GREMLIN Database
AMPH - D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH
UniProt: P0AD70 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12867
Length: 385 (318)
Sequences: 15322 (11981)
Seq/√Len: 671.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_K209_E3.7161.00
103_Q210_Q3.4141.00
58_G345_N3.3281.00
208_E213_R3.1981.00
110_D114_K3.0411.00
99_K210_Q3.0391.00
96_M206_L2.9451.00
107_K110_D2.9351.00
109_N133_V2.8831.00
77_P83_V2.5921.00
85_I256_S2.5711.00
202_P205_Q2.4181.00
110_D115_Y2.4121.00
99_K206_L2.3721.00
206_L210_Q2.3611.00
70_R73_N2.3131.00
65_S79_L2.3031.00
95_E264_W2.2841.00
36_D64_R2.2841.00
54_V262_M2.2671.00
193_D197_N2.2131.00
195_L206_L2.1991.00
199_S206_L2.1571.00
102_D281_D2.1511.00
63_F259_G2.1341.00
220_T256_S2.0911.00
281_D284_Q2.0551.00
69_T75_V2.0171.00
91_L264_W2.0101.00
99_K103_Q1.9801.00
96_M207_F1.9531.00
81_S233_M1.9061.00
193_D196_A1.9031.00
68_E74_N1.8761.00
102_D284_Q1.8651.00
265_M338_M1.8631.00
201_K206_L1.8521.00
192_A250_G1.8511.00
118_P197_N1.8481.00
265_M347_G1.8261.00
341_I344_K1.8061.00
87_S90_K1.8011.00
209_E213_R1.7651.00
207_F212_T1.7571.00
111_P114_K1.7551.00
175_A180_Q1.7261.00
287_I290_R1.6931.00
131_T134_N1.6901.00
56_I262_M1.6781.00
92_M254_V1.6661.00
205_Q209_E1.6621.00
217_M220_T1.6611.00
323_G343_Q1.6401.00
201_K205_Q1.6301.00
40_D44_Y1.5801.00
160_T163_Q1.5771.00
36_D40_D1.5751.00
97_L106_V1.5661.00
52_A258_P1.5551.00
201_K210_Q1.5461.00
100_L195_L1.5171.00
203_Y250_G1.5111.00
132_L194_A1.5101.00
134_N178_G1.5071.00
78_Q81_S1.4971.00
133_V310_L1.4871.00
86_A331_G1.4791.00
56_I347_G1.4721.00
101_L108_L1.4631.00
79_L259_G1.4521.00
97_L191_L1.4481.00
62_V66_Y1.4461.00
100_L199_S1.4451.00
54_V258_P1.4331.00
80_D259_G1.4191.00
212_T217_M1.4041.00
133_V292_Q1.4011.00
41_H45_G1.3971.00
203_Y207_F1.3921.00
97_L136_A1.3901.00
92_M264_W1.3901.00
137_T292_Q1.3801.00
98_V101_L1.3761.00
162_E166_K1.3611.00
57_D346_I1.3581.00
219_D231_R1.3511.00
97_L195_L1.3461.00
134_N139_T1.3381.00
36_D66_Y1.3301.00
268_Y289_Q1.3271.00
57_D60_Q1.3241.00
98_V108_L1.3201.00
63_F79_L1.3151.00
282_R286_L1.3121.00
140_S187_A1.3121.00
105_T198_A1.3051.00
133_V287_I1.2931.00
266_Q269_L1.2921.00
94_S136_A1.2781.00
50_G77_P1.2761.00
95_E268_Y1.2701.00
69_T81_S1.2601.00
340_M347_G1.2591.00
68_E73_N1.2551.00
88_L261_M1.2521.00
90_K183_Y1.2471.00
94_S188_F1.2371.00
100_L105_T1.2261.00
111_P129_P1.2261.00
185_N251_S1.2201.00
88_L338_M1.2111.00
309_G314_Y1.2091.00
101_L106_V1.2071.00
85_I89_T1.2041.00
129_P176_A1.2031.00
52_A77_P1.2001.00
