GREMLIN Database
BRNQ - Branched-chain amino acid transport system 2 carrier protein
UniProt: P0AD99 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12168
Length: 439 (425)
Sequences: 1604 (1191)
Seq/√Len: 57.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_V299_T5.4071.00
377_I419_M4.9001.00
378_S416_T4.3471.00
127_L326_M4.2501.00
134_I319_F4.1931.00
374_P420_V3.9461.00
188_N192_N3.9331.00
226_R230_W3.8221.00
133_V295_A3.7541.00
419_M423_A3.6431.00
324_F328_V3.5851.00
39_E177_A3.3591.00
201_G205_F3.1741.00
59_T202_A2.8891.00
57_V236_G2.8661.00
165_A169_W2.8591.00
9_D216_R2.7231.00
262_N334_S2.6561.00
233_L237_V2.5651.00
303_A317_L2.5141.00
41_V247_F2.4961.00
81_A375_M2.4681.00
19_A147_V2.4221.00
154_L289_I2.4161.00
299_T318_V2.3851.00
14_G234_M2.3821.00
103_A126_S2.3571.00
353_A378_S2.3341.00
126_S330_N2.2751.00
98_A200_L2.2641.00
85_L351_C2.2531.00
313_S316_T2.2421.00
59_T355_V2.2411.00
353_A416_T2.1981.00
373_P377_I2.1951.00
123_F127_L2.1641.00
164_V168_V2.1621.00
136_V296_V2.1201.00
134_I138_L2.1111.00
107_F121_P2.0171.00
299_T322_G1.9901.00
312_L316_T1.9701.00
133_V322_G1.9671.00
220_E223_L1.9371.00
52_A56_P1.9301.00
88_V347_I1.9291.00
15_F152_A1.9131.00
22_V27_I1.9101.00
132_I292_L1.8721.00
136_V144_L1.8681.00
213_A224_L1.8411.00
77_I81_A1.8220.99
134_I318_V1.8000.99
414_M418_V1.7860.99
331_L335_Q1.7760.99
103_A131_A1.7630.99
61_V229_V1.7520.99
335_Q338_Q1.7520.99
261_A265_A1.7510.99
102_T295_A1.7490.99
160_V164_V1.7450.99
45_A247_F1.7400.99
37_A44_A1.7250.99
368_S372_A1.7190.99
136_V292_L1.7030.99
103_A130_F1.7000.99
128_V132_I1.6690.99
222_R226_R1.6670.99
199_T355_V1.6250.99
83_V87_T1.6040.99
373_P423_A1.6040.99
97_F343_V1.6040.99
416_T419_M1.5890.99
163_S245_A1.5860.99
155_K286_L1.5850.98
156_I242_L1.5800.98
170_P252_D1.5670.98
292_L296_V1.5570.98
248_R252_D1.5480.98
312_L317_L1.5360.98
377_I423_A1.5290.98
6_R9_D1.5190.98
302_C321_L1.5180.98
158_A286_L1.5150.98
134_I322_G1.5060.98
104_T122_L1.5060.98
59_T199_T1.5060.98
377_I380_L1.5020.98
135_L146_T1.4960.98
137_S300_C1.4870.98
120_L124_I1.4790.98
174_I251_S1.4760.98
350_P379_L1.4730.98
45_A244_L1.4720.98
203_M351_C1.4660.97
113_P116_G1.4640.97
180_A188_N1.4550.97
103_A133_V1.4530.97
13_L213_A1.4480.97
346_A383_I1.4460.97
307_A313_S1.4450.97
31_P246_L1.4440.97
327_V331_L1.4230.97
31_P266_I1.4170.97
155_K293_V1.4100.97
17_T60_V1.4020.97
303_A318_V1.4010.97
376_F379_L1.3980.97
43_T46_F1.3960.97
341_V345_T1.3910.97
264_A333_L1.3890.97
385_D411_A1.3870.96
97_F337_I1.3690.96
125_Y288_F1.3670.96
238_G242_L1.3650.96
424_I428_R1.3650.96
282_L286_L1.3650.96
76_P361_R1.3630.96
93_V98_A1.3610.96
122_L126_S1.3570.96
46_F186_F1.3520.96
