PBP2 - ECOLI - GREMLIN Contacts

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PBP2 - Penicillin-binding protein 2

UniProt:	P0AD65	Sequences: MKLQNSFRDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGIPLALNRTIYQIEMMPEKVDNVQQTLDALRSVVDLTDDDIAAFRKERARSHRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVKGYKRRYYPYGSALTHVIGYVSKINDKDVERLNNDGKLANYAATHDIGKLGIERYYEDVLHGQTGYEEVEVNNRGRVIRQLKEVPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGVLALVSTPSYDPNLFVDGISSKDYSALLNDPNTPLVNRATQGVYPPASTVKPYVAVSALSAGVITRNTTLFDPGWWQLPGSEKRYRDWKKWGHGRLNVTRSLEESADTFFYQVAYDMGIDRLSEWMGKFGYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMILINDGIVKVPHLLMSTAEDGKQVPWVQPHEPPVGDIHSGYWELAKDGMYGVANRPNGTAHKYFASAPYKIAAKSGTAQVFGLKANETYNAHKIAERLRDHKLMTAFAPYNNPQVAVAMILENGGAGPAVGTLMRQILDHIMLGDNNTDLPAENPAVAAAEDH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10606
Length:	633 (518)
Sequences:	15975 (11570)
Seq/√Len:	508.4

ECOLI - PBP2 FTSI PBPC PBPB PBPA
BACSU - PBPH SP5D PBPB PBPC PBPI YQGF PBPA PBPG PBPF PBPD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
575_T	588_A	3.376	1.00
275_V	587_V	3.369	1.00
466_S	588_A	3.260	1.00
516_K	577_F	3.226	1.00
489_E	492_K	3.225	1.00
273_V	607_I	3.152	1.00
207_K	211_E	3.081	1.00
206_G	209_G	3.053	1.00
282_G	485_M	3.038	1.00
282_G	482_H	2.992	1.00
262_I	273_V	2.881	1.00
381_T	521_G	2.831	1.00
200_A	210_I	2.777	1.00
343_A	403_R	2.751	1.00
139_T	142_Q	2.748	1.00
477_I	505_G	2.742	1.00
266_L	271_A	2.727	1.00
278_P	586_A	2.701	1.00
378_L	388_A	2.605	1.00
351_T	377_R	2.586	1.00
160_G	170_S	2.533	1.00
520_Y	540_K	2.527	1.00
277_D	280_T	2.520	1.00
543_A	574_M	2.509	1.00
275_V	607_I	2.403	1.00
342_S	511_Y	2.383	1.00
251_Y	486_S	2.377	1.00
406_E	410_K	2.358	1.00
381_T	517_D	2.346	1.00
382_R	386_E	2.317	1.00
277_D	282_G	2.230	1.00
467_K	478_V	2.221	1.00
605_R	609_D	2.178	1.00
383_S	391_F	2.174	1.00
335_Y	468_A	2.152	1.00
385_E	527_N	2.107	1.00
261_Y	610_H	2.105	1.00
70_I	78_P	2.105	1.00
350_T	398_D	2.085	1.00
276_T	466_S	2.077	1.00
57_N	61_L	2.063	1.00
385_E	521_G	2.059	1.00
382_R	385_E	2.036	1.00
265_L	606_Q	2.035	1.00
284_L	585_V	2.019	1.00
347_T	350_T	2.014	1.00
332_V	408_M	2.013	1.00
375_H	388_A	2.013	1.00
353_F	377_R	1.992	1.00
200_A	207_K	1.968	1.00
379_N	382_R	1.941	1.00
258_L	611_I	1.930	1.00
403_R	406_E	1.913	1.00
339_S	407_W	1.904	1.00
210_I	214_Y	1.898	1.00
260_Q	264_T	1.880	1.00
338_V	511_Y	1.877	1.00
277_D	584_Q	1.869	1.00
