GREMLIN Database
LPTE - LPS-assembly lipoprotein LptE
UniProt: P0ADC1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10855
Length: 193 (156)
Sequences: 901 (652)
Seq/√Len: 52.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_K140_Q4.6211.00
85_D99_Q4.1711.00
36_M75_L3.5841.00
55_L60_V3.4601.00
102_M151_A3.3491.00
76_R107_T3.1031.00
136_K139_E3.0721.00
124_R147_M2.8821.00
108_V162_I2.5911.00
82_I148_Y2.4651.00
82_I144_V2.3841.00
39_D74_S2.2641.00
5_A8_L2.2341.00
118_I158_K2.2101.00
76_R109_L2.0981.00
104_V151_A2.0711.00
90_F93_G2.0681.00
78_G107_T2.0491.00
84_K98_Y1.9861.00
5_A12_A1.9320.99
122_V151_A1.9010.99
80_V148_Y1.8800.99
36_M62_L1.8750.99
103_T121_K1.8620.99
54_Q152_A1.6600.98
78_G105_N1.6590.98
102_M122_V1.6180.98
37_I71_D1.6010.98
120_A151_A1.5970.98
10_S13_V1.5580.98
47_L155_L1.5000.97
133_A158_K1.4850.97
9_L13_V1.4650.97
65_K70_K1.4580.96
105_N119_S1.4520.96
154_Q157_R1.4360.96
110_I113_R1.4240.96
145_K156_I1.3810.95
51_V77_L1.3590.95
87_A95_T1.3320.94
75_L159_L1.3150.94
17_A56_R1.3080.94
122_V147_M1.2920.93
150_R154_Q1.2680.92
50_A149_D1.2280.91
87_A129_N1.2210.91
10_S14_L1.2020.90
22_H143_I1.1970.90
86_T134_L1.1950.90
6_T9_L1.1910.90
126_F129_N1.1900.90
90_F154_Q1.1790.89
96_A139_E1.1690.89
36_M120_A1.1640.89
36_M112_G1.1610.89
24_R131_Q1.1410.88
12_A56_R1.1280.87
37_I155_L1.1220.87
140_Q144_V1.1200.87
86_T96_A1.0800.85
135_A138_N1.0780.85
159_L163_R1.0760.85
107_T117_P1.0680.84
128_D133_A1.0570.83
87_A99_Q1.0450.83
97_E128_D1.0430.83
98_Y137_D1.0260.82
110_I114_D1.0220.81
86_T98_Y0.9980.80
13_V17_A0.9950.80
80_V102_M0.9920.79
77_L104_V0.9860.79
86_T133_A0.9550.77
106_A118_I0.9460.76
5_A13_V0.9400.76
28_Q147_M0.9390.75
6_T14_L0.9300.75
118_I151_A0.9260.74
5_A9_L0.9210.74
33_M72_V0.9160.74
29_V73_P0.9140.73
40_S48_S0.9020.72
50_A73_P0.8930.72
108_V159_L0.8840.71
48_S77_L0.8820.71
96_A141_D0.8740.70
6_T13_V0.8720.70
10_S121_K0.8690.70
106_A155_L0.8680.70
152_A155_L0.8620.69
142_M146_E0.8610.69
101_I121_K0.8600.69
122_V155_L0.8570.69
61_E112_G0.8560.68
97_E157_R0.8540.68
25_D38_L0.8530.68
103_T119_S0.8470.68
7_L13_V0.8450.67
45_G80_V0.8420.67
82_I126_F0.8400.67
13_V16_T0.8360.67
58_N95_T0.8310.66
127_F146_E0.8290.66
128_D136_K0.8270.66
88_S97_E0.8250.66
21_W134_L0.8230.65
38_L48_S0.8160.65
7_L15_I0.8160.65
37_I64_D0.8140.65
133_A140_Q0.8090.64
56_R152_A0.8020.63
79_K105_N0.7910.62
40_S43_P0.7880.62
78_G117_P0.7880.62
5_A18_G0.7870.62
63_L70_K0.7800.61
35_V61_E0.7800.61
104_V125_S0.7760.61
50_A54_Q0.7740.61
36_M159_L0.7730.61
5_A16_T0.7710.60
83_A101_I0.7700.60
123_F143_I0.7700.60
102_M118_I0.7660.60
