GREMLIN Database
LPTG - Lipopolysaccharide export system permease protein LptG
UniProt: P0ADC6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12536
Length: 360 (347)
Sequences: 4441 (3268)
Seq/√Len: 175.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_A208_Q7.0881.00
164_E174_G5.7951.00
209_V225_T5.4081.00
194_T207_S4.5841.00
165_R173_G4.0131.00
7_L92_M3.7411.00
276_W342_L3.6241.00
171_E194_T3.5781.00
179_A188_S3.5671.00
262_K272_Q3.3771.00
8_D101_Q3.3211.00
255_H275_M3.2141.00
198_D205_R3.1081.00
82_M86_R3.0141.00
9_R13_K2.7801.00
80_L106_V2.7461.00
19_I75_G2.7291.00
131_M134_N2.6711.00
205_R227_S2.6561.00
171_E196_K2.6501.00
196_K207_S2.6361.00
13_K17_T2.5211.00
6_V9_R2.5151.00
203_V229_T2.4551.00
181_N185_R2.4321.00
110_A289_M2.3761.00
188_S211_E2.2921.00
127_Q131_M2.2841.00
205_R229_T2.2561.00
274_N278_K2.2491.00
207_S227_S2.2391.00
75_G79_G2.1181.00
277_S327_G2.0561.00
330_T340_G2.0481.00
280_F342_L2.0241.00
159_N179_A1.9911.00
195_A206_L1.9571.00
92_M97_F1.9401.00
210_D224_Q1.9281.00
287_V348_F1.9051.00
150_Q165_R1.8991.00
167_K173_G1.8671.00
197_F236_P1.8641.00
188_S213_D1.8521.00
284_S319_F1.8511.00
12_G109_T1.8051.00
71_A75_G1.7751.00
346_A350_L1.7511.00
111_I115_L1.7491.00
49_A53_G1.7171.00
192_A206_L1.7101.00
53_G57_L1.7011.00
350_L354_W1.6971.00
213_D221_T1.6911.00
23_L71_A1.6881.00
48_D51_G1.6861.00
103_A293_L1.6711.00
26_L67_F1.6641.00
172_L195_A1.6631.00
57_L61_P1.5971.00
213_D223_S1.5941.00
77_L312_G1.5941.00
114_V286_A1.5841.00
120_I124_V1.5721.00
346_A349_F1.5631.00
27_V60_V1.5631.00
268_A272_Q1.5581.00
23_L64_V1.5521.00
116_L120_I1.5351.00
115_L119_A1.5291.00
42_A52_A1.5251.00
14_T82_M1.5101.00
31_G56_T1.5051.00
211_E223_S1.5021.00
327_G331_L1.4941.00
291_M352_S1.4871.00
190_R211_E1.4771.00
14_T83_L1.4731.00
199_P202_K1.4681.00
269_G272_Q1.4601.00
163_I172_L1.4521.00
54_M58_L1.4521.00
83_L92_M1.4511.00
208_Q226_V1.4431.00
249_L257_Y1.4371.00
51_G54_M1.4281.00
257_Y271_Y1.4211.00
211_E225_T1.3811.00
65_Q121_G1.3801.00
19_I113_L1.3711.00
101_Q104_L1.3681.00
16_F20_M1.3671.00
72_A285_V1.3661.00
58_L128_G1.3651.00
22_T74_L1.3481.00
214_L220_I1.3241.00
167_K171_E1.3171.00
23_L27_V1.3151.00
208_Q224_Q1.3081.00
68_F117_T1.3061.00
119_A123_W1.2991.00
251_I275_M1.2981.00
282_P285_V1.2921.00
273_L331_L1.2861.00
196_K205_R1.2811.00
119_A124_V1.2731.00
104_L108_K1.2621.00
100_M104_L1.2551.00
338_I346_A1.2341.00
174_G193_A1.2291.00
250_S253_G1.2181.00
8_D104_L1.2181.00
73_L288_M1.2161.00
173_G194_T1.2091.00
273_L278_K1.1961.00
114_V282_P1.1951.00
258_V275_M1.1911.00
342_L345_S1.1891.00
275_M279_I1.1761.00
175_I195_A1.1751.00
58_L131_M1.1681.00
62_K129_E1.1541.00
255_H258_V1.1531.00
225_T228_G1.1531.00
246_P271_Y1.1501.00
51_G135_Y1.1471.00