279_R	584_Q	1.858	1.00
342_S	508_H	1.856	1.00
585_V	611_I	1.853	1.00
475_D	513_E	1.818	1.00
359_Q	366_R	1.813	1.00
249_D	488_A	1.811	1.00
508_H	511_Y	1.805	1.00
467_K	481_P	1.798	1.00
263_E	287_V	1.793	1.00
269_S	593_N	1.790	1.00
262_I	607_I	1.778	1.00
276_T	481_P	1.776	1.00
509_S	513_E	1.772	1.00
38_N	41_N	1.765	1.00
251_Y	485_M	1.765	1.00
604_M	608_L	1.759	1.00
258_L	284_L	1.758	1.00
370_W	596_A	1.749	1.00
273_V	589_M	1.742	1.00
542_A	577_F	1.739	1.00
475_D	509_S	1.730	1.00
462_P	588_A	1.727	1.00
507_I	512_W	1.715	1.00
520_Y	524_N	1.715	1.00
262_I	285_A	1.708	1.00
261_Y	265_L	1.700	1.00
576_A	604_M	1.700	1.00
396_A	452_G	1.698	1.00
470_M	586_A	1.687	1.00
197_A	214_Y	1.687	1.00
521_G	527_N	1.682	1.00
480_V	500_H	1.678	1.00
277_D	284_L	1.655	1.00
378_L	382_R	1.652	1.00
334_P	472_L	1.642	1.00
275_V	585_V	1.634	1.00
78_P	81_L	1.626	1.00
352_L	398_D	1.611	1.00
469_L	519_M	1.584	1.00
342_S	410_K	1.579	1.00
517_D	520_Y	1.575	1.00
589_M	604_M	1.566	1.00
357_W	366_R	1.557	1.00
57_N	60_K	1.547	1.00
69_G	198_N	1.534	1.00
274_V	463_I	1.531	1.00
328_P	460_A	1.528	1.00
81_L	84_T	1.522	1.00
486_S	496_W	1.518	1.00
59_I	159_K	1.516	1.00
283_V	483_L	1.512	1.00
394_Q	398_D	1.507	1.00
346_I	380_V	1.494	1.00
74_R	282_G	1.487	1.00
469_L	575_T	1.476	1.00
591_L	603_L	1.459	1.00
396_A	404_L	1.457	1.00
384_L	518_G	1.451	1.00
413_Y	460_A	1.444	1.00
338_V	507_I	1.441	1.00
576_A	608_L	1.433	1.00
267_A	289_T	1.431	1.00
369_D	388_A	1.427	1.00
253_T	282_G	1.420	1.00
475_D	516_K	1.420	1.00
383_S	392_F	1.412	1.00
338_V	411_F	1.412	1.00
117_A	120_R	1.410	1.00
472_L	515_A	1.408	1.00
51_Q	54_S	1.408	1.00
266_L	287_V	1.404	1.00
116_I	120_R	1.400	1.00
505_G	509_S	1.398	1.00
471_I	478_V	1.397	1.00
405_S	409_G	1.395	1.00
354_D	388_A	1.395	1.00
523_A	543_A	1.388	1.00
197_A	210_I	1.381	1.00
331_T	465_M	1.377	1.00
232_R	235_V	1.373	1.00
465_M	575_T	1.373	1.00
523_A	541_I	1.355	1.00
264_T	610_H	1.355	1.00
348_R	518_G	1.353	1.00
72_Y	249_D	1.344	1.00
493_Q	496_W	1.344	1.00
61_L	204_D	1.339	1.00
273_V	587_V	1.330	1.00
251_Y	488_A	1.328	1.00
58_R	61_L	1.328	1.00
550_V	592_E	1.324	1.00
473_I	542_A	1.323	1.00
473_I	577_F	1.319	1.00
52_T	60_K	1.313	1.00
72_Y	141_V	1.307	1.00
587_V	607_I	1.307	1.00
355_P	394_Q	1.304	1.00
274_V	462_P	1.300	1.00
359_Q	362_G	1.295	1.00
578_A	612_M	1.289	1.00
198_N	201_A	1.286	1.00
133_P	136_T	1.285	1.00
276_T	586_A	1.282	1.00
474_N	479_K	1.282	1.00
340_A	395_V	1.281	1.00
69_G	202_T	1.279	1.00