350_P375_M1.3460.96
91_L96_L1.3380.96
166_A249_L1.3250.95
186_F190_F1.3240.95
357_L370_V1.3170.95
260_S266_I1.2990.95
378_S382_G1.2970.95
405_L408_Q1.2920.95
373_P419_M1.2800.94
364_W370_V1.2790.94
414_M421_V1.2760.94
131_A135_L1.2760.94
124_I128_V1.2750.94
299_T321_L1.2720.94
92_A97_F1.2710.94
372_A376_F1.2710.94
157_I161_I1.2700.94
73_L358_S1.2570.94
82_G162_L1.2540.94
373_P426_W1.2520.94
70_V86_A1.2520.94
361_R371_I1.2440.94
165_A275_F1.2370.93
98_A306_F1.2360.93
99_T325_S1.2300.93
49_L240_T1.2250.93
369_R373_P1.2210.93
361_R366_N1.2200.93
20_L147_V1.2190.93
20_L336_L1.2180.93
20_L98_A1.2180.93
266_I270_Y1.2070.93
122_L330_N1.2030.92
170_P253_S1.2010.92
80_V84_L1.1980.92
317_L321_L1.1920.92
19_A293_V1.1740.91
49_L53_V1.1690.91
81_A350_P1.1680.91
353_A375_M1.1620.91
54_G95_P1.1560.91
32_M36_Q1.1480.91
15_F19_A1.1480.91
195_L336_L1.1450.90
346_A386_G1.1360.90
75_T82_G1.1260.90
310_V317_L1.1240.90
123_F326_M1.1230.90
326_M329_S1.1080.89
126_S329_S1.1070.89
373_P422_L1.1060.89
289_I293_V1.0980.88
47_G186_F1.0950.88
417_V430_A1.0910.88
319_F323_G1.0840.88
235_A239_L1.0780.88
63_L206_G1.0760.87
16_M20_L1.0700.87
187_S410_L1.0690.87
222_R418_V1.0640.87
426_W429_A1.0620.87
377_I381_F1.0610.87
49_L159_L1.0570.86
20_L105_V1.0520.86
41_V251_S1.0480.86
152_A155_K1.0450.86
91_L306_F1.0400.86
367_S427_D1.0290.85
51_T56_P1.0270.85
53_V240_T1.0210.85
195_L382_G1.0170.84
31_P267_L1.0120.84
40_H43_T1.0090.84
373_P420_V1.0080.84
55_L352_I1.0030.83
425_I429_A1.0020.83
106_S288_F1.0020.83
303_A339_I1.0010.83
96_L339_I0.9970.83
98_A205_F0.9960.83
385_D388_K0.9940.83
58_L356_V0.9920.83
62_A358_S0.9910.83
123_F330_N0.9830.82
346_A350_P0.9800.82
115_T121_P0.9800.82
19_A155_K0.9780.82
63_L210_V0.9780.82
307_A312_L0.9780.82
20_L205_F0.9770.82
139_Y146_T0.9730.82
109_V206_G0.9710.81
12_A19_A0.9650.81
10_I230_W0.9630.81
298_L340_S0.9610.81
377_I416_T0.9540.80
10_I238_G0.9520.80
92_A347_I0.9510.80
353_A374_P0.9470.80
107_F125_Y0.9390.79
62_A66_V0.9380.79
381_F403_L0.9370.79
211_N214_R0.9340.79
21_F60_V0.9320.79
89_C200_L0.9280.78
22_V156_I0.9270.78
162_L286_L0.9260.78
20_L337_I0.9260.78
86_A305_F0.9250.78
106_S125_Y0.9240.78
205_F209_I0.9230.78
63_L67_G0.9220.78
17_T22_V0.9220.78
263_G333_L0.9200.78
85_L89_C0.9170.78
380_L422_L0.9160.77
272_Q280_S0.9160.77
174_I252_D0.9100.77
239_L293_V0.9100.77
386_G390_S0.9080.77
79_K190_F0.9080.77
155_K239_L0.9060.77
12_A16_M0.9060.77
50_I186_F0.9040.77
63_L73_L0.9020.76
167_I248_R0.9010.76
27_I286_L0.9010.76
200_L347_I0.8970.76
132_I288_F0.8960.76
95_P344_L0.8960.76
394_D398_S0.8930.76
155_K290_A0.8870.75
145_D216_R0.8860.75
8_R12_A0.8850.75
401_Q417_V0.8850.75
261_A334_S0.8810.75
158_A285_A0.8810.75
