KPYK1 - ECOLI - GREMLIN Contacts

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KPYK1 - Pyruvate kinase I

UniProt:	P0AD61	Sequences: MKKTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAAILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNTVLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMNSRLEFNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVPQLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHVL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10804
Length:	470 (464)
Sequences:	4162 (2383)
Seq/√Len:	110.6

ECOLI - KPYK1 KPYK2
BACSU - KPYK
HALSA - Q9HSA5
SULSO - Q97ZD7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
135_T	145_K	4.354	1.00
21_A	56_K	4.322	1.00
219_S	237_S	4.321	1.00
231_D	266_K	4.087	1.00
44_G	48_Q	3.411	1.00
17_E	52_N	3.393	1.00
230_F	263_M	3.381	1.00
133_E	145_K	3.171	1.00
201_I	236_A	3.165	1.00
8_C	28_M	3.086	1.00
65_L	181_G	2.985	1.00
78_E	102_N	2.964	1.00
227_L	259_A	2.885	1.00
200_V	219_S	2.828	1.00
276_T	306_T	2.801	1.00
255_E	334_R	2.800	1.00
28_M	31_M	2.761	1.00
204_R	217_I	2.722	1.00
133_E	147_L	2.714	1.00
62_A	410_V	2.703	1.00
136_A	143_I	2.619	1.00
19_M	22_K	2.577	1.00
16_S	19_M	2.542	1.00
90_T	143_I	2.526	1.00
44_G	184_Q	2.473	1.00
86_K	89_Q	2.419	1.00
76_K	155_N	2.419	1.00
90_T	135_T	2.353	1.00
42_E	46_R	2.291	1.00
91_F	106_V	2.282	1.00
200_V	217_I	2.278	1.00
254_E	330_T	2.268	1.00
235_E	270_A	2.226	1.00
15_E	46_R	2.220	1.00
24_L	61_A	2.184	1.00
400_T	406_A	2.181	1.00
198_S	202_E	2.140	1.00
286_K	319_K	2.133	1.00
25_D	57_T	2.126	1.00
372_P	447_D	2.114	1.00
178_L	189_V	2.086	1.00
78_E	100_I	2.086	1.00
47_I	184_Q	2.078	1.00
251_I	259_A	2.036	1.00
218_I	239_G	2.034	1.00
261_K	304_D	2.019	1.00
112_G	115_T	2.007	1.00
125_V	152_L	1.997	1.00
89_Q	103_S	1.956	1.00
309_V	332_C	1.954	1.00
17_E	49_N	1.946	1.00
329_A	333_E	1.938	1.00
205_E	209_A	1.893	1.00
96_D	140_N	1.879	1.00
185_G	404_K	1.860	1.00
90_T	145_K	1.855	1.00
19_M	322_L	1.851	1.00
179_I	210_H	1.844	1.00
80_G	154_E	1.832	1.00
82_D	151_D	1.822	1.00
182_C	215_I	1.808	1.00
85_L	146_V	1.805	1.00
216_H	408_Q	1.798	1.00
105_M	141_K	1.775	1.00
264_I	276_T	1.762	1.00
119_V	137_I	1.758	1.00
47_I	63_I	1.752	1.00
230_F	234_L	1.747	1.00
122_T	131_G	1.737	1.00
51_R	54_M	1.732	1.00
175_K	179_I	1.730	1.00
375_V	449_V	1.726	1.00
