LOLC - ECOLI - GREMLIN Contacts

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LOLC - Lipoprotein-releasing system transmembrane protein LolC

UniProt:	P0ADC3	Sequences: MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNILGLMPQAILSSEHGSLNPQQLPETAVKLDGVNRVAPITTGDVVLQSARSVAVGVMLGIDPAQKDPLTPYLVNVKQTDLEPGKYNVILGEQLASQLGVNRGDQIRVMVPSASQFTPMGRIPSQRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKLPEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGASAGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAIEPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13439
Length:	399 (355)
Sequences:	37973 (33010)
Seq/√Len:	1752.0

ECOLI - LOLC LOLE YBBP MACB FTSX
BACSU - YTRF YKNZ YCLI YVRN YXDM YVCS BCEB FTSX
HALSA - Q9HT02
SULSO - Q7LXM6 Q97Z54 Q97XD5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
14_M	18_A	4.506	1.00
148_E	191_A	3.667	1.00
161_Q	183_L	3.596	1.00
161_Q	185_N	3.367	1.00
297_V	314_F	3.305	1.00
163_R	183_L	3.219	1.00
148_E	152_S	3.057	1.00
13_Y	18_A	3.023	1.00
143_N	185_N	2.710	1.00
143_N	187_I	2.707	1.00
293_K	317_Q	2.677	1.00
391_Q	394_E	2.638	1.00
144_V	201_M	2.544	1.00
77_P	80_L	2.536	1.00
151_A	189_T	2.524	1.00
81_P	85_V	2.468	1.00
128_Y	191_A	2.423	1.00
306_T	309_Q	2.365	1.00
326_A	369_A	2.349	1.00
145_I	188_G	2.304	1.00
381_L	385_W	2.279	1.00
301_Q	307_P	2.276	1.00
144_V	184_F	2.184	1.00
385_W	389_A	2.090	1.00
318_G	380_T	2.069	1.00
150_L	154_L	2.061	1.00
231_K	234_S	2.055	1.00
329_G	333_G	2.030	1.00
146_L	151_A	2.029	1.00
145_I	190_F	2.003	1.00
82_E	85_V	1.974	1.00
322_G	376_A	1.969	1.00
13_Y	17_R	1.965	1.00
91_N	227_D	1.946	1.00
89_G	227_D	1.925	1.00
35_T	328_L	1.924	1.00
142_Y	207_D	1.912	1.00
361_E	364_Q	1.881	1.00
31_T	35_T	1.881	1.00
234_S	238_Q	1.860	1.00
206_E	209_S	1.850	1.00
140_G	143_N	1.850	1.00
83_T	86_K	1.828	1.00
144_V	203_V	1.792	1.00
204_N	207_D	1.789	1.00
293_K	296_E	1.787	1.00
233_D	236_S	1.784	1.00
203_V	208_A	1.741	1.00
232_V	236_S	1.735	1.00
311_M	385_W	1.714	1.00
78_Q	82_E	1.703	1.00
42_V	333_G	1.699	1.00
184_F	207_D	1.692	1.00
117_I	121_Q	1.660	1.00
89_G	238_Q	1.632	1.00
91_N	225_W	1.613	1.00
53_R	57_N	1.610	1.00
146_L	150_L	1.597	1.00
146_L	186_V	1.597	1.00
136_D	143_N	1.587	1.00
146_L	201_M	1.584	1.00
133_K	187_I	1.583	1.00
79_Q	83_T	1.578	1.00
76_N	80_L	1.570	1.00
145_I	187_I	1.569	1.00
149_Q	192_A	1.566	1.00
157_N	160_D	1.560	1.00
158_R	189_T	1.560	1.00
228_E	231_K	1.547	1.00
149_Q	152_S	1.547	1.00
147_G	190_F	1.540	1.00
325_G	329_G	1.526	1.00
362_P	366_I	1.516	1.00
39_M	332_L	1.498	1.00
339_Q	343_L	1.488	1.00
309_Q	312_M	1.487	1.00
308_R	312_M	1.481	1.00
35_T	332_L	1.470	1.00
14_M	17_R	1.470	1.00
31_T	325_G	1.469	1.00
165_M	181_Q	1.465	1.00
