GREMLIN Database
YTFK - Uncharacterized protein YtfK
UniProt: P0ADE2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12511
Length: 68 (64)
Sequences: 109 (54)
Seq/√Len: 6.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_K12_V3.1290.85
1_M49_H2.2560.60
29_V32_F2.0980.54
23_R33_E1.9890.50
3_I15_Y1.8100.43
11_Q50_L1.8010.43
24_L39_I1.7460.41
3_I31_A1.7020.39
9_P22_G1.6680.38
21_R43_K1.6020.36
23_R49_H1.5920.36
47_K53_M1.5680.35
14_K35_D1.5560.34
19_L63_L1.5040.33
17_K46_D1.4830.32
1_M25_Y1.4820.32
14_K60_V1.4760.32
27_K56_V1.4580.31
21_R41_I1.4440.31
1_M8_N1.3750.28
2_K15_Y1.3450.28
13_A16_V1.2850.26
4_F9_P1.2460.25
12_V56_V1.2220.24
7_Y55_E1.2220.24
2_K60_V1.2140.24
6_R41_I1.2110.24
3_I21_R1.2040.24
28_D60_V1.1900.23
4_F7_Y1.1540.22
25_Y53_M1.1270.21
11_Q32_F1.1100.21
36_K54_S1.1070.21
29_V52_V1.0910.21
19_L50_L1.0890.21
41_I50_L1.0400.19
40_L51_S1.0380.19
1_M50_L1.0140.19
20_F26_I1.0110.19
17_K40_L1.0090.19
29_V35_D1.0080.19
39_I59_Q0.9900.18
7_Y20_F0.9640.18
28_D64_Q0.8910.16
32_F38_K0.8800.16
39_I44_V0.8520.15
25_Y49_H0.8470.15
23_R31_A0.8450.15
11_Q15_Y0.8420.15
35_D58_R0.8340.15
29_V50_L0.8270.15
15_Y24_L0.8170.15
3_I23_R0.8130.15
52_V56_V0.8100.15
1_M23_R0.8000.14
1_M6_R0.7850.14
39_I53_M0.7770.14
18_I63_L0.7680.14
60_V64_Q0.7560.14
18_I54_S0.7400.13
35_D41_I0.7310.13
33_E55_E0.7290.13
43_K54_S0.7280.13
4_F13_A0.7280.13
32_F63_L0.6890.12
7_Y36_K0.6760.12
2_K28_D0.6650.12
19_L60_V0.6560.12
8_N60_V0.6470.12
54_S58_R0.6380.12
5_Q56_V0.6320.12
11_Q49_H0.6220.11
32_F52_V0.6210.11
36_K58_R0.6200.11
10_L32_F0.6140.11
44_V61_M0.5930.11
6_R19_L0.5900.11
48_L61_M0.5890.11
35_D42_P0.5890.11
6_R63_L0.5870.11
8_N17_K0.5710.11
45_K55_E0.5660.11
7_Y26_I0.5590.10
59_Q64_Q0.5570.10
12_V47_K0.5530.10
18_I59_Q0.5520.10
14_K22_G0.5430.10
40_L44_V0.5310.10
5_Q14_K0.5300.10
18_I46_D0.5230.10
31_A36_K0.5140.10
22_G49_H0.5130.10
6_R25_Y0.5120.10
26_I38_K0.5110.10
35_D48_L0.5060.10
6_R52_V0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jroA 1 1 100 0.11 Contact Map
2p61A 1 0.75 14.6 0.915 Contact Map
3fvyA 1 0.9706 10.8 0.919 Contact Map
3uw2A 1 0.9706 9.9 0.921 Contact Map
4c2mA 1 1 9.8 0.921 Contact Map
4aybA 1 0.9853 9 0.922 Contact Map
4qiwA 2 1 8.4 0.923 Contact Map
1twfA 1 1 8.1 0.924 Contact Map
3h0gA 2 1 8 0.924 Contact Map
2ig8A 3 1 7.7 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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