21_A	25_D	1.724	1.00
172_E	176_Q	1.715	1.00
33_L	47_I	1.712	1.00
93_F	132_M	1.711	1.00
435_E	439_Q	1.710	1.00
198_S	201_I	1.708	1.00
132_M	144_C	1.699	1.00
84_S	151_D	1.696	1.00
92_T	143_I	1.681	1.00
365_T	465_A	1.679	1.00
116_D	166_A	1.678	1.00
197_R	232_E	1.675	1.00
91_F	144_C	1.655	1.00
406_A	419_L	1.654	1.00
17_E	56_K	1.651	1.00
191_A	203_I	1.644	1.00
10_I	20_L	1.636	1.00
173_K	177_D	1.632	1.00
67_T	71_E	1.619	1.00
224_Q	228_N	1.610	1.00
138_E	141_K	1.606	1.00
29_N	59_K	1.602	1.00
7_V	275_I	1.602	1.00
41_A	44_G	1.600	1.00
240_I	263_M	1.596	1.00
164_S	225_E	1.586	1.00
89_Q	146_V	1.585	1.00
262_M	266_K	1.582	1.00
52_N	56_K	1.570	1.00
22_K	25_D	1.564	1.00
83_V	103_S	1.559	1.00
96_D	105_M	1.543	1.00
24_L	53_V	1.540	1.00
323_E	326_S	1.540	1.00
30_V	64_L	1.531	1.00
92_T	141_K	1.522	1.00
175_K	202_E	1.500	1.00
7_V	30_V	1.494	1.00
118_S	121_N	1.493	1.00
31_M	50_L	1.485	1.00
122_T	133_E	1.483	1.00
218_I	275_I	1.474	1.00
17_E	53_V	1.466	1.00
65_L	186_V	1.461	1.00
320_Y	323_E	1.452	1.00
436_L	439_Q	1.443	1.00
95_T	114_T	1.438	1.00
2_K	329_A	1.433	1.00
77_L	154_E	1.419	1.00
21_A	57_T	1.415	1.00
45_Q	48_Q	1.399	1.00
96_D	141_K	1.398	1.00
229_N	232_E	1.388	1.00
94_T	105_M	1.383	1.00
38_G	43_H	1.383	1.00
409_L	412_S	1.383	1.00
285_I	313_G	1.374	1.00
176_Q	179_I	1.369	1.00
114_T	142_V	1.367	1.00
44_G	183_E	1.357	1.00
256_V	296_G	1.352	1.00
63_I	186_V	1.350	1.00
371_A	450_V	1.348	1.00
40_Y	180_F	1.343	1.00
253_V	327_I	1.340	1.00
436_L	440_S	1.330	1.00
26_A	326_S	1.318	0.99
137_I	142_V	1.318	0.99
45_Q	49_N	1.318	0.99
53_V	57_T	1.316	0.99
182_C	210_H	1.314	0.99
39_D	42_E	1.311	0.99
214_N	404_K	1.296	0.99
121_N	163_V	1.294	0.99
33_L	50_L	1.293	0.99
126_D	129_L	1.284	0.99
378_T	398_A	1.279	0.99
74_T	130_I	1.279	0.99
19_M	23_M	1.276	0.99
8_C	31_M	1.276	0.99
175_K	206_H	1.272	0.99
438_L	445_K	1.267	0.99
326_S	330_T	1.260	0.99
138_E	143_I	1.259	0.99
74_T	106_V	1.257	0.99
48_Q	52_N	1.246	0.99
181_G	186_V	1.245	0.99
96_D	99_V	1.244	0.99
125_V	132_M	1.241	0.99
302_I	332_C	1.237	0.99
75_M	107_A	1.235	0.99
197_R	236_A	1.234	0.99
266_K	270_A	1.233	0.99
18_E	21_A	1.223	0.99
10_I	46_R	1.221	0.99
16_S	49_N	1.215	0.99
282_D	286_K	1.212	0.99
223_N	226_G	1.211	0.99
117_L	142_V	1.200	0.99
14_T	19_M	1.196	0.99
87_A	149_N	1.192	0.99
182_C	207_L	1.182	0.99
334_R	337_R	1.180	0.99
