GREMLIN Database
TESA - Acyl-CoA thioesterase I
UniProt: P0ADA1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11542
Length: 208 (178)
Sequences: 11246 (8496)
Seq/√Len: 636.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_Q162_L3.7601.00
115_R158_F3.3381.00
119_Q158_F3.2341.00
111_E153_K3.1581.00
115_R157_E2.8911.00
73_S113_T2.8091.00
76_G96_L2.7911.00
92_V121_V2.6721.00
71_D79_R2.5211.00
81_P120_D2.4461.00
32_I38_S2.4381.00
30_L93_L2.2751.00
133_I148_S2.0011.00
155_A162_L1.9921.00
115_R119_Q1.9471.00
92_V126_A1.8641.00
111_E150_I1.8371.00
29_T62_S1.8271.00
164_P167_M1.8041.00
122_K158_F1.7751.00
39_A69_S1.7621.00
77_L116_Q1.7591.00
127_E161_P1.7331.00
56_K197_A1.7301.00
52_L190_P1.6931.00
130_L155_A1.6921.00
131_M196_M1.6881.00
32_I93_L1.6661.00
190_P194_D1.6181.00
71_D75_Q1.6071.00
195_W198_K1.5841.00
44_S186_R1.5791.00
37_L184_P1.5691.00
191_F194_D1.5641.00
41_Y69_S1.5281.00
33_L76_G1.4961.00
106_Q109_Q1.4791.00
184_P192_I1.4751.00
132_Q164_P1.4611.00
150_I153_K1.4611.00
73_S110_T1.4611.00
152_P162_L1.4601.00
154_L158_F1.4301.00
163_L199_Q1.4201.00
118_L160_V1.4131.00
47_A186_R1.4111.00
77_L113_T1.4111.00
120_D124_A1.3831.00
132_Q152_P1.3781.00
110_T147_F1.3701.00
165_F192_I1.3691.00
37_L98_G1.3111.00
118_L130_L1.3111.00
73_S114_L1.3091.00
38_S67_S1.3051.00
187_D190_P1.3011.00
149_A153_K1.2981.00
56_K194_D1.2931.00
111_E115_R1.2571.00
80_L121_V1.2551.00
31_L89_P1.2331.00
43_M186_R1.2311.00
32_I50_P1.2281.00
141_R145_E1.2111.00
116_Q120_D1.2101.00
144_N148_S1.1931.00
29_T90_R1.1851.00
115_R154_L1.1801.00
73_S117_I1.1701.00
91_W129_L1.1691.00
79_R83_L1.1601.00
121_V126_A1.1451.00
28_D90_R1.1071.00
114_L151_Y1.1071.00
152_P156_K1.1051.00
118_L158_F1.0991.00
95_E134_R1.0591.00
77_L120_D1.0531.00
118_L154_L1.0511.00
193_A197_A1.0491.00
48_A51_A1.0451.00
102_L182_I1.0321.00
89_P126_A1.0271.00
168_E195_W1.0251.00
134_R184_P1.0241.00
38_S95_E1.0221.00
85_K124_A1.0001.00
52_L193_A0.9971.00
129_L163_L0.9941.00
105_F109_Q0.9931.00
147_F151_Y0.9851.00
107_P146_A0.9831.00
109_Q112_Q0.9831.00
28_D61_T0.9801.00
94_V117_I0.9771.00
170_V173_K0.9621.00
73_S96_L0.9621.00
189_Q192_I0.9621.00
98_G182_I0.9611.00
74_Q78_A0.9541.00
110_T151_Y0.9521.00
54_N58_Q0.9471.00
119_Q123_A0.9451.00
93_L129_L0.9421.00
143_Y146_A0.9351.00
53_L197_A0.9331.00
100_D113_T0.9281.00
81_P85_K0.9271.00
49_W189_Q0.9261.00
91_W127_E0.9231.00
130_L151_Y0.9221.00
120_D123_A0.9121.00
29_T64_V0.9111.00
93_L131_M0.9081.00
110_T150_I0.9071.00
98_G136_P0.9041.00
191_F195_W0.9031.00
197_A201_Q0.8941.00
75_Q78_A0.8901.00
31_L66_A0.8891.00
142_R146_A0.8881.00
113_T117_I0.8831.00
80_L117_I0.8801.00
114_L118_L0.8801.00
149_A152_P0.8771.00
74_Q109_Q0.8751.00
51_A54_N0.8651.00
153_K157_E0.8531.00
68_I71_D0.8481.00
118_L128_P0.8471.00
111_E157_E0.8441.00
72_T75_Q0.8381.00
109_Q113_T0.8371.00
145_E149_A0.8321.00
112_Q115_R0.8291.00
169_E173_K0.8251.00
110_T114_L0.8211.00
114_L130_L0.8211.00
74_Q113_T0.8201.00