34_K38_Q1.1381.00
98_T101_Q1.1361.00
107_M110_A1.1201.00
106_V289_M1.1191.00
336_P339_I1.1031.00
326_F329_L1.0941.00
18_T79_G1.0941.00
174_G191_Y1.0931.00
11_I92_M1.0921.00
76_A289_M1.0901.00
172_L175_I1.0891.00
211_E228_G1.0891.00
78_L308_R1.0751.00
7_L97_F1.0651.00
283_L342_L1.0641.00
258_V268_A1.0621.00
8_D105_S1.0611.00
84_A89_L1.0601.00
274_N277_S1.0531.00
197_F204_W1.0431.00
330_T341_A1.0400.99
324_Q327_G1.0380.99
259_K262_K1.0330.99
249_L253_G1.0290.99
54_M131_M1.0250.99
324_Q328_P1.0220.99
283_L345_S1.0210.99
38_Q56_T1.0040.99
127_Q130_Q1.0000.99
203_V231_K0.9920.99
258_V272_Q0.9900.99
30_S67_F0.9900.99
290_L352_S0.9890.99
42_A45_G0.9880.99
254_L258_V0.9790.99
92_M102_V0.9760.99
64_V120_I0.9720.99
190_R209_V0.9650.99
276_W338_I0.9600.99
326_F344_P0.9590.99
280_F345_S0.9580.99
55_Y132_A0.9550.99
91_V94_A0.9540.99
353_L357_M0.9510.99
163_I195_A0.9430.99
134_N138_Q0.9410.99
55_Y136_R0.9380.99
123_W252_S0.9370.99
15_I109_T0.9260.99
51_G139_A0.9250.99
349_F353_L0.9240.99
122_E251_I0.9230.99
177_I206_L0.9220.99
262_K268_A0.9210.99
118_M122_E0.9190.99
30_S63_D0.9170.99
181_N187_Q0.9150.99
251_I279_I0.9120.99
320_Y323_D0.9110.99
349_F352_S0.9090.99
204_W236_P0.9080.99
93_Q99_R0.9070.99
287_V349_F0.9060.99
79_G83_L0.9050.99
28_S32_I0.9000.99
185_R216_N0.9000.99
15_I72_A0.8980.99
291_M318_V0.8950.98
72_A113_L0.8930.98
89_L297_F0.8920.98
18_T75_G0.8870.98
133_R248_A0.8860.98
10_Y92_M0.8810.98
287_V319_F0.8810.98
194_T208_Q0.8800.98
246_P249_L0.8750.98
182_E185_R0.8750.98
14_T17_T0.8700.98
50_L54_M0.8690.98
262_K265_G0.8670.98
287_V352_S0.8660.98
153_W162_Y0.8580.98
124_V128_G0.8580.98
38_Q47_Y0.8520.98
7_L10_Y0.8460.98
130_Q134_N0.8410.98
72_A76_A0.8400.98
206_L209_V0.8400.98
326_F340_G0.8390.98
336_P340_G0.8360.98
152_L155_K0.8360.98
47_Y52_A0.8340.98
33_I36_V0.8340.98
319_F345_S0.8340.98
191_Y210_D0.8330.98
10_Y14_T0.8330.98
299_P304_P0.8310.98
8_D11_I0.8290.97
22_T26_L0.8280.97
112_P115_L0.8280.97
257_Y268_A0.8280.97
216_N219_Q0.8270.97
251_I255_H0.8170.97
88_E254_L0.8130.97
267_D272_Q0.8120.97
287_V345_S0.8110.97
59_S62_K0.8110.97
251_I278_K0.8090.97
166_V172_L0.8090.97
347_S350_L0.8080.97
19_I71_A0.8050.97
99_R293_L0.8020.97
212_S220_I0.7990.97
72_A331_L0.7970.97
80_L293_L0.7940.97
198_D202_K0.7910.97
272_Q276_W0.7890.97
10_Y83_L0.7880.97
314_S318_V0.7880.97
122_E278_K0.7850.97
284_S352_S0.7810.96
276_W280_F0.7740.96
269_G333_Y0.7740.96
291_M348_F0.7710.96
15_I79_G0.7700.96
199_P203_V0.7700.96
326_F341_A0.7690.96
215_T219_Q0.7650.96
155_K158_N0.7650.96
164_E173_G0.7620.96
30_S34_K0.7620.96
124_V127_Q0.7600.96
232_T235_T0.7560.96
210_D222_G0.7550.96
277_S323_D0.7500.95
14_T90_V0.7500.95
209_V226_V0.7490.95
65_Q125_A0.7450.95
14_T79_G0.7410.95
8_D19_I0.7410.95