488_A	493_Q	1.274	1.00
258_L	285_A	1.273	1.00
180_S	207_K	1.272	1.00
610_H	613_L	1.271	1.00
348_R	514_L	1.266	1.00
411_F	507_I	1.262	1.00
214_Y	250_I	1.256	1.00
536_S	605_R	1.252	1.00
320_R	594_G	1.249	1.00
368_R	372_K	1.245	1.00
142_Q	145_R	1.243	1.00
253_T	482_H	1.240	1.00
262_I	287_V	1.237	1.00
318_V	324_G	1.237	1.00
341_L	518_G	1.236	1.00
402_D	406_E	1.236	1.00
230_N	234_R	1.236	1.00
337_A	392_F	1.234	1.00
276_T	470_M	1.229	1.00
156_V	165_Y	1.224	1.00
40_Y	44_I	1.224	1.00
478_V	504_V	1.220	1.00
198_N	202_T	1.217	1.00
587_V	608_L	1.213	1.00
257_K	614_G	1.213	1.00
358_W	397_Y	1.202	1.00
407_W	410_K	1.201	1.00
70_I	249_D	1.199	1.00
513_E	516_K	1.195	1.00
482_H	497_V	1.192	1.00
286_L	321_A	1.190	1.00
77_I	257_K	1.190	1.00
88_I	96_D	1.188	1.00
524_N	527_N	1.186	1.00
465_M	573_L	1.180	1.00
343_A	407_W	1.168	1.00
66_P	222_T	1.167	1.00
100_Q	104_A	1.165	1.00
516_K	542_A	1.164	1.00
274_V	466_S	1.163	1.00
612_M	615_D	1.160	1.00
397_Y	449_I	1.159	1.00
380_V	391_F	1.158	1.00
58_R	172_L	1.157	1.00
346_I	350_T	1.154	1.00
521_G	524_N	1.147	1.00
181_K	184_D	1.147	1.00
228_E	232_R	1.146	1.00
46_R	49_D	1.135	1.00
231_N	235_V	1.126	1.00
338_V	515_A	1.126	1.00
400_G	403_R	1.125	1.00
66_P	198_N	1.125	1.00
128_R	131_S	1.121	1.00
37_A	41_N	1.121	1.00
354_D	369_D	1.118	1.00
138_L	142_Q	1.112	1.00
116_I	121_K	1.111	1.00
117_A	121_K	1.110	1.00
345_V	398_D	1.110	1.00
407_W	411_F	1.109	1.00
38_N	42_L	1.105	1.00
390_T	394_Q	1.104	1.00
215_E	219_H	1.100	1.00
275_V	611_I	1.095	1.00
52_T	145_R	1.094	1.00
278_P	585_V	1.091	1.00
103_D	113_D	1.086	1.00
589_M	603_L	1.085	1.00
410_K	504_V	1.082	1.00
342_S	407_W	1.081	1.00
409_G	415_H	1.081	1.00
466_S	586_A	1.077	1.00
522_V	530_A	1.077	1.00
52_T	141_V	1.073	1.00
523_A	574_M	1.068	1.00
527_N	531_H	1.059	1.00
375_H	386_E	1.059	1.00
74_R	284_L	1.058	1.00
168_Y	256_L	1.053	1.00
286_L	319_N	1.050	1.00
486_S	493_Q	1.048	1.00
266_L	273_V	1.046	1.00
265_L	603_L	1.046	1.00
512_W	516_K	1.045	1.00
55_N	59_I	1.043	1.00
74_R	135_K	1.041	1.00
335_Y	411_F	1.038	1.00
104_A	107_S	1.038	1.00
338_V	407_W	1.035	1.00
72_Y	251_Y	1.034	1.00
477_I	503_P	1.033	1.00
472_L	516_K	1.032	1.00
541_I	578_A	1.029	1.00
550_V	593_N	1.024	1.00
479_K	503_P	1.024	1.00
378_L	391_F	1.021	1.00
341_L	514_L	1.021	1.00
510_G	514_L	1.020	1.00
70_I	81_L	1.018	1.00
338_V	512_W	1.012	1.00
343_A	399_M	1.012	1.00
63_P	176_I	1.012	1.00
261_Y	264_T	1.011	1.00
516_K	519_M	1.009	1.00
