GREMLIN Database
TAMA - Translocation and assembly module TamA
UniProt: P0ADE4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12513
Length: 577 (474)
Sequences: 5153 (3936)
Seq/√Len: 180.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_G255_P4.5321.00
443_H506_Y4.4231.00
447_T504_L4.4091.00
195_T257_T4.3771.00
520_V536_T4.2311.00
107_G178_F3.7481.00
103_P136_V3.7391.00
333_G348_T3.5661.00
271_G283_K3.5121.00
196_F206_L3.3001.00
193_H214_E3.2341.00
171_A174_L3.0501.00
110_D180_D2.9921.00
538_T559_V2.8661.00
555_F567_L2.8411.00
244_Q257_T2.8371.00
296_H315_Y2.7711.00
152_I156_K2.7471.00
285_T301_S2.6511.00
107_G176_K2.6271.00
508_Y516_G2.6211.00
522_S536_T2.6041.00
203_D207_Q2.5801.00
269_E285_T2.5351.00
453_W498_K2.5091.00
369_W384_M2.5001.00
237_N261_S2.4831.00
300_T313_F2.4631.00
197_E257_T2.4511.00
476_I484_I2.4271.00
496_A525_A2.4141.00
108_G178_F2.3911.00
454_I462_V2.3891.00
192_G253_V2.3731.00
273_G281_R2.3381.00
475_S501_T2.2281.00
266_N288_K2.2151.00
452_G468_F2.1731.00
430_Q468_F2.1651.00
197_E259_V2.1391.00
361_W392_I2.1071.00
366_N389_G2.0891.00
553_L569_F2.0651.00
398_R404_T2.0531.00
153_A185_S2.0341.00
326_Q355_W2.0291.00
518_V540_V2.0221.00
409_Q433_N2.0181.00
517_A543_R2.0131.00
367_L386_F1.9981.00
155_R221_K1.9841.00
299_T314_S1.9571.00
265_E288_K1.9501.00
477_R521_D1.9441.00
147_K151_S1.9411.00
122_D156_K1.9111.00
266_N286_W1.8721.00
536_T560_A1.8381.00
334_F347_T1.8371.00
135_T141_D1.8361.00
406_G416_S1.8181.00
219_E222_D1.8071.00
287_K299_T1.8061.00
329_L352_S1.8051.00
446_V507_Q1.7951.00
476_I537_G1.7781.00
102_V175_H1.7761.00
296_H317_M1.7761.00
478_G537_G1.7741.00
241_V258_G1.7711.00
394_R407_D1.7701.00
331_Q350_V1.7571.00
407_D435_W1.7571.00
426_F466_L1.7551.00
112_V180_D1.7371.00
193_H255_P1.7361.00
188_R217_E1.7361.00
510_V516_G1.7111.00
522_S534_F1.7001.00
112_V182_D1.6961.00
155_R219_E1.6961.00
190_R253_V1.6951.00
114_R185_S1.6921.00
519_F539_G1.6751.00
445_F504_L1.6641.00
151_S155_R1.6641.00
413_I429_F1.6551.00
502_G522_S1.6521.00
216_D222_D1.6431.00
107_G133_I1.6341.00
298_L313_F1.6221.00
120_D124_L1.6061.00
270_T284_A1.5911.00
470_A501_T1.5711.00
517_A554_D1.5691.00
211_P226_L1.5661.00
117_A185_S1.5621.00
141_D144_N1.5561.00
242_A259_V1.5541.00
213_K216_D1.5341.00
443_H508_Y1.5151.00
448_R503_S1.5131.00
192_G249_R1.5081.00
546_S549_G1.4941.00
240_V259_V1.4941.00
223_L256_L1.4861.00
105_L136_V1.4831.00
470_A523_G1.4761.00
138_N141_D1.4701.00
190_R217_E1.4691.00
517_A541_G1.4651.00
517_A552_K1.4561.00
403_P406_G1.4551.00