136_D	139_P	1.461	1.00
203_V	207_D	1.459	1.00
233_D	237_Q	1.448	1.00
80_L	83_T	1.441	1.00
144_V	162_I	1.435	1.00
363_L	367_V	1.419	1.00
307_P	388_A	1.414	1.00
163_R	181_Q	1.414	1.00
205_I	209_S	1.400	1.00
322_G	326_A	1.388	1.00
379_S	383_P	1.388	1.00
49_N	361_E	1.383	1.00
335_L	338_S	1.362	1.00
129_L	134_Q	1.361	1.00
384_S	388_A	1.350	1.00
92_R	225_W	1.342	1.00
130_V	148_E	1.332	1.00
82_E	86_K	1.329	1.00
226_L	235_L	1.328	1.00
331_A	335_L	1.322	1.00
268_G	272_S	1.318	1.00
335_L	339_Q	1.318	1.00
297_V	310_I	1.317	1.00
156_V	160_D	1.315	1.00
26_V	292_E	1.303	1.00
294_Q	395_A	1.302	1.00
305_L	309_Q	1.297	1.00
142_Y	182_R	1.292	1.00
25_F	28_W	1.287	1.00
147_G	150_L	1.284	1.00
366_I	370_L	1.282	1.00
38_V	329_G	1.282	1.00
386_R	389_A	1.278	1.00
146_L	189_T	1.273	1.00
248_D	251_D	1.268	1.00
327_I	331_A	1.267	1.00
156_V	186_V	1.266	1.00
333_G	337_A	1.263	1.00
35_T	39_M	1.254	1.00
12_R	15_R	1.243	1.00
340_L	343_L	1.235	1.00
120_A	123_D	1.231	1.00
296_E	300_L	1.230	1.00
158_R	187_I	1.230	1.00
298_A	302_T	1.221	1.00
134_Q	145_I	1.219	1.00
300_L	313_V	1.218	1.00
147_G	199_Y	1.217	1.00
130_V	191_A	1.208	1.00
15_R	18_A	1.199	1.00
122_K	134_Q	1.193	1.00
39_M	336_L	1.187	1.00
63_M	67_I	1.186	1.00
46_S	337_A	1.181	1.00
12_R	16_G	1.169	1.00
57_N	60_L	1.162	1.00
312_M	316_V	1.160	1.00
52_E	56_Q	1.159	1.00
79_Q	82_E	1.156	1.00
96_I	221_G	1.150	1.00
298_A	395_A	1.148	1.00
254_G	258_Q	1.147	1.00
80_L	84_A	1.146	1.00
339_Q	342_N	1.141	1.00
49_N	52_E	1.141	1.00
34_I	325_G	1.140	1.00
294_Q	390_T	1.132	1.00
234_S	237_Q	1.129	1.00
300_L	305_L	1.113	1.00
279_A	379_S	1.108	1.00
92_R	124_P	1.108	1.00
39_M	333_G	1.106	1.00
58_N	61_G	1.105	1.00
53_R	359_A	1.104	1.00
42_V	368_I	1.104	1.00
11_L	15_R	1.093	1.00
265_N	269_L	1.089	1.00
78_Q	81_P	1.083	1.00
64_P	68_L	1.075	1.00
338_S	342_N	1.073	1.00
37_G	271_L	1.067	1.00
27_S	321_A	1.065	1.00
129_L	188_G	1.061	1.00
39_M	329_G	1.055	1.00
385_W	388_A	1.050	1.00
63_M	66_A	1.048	1.00
87_L	235_L	1.045	1.00
139_P	142_Y	1.043	1.00
94_A	118_D	1.041	1.00
207_D	210_R	1.038	1.00
328_L	331_A	1.035	1.00
208_A	212_M	1.034	1.00
232_V	235_L	1.032	1.00
118_D	121_Q	1.031	1.00
363_L	366_I	1.025	1.00
57_N	61_G	1.024	1.00
232_V	238_Q	1.020	1.00
274_I	281_N	1.019	1.00
359_A	362_P	1.018	1.00
13_Y	16_G	1.018	1.00
340_L	344_M	1.013	1.00
52_E	264_K	1.007	1.00
49_N	364_Q	1.000	1.00
148_E	192_A	0.991	1.00
131_N	158_R	0.990	1.00
286_L	318_G	0.988	1.00
28_W	32_I	0.988	1.00
31_T	328_L	0.985	1.00
294_Q	298_A	0.983	1.00
13_Y	317_Q	0.982	1.00
149_Q	153_Q	0.981	1.00
322_G	372_A	0.979	1.00
330_A	365_V	0.974	1.00
311_M	381_L	0.967	1.00
222_W	226_L	0.966	1.00
319_A	377_L	0.963	1.00
35_T	38_V	0.962	1.00
293_K	314_F	0.960	1.00
85_V	93_V	0.956	1.00
