GREMLIN Database
LIVJ - Leu/Ile/Val-binding protein
UniProt: P0AD96 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10539
Length: 367 (342)
Sequences: 16341 (11783)
Seq/√Len: 637.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_D68_Q3.7501.00
54_A291_K3.5541.00
27_K68_Q3.4261.00
182_Q195_F3.3911.00
72_Y87_K3.0761.00
95_Y310_L3.0231.00
46_F50_E3.0081.00
163_R191_N2.9201.00
283_P287_A2.7661.00
286_D290_A2.7531.00
312_A315_N2.7121.00
56_I311_Q2.6831.00
25_D65_N2.6811.00
185_L190_A2.6381.00
75_A80_Q2.5841.00
289_K295_P2.5821.00
312_A316_Q2.5541.00
116_G136_L2.5511.00
55_D287_A2.5481.00
54_A58_A2.4821.00
81_A104_S2.4651.00
196_D211_R2.3651.00
319_D322_E2.3431.00
333_D338_P2.3151.00
76_C101_C2.3001.00
331_S338_P2.2151.00
25_D66_K2.1731.00
29_A88_V2.1171.00
184_G187_K2.0431.00
182_Q186_K2.0321.00
326_Y329_A1.9421.00
168_H197_G1.9411.00
311_Q315_N1.9401.00
72_Y84_V1.9061.00
165_A194_F1.9051.00
55_D304_Y1.9001.00
24_E65_N1.8941.00
96_V112_Y1.8681.00
53_V69_I1.8621.00
53_V307_L1.8611.00
31_V84_V1.8501.00
50_E54_A1.8421.00
31_V74_D1.8361.00
282_K286_D1.8151.00
287_A290_A1.8151.00
331_S340_T1.7861.00
12_C15_L1.7821.00
116_G321_A1.7251.00
321_A325_K1.7141.00
316_Q326_Y1.7111.00
153_K188_G1.7031.00
46_F71_K1.6901.00
162_Q218_D1.6851.00
55_D308_Q1.6371.00
307_L311_Q1.6331.00
153_K157_E1.6321.00
49_A307_L1.6251.00
157_E188_G1.6141.00
322_E325_K1.5841.00
55_D59_K1.5771.00
283_P286_D1.5681.00
324_A328_K1.5641.00
47_T50_E1.5601.00
47_T294_D1.5571.00
77_D80_Q1.5251.00
138_L328_K1.5231.00
325_K329_A1.5211.00
305_A334_T1.5161.00
255_S258_N1.5111.00
14_A17_F1.4981.00
47_T292_K1.4971.00
235_Q238_A1.4961.00
149_P184_G1.4781.00
27_K70_V1.4741.00
161_P219_F1.4731.00
183_D187_K1.4721.00
138_L324_A1.4681.00
118_L320_P1.4621.00
139_R346_D1.4541.00
85_A112_Y1.4391.00
89_V117_I1.4261.00
80_Q84_V1.4211.00
260_A264_A1.4111.00
170_K199_T1.3901.00
163_R218_D1.3731.00
148_G152_A1.3671.00
179_R183_D1.3631.00
279_P283_P1.3491.00
87_K91_D1.3431.00
209_V235_Q1.3371.00
72_Y88_V1.3361.00
198_I224_G1.3231.00
112_Y119_M1.3171.00
310_L314_L1.3171.00
30_V49_A1.3171.00
50_E71_K1.3121.00
67_L311_Q1.3071.00
33_A74_D1.3021.00
166_I178_A1.3021.00
161_P218_D1.3021.00
47_T288_I1.2911.00
99_H108_A1.2771.00
164_I219_F1.2751.00
72_Y91_D1.2721.00
165_A217_I1.2641.00
168_H178_A1.2641.00
236_A241_L1.2611.00
113_E135_Q1.2601.00
43_D47_T1.2571.00
163_R216_N1.2531.00
175_E197_G1.2391.00
102_S126_A1.2331.00
9_L12_C1.2311.00
155_I246_M1.2201.00
110_D114_D1.2151.00
51_Q55_D1.2111.00
247_G251_V1.2091.00
280_A333_D1.2081.00
209_V236_A1.2081.00
165_A196_D1.2051.00
136_L324_A1.1991.00
286_D289_K1.1991.00
48_G303_T1.1931.00
56_I308_Q1.1881.00
277_Q282_K1.1821.00