382_G386_G0.8800.75
144_L212_A0.8790.74
16_M263_G0.8790.74
109_V287_I0.8790.74
102_T106_S0.8780.74
99_T295_A0.8740.74
80_V296_V0.8730.74
169_W274_T0.8730.74
224_L228_T0.8720.74
42_W46_F0.8680.74
93_V201_G0.8650.73
175_S254_A0.8640.73
71_D308_Q0.8640.73
58_L359_F0.8600.73
152_A293_V0.8580.73
44_A192_N0.8550.72
97_F340_S0.8530.72
57_V264_A0.8520.72
125_Y287_I0.8510.72
89_C347_I0.8500.72
61_V225_T0.8470.72
111_I114_L0.8440.71
151_L294_T0.8410.71
232_G266_I0.8410.71
234_M352_I0.8400.71
157_I421_V0.8390.71
77_I375_M0.8390.71
96_L328_V0.8360.71
385_D389_A0.8320.70
144_L293_V0.8290.70
204_V239_L0.8290.70
168_V171_A0.8280.70
81_A85_L0.8270.70
76_P358_S0.8270.70
116_G350_P0.8260.70
323_G327_V0.8220.69
411_A421_V0.8210.69
155_K305_F0.8190.69
102_T321_L0.8160.69
395_I398_S0.8150.69
224_L231_A0.8140.69
386_G389_A0.8130.69
9_D14_G0.8120.68
75_T79_K0.8080.68
52_A203_M0.8080.68
21_F202_A0.8060.68
162_L271_V0.8030.68
95_P298_L0.8030.68
235_A289_I0.8010.67
142_K145_D0.8000.67
124_I421_V0.8000.67
142_K146_T0.7910.66
68_G72_S0.7880.66
144_L155_K0.7870.66
55_L110_G0.7870.66
167_I245_A0.7820.66
181_Y333_L0.7820.66
369_R426_W0.7820.66
20_L60_V0.7800.65
90_Y204_V0.7800.65
385_D406_A0.7790.65
10_I234_M0.7760.65
143_L242_L0.7760.65
102_T325_S0.7750.65
87_T309_Y0.7750.65
331_L336_L0.7720.65
69_G206_G0.7710.64
345_T389_A0.7680.64
132_I135_L0.7680.64
287_I308_Q0.7630.64
204_V301_A0.7620.64
69_G308_Q0.7590.63
46_F50_I0.7580.63
174_I248_R0.7570.63
74_S354_L0.7570.63
262_N265_A0.7550.63
402_R418_V0.7540.63
35_L253_S0.7520.63
397_P401_Q0.7520.63
183_N187_S0.7500.62
120_L164_V0.7500.62
95_P99_T0.7490.62
70_V89_C0.7470.62
293_V305_F0.7470.62
19_A195_L0.7470.62
19_A239_L0.7470.62
18_F22_V0.7450.62
19_A236_G0.7450.62
109_V268_H0.7450.62
271_V275_F0.7450.62
239_L305_F0.7450.62
369_R372_A0.7450.62
121_P124_I0.7450.62
218_V223_L0.7390.61
20_L97_F0.7370.61
140_P304_E0.7330.61
139_Y315_R0.7310.60
95_P340_S0.7290.60
16_M19_A0.7290.60
274_T371_I0.7290.60
97_F336_L0.7290.60
26_N29_F0.7260.60
125_Y163_S0.7260.60
87_T306_F0.7250.60
323_G421_V0.7250.60
119_A123_F0.7230.59
105_V328_V0.7210.59
104_T245_A0.7200.59
237_V240_T0.7200.59
186_F192_N0.7190.59
108_E112_A0.7180.59
340_S346_A0.7170.59
22_V238_G0.7170.59
305_F309_Y0.7160.59
65_K208_V0.7150.59
287_I340_S0.7150.59
387_I392_F0.7090.58
129_Y286_L0.7080.58
357_L371_I0.7080.58
25_G29_F0.7060.58
61_V232_G0.7050.58
147_V347_I0.7030.57
182_Q185_A0.7030.57
207_I302_C0.7020.57
374_P423_A0.7010.57
64_A197_M0.6980.57
256_L273_H0.6980.57
173_S418_V0.6960.57
369_R417_V0.6940.56
96_L343_V0.6940.56
94_G98_A0.6930.56
106_S280_S0.6910.56
31_P208_V0.6890.56
248_R251_S0.6890.56
253_S270_Y0.6890.56
