GREMLIN Database
LOLC - Lipoprotein-releasing system transmembrane protein LolC
UniProt: P0ADC3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13439
Length: 399 (355)
Sequences: 37973 (33010)
Seq/√Len: 1752.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_M18_A4.5061.00
148_E191_A3.6671.00
161_Q183_L3.5961.00
161_Q185_N3.3671.00
297_V314_F3.3051.00
163_R183_L3.2191.00
148_E152_S3.0571.00
13_Y18_A3.0231.00
143_N185_N2.7101.00
143_N187_I2.7071.00
293_K317_Q2.6771.00
391_Q394_E2.6381.00
144_V201_M2.5441.00
77_P80_L2.5361.00
151_A189_T2.5241.00
81_P85_V2.4681.00
128_Y191_A2.4231.00
306_T309_Q2.3651.00
326_A369_A2.3491.00
145_I188_G2.3041.00
381_L385_W2.2791.00
301_Q307_P2.2761.00
144_V184_F2.1841.00
385_W389_A2.0901.00
318_G380_T2.0691.00
150_L154_L2.0611.00
231_K234_S2.0551.00
329_G333_G2.0301.00
146_L151_A2.0291.00
145_I190_F2.0031.00
82_E85_V1.9741.00
322_G376_A1.9691.00
13_Y17_R1.9651.00
91_N227_D1.9461.00
89_G227_D1.9251.00
35_T328_L1.9241.00
142_Y207_D1.9121.00
361_E364_Q1.8811.00
31_T35_T1.8811.00
234_S238_Q1.8601.00
206_E209_S1.8501.00
140_G143_N1.8501.00
83_T86_K1.8281.00
144_V203_V1.7921.00
204_N207_D1.7891.00
293_K296_E1.7871.00
233_D236_S1.7841.00
203_V208_A1.7411.00
232_V236_S1.7351.00
311_M385_W1.7141.00
78_Q82_E1.7031.00
42_V333_G1.6991.00
184_F207_D1.6921.00
117_I121_Q1.6601.00
89_G238_Q1.6321.00
91_N225_W1.6131.00
53_R57_N1.6101.00
146_L150_L1.5971.00
146_L186_V1.5971.00
136_D143_N1.5871.00
146_L201_M1.5841.00
133_K187_I1.5831.00
79_Q83_T1.5781.00
76_N80_L1.5701.00
145_I187_I1.5691.00
149_Q192_A1.5661.00
157_N160_D1.5601.00
158_R189_T1.5601.00
228_E231_K1.5471.00
149_Q152_S1.5471.00
147_G190_F1.5401.00
325_G329_G1.5261.00
362_P366_I1.5161.00
39_M332_L1.4981.00
339_Q343_L1.4881.00
309_Q312_M1.4871.00
308_R312_M1.4811.00
35_T332_L1.4701.00
14_M17_R1.4701.00
31_T325_G1.4691.00
165_M181_Q1.4651.00
136_D139_P1.4611.00
203_V207_D1.4591.00
233_D237_Q1.4481.00
80_L83_T1.4411.00
144_V162_I1.4351.00
363_L367_V1.4191.00
307_P388_A1.4141.00
163_R181_Q1.4141.00
205_I209_S1.4001.00
322_G326_A1.3881.00
379_S383_P1.3881.00
49_N361_E1.3831.00
335_L338_S1.3621.00
129_L134_Q1.3611.00
384_S388_A1.3501.00
92_R225_W1.3421.00
130_V148_E1.3321.00
82_E86_K1.3291.00
226_L235_L1.3281.00
331_A335_L1.3221.00
268_G272_S1.3181.00
335_L339_Q1.3181.00
297_V310_I1.3171.00
156_V160_D1.3151.00
26_V292_E1.3031.00
294_Q395_A1.3021.00
305_L309_Q1.2971.00
142_Y182_R1.2921.00
25_F28_W1.2871.00
147_G150_L1.2841.00
366_I370_L1.2821.00
38_V329_G1.2821.00
386_R389_A1.2781.00
146_L189_T1.2731.00
248_D251_D1.2681.00
327_I331_A1.2671.00
156_V186_V1.2661.00
333_G337_A1.2631.00
35_T39_M1.2541.00
12_R15_R1.2431.00
340_L343_L1.2351.00
120_A123_D1.2311.00
296_E300_L1.2301.00
158_R187_I1.2301.00
298_A302_T1.2211.00
134_Q145_I1.2191.00
300_L313_V1.2181.00
147_G199_Y1.2171.00
