_E1.0450.97
108_S112_K1.0330.97
108_S138_I1.0160.97
66_A70_I0.9980.97
139_Y142_Q0.9850.96
74_V78_S0.9840.96
107_L144_L0.9740.96
109_A113_Q0.9570.96
5_N82_S0.9500.95
2_G25_D0.9460.95
123_K126_E0.9360.95
109_A135_P0.9280.95
111_S120_L0.9110.94
26_D29_K0.9050.94
9_D13_K0.9020.94
90_A93_A0.8910.94
111_S119_N0.8900.94
5_N16_D0.8880.94
32_Q40_I0.8840.93
114_V118_A0.8830.93
24_K30_K0.8770.93
67_K71_L0.8680.93
91_T94_T0.8670.93
6_F16_D0.8550.92
89_T92_P0.8400.92
21_Q86_Q0.8390.91
22_H28_A0.8150.90
24_K83_V0.8100.90
119_N146_I0.8100.90
63_S77_I0.7990.89
105_D140_P0.7990.89
77_I84_D0.7960.89
88_K92_P0.7930.89
66_A81_A0.7930.89
18_V85_D0.7920.89
99_Y113_Q0.7890.89
10_A16_D0.7870.89
20_G86_Q0.7870.89
102_K137_K0.7810.88
35_L43_A0.7810.88
67_K85_D0.7760.88
3_L28_A0.7730.88
24_K27_Q0.7720.88
4_F27_Q0.7720.88
96_S127_A0.7690.87
127_A146_I0.7610.87
107_L125_F0.7590.87
4_F23_D0.7540.86
109_A112_K0.7540.86
112_K118_A0.7540.86
111_S122_N0.7460.86
100_T134_S0.7340.85
46_V50_I0.7310.85
88_K93_A0.7230.84
2_G5_N0.7130.83
110_I124_I0.7110.83
5_N19_T0.7020.82
76_N79_G0.6970.82
108_S119_N0.6960.82
16_D23_D0.6950.82
50_I80_I0.6940.82
138_I141_G0.6930.81
2_G23_D0.6840.81
107_L135_P0.6830.81
105_D109_A0.6720.79
18_V23_D0.6710.79
6_F14_L0.6710.79
64_Q68_E0.6590.78
106_T110_I0.6590.78
101_V131_M0.6570.78
119_N147_P0.6560.78
101_V139_Y0.6520.77
97_Q124_I0.6520.77
101_V144_L0.6450.77
24_K28_A0.6450.77
40_I102_K0.6440.77
53_G57_V0.6420.76
98_F145_R0.6420.76
46_V52_D0.6410.76
71_L79_G0.6360.76
4_F71_L0.6340.75
104_G107_L0.6330.75
105_D138_I0.6300.75
103_S125_F0.6280.75
51_A95_A0.6260.74
58_T71_L0.6210.74
6_F44_D0.6180.74
102_K126_E0.6150.73
107_L110_I0.6080.72
63_S84_D0.6050.72
56_T94_T0.6000.71
22_H83_V0.5990.71
15_W60_D0.5990.71
60_D91_T0.5970.71
43_A70_I0.5930.70
67_K81_A0.5900.70
19_T24_K0.5900.70
101_V143_V0.5890.70
72_V77_I0.5870.70
37_K44_D0.5870.70
20_G96_S0.5840.69
125_F132_L0.5810.69
69_K80_I0.5800.69
25_D81_A0.5780.69
71_L81_A0.5760.68
52_D84_D0.5740.68
5_N10_A0.5740.68
24_K29_K0.5730.68
57_V67_K0.5720.68
107_L132_L0.5720.68
121_Y136_D0.5710.68
12_E34_H0.5710.68
13_K30_K0.5650.67
18_V21_Q0.5620.66
65_E69_K0.5590.66
16_D19_T0.5590.66
62_L87_V0.5590.66
103_S110_I0.5560.66
132_L136_D0.5550.65
124_I144_L0.5520.65
114_V146_I0.5480.64
16_D25_D0.5450.64
11_G51_A0.5440.64
2_G81_A0.5420.64
11_G17_A0.5410.63
121_Y142_Q0.5370.63
63_S74_V0.5340.62
14_L85_D0.5340.62
106_T138_I0.5320.62
4_F16_D0.5290.62
60_D132_L0.5280.62
54_K84_D0.5210.61
111_S135_P0.5200.60
2_G27_Q0.5180.60
76_N145_R0.5150.60
3_L11_G0.5140.60
88_K96_S0.5140.60
81_A84_D0.5130.59
9_D12_E0.5130.59
70_I74_V0.5120.59
111_S118_A0.5100.59
26_D85_D0.5070.59
8_K52_D0.5060.58
71_L85_D0.5050.58
102_K134_S0.5040.58
45_K49_Q0.5040.58
101_V141_G0.5030.58
33_E49_Q0.5020.58
72_V76_N0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2djpA 1 0.4228 99.2 0.652 Contact Map
2mkxA 1 0.3356 99.2 0.658 Contact Map
2mpwA 1 0.4832 99.1 0.667 Contact Map
4uz3A 1 0.6174 99.1 0.667 Contact Map
4xcmA 2 0.604 99.1 0.671 Contact Map
2l9yA 1 0.7383 99.1 0.673 Contact Map
2gu1A 1 0.3289 99.1 0.68 Contact Map
4pxvA 1 0.3221 99 0.683 Contact Map
2ltfA 1 0.349 99 0.687 Contact Map
1e0gA 1 0.3221 99 0.691 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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