108_G133_I1.4471.00
195_T255_P1.4301.00
140_G144_N1.4141.00
199_S203_D1.4091.00
328_Y353_R1.4071.00
451_L500_I1.4041.00
353_R357_L1.4031.00
409_Q431_A1.3761.00
192_G248_A1.3721.00
228_R232_A1.3621.00
192_G246_D1.3591.00
485_A493_L1.3581.00
311_L334_F1.3491.00
479_Y558_P1.3441.00
199_S262_P1.3381.00
194_V214_E1.3361.00
237_N263_R1.3281.00
191_F212_F1.3281.00
171_A176_K1.3271.00
292_N296_H1.3251.00
363_R390_V1.3171.00
144_N148_S1.3071.00
472_G475_S1.3071.00
407_D433_N1.3031.00
210_V226_L1.2911.00
540_V557_V1.2911.00
361_W394_R1.2821.00
137_L142_Y1.2741.00
194_V212_F1.2711.00
340_N344_S1.2711.00
132_A135_T1.2681.00
470_A499_L1.2681.00
358_S361_W1.2661.00
396_R407_D1.2551.00
198_G262_P1.2541.00
535_K562_K1.2461.00
171_A178_F1.2411.00
432_Q448_R1.2381.00
235_W295_G1.2251.00
227_N231_S1.2211.00
371_L384_M1.2151.00
442_R509_N1.2121.00
363_R392_I1.2091.00
488_Y492_D1.2091.00
452_G499_L1.2051.00
201_I262_P1.2041.00
118_R122_D1.2001.00
543_R554_D1.1951.00
507_Q515_W1.1951.00
446_V505_E1.1941.00
564_E567_L1.1911.00
314_S331_Q1.1821.00
503_S521_D1.1761.00
432_Q450_T1.1761.00
284_A302_T1.1571.00
190_R216_D1.1531.00
357_L363_R1.1531.00
331_Q352_S1.1491.00
540_V555_F1.1481.00
117_A123_Y1.1441.00
302_T311_L1.1441.00
480_K483_S1.1331.00
471_G475_S1.1301.00
350_V368_R1.1301.00
297_S316_K1.1241.00
142_Y179_W1.1211.00
122_D152_I1.1151.00
218_Y223_L1.1151.00
162_E184_N1.1141.00
504_L520_V1.1131.00
505_E543_R1.1101.00
449_G502_G1.1071.00
301_S312_D1.1071.00
428_V466_L1.1061.00
220_S224_A1.1021.00
520_V538_T1.0981.00
414_D428_V1.0941.00
104_V177_A1.0931.00
267_T287_K1.0921.00
309_Q336_R1.0921.00
286_W300_T1.0921.00
479_Y560_A1.0901.00
314_S329_L1.0891.00
250_E253_V1.0881.00
160_D189_Y1.0831.00
211_P229_R1.0821.00
524_E534_F1.0821.00
541_G554_D1.0791.00
316_K327_Y1.0781.00
440_Y443_H1.0771.00
114_R120_D1.0681.00
224_A228_R1.0621.00
538_T557_V1.0591.00
242_A257_T1.0581.00
393_S408_S1.0521.00
121_K124_L1.0491.00
194_V258_G1.0471.00
226_L258_G1.0471.00
430_Q450_T1.0431.00
473_D570_Y1.0421.00
368_R387_Y1.0391.00
346_S372_D1.0391.00
329_L332_G1.0371.00
513_K544_W1.0351.00
238_S261_S1.0341.00
387_Y416_S1.0301.00
439_L443_H1.0291.00
110_D178_F1.0271.00
345_D373_H1.0250.99
500_I524_E1.0210.99
328_Y351_A1.0210.99
434_V448_R1.0190.99
111_V123_Y1.0180.99
477_R519_F1.0170.99
477_R505_E1.0140.99
275_S278_V1.0090.99
408_S434_V1.0060.99
415_Y427_S1.0050.99
338_D342_T1.0050.99
479_Y535_K1.0040.99
272_V282_V1.0010.99
445_F506_Y0.9980.99
451_L499_L0.9980.99
194_V210_V0.9960.99