53_R	56_Q	0.952	1.00
226_L	229_P	0.950	1.00
251_D	254_G	0.947	1.00
305_L	310_I	0.944	1.00
326_A	372_A	0.939	1.00
90_V	93_V	0.939	1.00
87_L	238_Q	0.935	1.00
139_P	143_N	0.933	1.00
318_G	322_G	0.928	1.00
226_L	232_V	0.927	1.00
283_I	287_G	0.927	1.00
49_N	53_R	0.926	1.00
390_T	394_E	0.923	1.00
227_D	231_K	0.916	1.00
261_R	265_N	0.909	1.00
386_R	390_T	0.906	1.00
155_G	160_D	0.905	1.00
46_S	50_G	0.904	1.00
90_V	224_L	0.903	1.00
384_S	387_A	0.901	1.00
279_A	375_I	0.897	1.00
136_D	187_I	0.896	1.00
307_P	389_A	0.893	1.00
372_A	376_A	0.892	1.00
258_Q	261_R	0.885	1.00
338_S	341_N	0.882	1.00
141_K	206_E	0.881	1.00
31_T	324_I	0.879	1.00
95_P	118_D	0.878	1.00
360_I	365_V	0.878	1.00
34_I	38_V	0.877	1.00
382_Y	385_W	0.876	1.00
76_N	79_Q	0.874	1.00
307_P	311_M	0.868	1.00
81_P	95_P	0.862	1.00
370_L	374_A	0.854	1.00
331_A	334_A	0.853	1.00
255_E	258_Q	0.851	1.00
129_L	190_F	0.851	1.00
390_T	395_A	0.850	1.00
64_P	67_I	0.850	1.00
236_S	248_D	0.847	1.00
56_Q	60_L	0.844	1.00
87_L	90_V	0.844	1.00
138_E	143_N	0.843	1.00
223_R	226_L	0.838	1.00
205_I	208_A	0.836	1.00
114_M	203_V	0.835	1.00
131_N	189_T	0.834	1.00
116_G	208_A	0.833	1.00
81_P	93_V	0.831	1.00
96_I	223_R	0.830	1.00
116_G	205_I	0.830	1.00
77_P	81_P	0.829	1.00
146_L	156_V	0.827	1.00
301_Q	310_I	0.827	1.00
367_V	370_L	0.825	1.00
239_K	243_G	0.822	1.00
38_V	372_A	0.820	1.00
374_A	378_L	0.820	1.00
289_M	317_Q	0.818	1.00
35_T	325_G	0.818	1.00
105_S	108_S	0.818	1.00
127_P	190_F	0.817	1.00
133_K	136_D	0.817	1.00
330_A	369_A	0.811	1.00
220_T	223_R	0.810	1.00
147_G	198_G	0.809	1.00
148_E	151_A	0.809	1.00
368_I	372_A	0.806	1.00
112_G	201_M	0.805	1.00
158_R	188_G	0.804	1.00
147_G	192_A	0.803	1.00
240_L	243_G	0.802	1.00
250_R	254_G	0.801	1.00
83_T	87_L	0.800	1.00
33_G	37_G	0.799	1.00
319_A	376_A	0.798	1.00
235_L	238_Q	0.796	1.00
54_E	58_N	0.794	1.00
334_A	360_I	0.794	1.00
272_S	276_A	0.793	1.00
117_I	122_K	0.792	1.00
301_Q	392_P	0.790	1.00
337_A	358_V	0.789	1.00
245_K	248_D	0.789	1.00
123_D	134_Q	0.787	1.00
290_V	297_V	0.786	1.00
141_K	204_N	0.786	1.00
337_A	341_N	0.782	1.00
114_M	201_M	0.781	1.00
260_V	264_K	0.780	1.00
33_G	281_N	0.777	1.00
164_V	184_F	0.776	1.00
367_V	371_V	0.772	1.00
291_M	294_Q	0.771	1.00
211_L	214_Y	0.770	1.00
338_S	358_V	0.768	1.00
199_Y	202_L	0.767	1.00
222_W	225_W	0.765	1.00
81_P	222_W	0.763	1.00
43_T	333_G	0.762	1.00
219_I	222_W	0.761	1.00
262_M	266_M	0.757	1.00
101_V	114_M	0.756	1.00
30_S	33_G	0.755	1.00
146_L	162_I	0.752	1.00
371_V	374_A	0.748	1.00
382_Y	386_R	0.747	1.00
127_P	130_V	0.746	1.00
315_M	377_L	0.746	1.00
97_T	208_A	0.743	1.00
162_I	184_F	0.742	1.00
371_V	375_I	0.742	1.00
147_G	200_E	0.742	1.00
318_G	376_A	0.742	1.00
253_K	257_F	0.740	1.00
364_Q	368_I	0.740	1.00