274_V	286_L	1.004	1.00
334_P	519_M	1.000	1.00
371_K	375_H	1.000	1.00
473_I	586_A	1.000	1.00
479_K	499_P	0.999	1.00
248_H	494_V	0.995	1.00
388_A	391_F	0.991	1.00
138_L	146_F	0.990	1.00
278_P	470_M	0.988	1.00
334_P	469_L	0.985	1.00
232_R	236_I	0.983	1.00
406_E	409_G	0.983	1.00
371_K	374_G	0.981	1.00
173_T	291_S	0.980	1.00
598_P	601_G	0.978	1.00
92_P	95_V	0.977	1.00
65_A	204_D	0.973	1.00
335_Y	408_M	0.971	1.00
256_L	260_Q	0.967	1.00
211_E	215_E	0.965	1.00
113_D	117_A	0.965	1.00
572_K	597_G	0.961	1.00
606_Q	609_D	0.961	1.00
257_K	260_Q	0.961	1.00
337_A	380_V	0.960	1.00
265_L	610_H	0.960	1.00
60_K	141_V	0.959	1.00
334_P	384_L	0.955	1.00
455_Q	549_Q	0.952	1.00
276_T	467_K	0.949	1.00
460_A	465_M	0.949	1.00
467_K	480_V	0.948	1.00
381_T	518_G	0.948	1.00
319_N	322_T	0.944	1.00
462_P	466_S	0.939	1.00
579_P	584_Q	0.939	1.00
272_A	462_P	0.938	1.00
393_Y	453_I	0.936	1.00
271_A	591_L	0.934	1.00
197_A	201_A	0.933	1.00
352_L	391_F	0.932	1.00
59_I	63_P	0.931	1.00
403_R	407_W	0.930	1.00
258_L	275_V	0.929	1.00
52_T	55_N	0.927	1.00
597_G	601_G	0.926	1.00
587_V	604_M	0.926	1.00
378_L	386_E	0.925	1.00
68_R	74_R	0.924	1.00
169_G	293_D	0.923	1.00
33_G	37_A	0.921	1.00
338_V	472_L	0.920	1.00
375_H	378_L	0.917	1.00
414_G	464_Q	0.916	1.00
164_R	168_Y	0.916	1.00
380_V	395_V	0.915	1.00
407_W	507_I	0.915	1.00
175_V	254_L	0.915	1.00
151_Y	179_V	0.913	1.00
511_Y	515_A	0.913	1.00
207_K	210_I	0.913	1.00
351_T	379_N	0.912	1.00
413_Y	468_A	0.912	1.00
572_K	600_V	0.912	1.00
133_P	137_N	0.911	1.00
210_I	252_L	0.910	1.00
573_L	590_I	0.908	1.00
336_V	404_L	0.906	1.00
149_N	152_R	0.906	1.00
584_Q	618_T	0.903	1.00
97_N	100_Q	0.902	1.00
70_I	73_D	0.900	1.00
127_H	130_T	0.898	1.00
233_G	236_I	0.895	1.00
336_V	452_G	0.894	1.00
524_N	535_A	0.894	1.00
591_L	600_V	0.894	1.00
415_H	464_Q	0.890	1.00
115_D	119_F	0.889	1.00
584_Q	615_D	0.889	1.00
208_L	212_R	0.886	1.00
530_A	545_S	0.885	1.00
346_I	395_V	0.884	1.00
354_D	375_H	0.881	1.00
40_Y	43_Q	0.880	1.00
404_L	408_M	0.879	1.00
140_E	144_A	0.873	1.00
225_E	228_E	0.869	1.00
221_Q	245_Q	0.867	1.00
56_E	59_I	0.866	1.00
131_S	136_T	0.866	1.00
571_H	590_I	0.866	1.00
578_A	608_L	0.863	1.00
60_K	72_Y	0.862	1.00
272_A	321_A	0.861	1.00
358_W	394_Q	0.861	1.00
211_E	214_Y	0.859	1.00
484_L	487_T	0.858	1.00
262_I	275_V	0.855	1.00
72_Y	78_P	0.855	1.00
63_P	153_F	0.854	1.00
444_Y	447_D	0.853	1.00
278_P	473_I	0.853	1.00
230_N	233_G	0.852	1.00
352_L	394_Q	0.849	1.00
270_R	320_R	0.848	1.00