225_E229_R0.9960.99
433_N449_G0.9950.99
558_P570_Y0.9940.99
312_D331_Q0.9900.99
288_K291_M0.9900.99
159_F218_Y0.9860.99
149_L153_A0.9860.99
287_K297_S0.9800.99
225_E228_R0.9790.99
336_R345_D0.9790.99
234_G263_R0.9770.99
137_L177_A0.9770.99
398_R406_G0.9710.99
289_P297_S0.9700.99
371_L382_T0.9670.99
327_Y354_Y0.9630.99
470_A525_A0.9610.99
313_F332_G0.9610.99
397_S408_S0.9600.99
187_E252_K0.9590.99
201_I293_S0.9580.99
320_L328_Y0.9560.99
391_M412_S0.9540.99
102_V105_L0.9450.99
322_N326_Q0.9430.99
291_M298_L0.9410.99
449_G500_I0.9410.99
509_N515_W0.9400.99
479_Y561_D0.9390.99
316_K329_L0.9390.99
450_T501_T0.9390.99
244_Q255_P0.9360.99
337_T342_T0.9350.99
508_Y518_V0.9340.99
411_Y431_A0.9310.99
338_D343_E0.9270.99
107_G134_G0.9230.99
520_V537_G0.9210.99
346_S370_S0.9120.99
104_V175_H0.9110.99
436_I446_V0.9110.99
398_R405_W0.9090.99
196_F203_D0.9040.99
406_G411_Y0.9040.99
536_T559_V0.9010.99
338_D341_D0.9010.99
395_T408_S0.8980.99
354_Y357_L0.8950.99
285_T299_T0.8950.99
364_A391_M0.8940.99
144_N147_K0.8900.99
370_S374_F0.8900.99
408_S411_Y0.8890.99
143_E146_K0.8790.98
537_G570_Y0.8780.98
468_F499_L0.8780.98
145_F181_I0.8760.98
202_R294_Y0.8740.98
337_T341_D0.8740.98
209_L319_L0.8690.98
433_N447_T0.8640.98
205_Y209_L0.8640.98
554_D570_Y0.8610.98
437_R447_T0.8590.98
304_I309_Q0.8590.98
212_F256_L0.8560.98
555_F568_Q0.8540.98
281_R305_S0.8540.98
394_R409_Q0.8510.98
248_A253_V0.8510.98
414_D466_L0.8500.98
416_S420_W0.8480.98
488_Y494_K0.8480.98
241_V256_L0.8450.98
516_G540_V0.8430.98
230_L236_F0.8430.98
411_Y429_F0.8390.98
387_Y414_D0.8380.98
436_I444_R0.8360.98
199_S206_L0.8360.98
164_T184_N0.8350.98
114_R153_A0.8330.98
211_P359_S0.8290.98
397_S403_P0.8280.98
514_W542_V0.8250.98
405_W437_R0.8230.98
206_L258_G0.8200.98
484_I524_E0.8170.97
113_L116_G0.8170.97
565_H568_Q0.8160.97
300_T311_L0.8140.97
337_T340_N0.8130.97
462_V497_S0.8100.97
408_S416_S0.8080.97
543_R552_K0.8080.97
352_S366_N0.8080.97
415_Y418_T0.8060.97
143_E147_K0.8040.97
481_Y570_Y0.8030.97
446_V503_S0.8020.97
282_V304_I0.8020.97
262_P293_S0.8020.97
151_S224_A0.8000.97
447_T506_Y0.7980.97
126_L152_I0.7980.97
152_I155_R0.7970.97
191_F218_Y0.7960.97
564_E568_Q0.7950.97
286_W298_L0.7940.97
391_M410_R0.7940.97
390_V413_I0.7910.97
413_I427_S0.7850.97
281_R303_S0.7840.97
500_I522_S0.7830.97
205_Y208_N0.7830.97
500_I534_F0.7820.97
470_A475_S0.7810.97
397_S406_G0.7790.97
151_S154_L0.7750.97
122_D125_K0.7750.97
470_A476_I0.7730.97
360_G394_R0.7730.97
450_T499_L0.7710.96
106_I133_I0.7710.96
290_W293_S0.7710.96