130_V191_A1.2081.00
15_R18_A1.1991.00
122_K134_Q1.1931.00
39_M336_L1.1871.00
63_M67_I1.1861.00
46_S337_A1.1811.00
12_R16_G1.1691.00
57_N60_L1.1621.00
312_M316_V1.1601.00
52_E56_Q1.1591.00
79_Q82_E1.1561.00
96_I221_G1.1501.00
298_A395_A1.1481.00
254_G258_Q1.1471.00
80_L84_A1.1461.00
339_Q342_N1.1411.00
49_N52_E1.1411.00
34_I325_G1.1401.00
294_Q390_T1.1321.00
234_S237_Q1.1291.00
300_L305_L1.1131.00
279_A379_S1.1081.00
92_R124_P1.1081.00
39_M333_G1.1061.00
58_N61_G1.1051.00
53_R359_A1.1041.00
42_V368_I1.1041.00
11_L15_R1.0931.00
265_N269_L1.0891.00
78_Q81_P1.0831.00
64_P68_L1.0751.00
338_S342_N1.0731.00
37_G271_L1.0671.00
27_S321_A1.0651.00
129_L188_G1.0611.00
39_M329_G1.0551.00
385_W388_A1.0501.00
63_M66_A1.0481.00
87_L235_L1.0451.00
139_P142_Y1.0431.00
94_A118_D1.0411.00
207_D210_R1.0381.00
328_L331_A1.0351.00
208_A212_M1.0341.00
232_V235_L1.0321.00
118_D121_Q1.0311.00
363_L366_I1.0251.00
57_N61_G1.0241.00
232_V238_Q1.0201.00
274_I281_N1.0191.00
359_A362_P1.0181.00
13_Y16_G1.0181.00
340_L344_M1.0131.00
52_E264_K1.0071.00
49_N364_Q1.0001.00
148_E192_A0.9911.00
131_N158_R0.9901.00
286_L318_G0.9881.00
28_W32_I0.9881.00
31_T328_L0.9851.00
294_Q298_A0.9831.00
13_Y317_Q0.9821.00
149_Q153_Q0.9811.00
322_G372_A0.9791.00
330_A365_V0.9741.00
311_M381_L0.9671.00
222_W226_L0.9661.00
319_A377_L0.9631.00
35_T38_V0.9621.00
293_K314_F0.9601.00
85_V93_V0.9561.00
53_R56_Q0.9521.00
226_L229_P0.9501.00
251_D254_G0.9471.00
305_L310_I0.9441.00
326_A372_A0.9391.00
90_V93_V0.9391.00
87_L238_Q0.9351.00
139_P143_N0.9331.00
318_G322_G0.9281.00
226_L232_V0.9271.00
283_I287_G0.9271.00
49_N53_R0.9261.00
390_T394_E0.9231.00
227_D231_K0.9161.00
261_R265_N0.9091.00
386_R390_T0.9061.00
155_G160_D0.9051.00
46_S50_G0.9041.00
90_V224_L0.9031.00
384_S387_A0.9011.00
279_A375_I0.8971.00
136_D187_I0.8961.00
307_P389_A0.8931.00
372_A376_A0.8921.00
258_Q261_R0.8851.00
338_S341_N0.8821.00
141_K206_E0.8811.00
31_T324_I0.8791.00
95_P118_D0.8781.00
360_I365_V0.8781.00
34_I38_V0.8771.00
382_Y385_W0.8761.00
76_N79_Q0.8741.00
307_P311_M0.8681.00
81_P95_P0.8621.00
370_L374_A0.8541.00
331_A334_A0.8531.00
255_E258_Q0.8511.00
129_L190_F0.8511.00
390_T395_A0.8501.00
64_P67_I0.8501.00
236_S248_D0.8471.00
56_Q60_L0.8441.00
87_L90_V0.8441.00
138_E143_N0.8431.00
223_R226_L0.8381.00
205_I208_A0.8361.00
114_M203_V0.8351.00
131_N189_T0.8341.00
116_G208_A0.8331.00
81_P93_V0.8311.00
96_I223_R0.8301.00
116_G205_I0.8301.00
77_P81_P0.8291.00
146_L156_V0.8271.00
301_Q310_I0.8271.00
367_V370_L0.8251.00
239_K243_G0.8221.00
38_V372_A0.8201.00
374_A378_L0.8201.00
289_M317_Q0.8181.00
35_T325_G0.8181.00
105_S108_S0.8181.00
127_P190_F0.8171.00
133_K136_D0.8171.00
330_A369_A0.8111.00
220_T223_R0.8101.00
147_G198_G0.8091.00
148_E151_A0.8091.00
368_I372_A0.8061.00
112_G201_M0.8051.00
158_R188_G0.8041.00
147_G192_A0.8031.00