77_P81_S1.1991.00
217_M260_D1.1991.00
220_T260_D1.1961.00
65_S77_P1.1941.00
330_G335_I1.1891.00
88_L336_T1.1861.00
92_M207_F1.1771.00
175_A179_S1.1731.00
217_M264_W1.1731.00
98_V284_Q1.1711.00
36_D62_V1.1691.00
261_M351_V1.1691.00
176_A179_S1.1671.00
215_L267_Q1.1621.00
52_A65_S1.1621.00
271_S286_L1.1591.00
93_T250_G1.1351.00
222_Y254_V1.1271.00
134_N137_T1.1241.00
212_T254_V1.1221.00
269_L340_M1.1211.00
101_L287_I1.1171.00
37_R41_H1.1161.00
89_T254_V1.1071.00
184_S187_A1.1041.00
308_L313_V1.0981.00
87_S183_Y1.0961.00
163_Q166_K1.0941.00
235_A334_F1.0821.00
115_Y198_A1.0791.00
204_T248_A1.0741.00
68_E76_R1.0651.00
175_A182_A1.0651.00
266_Q270_S1.0531.00
92_M217_M1.0531.00
50_G83_V1.0521.00
106_V198_A1.0431.00
93_T203_Y1.0301.00
70_R75_V1.0291.00
165_W193_D1.0281.00
96_M195_L1.0211.00
96_M210_Q1.0181.00
258_P351_V1.0161.00
212_T220_T1.0101.00
112_L135_L1.0071.00
82_V231_R1.0031.00
82_V219_D1.0001.00
265_M340_M0.9981.00
138_H187_A0.9961.00
273_F276_R0.9941.00
208_E212_T0.9921.00
217_M256_S0.9911.00
113_S128_T0.9901.00
54_V349_F0.9891.00
43_F66_Y0.9861.00
289_Q325_I0.9841.00
56_I266_Q0.9821.00
53_L350_V0.9801.00
267_Q272_D0.9791.00
174_K182_A0.9791.00
94_S311_G0.9791.00
112_L194_A0.9751.00
102_D275_Q0.9711.00
84_R255_Y0.9681.00
328_T337_Y0.9651.00
205_Q208_E0.9641.00
188_F191_L0.9641.00
115_Y194_A0.9631.00
99_K279_Q0.9631.00
325_I340_M0.9601.00
166_K170_T0.9571.00
133_V137_T0.9551.00
339_A348_A0.9541.00
106_V132_L0.9531.00
261_M349_F0.9491.00
70_R74_N0.9481.00
40_D43_F0.9441.00
259_G263_R0.9441.00
194_A198_A0.9411.00
99_K211_I0.9401.00
96_M199_S0.9371.00
181_A308_L0.9361.00
268_Y288_Y0.9361.00
70_R234_V0.9241.00
38_Y42_I0.9201.00
110_D132_L0.9181.00
100_L103_Q0.9171.00
338_M349_F0.9171.00
219_D260_D0.9151.00
136_A191_L0.9121.00
324_I341_I0.9021.00
98_V288_Y0.9001.00
95_E280_A0.8971.00
216_G263_R0.8961.00
271_S282_R0.8951.00
40_D66_Y0.8921.00
96_M211_I0.8911.00
84_R331_G0.8841.00
314_Y323_G0.8831.00
192_A203_Y0.8831.00
132_L191_L0.8821.00
82_V255_Y0.8811.00
188_F311_G0.8811.00
285_T289_Q0.8791.00
116_A197_N0.8771.00
82_V221_T0.8761.00
217_M263_R0.8731.00
95_E99_K0.8671.00
37_R40_D0.8671.00
262_M347_G0.8671.00
52_A83_V0.8661.00
291_A294_T0.8631.00
132_L198_A0.8621.00
268_Y312_W0.8601.00
285_T288_Y0.8601.00
92_M261_M0.8391.00
85_I261_M0.8331.00
39_A53_L0.8311.00
126_N176_A0.8291.00
195_L199_S0.8251.00
263_R266_Q0.8241.00
196_A199_S0.8231.00
196_A202_P0.8221.00
116_A194_A0.8181.00
101_L284_Q0.8121.00
219_D257_T0.8101.00
54_V63_F0.8081.00
95_E211_I0.8071.00
106_V194_A0.8071.00