281_N	284_T	0.740	1.00
295_G	299_I	0.738	1.00
145_I	202_L	0.737	1.00
311_M	388_A	0.735	1.00
200_E	204_N	0.734	1.00
332_L	335_L	0.734	1.00
92_R	123_D	0.734	1.00
326_A	376_A	0.734	1.00
227_D	230_L	0.734	1.00
110_A	153_Q	0.733	1.00
41_L	45_L	0.732	1.00
190_F	202_L	0.730	1.00
318_G	383_P	0.730	1.00
65_Q	69_S	0.729	1.00
208_A	211_L	0.728	1.00
365_V	369_A	0.727	1.00
392_P	395_A	0.725	1.00
278_A	281_N	0.723	1.00
296_E	317_Q	0.723	1.00
271_L	275_V	0.723	1.00
257_F	261_R	0.723	1.00
283_I	379_S	0.720	1.00
89_G	235_L	0.720	1.00
142_Y	185_N	0.717	1.00
284_T	288_L	0.716	1.00
151_A	154_L	0.715	1.00
380_T	384_S	0.715	1.00
65_Q	68_L	0.714	1.00
364_Q	367_V	0.712	1.00
220_T	224_L	0.711	1.00
289_M	293_K	0.705	1.00
393_A	396_L	0.704	1.00
324_I	327_I	0.701	1.00
317_Q	320_S	0.699	1.00
55_L	59_I	0.699	1.00
13_Y	296_E	0.698	1.00
119_P	122_K	0.696	1.00
311_M	384_S	0.695	1.00
326_A	373_M	0.691	1.00
369_A	373_M	0.690	1.00
43_T	336_L	0.689	1.00
81_P	84_A	0.689	1.00
92_R	120_A	0.686	1.00
318_G	384_S	0.686	1.00
129_L	132_V	0.685	1.00
383_P	387_A	0.684	1.00
239_K	242_E	0.684	1.00
316_V	320_S	0.683	1.00
151_A	157_N	0.683	1.00
298_A	392_P	0.683	1.00
299_I	302_T	0.682	1.00
230_L	234_S	0.680	1.00
326_A	330_A	0.680	1.00
133_K	143_N	0.679	1.00
299_I	303_Q	0.676	1.00
70_S	73_G	0.675	1.00
33_G	284_T	0.672	1.00
30_S	285_S	0.672	1.00
197_D	200_E	0.671	1.00
112_G	150_L	0.668	1.00
290_V	314_F	0.664	1.00
25_F	29_L	0.661	1.00
93_V	224_L	0.655	1.00
118_D	122_K	0.655	1.00
240_L	244_S	0.651	1.00
322_G	380_T	0.650	1.00
30_S	34_I	0.648	1.00
131_N	157_N	0.648	1.00
130_V	189_T	0.643	1.00
316_V	319_A	0.642	1.00
52_E	55_L	0.642	1.00
254_G	257_F	0.641	1.00
258_Q	262_M	0.640	1.00
182_R	210_R	0.639	1.00
285_S	289_M	0.639	1.00
38_V	42_V	0.637	1.00
54_E	57_N	0.636	1.00
264_K	268_G	0.636	1.00
323_I	373_M	0.635	1.00
152_S	157_N	0.634	1.00
151_A	186_V	0.634	1.00
159_G	185_N	0.628	1.00
130_V	190_F	0.627	1.00
229_P	232_V	0.623	1.00
243_G	246_W	0.623	1.00
334_A	365_V	0.622	1.00
230_L	235_L	0.622	1.00
219_I	223_R	0.621	1.00
362_P	365_V	0.621	1.00
95_P	219_I	0.618	1.00
66_A	224_L	0.616	1.00
296_E	299_I	0.616	1.00
94_A	121_Q	0.615	1.00
226_L	231_K	0.615	1.00
96_I	99_G	0.614	1.00
93_V	96_I	0.614	1.00
94_A	124_P	0.613	1.00
199_Y	204_N	0.611	1.00
311_M	315_M	0.608	1.00
291_M	386_R	0.607	1.00
200_E	203_V	0.606	1.00
241_P	244_S	0.606	1.00
104_Q	107_R	0.606	1.00
383_P	388_A	0.606	1.00
120_A	124_P	0.606	1.00
85_V	92_R	0.602	1.00
148_E	189_T	0.602	1.00
226_L	230_L	0.602	1.00
313_V	316_V	0.601	1.00
334_A	338_S	0.601	1.00
277_V	281_N	0.600	1.00
286_L	380_T	0.598	1.00
247_Q	252_R	0.597	1.00
91_N	95_P	0.597	1.00
266_M	270_L	0.596	1.00
26_V	30_S	0.594	1.00
136_D	140_G	0.592	1.00
48_M	264_K	0.589	1.00