129_F	132_I	0.847	1.00
89_E	92_P	0.844	1.00
362_G	365_K	0.841	1.00
360_L	449_I	0.841	1.00
74_R	255_D	0.841	1.00
380_V	518_G	0.840	1.00
135_K	142_Q	0.839	1.00
450_P	455_Q	0.839	1.00
231_N	234_R	0.838	1.00
327_P	548_A	0.836	1.00
450_P	456_G	0.834	1.00
98_V	102_L	0.833	1.00
99_Q	117_A	0.831	1.00
227_V	230_N	0.830	1.00
152_R	155_G	0.830	1.00
114_D	118_A	0.829	1.00
128_R	132_I	0.829	1.00
341_L	511_Y	0.827	1.00
273_V	603_L	0.821	1.00
396_A	401_I	0.820	1.00
517_D	521_G	0.818	1.00
369_D	375_H	0.813	1.00
112_T	115_D	0.812	1.00
511_Y	514_L	0.812	1.00
154_P	186_D	0.811	1.00
217_V	248_H	0.811	1.00
209_G	212_R	0.809	1.00
585_V	615_D	0.808	1.00
205_I	210_I	0.807	1.00
530_A	533_Y	0.805	1.00
523_A	530_A	0.805	1.00
228_E	253_T	0.803	1.00
59_I	172_L	0.798	1.00
253_T	485_M	0.795	1.00
262_I	265_L	0.794	1.00
466_S	575_T	0.792	1.00
286_L	322_T	0.792	1.00
331_T	575_T	0.792	1.00
357_W	360_L	0.792	1.00
461_T	464_Q	0.791	1.00
40_Y	45_V	0.790	1.00
200_A	214_Y	0.789	1.00
356_G	374_G	0.789	1.00
540_K	617_N	0.788	1.00
258_L	607_I	0.787	1.00
29_L	33_G	0.785	1.00
283_V	463_I	0.783	1.00
200_A	205_I	0.783	1.00
186_D	207_K	0.782	1.00
197_A	200_A	0.781	1.00
272_A	590_I	0.780	1.00
84_T	96_D	0.780	1.00
22_L	26_L	0.778	1.00
105_L	146_F	0.775	1.00
514_L	517_D	0.775	1.00
23_V	27_G	0.774	1.00
286_L	483_L	0.774	1.00
530_A	574_M	0.772	1.00
513_E	517_D	0.772	1.00
371_K	388_A	0.767	1.00
608_L	612_M	0.767	1.00
399_M	403_R	0.766	1.00
335_Y	465_M	0.765	1.00
127_H	131_S	0.764	1.00
512_W	515_A	0.763	1.00
533_Y	601_G	0.763	1.00
49_D	53_R	0.761	1.00
231_N	236_I	0.761	1.00
111_L	116_I	0.760	1.00
384_L	519_M	0.758	1.00
55_N	60_K	0.756	1.00
229_V	232_R	0.750	1.00
87_Q	161_Y	0.750	1.00
514_L	518_G	0.746	1.00
447_D	450_P	0.744	1.00
382_R	527_N	0.743	1.00
354_D	376_G	0.740	1.00
237_R	240_K	0.740	1.00
510_G	513_E	0.739	1.00
280_T	479_K	0.737	1.00
106_R	134_V	0.736	1.00
255_D	258_L	0.735	1.00
67_S	246_A	0.735	1.00
374_G	390_T	0.733	1.00
462_P	573_L	0.733	1.00
127_H	132_I	0.733	1.00
88_I	138_L	0.731	1.00
52_T	72_Y	0.731	1.00
394_Q	397_Y	0.730	1.00
465_M	588_A	0.728	1.00
160_G	164_R	0.726	1.00
88_I	92_P	0.725	1.00
210_I	250_I	0.725	1.00
226_E	229_V	0.724	1.00
335_Y	413_Y	0.722	1.00
543_A	601_G	0.722	1.00
413_Y	465_M	0.722	1.00
30_L	34_V	0.721	1.00
65_A	202_T	0.720	1.00
130_T	133_P	0.720	1.00
135_K	143_V	0.719	1.00
263_E	267_A	0.718	1.00
515_A	518_G	0.716	1.00
257_K	261_Y	0.716	1.00
274_V	588_A	0.714	1.00