164_I185_L1.1721.00
105_T124_A1.1521.00
201_G228_E1.1511.00
63_K315_N1.1461.00
284_I300_V1.1461.00
186_K191_N1.1311.00
154_Y268_L1.1311.00
170_K175_E1.1251.00
48_G300_V1.1161.00
80_Q83_A1.1161.00
49_A69_I1.1101.00
178_A182_Q1.1101.00
99_H105_T1.1101.00
70_V91_D1.1081.00
90_N115_E1.1081.00
209_V239_A1.1061.00
74_D104_S1.1011.00
125_T144_D1.1011.00
49_A303_T1.1001.00
202_E208_L1.0981.00
52_A311_Q1.0981.00
56_I307_L1.0971.00
165_A212_L1.0941.00
89_V111_I1.0901.00
328_K345_G1.0881.00
105_T119_M1.0801.00
180_A183_D1.0801.00
18_S21_A1.0761.00
85_A96_V1.0751.00
322_E326_Y1.0751.00
309_S327_L1.0741.00
34_M71_K1.0701.00
185_L192_V1.0591.00
127_P145_S1.0561.00
285_V289_K1.0541.00
52_A304_Y1.0541.00
86_N90_N1.0531.00
99_H119_M1.0491.00
279_P282_K1.0471.00
316_Q329_A1.0451.00
308_Q311_Q1.0451.00
45_E303_T1.0431.00
210_A239_A1.0381.00
206_S235_Q1.0361.00
178_A195_F1.0361.00
50_E69_I1.0341.00
52_A307_L1.0301.00
27_K93_I1.0251.00
120_I310_L1.0181.00
35_S73_D1.0131.00
163_R193_V1.0131.00
184_G188_G1.0061.00
219_F246_M1.0041.00
309_S341_W1.0041.00
167_V232_I1.0031.00
85_A108_A1.0021.00
211_R215_E0.9981.00
210_A214_K0.9911.00
152_A181_V0.9851.00
151_A221_Y0.9831.00
128_E131_A0.9791.00
213_K241_L0.9771.00
31_V108_A0.9751.00
43_D46_F0.9701.00
177_L223_G0.9661.00
16_A19_N0.9661.00
235_Q239_A0.9661.00
15_L18_S0.9641.00
288_I292_K0.9631.00
30_V69_I0.9621.00
106_Q128_E0.9551.00
317_S322_E0.9541.00
262_E265_E0.9501.00
17_F20_M0.9491.00
86_N111_I0.9411.00
140_T309_S0.9391.00
342_D346_D0.9381.00
51_Q287_A0.9361.00
49_A97_I0.9321.00
149_P153_K0.9291.00
31_V85_A0.9291.00
199_T202_E0.9271.00
52_A308_Q0.9221.00
168_H195_F0.9181.00
29_A93_I0.9161.00
165_A215_E0.9141.00
236_A245_F0.9111.00
213_K239_A0.9101.00
94_K320_P0.9101.00
84_V87_K0.9061.00
28_V95_Y0.9021.00
82_V86_N0.9001.00
224_G232_I0.8981.00
121_T124_A0.8961.00
130_T139_R0.8921.00
50_E291_K0.8921.00
56_I67_L0.8861.00
53_V57_N0.8851.00
34_M46_F0.8821.00
89_V115_E0.8821.00
30_V71_K0.8801.00
85_A115_E0.8791.00
181_V185_L0.8781.00
119_M137_I0.8771.00
167_V208_L0.8751.00
138_L327_L0.8721.00
118_L324_A0.8671.00
278_V282_K0.8641.00
121_T137_I0.8631.00
280_A283_P0.8621.00
305_A336_M0.8611.00
325_K328_K0.8581.00
209_V241_L0.8571.00
55_D58_A0.8521.00
152_A185_L0.8511.00
308_Q312_A0.8511.00
30_V53_V0.8491.00
179_R182_Q0.8481.00
194_F211_R0.8471.00
342_D345_G0.8451.00
11_G14_A0.8431.00
153_K184_G0.8411.00
138_L341_W0.8411.00
51_Q292_K0.8391.00
153_K158_K0.8311.00
175_E179_R0.8301.00
74_D99_H0.8301.00
109_S137_I0.8291.00
95_Y323_I0.8291.00
183_D186_K0.8291.00
193_V217_I0.8261.00
122_P303_T0.8251.00
164_I190_A0.8171.00
316_Q330_N0.8171.00
194_F215_E0.8141.00
281_N285_V0.8121.00
312_A330_N0.8081.00