240_L243_G0.8021.00
250_R254_G0.8011.00
83_T87_L0.8001.00
33_G37_G0.7991.00
319_A376_A0.7981.00
235_L238_Q0.7961.00
54_E58_N0.7941.00
334_A360_I0.7941.00
272_S276_A0.7931.00
117_I122_K0.7921.00
301_Q392_P0.7901.00
337_A358_V0.7891.00
245_K248_D0.7891.00
123_D134_Q0.7871.00
290_V297_V0.7861.00
141_K204_N0.7861.00
337_A341_N0.7821.00
114_M201_M0.7811.00
260_V264_K0.7801.00
33_G281_N0.7771.00
164_V184_F0.7761.00
367_V371_V0.7721.00
291_M294_Q0.7711.00
211_L214_Y0.7701.00
338_S358_V0.7681.00
199_Y202_L0.7671.00
222_W225_W0.7651.00
81_P222_W0.7631.00
43_T333_G0.7621.00
219_I222_W0.7611.00
262_M266_M0.7571.00
101_V114_M0.7561.00
30_S33_G0.7551.00
146_L162_I0.7521.00
371_V374_A0.7481.00
382_Y386_R0.7471.00
127_P130_V0.7461.00
315_M377_L0.7461.00
97_T208_A0.7431.00
162_I184_F0.7421.00
371_V375_I0.7421.00
147_G200_E0.7421.00
318_G376_A0.7421.00
253_K257_F0.7401.00
364_Q368_I0.7401.00
281_N284_T0.7401.00
295_G299_I0.7381.00
145_I202_L0.7371.00
311_M388_A0.7351.00
200_E204_N0.7341.00
332_L335_L0.7341.00
92_R123_D0.7341.00
326_A376_A0.7341.00
227_D230_L0.7341.00
110_A153_Q0.7331.00
41_L45_L0.7321.00
190_F202_L0.7301.00
318_G383_P0.7301.00
65_Q69_S0.7291.00
208_A211_L0.7281.00
365_V369_A0.7271.00
392_P395_A0.7251.00
278_A281_N0.7231.00
296_E317_Q0.7231.00
271_L275_V0.7231.00
257_F261_R0.7231.00
283_I379_S0.7201.00
89_G235_L0.7201.00
142_Y185_N0.7171.00
284_T288_L0.7161.00
151_A154_L0.7151.00
380_T384_S0.7151.00
65_Q68_L0.7141.00
364_Q367_V0.7121.00
220_T224_L0.7111.00
289_M293_K0.7051.00
393_A396_L0.7041.00
324_I327_I0.7011.00
317_Q320_S0.6991.00
55_L59_I0.6991.00
13_Y296_E0.6981.00
119_P122_K0.6961.00
311_M384_S0.6951.00
326_A373_M0.6911.00
369_A373_M0.6901.00
43_T336_L0.6891.00
81_P84_A0.6891.00
92_R120_A0.6861.00
318_G384_S0.6861.00
129_L132_V0.6851.00
383_P387_A0.6841.00
239_K242_E0.6841.00
316_V320_S0.6831.00
151_A157_N0.6831.00
298_A392_P0.6831.00
299_I302_T0.6821.00
230_L234_S0.6801.00
326_A330_A0.6801.00
133_K143_N0.6791.00
299_I303_Q0.6761.00
70_S73_G0.6751.00
33_G284_T0.6721.00
30_S285_S0.6721.00
197_D200_E0.6711.00
112_G150_L0.6681.00
290_V314_F0.6641.00
25_F29_L0.6611.00
93_V224_L0.6551.00
118_D122_K0.6551.00
240_L244_S0.6511.00
322_G380_T0.6501.00
30_S34_I0.6481.00
131_N157_N0.6481.00
130_V189_T0.6431.00
316_V319_A0.6421.00
52_E55_L0.6421.00
254_G257_F0.6411.00
258_Q262_M0.6401.00
182_R210_R0.6391.00
285_S289_M0.6391.00
38_V42_V0.6371.00
54_E57_N0.6361.00
264_K268_G0.6361.00
323_I373_M0.6351.00
152_S157_N0.6341.00
151_A186_V0.6341.00
159_G185_N0.6281.00
130_V190_F0.6271.00
229_P232_V0.6231.00
243_G246_W0.6231.00
334_A365_V0.6221.00
230_L235_L0.6221.00
219_I223_R0.6211.00
362_P365_V0.6211.00
95_P219_I0.6181.00
66_A224_L0.6161.00
296_E299_I0.6161.00
94_A121_Q0.6151.00
226_L231_K0.6151.00
96_I99_G0.6141.00
93_V96_I0.6141.00
94_A124_P0.6131.00