341_L	515_A	0.713	1.00
235_V	238_Q	0.713	1.00
550_V	570_D	0.712	1.00
47_F	51_Q	0.711	1.00
280_T	482_H	0.711	1.00
326_Y	571_H	0.710	1.00
50_Y	55_N	0.707	1.00
340_A	346_I	0.707	1.00
186_D	189_R	0.705	1.00
112_T	116_I	0.703	1.00
346_I	398_D	0.702	1.00
463_I	481_P	0.697	1.00
41_N	46_R	0.697	1.00
392_F	395_V	0.695	1.00
101_T	104_A	0.695	1.00
469_L	586_A	0.694	1.00
353_F	394_Q	0.692	1.00
75_N	79_L	0.691	1.00
541_I	604_M	0.691	1.00
79_L	82_N	0.691	1.00
63_P	179_V	0.691	1.00
519_M	577_F	0.690	1.00
172_L	254_L	0.689	1.00
274_V	321_A	0.687	1.00
39_L	43_Q	0.685	1.00
229_V	233_G	0.684	1.00
55_N	58_R	0.682	1.00
103_D	107_S	0.682	1.00
148_V	151_Y	0.681	1.00
607_I	611_I	0.680	1.00
378_L	383_S	0.679	1.00
47_F	50_Y	0.678	1.00
337_A	384_L	0.677	1.00
539_Y	584_Q	0.677	1.00
328_P	332_V	0.677	1.00
470_M	479_K	0.675	1.00
572_K	599_A	0.675	1.00
339_S	343_A	0.674	1.00
329_A	548_A	0.674	1.00
113_D	116_I	0.674	1.00
58_R	209_G	0.673	1.00
64_I	72_Y	0.672	1.00
32_T	36_I	0.671	1.00
41_N	45_V	0.671	1.00
345_V	403_R	0.670	1.00
126_S	129_F	0.667	1.00
520_Y	523_A	0.666	1.00
475_D	512_W	0.666	1.00
225_E	229_V	0.664	1.00
254_L	483_L	0.662	1.00
375_H	382_R	0.661	1.00
336_V	396_A	0.660	1.00
279_R	475_D	0.659	1.00
62_V	199_Y	0.659	1.00
101_T	153_F	0.659	1.00
265_L	607_I	0.658	1.00
228_E	231_N	0.658	1.00
212_R	216_D	0.658	1.00
384_L	392_F	0.657	1.00
474_N	477_I	0.656	1.00
262_I	271_A	0.656	1.00
599_A	602_T	0.656	1.00
126_S	130_T	0.655	1.00
536_S	609_D	0.654	1.00
381_T	385_E	0.654	1.00
31_L	35_L	0.653	1.00
46_R	50_Y	0.653	1.00
227_V	232_R	0.652	1.00
522_V	529_T	0.652	1.00
115_D	118_A	0.650	1.00
360_L	397_Y	0.648	1.00
131_S	135_K	0.648	1.00
174_H	177_G	0.647	1.00
467_K	470_M	0.647	1.00
23_V	26_L	0.646	1.00
28_I	32_T	0.646	1.00
64_I	204_D	0.646	1.00
589_M	600_V	0.646	1.00
79_L	83_R	0.646	1.00
223_G	226_E	0.644	1.00
541_I	574_M	0.642	1.00
27_G	31_L	0.640	1.00
172_L	175_V	0.640	1.00
39_L	42_L	0.640	1.00
597_G	602_T	0.637	1.00
98_V	107_S	0.637	1.00
606_Q	610_H	0.637	1.00
369_D	374_G	0.636	1.00
574_M	604_M	0.635	1.00
345_V	399_M	0.634	1.00
390_T	393_Y	0.634	1.00
19_R	23_V	0.634	1.00
328_P	456_G	0.634	1.00
153_F	159_K	0.632	1.00
332_V	336_V	0.632	1.00
99_Q	103_D	0.632	1.00
258_L	261_Y	0.631	1.00
591_L	599_A	0.630	1.00
411_F	468_A	0.629	1.00
477_I	504_V	0.628	1.00
326_Y	592_E	0.628	1.00
129_F	133_P	0.624	1.00
332_V	335_Y	0.624	1.00
571_H	592_E	0.624	1.00
572_K	598_P	0.623	1.00
516_K	520_Y	0.620	1.00
24_A	28_I	0.620	1.00