54_Q149_D0.7640.60
149_D153_E0.7570.59
17_A79_K0.7530.58
26_T145_K0.7510.58
121_K125_S0.7390.57
25_D161_S0.7340.57
40_S44_N0.7310.56
97_E126_F0.7240.56
83_A103_T0.7230.55
37_I74_S0.7230.55
128_D157_R0.7230.55
22_H39_D0.7200.55
20_G25_D0.7190.55
128_D137_D0.7140.54
14_L17_A0.7140.54
29_V58_N0.7140.54
120_A144_V0.7120.54
139_E142_M0.7120.54
105_N117_P0.7100.54
84_K95_T0.7070.54
12_A17_A0.7030.53
32_T110_I0.6970.53
156_I159_L0.6950.53
24_R158_K0.6920.52
9_L18_G0.6910.52
139_E146_E0.6890.52
29_V33_M0.6870.52
7_L12_A0.6860.52
104_V155_L0.6850.51
124_R146_E0.6850.51
48_S52_R0.6790.51
155_L161_S0.6780.51
93_G139_E0.6760.51
56_R62_L0.6750.50
54_Q156_I0.6740.50
93_G135_A0.6730.50
87_A136_K0.6690.50
96_A148_Y0.6670.50
47_L102_M0.6660.49
36_M60_V0.6610.49
130_P134_L0.6610.49
27_T30_P0.6600.49
123_F159_L0.6550.48
130_P137_D0.6450.47
60_V132_M0.6430.47
101_I106_A0.6390.47
24_R161_S0.6370.46
38_L164_A0.6360.46
23_L30_P0.6300.46
91_R115_I0.6280.45
16_T91_R0.6260.45
130_P136_K0.6240.45
80_V146_E0.6210.45
49_R86_T0.6180.44
130_P146_E0.6120.44
50_A143_I0.6100.44
63_L72_V0.6080.43
53_N57_L0.6010.43
95_T98_Y0.5960.42
51_V101_I0.5930.42
12_A18_G0.5910.42
65_K119_S0.5880.41
88_S94_Q0.5870.41
15_I58_N0.5870.41
54_Q153_E0.5830.41
35_V123_F0.5820.41
19_C23_L0.5810.41
86_T132_M0.5760.40
38_L104_V0.5740.40
47_L80_V0.5640.39
83_A123_F0.5630.39
18_G142_M0.5620.39
102_M148_Y0.5610.39
36_M41_G0.5610.39
83_A160_P0.5590.38
73_P108_V0.5590.38
38_L60_V0.5590.38
46_P50_A0.5570.38
114_D137_D0.5560.38
74_S114_D0.5510.38
74_S103_T0.5490.37
54_Q105_N0.5460.37
12_A145_K0.5450.37
130_P154_Q0.5440.37
65_K69_R0.5420.37
54_Q57_L0.5420.37
86_T102_M0.5320.36
134_L159_L0.5250.35
60_V130_P0.5250.35
85_D126_F0.5250.35
154_Q158_K0.5240.35
123_F141_D0.5240.35
45_G89_V0.5180.34
82_I101_I0.5170.34
90_F96_A0.5160.34
77_L147_M0.5160.34
40_S45_G0.5150.34
38_L92_N0.5140.34
121_K127_F0.5100.34
60_V69_R0.5090.34
91_R158_K0.5090.34
21_W148_Y0.5070.33
21_W143_I0.5060.33
113_R116_Y0.5050.33
75_L92_N0.5050.33
135_A154_Q0.5050.33
80_V85_D0.5030.33
59_G113_R0.5010.33
92_N134_L0.5010.33
105_N125_S0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n4rB 1 0.772 100 0.263 Contact Map
4nhrA 2 0.6995 100 0.271 Contact Map
2r76A 2 0.6839 100 0.301 Contact Map
2jxpA 1 0.7824 100 0.348 Contact Map
3bf2A 2 0.6269 100 0.352 Contact Map
4kwyA 1 0.7098 96.2 0.869 Contact Map
3j6da 3 0.5855 54.6 0.926 Contact Map
4av2M 1 0.3886 37.2 0.933 Contact Map
2cc6A 5 0.3316 28.1 0.937 Contact Map
2ux9A 5 0.3523 25.8 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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