80_D219_D0.8031.00
53_L64_R0.8011.00
59_N266_Q0.7991.00
291_A307_A0.7991.00
263_R274_Y0.7961.00
269_L347_G0.7901.00
39_A51_M0.7901.00
92_M212_T0.7861.00
63_F258_P0.7861.00
318_K321_R0.7851.00
325_I342_P0.7851.00
312_W340_M0.7821.00
51_M350_V0.7821.00
284_Q288_Y0.7801.00
203_Y222_Y0.7791.00
49_T71_P0.7791.00
287_I292_Q0.7761.00
40_D64_R0.7751.00
195_L203_Y0.7751.00
93_T192_A0.7701.00
313_V327_K0.7691.00
166_K169_S0.7691.00
71_P236_E0.7671.00
57_D61_R0.7651.00
54_V347_G0.7651.00
265_M349_F0.7641.00
55_V348_A0.7631.00
108_L310_L0.7621.00
215_L263_R0.7561.00
162_E193_D0.7561.00
189_D251_S0.7541.00
135_L191_L0.7521.00
286_L289_Q0.7521.00
139_T178_G0.7451.00
118_P166_K0.7441.00
107_K132_L0.7441.00
109_N131_T0.7431.00
33_D37_R0.7431.00
161_R193_D0.7421.00
51_M352_V0.7411.00
115_Y132_L0.7411.00
88_L91_L0.7411.00
91_L265_M0.7411.00
135_L140_S0.7401.00
99_K102_D0.7391.00
112_L116_A0.7381.00
199_S202_P0.7341.00
289_Q342_P0.7341.00
134_N177_P0.7331.00
101_L107_K0.7331.00
283_M286_L0.7321.00
258_P262_M0.7311.00
33_D36_D0.7311.00
53_L62_V0.7291.00
308_L312_W0.7271.00
116_A193_D0.7231.00
100_L198_A0.7221.00
257_T260_D0.7181.00
163_Q167_Y0.7171.00
262_M349_F0.7161.00
91_L312_W0.7111.00
303_G306_D0.7101.00
157_V163_Q0.7091.00
68_E75_V0.7091.00
204_T208_E0.7081.00
39_A43_F0.7041.00
326_Q339_A0.7021.00
75_V81_S0.7021.00
130_I142_L0.7011.00
262_M266_Q0.7001.00
107_K115_Y0.6971.00
199_S210_Q0.6961.00
211_I214_P0.6941.00
85_I336_T0.6931.00
69_T78_Q0.6911.00
138_H188_F0.6901.00
239_A242_C0.6891.00
280_A285_T0.6881.00
43_F51_M0.6881.00
96_M99_K0.6871.00
286_L290_R0.6821.00
34_I37_R0.6821.00
225_S228_Q0.6811.00
289_Q312_W0.6771.00
31_A34_I0.6761.00
270_S273_F0.6701.00
272_D276_R0.6701.00
130_I140_S0.6691.00
105_T199_S0.6681.00
91_L338_M0.6661.00
68_E71_P0.6641.00
82_V257_T0.6631.00
49_T354_R0.6551.00
83_V351_V0.6551.00
221_T224_P0.6531.00
85_I88_L0.6511.00
314_Y325_I0.6481.00
41_H44_Y0.6471.00
90_K185_N0.6451.00
307_A314_Y0.6401.00
113_S129_P0.6401.00
112_L119_G0.6391.00
90_K329_G0.6321.00
68_E72_G0.6321.00
206_L209_E0.6261.00
181_A313_V0.6241.00
136_A188_F0.6241.00
207_F211_I0.6231.00
241_P244_N0.6221.00
86_A252_G0.6221.00
42_I48_A0.6221.00
52_A56_I0.6201.00
161_R196_A0.6201.00
207_F222_Y0.6191.00
39_A66_Y0.6171.00
336_T351_V0.6171.00
321_R344_K0.6131.00
256_S260_D0.6111.00
53_L66_Y0.6111.00
228_Q232_L0.6111.00
145_E186_L0.6101.00
91_L94_S0.6101.00
137_T310_L0.6081.00
324_I339_A0.6061.00
327_K330_G0.6061.00
100_L206_L0.6061.00
288_Y312_W0.6021.00
107_K114_K0.6011.00
267_Q274_Y0.6011.00
207_F254_V0.6001.00