258_V271_Y0.7390.95
242_V343_L0.7370.95
321_V325_I0.7360.95
317_F320_Y0.7330.95
67_F71_A0.7330.95
17_T21_M0.7320.95
294_S352_S0.7320.95
335_I340_G0.7310.95
80_L296_I0.7300.95
123_W126_P0.7300.95
112_P213_D0.7280.95
73_L292_A0.7260.95
320_Y324_Q0.7250.95
245_D248_A0.7250.95
319_F323_D0.7240.95
87_S90_V0.7240.95
252_S256_N0.7190.94
53_G140_M0.7130.94
339_I346_A0.7100.94
143_G146_L0.7090.94
175_I192_A0.7040.94
174_G215_T0.7010.94
323_D345_S0.7010.94
30_S35_F0.7000.93
180_F186_L0.6960.93
77_L326_F0.6950.93
108_K112_P0.6950.93
111_I286_A0.6930.93
116_L255_H0.6930.93
186_L204_W0.6890.93
296_I304_P0.6880.93
77_L284_S0.6870.93
40_K82_M0.6830.93
107_M286_A0.6830.93
296_I303_V0.6810.93
318_V348_F0.6800.92
122_E279_I0.6770.92
26_L31_G0.6750.92
99_R105_S0.6740.92
234_L288_M0.6740.92
94_A264_S0.6720.92
49_A207_S0.6700.92
176_S189_V0.6700.92
354_W357_M0.6670.92
198_D203_V0.6660.92
208_Q211_E0.6660.92
133_R136_R0.6620.91
39_L42_A0.6620.91
195_A225_T0.6620.91
125_A129_E0.6580.91
107_M290_L0.6570.91
345_S349_F0.6560.91
170_E224_Q0.6550.91
33_I63_D0.6550.91
95_S99_R0.6540.91
344_P348_F0.6510.91
84_A296_I0.6510.91
37_D40_K0.6480.91
274_N295_F0.6460.90
329_L351_I0.6460.90
273_L330_T0.6450.90
268_A271_Y0.6450.90
135_Y139_A0.6440.90
110_A113_L0.6430.90
205_R208_Q0.6430.90
345_S348_F0.6420.90
179_A187_Q0.6400.90
159_N177_I0.6380.90
300_L304_P0.6380.90
175_I206_L0.6380.90
148_T204_W0.6380.90
59_S267_D0.6360.90
168_G335_I0.6350.90
168_G326_F0.6340.90
179_A190_R0.6340.90
156_D232_T0.6340.90
126_P278_K0.6340.90
288_M348_F0.6320.90
255_H259_K0.6320.90
55_Y135_Y0.6290.89
92_M95_S0.6290.89
322_L326_F0.6290.89
84_A304_P0.6290.89
93_Q297_F0.6280.89
59_S132_A0.6280.89
259_K263_S0.6270.89
74_L91_V0.6260.89
56_T139_A0.6230.89
252_S255_H0.6220.89
87_S299_P0.6220.89
130_Q245_D0.6210.89
195_A246_P0.6210.89
117_T285_V0.6190.89
11_I83_L0.6190.89
16_F50_L0.6180.88
61_P128_G0.6180.88
35_F296_I0.6160.88
285_V288_M0.6150.88
329_L335_I0.6150.88
230_W351_I0.6140.88
276_W341_A0.6140.88
161_V234_L0.6130.88
31_G60_V0.6130.88
103_A107_M0.6130.88
337_P341_A0.6130.88
12_G105_S0.6130.88
103_A170_E0.6120.88
12_G15_I0.6120.88
284_S345_S0.6100.88
136_R140_M0.6090.88
179_A183_N0.6090.88
190_R228_G0.6060.87
57_L135_Y0.6060.87
38_Q132_A0.6060.87
296_I308_R0.6050.87
50_L53_G0.6040.87
260_Y263_S0.6040.87
294_S297_F0.6030.87
227_S339_I0.6030.87
295_F355_L0.6020.87
39_L314_S0.5990.87
192_A209_V0.5970.87
323_D327_G0.5970.87
16_F109_T0.5940.86
194_T351_I0.5920.86
311_T315_F0.5900.86
331_L334_G0.5880.86
293_L355_L0.5870.86
73_L76_A0.5870.86
258_V265_G0.5870.86
78_L82_M0.5860.86
18_T30_S0.5850.86
261_L278_K0.5850.86
14_T86_R0.5850.86
68_F71_A0.5810.85
19_I23_L0.5790.85
27_V64_V0.5780.85
6_V103_A0.5770.85
168_G171_E0.5750.85