328_P	465_M	0.619	1.00
411_F	471_I	0.619	1.00
467_K	471_I	0.618	1.00
327_P	571_H	0.617	1.00
83_R	87_Q	0.617	1.00
386_E	527_N	0.617	1.00
337_A	518_G	0.617	1.00
531_H	535_A	0.616	1.00
131_S	134_V	0.615	1.00
345_V	395_V	0.615	1.00
385_E	522_V	0.613	1.00
37_A	40_Y	0.613	1.00
180_S	185_K	0.612	1.00
70_I	80_A	0.609	1.00
577_F	586_A	0.608	1.00
405_S	451_V	0.605	0.99
275_V	278_P	0.605	0.99
226_E	240_K	0.605	0.99
328_P	455_Q	0.604	0.99
339_S	399_M	0.604	0.99
101_T	105_L	0.603	0.99
35_L	38_N	0.603	0.99
532_K	601_G	0.603	0.99
89_E	157_E	0.602	0.99
106_R	110_D	0.602	0.99
214_Y	217_V	0.601	0.99
238_Q	241_E	0.599	0.99
539_Y	617_N	0.599	0.99
396_A	449_I	0.598	0.99
88_I	156_V	0.598	0.99
345_V	350_T	0.598	0.99
478_V	506_D	0.598	0.99
352_L	395_V	0.595	0.99
41_N	44_I	0.595	0.99
91_M	94_K	0.595	0.99
51_Q	55_N	0.595	0.99
52_T	56_E	0.595	0.99
77_I	256_L	0.594	0.99
227_V	235_V	0.594	0.99
341_L	380_V	0.593	0.99
405_S	447_D	0.592	0.99
608_L	611_I	0.591	0.99
467_K	479_K	0.587	0.99
242_V	246_A	0.587	0.99
181_K	202_T	0.585	0.99
572_K	596_A	0.585	0.99
325_V	464_Q	0.585	0.99
68_R	71_I	0.585	0.99
164_R	170_S	0.585	0.99
409_G	414_G	0.584	0.99
248_H	487_T	0.582	0.99
36_I	40_Y	0.580	0.99
539_Y	612_M	0.580	0.99
401_I	448_T	0.580	0.99
173_T	292_Y	0.580	0.99
83_R	86_Y	0.579	0.99
283_V	286_L	0.579	0.99
367_Y	453_I	0.578	0.99
89_E	95_V	0.578	0.99
463_I	467_K	0.578	0.99
152_R	157_E	0.577	0.99
355_P	390_T	0.577	0.99
54_S	57_N	0.577	0.99
578_A	585_V	0.576	0.99
471_I	506_D	0.574	0.99
257_K	610_H	0.574	0.99
343_A	346_I	0.573	0.99
132_I	135_K	0.573	0.99
539_Y	609_D	0.573	0.99
293_D	296_L	0.572	0.99
235_V	239_L	0.572	0.99
29_L	36_I	0.569	0.99
260_Q	263_E	0.569	0.99
402_D	447_D	0.569	0.99
369_D	390_T	0.569	0.99
508_H	512_W	0.569	0.99
36_I	43_Q	0.568	0.99
86_Y	89_E	0.568	0.99
400_G	448_T	0.566	0.99
276_T	479_K	0.566	0.99
62_V	65_A	0.565	0.99
51_Q	145_R	0.564	0.99
214_Y	484_L	0.563	0.99
102_L	106_R	0.562	0.99
349_N	381_T	0.562	0.99
507_I	511_Y	0.561	0.99
348_R	381_T	0.561	0.99
106_R	109_V	0.560	0.99
354_D	374_G	0.559	0.99
537_A	605_R	0.558	0.99
322_T	463_I	0.557	0.99
341_L	346_I	0.557	0.99
250_I	487_T	0.556	0.99
489_E	494_V	0.556	0.99
365_K	393_Y	0.556	0.99
116_I	119_F	0.556	0.99
70_I	82_N	0.556	0.99
199_Y	215_E	0.555	0.99
200_A	211_E	0.554	0.99
354_D	378_L	0.553	0.99
39_L	44_I	0.553	0.99
104_A	108_V	0.551	0.99
223_G	244_P	0.551	0.99
367_Y	393_Y	0.551	0.99
213_Y	422_A	0.551	0.99
132_I	136_T	0.549	0.99