286_L	289_M	0.589	1.00
144_V	186_V	0.586	1.00
37_G	41_L	0.586	1.00
160_D	186_V	0.585	1.00
42_V	46_S	0.584	1.00
129_L	191_A	0.583	1.00
45_L	49_N	0.582	1.00
290_V	387_A	0.582	1.00
314_F	318_G	0.578	1.00
35_T	329_G	0.578	1.00
302_T	392_P	0.576	1.00
129_L	145_I	0.575	1.00
42_V	329_G	0.575	1.00
375_I	379_S	0.574	1.00
296_E	313_V	0.574	1.00
376_A	379_S	0.574	1.00
66_A	226_L	0.573	1.00
228_E	232_V	0.571	1.00
18_A	25_F	0.570	1.00
29_L	33_G	0.567	1.00
76_N	81_P	0.566	1.00
315_M	381_L	0.566	1.00
69_S	72_H	0.565	1.00
13_Y	293_K	0.565	1.00
115_L	202_L	0.563	1.00
39_M	43_T	0.563	1.00
37_G	40_A	0.563	1.00
151_A	158_R	0.561	1.00
94_A	97_T	0.560	1.00
45_L	48_M	0.559	1.00
184_F	203_V	0.558	1.00
327_I	330_A	0.557	1.00
55_L	58_N	0.556	1.00
359_A	363_L	0.555	1.00
252_R	255_E	0.555	1.00
97_T	209_S	0.554	1.00
46_S	333_G	0.552	1.00
17_R	26_V	0.552	1.00
99_G	103_L	0.552	1.00
67_I	221_G	0.551	1.00
330_A	334_A	0.550	1.00
65_Q	225_W	0.546	1.00
118_D	205_I	0.546	1.00
40_A	314_F	0.546	1.00
315_M	319_A	0.545	1.00
274_I	278_A	0.544	1.00
92_R	95_P	0.543	1.00
317_Q	321_A	0.539	1.00
69_S	73_G	0.538	1.00
71_E	74_S	0.538	1.00
294_Q	386_R	0.537	1.00
124_P	225_W	0.537	1.00
342_N	345_P	0.536	1.00
91_N	226_L	0.536	1.00
110_A	114_M	0.536	1.00
241_P	245_K	0.535	1.00
27_S	31_T	0.535	1.00
301_Q	395_A	0.533	1.00
141_K	207_D	0.532	1.00
139_P	187_I	0.532	1.00
314_F	317_Q	0.531	1.00
376_A	380_T	0.530	1.00
102_V	109_V	0.529	1.00
209_S	214_Y	0.528	1.00
156_V	162_I	0.525	1.00
159_G	162_I	0.522	1.00
99_G	102_V	0.520	1.00
33_G	288_L	0.519	1.00
37_G	281_N	0.519	1.00
104_Q	109_V	0.519	1.00
121_Q	124_P	0.518	1.00
360_I	364_Q	0.516	1.00
100_D	103_L	0.516	1.00
34_I	282_I	0.516	1.00
287_G	290_V	0.515	1.00
108_S	111_V	0.515	1.00
26_V	289_M	0.514	1.00
116_G	119_P	0.514	1.00
137_L	145_I	0.511	1.00
138_E	145_I	0.510	1.00
260_V	263_E	0.507	1.00
267_M	271_L	0.506	1.00
271_L	274_I	0.505	1.00
131_N	151_A	0.505	1.00
279_A	283_I	0.505	1.00
310_I	387_A	0.505	1.00
12_R	17_R	0.503	1.00
56_Q	59_I	0.503	1.00
366_I	369_A	0.503	1.00
251_D	255_E	0.502	1.00
323_I	326_A	0.502	1.00
326_A	329_G	0.502	1.00
138_E	187_I	0.502	1.00
286_L	290_V	0.501	1.00
94_A	117_I	0.500	1.00
186_V	189_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ftjA	1	0.4737	99.2	0.751	Contact Map
3is6A	2	0.5363	98.9	0.782	Contact Map
2l66A	2	0.1328	15.6	0.946	Contact Map
4av3A	2	0.2707	13.3	0.948	Contact Map
2kogA	1	0.1028	10.8	0.95	Contact Map
1rz2A	1	0.4361	10.5	0.95	Contact Map
2fhdA	5	0.3684	10.4	0.95	Contact Map
2mrnA	2	0.1679	10.1	0.95	Contact Map
1yfbA	2	0.1303	8.9	0.952	Contact Map
4pl0A	2	0.2456	7.9	0.953	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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