407_D411_Y0.7700.96
332_G349_L0.7690.96
473_D554_D0.7670.96
319_L328_Y0.7650.96
399_G402_M0.7650.96
146_K166_A0.7640.96
374_F377_G0.7630.96
443_H447_T0.7610.96
561_D566_G0.7600.96
109_T179_W0.7600.96
209_L229_R0.7590.96
387_Y426_F0.7590.96
221_K225_E0.7580.96
470_A484_I0.7580.96
471_G541_G0.7580.96
501_T523_G0.7570.96
122_D126_L0.7550.96
139_Q143_E0.7550.96
224_A227_N0.7540.96
330_V351_A0.7530.96
520_V559_V0.7530.96
557_V567_L0.7510.96
373_H382_T0.7500.96
145_F148_S0.7480.96
435_W447_T0.7470.96
464_P467_R0.7450.96
317_M320_L0.7440.96
416_S426_F0.7420.96
454_I497_S0.7400.96
471_G523_G0.7390.95
451_L502_G0.7390.95
359_S362_Q0.7370.95
169_G180_D0.7370.95
303_S310_T0.7360.95
449_G504_L0.7360.95
212_F226_L0.7360.95
414_D417_N0.7350.95
407_D416_S0.7340.95
480_K568_Q0.7320.95
475_S478_G0.7320.95
294_Y317_M0.7310.95
146_K165_K0.7310.95
159_F189_Y0.7300.95
412_S430_Q0.7300.95
163_F183_Y0.7300.95
169_G178_F0.7290.95
153_A183_Y0.7290.95
524_E532_S0.7280.95
209_L233_T0.7270.95
233_T236_F0.7250.95
418_T421_G0.7220.95
498_K526_V0.7220.95
283_K303_S0.7220.95
431_A451_L0.7210.95
326_Q353_R0.7200.95
455_E497_S0.7190.95
161_S183_Y0.7190.95
406_G415_Y0.7180.95
428_V452_G0.7180.95
280_P306_A0.7170.95
438_T441_D0.7150.95
339_L343_E0.7150.95
115_G123_Y0.7140.95
469_F495_G0.7130.95
457_G460_D0.7110.94
117_A153_A0.7090.94
106_I179_W0.7090.94
509_N516_G0.7050.94
146_K150_T0.7040.94
346_S357_L0.7000.94
410_R432_Q0.6990.94
406_G418_T0.6990.94
450_T475_S0.6990.94
439_L506_Y0.6980.94
121_K125_K0.6970.94
123_Y126_L0.6960.94
467_R495_G0.6960.94
467_R497_S0.6950.94
205_Y233_T0.6950.94
116_G185_S0.6940.94
510_V542_V0.6910.94
378_E381_N0.6910.94
160_D254_L0.6890.93
386_F421_G0.6860.93
444_R515_W0.6850.93
402_M405_W0.6840.93
444_R507_Q0.6840.93
149_L163_F0.6820.93
267_T289_P0.6820.93
365_I390_V0.6820.93
412_S416_S0.6810.93
379_I383_T0.6800.93
484_I535_K0.6790.93
115_G185_S0.6770.93
110_D120_D0.6750.93
106_I109_T0.6750.93
334_F345_D0.6750.93
117_A156_K0.6750.93
566_G569_F0.6720.93
331_Q335_K0.6680.92
196_F207_Q0.6660.92
386_F420_W0.6650.92
437_R445_F0.6650.92
418_T425_D0.6650.92
113_L118_R0.6630.92
196_F260_V0.6630.92
289_P299_T0.6610.92
535_K564_E0.6610.92
500_I531_R0.6590.92
414_D418_T0.6590.92
363_R367_L0.6580.92
105_L176_K0.6570.92
353_R356_D0.6570.92
347_T351_A0.6540.92
438_T442_R0.6530.92
428_V454_I0.6520.91
387_Y466_L0.6520.91
160_D187_E0.6510.91
229_R232_A0.6490.91
243_P256_L0.6490.91
357_L361_W0.6470.91
148_S151_S0.6460.91
439_L445_F0.6450.91
150_T161_S0.6450.91
564_E569_F0.6450.91