323_G326_M0.6890.56
379_L383_I0.6870.56
144_L147_V0.6850.55
369_R387_I0.6840.55
345_T386_G0.6830.55
155_K289_I0.6820.55
227_Y336_L0.6810.55
80_V83_V0.6790.55
124_I356_V0.6770.55
102_T245_A0.6760.54
353_A356_V0.6750.54
137_S201_G0.6750.54
105_V122_L0.6730.54
107_F156_I0.6730.54
175_S323_G0.6730.54
181_Y263_G0.6720.54
171_A252_D0.6710.54
14_G238_G0.6700.54
89_C236_G0.6660.53
405_L410_L0.6650.53
129_Y371_I0.6640.53
41_V45_A0.6630.53
302_C306_F0.6630.53
6_R46_F0.6630.53
205_F298_L0.6620.53
222_R380_L0.6620.53
181_Y185_A0.6610.53
264_A406_A0.6600.53
33_V104_T0.6550.52
69_G72_S0.6550.52
90_Y185_A0.6540.52
395_I399_W0.6500.52
90_Y297_G0.6490.51
361_R364_W0.6480.51
21_F26_N0.6480.51
27_I324_F0.6470.51
49_L55_L0.6460.51
64_A232_G0.6460.51
102_T130_F0.6450.51
93_V303_A0.6440.51
184_A326_M0.6440.51
261_A296_V0.6420.51
313_S320_I0.6390.50
98_A102_T0.6380.50
98_A298_L0.6380.50
286_L336_L0.6370.50
199_T345_T0.6350.50
398_S401_Q0.6340.50
124_I418_V0.6340.50
90_Y263_G0.6330.50
170_P217_G0.6320.50
108_E262_N0.6310.49
261_A266_I0.6300.49
243_Y291_C0.6270.49
171_A273_H0.6270.49
269_A272_Q0.6260.49
19_A51_T0.6260.49
406_A411_A0.6260.49
369_R418_V0.6250.49
67_G72_S0.6250.49
133_V292_L0.6240.49
320_I383_I0.6220.48
393_S413_L0.6210.48
320_I373_P0.6200.48
312_L320_I0.6200.48
391_A396_L0.6190.48
10_I227_Y0.6190.48
22_V270_Y0.6180.48
52_A236_G0.6170.48
163_S214_R0.6140.48
417_V420_V0.6140.48
33_V247_F0.6140.48
70_V204_V0.6110.47
319_F426_W0.6110.47
357_L374_P0.6100.47
59_T238_G0.6100.47
152_A156_I0.6090.47
77_I270_Y0.6090.47
363_W421_V0.6080.47
310_V346_A0.6080.47
21_F231_A0.6050.47
260_S265_A0.6050.47
353_A406_A0.6050.47
23_G26_N0.6040.46
195_L410_L0.6010.46
99_T103_A0.6010.46
280_S284_A0.6010.46
222_R285_A0.6000.46
107_F123_F0.5960.46
124_I131_A0.5940.45
109_V247_F0.5940.45
110_G113_P0.5940.45
364_W420_V0.5940.45
131_A272_Q0.5930.45
403_L416_T0.5930.45
307_A317_L0.5920.45
37_A285_A0.5920.45
290_A296_V0.5910.45
90_Y301_A0.5910.45
111_I242_L0.5880.45
254_A257_V0.5860.45
384_L396_L0.5860.45
59_T201_G0.5850.44
167_I226_R0.5850.44
168_V398_S0.5850.44
376_F380_L0.5850.44
28_I264_A0.5840.44
175_S183_N0.5840.44
52_A271_V0.5830.44
192_N195_L0.5820.44
228_T234_M0.5790.44
360_T363_W0.5780.44
137_S318_V0.5770.44
12_A143_L0.5770.44
58_L355_V0.5770.44
154_L157_I0.5760.43
103_A295_A0.5760.43
213_A287_I0.5750.43
20_L201_G0.5740.43
192_N263_G0.5730.43
361_R367_S0.5720.43
187_S191_V0.5720.43
19_A283_L0.5720.43
373_P376_F0.5720.43
53_V239_L0.5710.43
223_L227_Y0.5710.43
13_L17_T0.5700.43
218_V245_A0.5690.43
67_G73_L0.5680.43
162_L337_I0.5680.43
362_S365_H0.5680.43
265_A269_A0.5670.42
72_S75_T0.5670.42
390_S393_S0.5670.42
84_L323_G0.5670.42