78_Q231_R0.5991.00
218_K260_D0.5981.00
167_Y170_T0.5951.00
89_T253_G0.5941.00
274_Y277_S0.5931.00
232_L235_A0.5891.00
117_P120_A0.5891.00
235_A238_G0.5881.00
161_R165_W0.5871.00
107_K133_V0.5871.00
125_Y128_T0.5871.00
127_G130_I0.5871.00
233_M236_E0.5861.00
112_L190_L0.5861.00
86_A334_F0.5851.00
38_Y41_H0.5851.00
229_C232_L0.5841.00
284_Q287_I0.5831.00
139_T181_A0.5781.00
144_R186_L0.5781.00
260_D263_R0.5781.00
267_Q279_Q0.5761.00
101_L110_D0.5761.00
271_S285_T0.5761.00
270_S345_N0.5761.00
159_P163_Q0.5761.00
126_N130_I0.5741.00
111_P131_T0.5731.00
317_P320_G0.5731.00
82_V228_Q0.5721.00
272_D285_T0.5721.00
256_S261_M0.5721.00
258_P349_F0.5691.00
136_A310_L0.5671.00
161_R164_R0.5671.00
269_L345_N0.5661.00
266_Q347_G0.5641.00
263_R267_Q0.5631.00
194_A197_N0.5631.00
97_L132_L0.5601.00
113_S120_A0.5601.00
85_I220_T0.5591.00
273_F277_S0.5571.00
87_S185_N0.5571.00
111_P115_Y0.5551.00
98_V102_D0.5541.00
130_I134_N0.5531.00
292_Q310_L0.5521.00
317_P321_R0.5511.00
143_P171_A0.5501.00
55_V346_I0.5451.00
87_S329_G0.5441.00
86_A330_G0.5441.00
326_Q329_G0.5441.00
57_D345_N0.5441.00
222_Y249_I0.5431.00
85_I92_M0.5421.00
143_P174_K0.5421.00
118_P193_D0.5411.00
196_A203_Y0.5391.00
48_A51_M0.5391.00
220_T257_T0.5381.00
316_A323_G0.5381.00
306_D313_V0.5351.00
119_G130_I0.5351.00
273_F282_R0.5341.00
85_I351_V0.5341.00
249_I252_G0.5341.00
91_L327_K0.5331.00
97_L194_A0.5331.00
94_S98_V0.5331.00
214_P217_M0.5321.00
228_Q231_R0.5321.00
50_G67_G0.5311.00
52_A351_V0.5281.00
113_S127_G0.5281.00
90_K327_K0.5271.00
221_T255_Y0.5261.00
75_V78_Q0.5261.00
142_L190_L0.5250.99
30_F33_D0.5240.99
138_H327_K0.5240.99
43_F46_S0.5230.99
175_A178_G0.5200.99
112_L115_Y0.5190.99
211_I267_Q0.5180.99
326_Q330_G0.5180.99
59_N270_S0.5170.99
321_R343_Q0.5170.99
288_Y309_G0.5160.99
315_M324_I0.5140.99
341_I346_I0.5140.99
315_M326_Q0.5140.99
263_R275_Q0.5130.99
130_I177_P0.5130.99
48_A352_V0.5130.99
219_D259_G0.5120.99
113_S118_P0.5120.99
291_A314_Y0.5070.99
165_W169_S0.5030.99
261_M338_M0.5030.99
267_Q285_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rjuA 1 0.9039 100 0.215 Contact Map
4ivkA 4 0.9195 100 0.221 Contact Map
4p6bA 5 0.8857 100 0.223 Contact Map
2qmiA 5 0.8857 100 0.231 Contact Map
1yqsA 1 0.8545 100 0.24 Contact Map
3wrzA 1 0.8468 100 0.24 Contact Map
2qz6A 1 0.8156 100 0.241 Contact Map
4netA 1 0.8494 100 0.243 Contact Map
3w8kA 1 0.826 100 0.245 Contact Map
4wz4A 1 0.8468 100 0.246 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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