199_Y204_N0.6111.00
311_M315_M0.6081.00
291_M386_R0.6071.00
200_E203_V0.6061.00
241_P244_S0.6061.00
104_Q107_R0.6061.00
383_P388_A0.6061.00
120_A124_P0.6061.00
85_V92_R0.6021.00
148_E189_T0.6021.00
226_L230_L0.6021.00
313_V316_V0.6011.00
334_A338_S0.6011.00
277_V281_N0.6001.00
286_L380_T0.5981.00
247_Q252_R0.5971.00
91_N95_P0.5971.00
266_M270_L0.5961.00
26_V30_S0.5941.00
136_D140_G0.5921.00
48_M264_K0.5891.00
286_L289_M0.5891.00
144_V186_V0.5861.00
37_G41_L0.5861.00
160_D186_V0.5851.00
42_V46_S0.5841.00
129_L191_A0.5831.00
45_L49_N0.5821.00
290_V387_A0.5821.00
314_F318_G0.5781.00
35_T329_G0.5781.00
302_T392_P0.5761.00
129_L145_I0.5751.00
42_V329_G0.5751.00
375_I379_S0.5741.00
296_E313_V0.5741.00
376_A379_S0.5741.00
66_A226_L0.5731.00
228_E232_V0.5711.00
18_A25_F0.5701.00
29_L33_G0.5671.00
76_N81_P0.5661.00
315_M381_L0.5661.00
69_S72_H0.5651.00
13_Y293_K0.5651.00
115_L202_L0.5631.00
39_M43_T0.5631.00
37_G40_A0.5631.00
151_A158_R0.5611.00
94_A97_T0.5601.00
45_L48_M0.5591.00
184_F203_V0.5581.00
327_I330_A0.5571.00
55_L58_N0.5561.00
359_A363_L0.5551.00
252_R255_E0.5551.00
97_T209_S0.5541.00
46_S333_G0.5521.00
17_R26_V0.5521.00
99_G103_L0.5521.00
67_I221_G0.5511.00
330_A334_A0.5501.00
65_Q225_W0.5461.00
118_D205_I0.5461.00
40_A314_F0.5461.00
315_M319_A0.5451.00
274_I278_A0.5441.00
92_R95_P0.5431.00
317_Q321_A0.5391.00
69_S73_G0.5381.00
71_E74_S0.5381.00
294_Q386_R0.5371.00
124_P225_W0.5371.00
342_N345_P0.5361.00
91_N226_L0.5361.00
110_A114_M0.5361.00
241_P245_K0.5351.00
27_S31_T0.5351.00
301_Q395_A0.5331.00
141_K207_D0.5321.00
139_P187_I0.5321.00
314_F317_Q0.5311.00
376_A380_T0.5301.00
102_V109_V0.5291.00
209_S214_Y0.5281.00
156_V162_I0.5251.00
159_G162_I0.5221.00
99_G102_V0.5201.00
33_G288_L0.5191.00
37_G281_N0.5191.00
104_Q109_V0.5191.00
121_Q124_P0.5181.00
360_I364_Q0.5161.00
100_D103_L0.5161.00
34_I282_I0.5161.00
287_G290_V0.5151.00
108_S111_V0.5151.00
26_V289_M0.5141.00
116_G119_P0.5141.00
137_L145_I0.5111.00
138_E145_I0.5101.00
260_V263_E0.5071.00
267_M271_L0.5061.00
271_L274_I0.5051.00
131_N151_A0.5051.00
279_A283_I0.5051.00
310_I387_A0.5051.00
12_R17_R0.5031.00
56_Q59_I0.5031.00
366_I369_A0.5031.00
251_D255_E0.5021.00
323_I326_A0.5021.00
326_A329_G0.5021.00
138_E187_I0.5021.00
286_L290_V0.5011.00
94_A117_I0.5001.00
186_V189_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ftjA 1 0.4737 99.2 0.751 Contact Map
3is6A 2 0.5363 98.9 0.782 Contact Map
2l66A 2 0.1328 15.6 0.946 Contact Map
4av3A 2 0.2707 13.3 0.948 Contact Map
2kogA 1 0.1028 10.8 0.95 Contact Map
1rz2A 1 0.4361 10.5 0.95 Contact Map
2fhdA 5 0.3684 10.4 0.95 Contact Map
2mrnA 2 0.1679 10.1 0.95 Contact Map
1yfbA 2 0.1303 8.9 0.952 Contact Map
4pl0A 2 0.2456 7.9 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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