GREMLIN Database
OSMB - Osmotically-inducible lipoprotein B
UniProt: P0ADA7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10679
Length: 72 (67)
Sequences: 149 (95)
Seq/√Len: 11.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_T57_L3.1690.97
31_D66_I2.9770.95
36_I40_A2.3730.85
26_N69_Q2.2690.82
20_S23_A1.7730.64
13_L54_L1.6820.60
16_T36_I1.6310.57
27_W35_A1.5780.55
50_D54_L1.5760.54
10_A23_A1.5760.54
13_L44_G1.5320.52
39_G42_A1.5260.52
25_S30_R1.4860.50
30_R71_G1.4660.49
9_T62_V1.4590.49
30_R69_Q1.4530.48
28_S31_D1.4240.47
40_A70_V1.3680.44
54_L66_I1.3410.43
31_D69_Q1.3230.42
6_K57_L1.2880.40
32_R54_L1.2650.39
12_V16_T1.2570.39
14_A17_L1.2540.39
34_T69_Q1.2490.38
15_I65_V1.1810.35
50_D62_V1.1730.35
43_L46_A1.1690.35
52_S68_H1.1550.34
18_A29_K1.0880.31
26_N29_K1.0840.31
53_T71_G1.0700.30
33_N40_A1.0370.29
50_D65_V1.0340.29
14_A31_D1.0170.28
15_I62_V1.0150.28
49_T53_T1.0120.28
31_D70_V0.9530.26
62_V65_V0.9510.26
29_K32_R0.9450.26
19_M25_S0.9430.25
39_G44_G0.9350.25
32_R57_L0.9350.25
7_K10_A0.9250.25
33_N71_G0.8970.24
23_A61_A0.8880.23
11_A29_K0.8720.23
32_R70_V0.8540.22
8_M17_L0.8450.22
17_L46_A0.8430.22
52_S65_V0.8390.22
9_T13_L0.8390.22
11_A14_A0.8380.22
46_A56_T0.8340.22
7_K19_M0.8310.21
32_R71_G0.8310.21
5_S50_D0.8270.21
5_S31_D0.8240.21
17_L69_Q0.8240.21
21_L30_R0.8230.21
14_A25_S0.8190.21
6_K32_R0.8070.21
25_S31_D0.8010.20
21_L26_N0.7920.20
12_V53_T0.7800.20
7_K12_V0.7790.20
20_S30_R0.7480.19
17_L22_S0.7320.18
23_A39_G0.7230.18
11_A40_A0.7180.18
12_V19_M0.7110.18
18_A22_S0.6990.17
30_R54_L0.6830.17
30_R68_H0.6620.16
26_N30_R0.6590.16
9_T36_I0.6580.16
47_V53_T0.6530.16
27_W36_I0.6460.16
18_A61_A0.6380.16
10_A32_R0.6360.16
27_W49_T0.6330.16
7_K23_A0.6170.15
8_M15_I0.6150.15
30_R56_T0.6010.15
14_A70_V0.5990.15
20_S28_S0.5980.15
10_A29_K0.5970.15
20_S71_G0.5970.15
13_L65_V0.5700.14
33_N65_V0.5660.14
35_A49_T0.5550.14
32_R50_D0.5500.14
13_L32_R0.5440.13
53_T66_I0.5290.13
19_M22_S0.5230.13
43_L70_V0.5160.13
22_S65_V0.5150.13
11_A32_R0.5080.13
9_T16_T0.5000.12
46_A71_G0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yv7A 1 0.3611 29.4 0.89 Contact Map
2j69A 1 0.875 27 0.893 Contact Map
4kysA 1 0.3056 24.7 0.894 Contact Map
3ombA 1 0.4167 23.8 0.895 Contact Map
4lmhA 3 0.4167 20.7 0.898 Contact Map
3vxbA 1 0.2917 20.6 0.898 Contact Map
3ldtA 2 0.1389 20.3 0.898 Contact Map
4lm8A 1 0.0556 19.3 0.9 Contact Map
4r9fA 1 0.3472 17.4 0.901 Contact Map
3pmqA 1 0.125 16.1 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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