62_I311_Q0.8071.00
27_K91_D0.8071.00
48_G52_A0.8061.00
15_L20_M0.8051.00
97_I306_A0.8021.00
254_V258_N0.8011.00
148_G177_L0.7991.00
135_Q324_A0.7971.00
136_L321_A0.7961.00
303_T307_L0.7961.00
264_A267_L0.7961.00
282_K285_V0.7951.00
314_L323_I0.7941.00
23_A65_N0.7931.00
128_E132_R0.7911.00
193_V215_E0.7881.00
309_S332_V0.7881.00
257_S261_G0.7871.00
305_A335_V0.7861.00
52_A56_I0.7851.00
206_S238_A0.7801.00
82_V111_I0.7801.00
165_A193_V0.7771.00
59_K315_N0.7751.00
169_D174_G0.7741.00
287_A291_K0.7691.00
278_V281_N0.7681.00
57_N61_G0.7681.00
308_Q332_V0.7641.00
178_A197_G0.7591.00
176_G179_R0.7581.00
231_Q235_Q0.7581.00
17_F21_A0.7571.00
15_L19_N0.7561.00
324_A327_L0.7561.00
273_K281_N0.7531.00
140_T306_A0.7531.00
85_A89_V0.7441.00
313_G327_L0.7421.00
31_V99_H0.7391.00
301_W335_V0.7381.00
340_T348_K0.7381.00
13_I16_A0.7381.00
154_Y159_V0.7381.00
170_K197_G0.7371.00
45_E100_L0.7351.00
26_I65_N0.7321.00
152_A188_G0.7311.00
120_I327_L0.7301.00
237_R262_E0.7291.00
74_D81_A0.7291.00
149_P187_K0.7281.00
334_T337_G0.7281.00
111_I114_D0.7281.00
67_L307_L0.7221.00
290_A293_Q0.7221.00
44_Q297_G0.7211.00
171_Q174_G0.7191.00
51_Q54_A0.7181.00
84_V88_V0.7161.00
117_I320_P0.7151.00
256_L264_A0.7151.00
97_I120_I0.7131.00
93_I96_V0.7121.00
213_K216_N0.7091.00
13_I17_F0.7031.00
212_L217_I0.7021.00
13_I18_S0.7001.00
101_C104_S0.6991.00
16_A20_M0.6991.00
222_Y232_I0.6981.00
99_H112_Y0.6971.00
12_C17_F0.6961.00
127_P176_G0.6941.00
327_L330_N0.6921.00
233_L245_F0.6881.00
51_Q291_K0.6881.00
288_I294_D0.6871.00
11_G15_L0.6861.00
70_V93_I0.6861.00
57_N66_K0.6851.00
26_I314_L0.6811.00
229_M251_V0.6811.00
289_K293_Q0.6801.00
94_K117_I0.6771.00
152_A184_G0.6771.00
19_N22_L0.6761.00
130_T346_D0.6751.00
33_A42_G0.6721.00
31_V88_V0.6671.00
20_M23_A0.6671.00
86_N115_E0.6661.00
85_A111_I0.6661.00
89_V112_Y0.6621.00
205_F235_Q0.6611.00
204_D207_T0.6601.00
181_V221_Y0.6591.00
232_I236_A0.6581.00
154_Y158_K0.6561.00
151_A270_T0.6561.00
185_L188_G0.6531.00
332_V339_L0.6521.00
51_Q288_I0.6521.00
182_Q192_V0.6511.00
21_A24_E0.6491.00
198_I228_E0.6471.00
196_D208_L0.6451.00
41_Y100_L0.6451.00
22_L65_N0.6431.00
95_Y118_L0.6411.00
321_A324_A0.6411.00
234_R238_A0.6401.00
141_T302_T0.6371.00
180_A184_G0.6341.00
202_E205_F0.6331.00
62_I67_L0.6291.00
121_T129_L0.6261.00
209_V213_K0.6251.00
120_I140_T0.6231.00
237_R263_S0.6231.00
326_Y330_N0.6221.00
28_V307_L0.6221.00
168_H175_E0.6211.00
258_N261_G0.6211.00
277_Q281_N0.6201.00
347_L350_F0.6191.00
166_I192_V0.6181.00
125_T141_T0.6171.00
129_L137_I0.6151.00
312_A332_V0.6141.00
256_L260_A0.6141.00
310_L323_I0.6121.00
86_N114_D0.6111.00
211_R214_K0.6101.00
255_S259_I0.6091.00
245_F248_P0.6091.00
95_Y120_I0.6071.00