76_P371_I0.5650.42
96_L324_F0.5630.42
403_L411_A0.5630.42
22_V33_V0.5630.42
52_A206_G0.5620.42
52_A65_K0.5620.42
94_G298_L0.5610.42
15_F195_L0.5580.41
129_Y133_V0.5570.41
130_F235_A0.5570.41
219_T425_I0.5570.41
286_L289_I0.5560.41
8_R141_G0.5550.41
108_E209_I0.5540.41
140_P300_C0.5540.41
94_G205_F0.5530.41
218_V227_Y0.5530.41
213_A228_T0.5530.41
324_F327_V0.5520.41
22_V163_S0.5520.41
164_V393_S0.5520.41
219_T418_V0.5510.41
204_V351_C0.5500.41
48_F64_A0.5490.41
210_V232_G0.5480.40
179_E183_N0.5480.40
260_S270_Y0.5480.40
88_V143_L0.5480.40
103_A238_G0.5470.40
207_I333_L0.5460.40
88_V343_V0.5440.40
418_V422_L0.5440.40
138_L319_F0.5440.40
167_I372_A0.5430.40
281_F382_G0.5430.40
110_G284_A0.5420.40
52_A287_I0.5410.40
15_F159_L0.5400.40
36_Q40_H0.5400.40
93_V110_G0.5400.40
23_G30_P0.5390.39
212_A307_A0.5380.39
131_A134_I0.5380.39
89_C318_V0.5360.39
235_A406_A0.5360.39
88_V417_V0.5340.39
16_M90_Y0.5340.39
19_A31_P0.5340.39
98_A201_G0.5340.39
102_T340_S0.5320.39
319_F375_M0.5320.39
316_T380_L0.5310.39
53_V190_F0.5300.39
61_V64_A0.5290.38
79_K84_L0.5280.38
173_S176_T0.5270.38
85_L204_V0.5270.38
36_Q103_A0.5270.38
47_G56_P0.5260.38
422_L426_W0.5250.38
33_V192_N0.5250.38
358_S415_P0.5250.38
8_R75_T0.5240.38
14_G19_A0.5240.38
320_I407_E0.5230.38
169_W219_T0.5230.38
54_G347_I0.5230.38
320_I356_V0.5220.38
43_T185_A0.5210.38
333_L337_I0.5210.38
161_I278_G0.5190.37
346_A380_L0.5190.37
72_S346_A0.5190.37
90_Y207_I0.5190.37
103_A106_S0.5180.37
179_E414_M0.5180.37
256_L286_L0.5170.37
146_T150_F0.5170.37
10_I186_F0.5160.37
323_G424_I0.5160.37
268_H280_S0.5150.37
380_L418_V0.5150.37
43_T277_G0.5140.37
125_Y131_A0.5140.37
299_T334_S0.5130.37
328_V420_V0.5130.37
249_L270_Y0.5130.37
19_A144_L0.5130.37
114_L143_L0.5120.37
235_A290_A0.5120.37
85_L203_M0.5120.37
35_L254_A0.5120.37
237_V241_L0.5120.37
402_R429_A0.5110.37
83_V309_Y0.5110.37
138_L315_R0.5090.36
66_V151_L0.5090.36
129_Y295_A0.5090.36
272_Q277_G0.5080.36
144_L152_A0.5070.36
231_A387_I0.5070.36
85_L90_Y0.5060.36
398_S402_R0.5040.36
152_A305_F0.5040.36
22_V336_L0.5030.36
177_A182_Q0.5020.36
139_Y293_V0.5010.36
19_A301_A0.5010.36
257_V269_A0.5010.36
416_T423_A0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3giaA 1 0.9317 100 0.813 Contact Map
3l1lA 2 0.8815 99.2 0.908 Contact Map
3dh4A 3 0.877 98.9 0.921 Contact Map
2xq2A 2 0.8975 98.6 0.927 Contact Map
4djkA 2 0.877 98.4 0.932 Contact Map
2a65A 2 0.9476 97.3 0.947 Contact Map
4us3A 1 0.8952 96.8 0.951 Contact Map
2jlnA 1 0.9043 96.8 0.951 Contact Map
4wgvA 2 0.8041 96.2 0.954 Contact Map
4xp4A 1 0.9431 89.7 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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