125_A128_G0.5740.85
118_M279_I0.5740.85
257_Y261_L0.5720.84
156_D159_N0.5690.84
134_N143_G0.5680.84
54_M135_Y0.5670.84
315_F348_F0.5670.84
115_L219_Q0.5670.84
266_Q288_M0.5660.84
70_M316_G0.5630.83
35_F49_A0.5610.83
76_A292_A0.5610.83
352_S356_L0.5600.83
286_A294_S0.5600.83
340_G347_S0.5590.83
84_A234_L0.5590.83
328_P332_V0.5590.83
273_L341_A0.5590.83
254_L278_K0.5580.83
258_V262_K0.5580.83
19_I58_L0.5580.83
131_M135_Y0.5570.83
108_K115_L0.5560.83
288_M312_G0.5560.83
41_K44_Q0.5560.83
29_L62_K0.5550.83
115_L123_W0.5530.82
34_K37_D0.5530.82
61_P105_S0.5530.82
56_T78_L0.5530.82
89_L310_V0.5520.82
79_G324_Q0.5510.82
251_I254_L0.5510.82
290_L356_L0.5510.82
8_D20_M0.5470.82
82_M94_A0.5470.82
177_I230_W0.5460.81
192_A217_P0.5460.81
62_K66_I0.5460.81
71_A292_A0.5460.81
169_D346_A0.5440.81
310_V313_I0.5420.81
300_L303_V0.5420.81
80_L102_V0.5400.81
28_S46_S0.5400.81
6_V25_M0.5400.81
249_L271_Y0.5390.81
133_R332_V0.5390.81
139_A145_L0.5380.81
10_Y69_P0.5380.81
220_I224_Q0.5360.80
117_T120_I0.5350.80
115_L226_V0.5340.80
105_S110_A0.5330.80
17_T20_M0.5330.80
91_V95_S0.5320.80
148_T163_I0.5310.80
40_K43_G0.5310.80
81_G91_V0.5310.80
72_A109_T0.5310.80
124_V179_A0.5300.80
153_W156_D0.5300.80
86_R288_M0.5280.79
258_V261_L0.5280.79
16_F171_E0.5270.79
322_L338_I0.5270.79
63_D66_I0.5270.79
194_T205_R0.5250.79
67_F312_G0.5250.79
19_I68_F0.5240.79
30_S303_V0.5240.79
69_P83_L0.5230.79
207_S226_V0.5230.79
87_S302_S0.5230.79
291_M333_Y0.5210.78
214_L217_P0.5200.78
256_N259_K0.5200.78
319_F337_P0.5200.78
36_V159_N0.5190.78
112_P116_L0.5180.78
296_I342_L0.5180.78
81_G308_R0.5160.78
89_L303_V0.5160.78
7_L348_F0.5150.78
176_S191_Y0.5140.78
90_V300_L0.5140.78
114_V118_M0.5140.78
273_L277_S0.5130.77
22_T145_L0.5130.77
61_P69_P0.5130.77
84_A306_G0.5130.77
73_L320_Y0.5110.77
315_F324_Q0.5100.77
252_S347_S0.5100.77
153_W266_Q0.5090.77
122_E293_L0.5070.77
21_M24_F0.5070.77
26_L151_G0.5050.76
180_F204_W0.5050.76
165_R227_S0.5050.76
83_L91_V0.5050.76
146_L151_G0.5040.76
130_Q169_D0.5040.76
182_E203_V0.5030.76
222_G350_L0.5030.76
208_Q225_T0.5020.76
188_S311_T0.5020.76
193_A219_Q0.5020.76
299_P302_S0.5010.76
47_Y80_L0.5010.76
86_R322_L0.5010.76
292_A307_V0.5010.76
68_F113_L0.5000.76
61_P283_L0.5000.76
110_A286_A0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zojA 3 0.3194 3.9 0.97 Contact Map
3wvfA 1 0.2972 3.6 0.97 Contact Map
4us3A 1 0.2917 3.5 0.971 Contact Map
4uu4A 1 0.35 3.4 0.971 Contact Map
4cadC 1 0.15 3.1 0.972 Contact Map
4lxjA 1 0.2083 3 0.972 Contact Map
2l9uA 2 0.0806 2.9 0.972 Contact Map
2mofA 1 0.0944 2.8 0.972 Contact Map
2l5bA 1 0.0806 2.6 0.973 Contact Map
3j1zP 8 0.2556 2.5 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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