339_L347_L0.6041.00
36_G42_G0.6031.00
31_V112_Y0.5991.00
109_S134_Y0.5991.00
330_N340_T0.5971.00
16_A21_A0.5961.00
26_I318_D0.5951.00
10_A13_I0.5941.00
14_A18_S0.5941.00
15_L21_A0.5931.00
155_I161_P0.5921.00
61_G65_N0.5911.00
144_D176_G0.5901.00
55_D283_P0.5881.00
313_G326_Y0.5881.00
313_G323_I0.5871.00
231_Q234_R0.5861.00
171_Q200_A0.5861.00
281_N284_I0.5831.00
320_P324_A0.5821.00
50_E292_K0.5821.00
106_Q129_L0.5811.00
76_C104_S0.5811.00
38_V101_C0.5811.00
172_Q175_E0.5811.00
26_I94_K0.5811.00
147_Q249_E0.5801.00
260_A263_S0.5791.00
61_G66_K0.5791.00
234_R261_G0.5781.00
56_I62_I0.5781.00
105_T129_L0.5781.00
288_I291_K0.5751.00
118_L136_L0.5751.00
135_Q321_A0.5741.00
345_G349_G0.5741.00
213_K243_T0.5721.00
88_V93_I0.5721.00
111_I115_E0.5721.00
323_I326_Y0.5721.00
164_I181_V0.5711.00
152_A190_A0.5691.00
166_I181_V0.5691.00
209_V232_I0.5691.00
60_G63_K0.5681.00
144_D147_Q0.5671.00
345_G350_F0.5661.00
122_P306_A0.5651.00
49_A53_V0.5641.00
89_V96_V0.5641.00
207_T210_A0.5621.00
126_A129_L0.5621.00
10_A15_L0.5601.00
342_D348_K0.5591.00
79_K83_A0.5561.00
159_V268_L0.5521.00
204_D235_Q0.5501.00
166_I195_F0.5491.00
33_A76_C0.5471.00
233_L256_L0.5461.00
179_R195_F0.5461.00
206_S239_A0.5451.00
83_A86_N0.5451.00
280_A308_Q0.5451.00
124_A129_L0.5451.00
123_A299_F0.5441.00
113_E134_Y0.5431.00
108_A112_Y0.5431.00
110_D113_E0.5421.00
45_E122_P0.5401.00
52_A55_D0.5390.99
304_Y308_Q0.5390.99
33_A100_L0.5380.99
85_A99_H0.5370.99
173_Y177_L0.5370.99
118_L323_I0.5360.99
174_G223_G0.5340.99
205_F231_Q0.5320.99
155_I221_Y0.5310.99
337_G347_L0.5310.99
314_L318_D0.5300.99
51_Q284_I0.5300.99
81_A108_A0.5290.99
50_E53_V0.5280.99
51_Q304_Y0.5280.99
108_A119_M0.5250.99
206_S210_A0.5230.99
16_A23_A0.5230.99
220_V241_L0.5210.99
208_L212_L0.5200.99
27_K30_V0.5200.99
105_T137_I0.5190.99
97_I310_L0.5170.99
120_I306_A0.5160.99
127_P144_D0.5160.99
57_N60_G0.5150.99
230_G260_A0.5150.99
237_R242_K0.5150.99
34_M43_D0.5140.99
284_I288_I0.5140.99
220_V236_A0.5140.99
126_A130_T0.5130.99
171_Q225_Y0.5120.99
23_A66_K0.5090.99
9_L15_L0.5080.99
29_A72_Y0.5070.99
309_S330_N0.5060.99
222_Y229_M0.5060.99
18_S22_L0.5050.99
305_A308_Q0.5040.99
58_A61_G0.5040.99
34_M73_D0.5020.99
220_V245_F0.5010.99
22_L25_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xaqA 2 0.9428 100 0.225 Contact Map
4n0qA 1 0.9292 100 0.24 Contact Map
4ms4A 1 0.921 100 0.245 Contact Map
4ms4B 1 0.9264 100 0.251 Contact Map
3sm9A 2 0.9428 100 0.253 Contact Map
3ipcA 1 0.9346 100 0.255 Contact Map
1usgA 2 0.9346 100 0.255 Contact Map
1dp4A 2 0.9264 100 0.264 Contact Map
4mptA 1 0.9319 100 0.267 Contact Map
2e4uA 2 0.9537 100 0.268 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.012 seconds.