472_G519_F0.6440.91
222_D225_E0.6440.91
109_T127_L0.6430.91
189_Y254_L0.6410.91
473_D481_Y0.6390.91
535_K560_A0.6380.91
476_I523_G0.6370.91
463_P485_A0.6370.91
558_P567_L0.6360.90
364_A393_S0.6320.90
507_Q552_K0.6310.90
315_Y330_V0.6310.90
551_I573_L0.6310.90
505_E519_F0.6300.90
438_T444_R0.6300.90
427_S455_E0.6280.90
114_R121_K0.6260.90
405_W408_S0.6260.90
239_V243_P0.6260.90
114_R123_Y0.6260.90
423_D437_R0.6260.90
149_L183_Y0.6250.90
510_V514_W0.6240.90
567_L570_Y0.6230.90
484_I525_A0.6220.89
570_Y573_L0.6210.89
146_K181_I0.6210.89
357_L392_I0.6200.89
347_T371_L0.6180.89
502_G534_F0.6170.89
132_A137_L0.6160.89
405_W409_Q0.6150.89
487_K493_L0.6150.89
328_Y335_K0.6140.89
123_Y152_I0.6130.89
328_Y336_R0.6130.89
417_N420_W0.6130.89
274_Y551_I0.6110.89
487_K494_K0.6110.89
124_L127_L0.6100.89
312_D333_G0.6090.88
111_V114_R0.6080.88
271_G547_P0.6060.88
516_G542_V0.6060.88
558_P561_D0.6060.88
479_Y559_V0.6050.88
236_F260_V0.6050.88
505_E552_K0.6030.88
403_P416_S0.5990.88
456_T459_F0.5990.88
413_I416_S0.5990.88
236_F239_V0.5990.88
319_L353_R0.5960.87
407_D413_I0.5960.87
366_N372_D0.5930.87
530_R533_D0.5930.87
434_V446_V0.5920.87
131_P145_F0.5920.87
142_Y146_K0.5920.87
344_S465_D0.5910.87
339_L342_T0.5910.87
341_D493_L0.5910.87
553_L571_I0.5900.87
317_M330_V0.5900.87
539_G556_A0.5890.87
206_L236_F0.5890.87
201_I235_W0.5890.87
555_F569_F0.5890.87
205_Y295_G0.5880.87
451_L498_K0.5880.87
407_D418_T0.5880.87
298_L315_Y0.5870.87
198_G478_G0.5860.87
206_L260_V0.5850.86
367_L388_P0.5850.86
410_R414_D0.5850.86
401_L410_R0.5840.86
343_E376_Q0.5830.86
278_V281_R0.5830.86
391_M430_Q0.5820.86
463_P472_G0.5810.86
165_K168_L0.5810.86
160_D245_F0.5800.86
476_I521_D0.5800.86
515_W543_R0.5790.86
225_E359_S0.5780.86
200_Q262_P0.5770.86
148_S152_I0.5770.86
310_T335_K0.5770.86
206_L233_T0.5750.86
268_I286_W0.5740.85
476_I522_S0.5730.85
210_V258_G0.5720.85
352_S391_M0.5720.85
430_Q499_L0.5710.85
202_R293_S0.5710.85
345_D375_T0.5710.85
141_D340_N0.5700.85
524_E531_R0.5690.85
109_T133_I0.5690.85
551_I567_L0.5680.85
368_R414_D0.5670.85
406_G413_I0.5670.85
372_D465_D0.5660.85
472_G505_E0.5620.84
507_Q517_A0.5600.84
154_L220_S0.5600.84
409_Q416_S0.5600.84
406_G409_Q0.5600.84
459_F462_V0.5590.84
113_L117_A0.5570.84
402_M406_G0.5570.84
290_W295_G0.5570.84
448_R501_T0.5550.83
283_K301_S0.5550.83
142_Y514_W0.5540.83
352_S364_A0.5530.83
125_K152_I0.5530.83
445_F449_G0.5520.83
363_R370_S0.5520.83
113_L153_A0.5510.83
203_D206_L0.5510.83
173_G492_D0.5510.83
246_D249_R0.5500.83
128_D131_P0.5500.83