121_V128_P0.8141.00
119_Q122_K0.8061.00
37_L134_R0.8001.00
35_D97_G0.7991.00
95_E131_M0.7931.00
50_P54_N0.7921.00
32_I53_L0.7901.00
73_S77_L0.7891.00
30_L63_V0.7881.00
169_E174_P0.7871.00
152_P164_P0.7821.00
56_K193_A0.7751.00
112_Q116_Q0.7741.00
107_P150_I0.7731.00
108_Q150_I0.7631.00
66_A83_L0.7611.00
107_P111_E0.7561.00
108_Q112_Q0.7531.00
148_S151_Y0.7521.00
82_A85_K0.7521.00
166_F170_V0.7461.00
177_M191_F0.7441.00
154_L157_E0.7401.00
111_E154_L0.7371.00
154_L160_V0.7371.00
52_L56_K0.7361.00
101_G136_P0.7341.00
155_A160_V0.7341.00
116_Q119_Q0.7311.00
130_L154_L0.7301.00
113_T116_Q0.7301.00
93_L196_M0.7281.00
195_W199_Q0.7261.00
99_N183_H0.7221.00
169_E172_L0.7201.00
68_I79_R0.7131.00
76_G117_I0.7081.00
95_E98_G0.6961.00
146_A149_A0.6891.00
98_G133_I0.6831.00
53_L193_A0.6831.00
118_L122_K0.6811.00
146_A150_I0.6761.00
141_R144_N0.6721.00
30_L91_W0.6671.00
131_M192_I0.6661.00
38_S49_W0.6641.00
158_F161_P0.6591.00
44_S47_A0.6581.00
43_M48_A0.6571.00
162_L165_F0.6551.00
60_K201_Q0.6551.00
36_S183_H0.6431.00
31_L83_L0.6391.00
98_G134_R0.6391.00
49_W196_M0.6381.00
33_L83_L0.6381.00
101_G110_T0.6301.00
33_L66_A0.6281.00
52_L189_Q0.6271.00
56_K190_P0.6271.00
43_M189_Q0.6261.00
105_F110_T0.6241.00
177_M181_G0.6231.00
54_N63_V0.6221.00
142_R145_E0.6141.00
37_L182_I0.6091.00
125_N128_P0.6091.00
39_A67_S0.6061.00
151_Y154_L0.6061.00
38_S93_L0.6051.00
61_T91_W0.6051.00
101_G143_Y0.6031.00
36_S99_N0.5991.00
148_S152_P0.5981.00
77_L81_P0.5941.00
128_P160_V0.5921.00
129_L199_Q0.5921.00
108_Q111_E0.5881.00
114_L154_L0.5851.00
162_L167_M0.5791.00
84_L89_P0.5781.00
47_A52_L0.5741.00
67_S79_R0.5721.00
94_V121_V0.5701.00
129_L161_P0.5691.00
77_L117_I0.5691.00
168_E171_Y0.5681.00
25_A28_D0.5661.00
24_A28_D0.5651.00
37_L95_E0.5641.00
32_I63_V0.5601.00
178_Q181_G0.5521.00
145_E166_F0.5521.00
65_N68_I0.5511.00
33_L80_L0.5471.00
175_Q187_D0.5471.00
56_K60_K0.5461.00
52_L55_D0.5390.99
184_P189_Q0.5370.99
163_L196_M0.5360.99
35_D95_E0.5350.99
66_A87_H0.5330.99
31_L64_V0.5300.99
92_V128_P0.5270.99
196_M199_Q0.5250.99
180_D183_H0.5250.99
94_V128_P0.5230.99
32_I49_W0.5220.99
132_Q151_Y0.5220.99
77_L112_Q0.5220.99
33_L96_L0.5200.99
187_D191_F0.5170.99
176_W179_D0.5160.99
170_V174_P0.5150.99
161_P199_Q0.5130.99
108_Q146_A0.5130.99
144_N147_F0.5120.99
69_S102_L0.5120.99
32_I67_S0.5110.99
136_P182_I0.5090.99
40_G189_Q0.5060.99
72_T103_R0.5060.99
83_L86_Q0.5040.99
163_L195_W0.5030.99
168_E191_F0.5020.99
134_R148_S0.5000.99
153_K156_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jggA 1 0.851 100 0.294 Contact Map
1ivnA 2 0.8606 100 0.296 Contact Map
3hp4A 1 0.8606 100 0.31 Contact Map
4q9aA 2 0.8894 100 0.313 Contact Map
2o14A 1 1 100 0.322 Contact Map
4jhlA 5 0.899 100 0.322 Contact Map
3milA 2 0.8846 100 0.323 Contact Map
4rw0A 1 0.8462 100 0.324 Contact Map
4tx1A 5 0.8413 100 0.328 Contact Map
3rjtA 2 0.875 100 0.328 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0083 seconds.