466_S	470_M	0.549	0.99
578_A	584_Q	0.549	0.99
76_G	251_Y	0.548	0.99
331_T	573_L	0.548	0.99
77_I	128_R	0.547	0.99
259_Q	263_E	0.546	0.99
118_A	126_S	0.546	0.99
396_A	451_V	0.546	0.99
533_Y	536_S	0.545	0.99
392_F	452_G	0.545	0.99
572_K	591_L	0.545	0.99
453_I	549_Q	0.545	0.99
358_W	361_P	0.544	0.99
330_S	333_K	0.544	0.99
83_R	165_Y	0.543	0.99
168_Y	171_A	0.543	0.99
130_T	134_V	0.543	0.99
478_V	481_P	0.542	0.99
205_I	215_E	0.541	0.99
399_M	404_L	0.541	0.99
522_V	574_M	0.541	0.99
276_T	283_V	0.540	0.99
279_R	474_N	0.538	0.99
107_S	113_D	0.536	0.99
228_E	233_G	0.536	0.99
334_P	515_A	0.535	0.99
473_I	516_K	0.535	0.99
144_A	148_V	0.535	0.99
535_A	538_P	0.535	0.99
128_R	135_K	0.535	0.99
482_H	485_M	0.534	0.99
20_R	24_A	0.534	0.99
270_R	592_E	0.534	0.99
25_F	29_L	0.533	0.99
276_T	588_A	0.532	0.99
485_M	496_W	0.532	0.99
480_V	503_P	0.530	0.99
367_Y	450_P	0.529	0.99
542_A	579_P	0.529	0.99
291_S	294_P	0.528	0.99
230_N	236_I	0.528	0.99
523_A	533_Y	0.528	0.99
345_V	348_R	0.528	0.99
148_V	159_K	0.527	0.99
87_Q	91_M	0.527	0.99
523_A	531_H	0.527	0.99
58_R	228_E	0.527	0.99
337_A	395_V	0.526	0.99
227_V	231_N	0.526	0.99
242_V	245_Q	0.526	0.99
585_V	608_L	0.526	0.99
472_L	577_F	0.525	0.99
385_E	518_G	0.524	0.99
522_V	528_G	0.524	0.99
102_L	117_A	0.523	0.99
222_T	225_E	0.522	0.99
288_S	321_A	0.522	0.99
520_Y	619_D	0.521	0.99
401_I	451_V	0.521	0.99
220_G	223_G	0.520	0.98
250_I	484_L	0.519	0.98
88_I	158_V	0.518	0.98
141_V	145_R	0.517	0.98
47_F	52_T	0.516	0.98
79_L	132_I	0.516	0.98
183_N	186_D	0.516	0.98
61_L	224_Y	0.515	0.98
143_V	147_A	0.512	0.98
140_E	143_V	0.512	0.98
612_M	617_N	0.509	0.98
228_E	235_V	0.506	0.98
358_W	393_Y	0.505	0.98
70_I	74_R	0.505	0.98
224_Y	230_N	0.505	0.98
272_A	320_R	0.504	0.98
88_I	91_M	0.504	0.98
38_N	43_Q	0.504	0.98
269_S	595_G	0.503	0.98
172_L	263_E	0.503	0.98
143_V	158_V	0.503	0.98
245_Q	248_H	0.502	0.98
27_G	34_V	0.502	0.98
536_S	541_I	0.500	0.98
31_L	34_V	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2wadA	1	0.7962	100	0.249	Contact Map
4ovdA	2	0.6461	100	0.251	Contact Map
4ye5A	1	0.7994	100	0.257	Contact Map
3equA	1	0.6603	100	0.261	Contact Map
3vskA	2	0.8246	100	0.276	Contact Map
3ue3A	1	0.6682	100	0.289	Contact Map
1qmeA	1	0.6635	100	0.29	Contact Map
3pbtA	1	0.7678	100	0.293	Contact Map
4bjpA	2	0.6335	100	0.293	Contact Map
1vqqA	1	0.8973	100	0.3	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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