236_F265_E0.5490.83
389_G412_S0.5490.83
406_G436_I0.5480.83
365_I388_P0.5480.83
359_S363_R0.5470.83
115_G118_R0.5470.83
436_I439_L0.5460.82
498_K527_S0.5450.82
159_F254_L0.5450.82
406_G410_R0.5440.82
95_I540_V0.5430.82
201_I236_F0.5430.82
496_A523_G0.5430.82
227_N241_V0.5420.82
279_G517_A0.5410.82
408_S412_S0.5400.82
243_P254_L0.5390.82
337_T344_S0.5380.82
237_N240_V0.5380.82
191_F222_D0.5380.82
297_S314_S0.5370.81
153_A161_S0.5370.81
405_W435_W0.5360.81
394_R433_N0.5360.81
215_G286_W0.5350.81
407_D412_S0.5340.81
112_V313_F0.5340.81
568_Q574_G0.5340.81
221_K224_A0.5320.81
235_W289_P0.5320.81
409_Q412_S0.5320.81
369_W373_H0.5320.81
273_G549_G0.5310.81
354_Y364_A0.5310.81
479_Y564_E0.5300.81
191_F256_L0.5300.81
360_G396_R0.5290.80
299_T313_F0.5290.80
197_E242_A0.5280.80
338_D344_S0.5280.80
446_V517_A0.5280.80
500_I504_L0.5270.80
412_S551_I0.5270.80
235_W297_S0.5270.80
194_V256_L0.5270.80
230_L472_G0.5270.80
117_A152_I0.5260.80
349_L353_R0.5260.80
409_Q435_W0.5260.80
463_P471_G0.5250.80
557_V566_G0.5250.80
405_W411_Y0.5230.80
224_A276_T0.5220.80
118_R121_K0.5220.80
163_F443_H0.5220.80
433_N437_R0.5210.79
204_E230_L0.5190.79
472_G523_G0.5190.79
277_D481_Y0.5190.79
546_S550_P0.5180.79
567_L573_L0.5180.79
400_G404_T0.5170.79
515_W545_E0.5160.79
512_G544_W0.5160.79
503_S517_A0.5150.79
502_G520_V0.5150.79
326_Q354_Y0.5150.79
307_P556_A0.5150.79
528_D531_R0.5130.78
234_G297_S0.5130.78
268_I288_K0.5130.78
514_W544_W0.5130.78
155_R220_S0.5100.78
104_V137_L0.5080.78
249_R253_V0.5080.78
418_T424_V0.5070.78
111_V127_L0.5070.78
397_S400_G0.5070.78
426_F493_L0.5070.78
450_T468_F0.5070.78
201_I266_N0.5060.77
209_L325_E0.5060.77
475_S541_G0.5050.77
156_K258_G0.5050.77
291_M315_Y0.5040.77
316_K352_S0.5040.77
335_K344_S0.5030.77
126_L148_S0.5030.77
552_K572_G0.5030.77
429_F453_W0.5030.77
326_Q330_V0.5030.77
406_G414_D0.5020.77
541_G558_P0.5020.77
100_P113_L0.5020.77
424_V456_T0.5020.77
403_P408_S0.5020.77
346_S356_D0.5010.77
134_G267_T0.5000.77
164_T182_D0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c00A 1 0.9393 100 0.194 Contact Map
4k3bA 1 0.9861 100 0.241 Contact Map
4k3cA 1 0.8076 100 0.343 Contact Map
4ql0A 2 0.8232 100 0.429 Contact Map
4c4vA 1 0.6638 100 0.451 Contact Map
4n75A 1 0.5321 100 0.581 Contact Map
4pk1A 1 0.5529 100 0.67 Contact Map
4bzaA 1 0.4211 100 0.674 Contact Map
2qdfA 1 0.4489 100 0.701 Contact Map
3efcA 1 0.4558 100 0.707 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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