354_I	448_V	1.178	0.99
43_H	46_R	1.177	0.99
33_L	186_V	1.171	0.99
201_I	205_E	1.164	0.99
86_K	149_N	1.158	0.99
259_A	263_M	1.158	0.99
94_T	141_K	1.154	0.99
23_M	325_V	1.147	0.99
21_A	53_V	1.143	0.99
425_S	428_D	1.136	0.98
365_T	467_V	1.134	0.98
179_I	183_E	1.131	0.98
234_L	266_K	1.129	0.98
49_N	52_N	1.128	0.98
357_A	365_T	1.126	0.98
22_K	326_S	1.124	0.98
4_T	332_C	1.123	0.98
398_A	409_L	1.123	0.98
15_E	45_Q	1.121	0.98
197_R	201_I	1.119	0.98
183_E	210_H	1.119	0.98
111_E	114_T	1.118	0.98
83_V	152_L	1.116	0.98
264_I	306_T	1.104	0.98
47_I	180_F	1.101	0.98
24_L	59_K	1.092	0.98
40_Y	177_D	1.088	0.98
15_E	49_N	1.074	0.98
76_K	100_I	1.073	0.98
112_G	116_D	1.072	0.98
398_A	415_V	1.070	0.98
160_L	163_V	1.070	0.98
10_I	14_T	1.063	0.98
208_K	213_E	1.062	0.98
68_K	71_E	1.061	0.98
131_G	147_L	1.060	0.98
356_E	389_K	1.058	0.98
35_F	65_L	1.052	0.98
33_L	63_I	1.050	0.97
22_K	322_L	1.050	0.97
280_M	298_V	1.047	0.97
82_D	153_G	1.047	0.97
373_L	397_L	1.044	0.97
258_F	303_L	1.041	0.97
17_E	21_A	1.040	0.97
453_S	464_T	1.036	0.97
49_N	53_V	1.034	0.97
282_D	285_I	1.032	0.97
93_F	108_V	1.027	0.97
288_P	320_Y	1.026	0.97
55_S	403_E	1.026	0.97
50_L	63_I	1.023	0.97
14_T	23_M	1.021	0.97
207_L	213_E	1.017	0.97
146_V	149_N	1.015	0.97
179_I	209_A	1.012	0.97
385_R	412_S	1.011	0.97
376_V	387_V	1.008	0.97
132_M	146_V	0.999	0.97
202_E	205_E	0.999	0.97
187_D	407_H	0.998	0.97
135_T	143_I	0.997	0.97
197_R	229_N	0.995	0.97
282_D	313_G	0.994	0.96
298_V	331_I	0.993	0.96
195_R	225_E	0.990	0.96
295_A	331_I	0.989	0.96
114_T	137_I	0.987	0.96
10_I	50_L	0.986	0.96
253_V	295_A	0.979	0.96
86_K	103_S	0.978	0.96
90_T	136_A	0.977	0.96
170_L	175_K	0.974	0.96
4_T	302_I	0.971	0.96
360_R	364_E	0.965	0.96
388_R	412_S	0.959	0.96
102_N	105_M	0.954	0.96
125_V	144_C	0.951	0.95
76_K	154_E	0.951	0.95
178_L	203_I	0.947	0.95
237_S	240_I	0.946	0.95
453_S	456_L	0.943	0.95
64_L	190_A	0.941	0.95
122_T	147_L	0.941	0.95
30_V	308_A	0.938	0.95
204_R	238_D	0.937	0.95
48_Q	184_Q	0.936	0.95
71_E	223_N	0.933	0.95
372_P	444_H	0.931	0.95
207_L	215_I	0.930	0.95
47_I	186_V	0.930	0.95
172_E	175_K	0.928	0.95
7_V	308_A	0.924	0.95
175_K	205_E	0.921	0.95
87_A	319_K	0.921	0.95
160_L	165_I	0.919	0.95
42_E	45_Q	0.914	0.94
74_T	153_G	0.911	0.94
126_D	153_G	0.911	0.94
84_S	149_N	0.908	0.94
196_K	199_D	0.907	0.94
399_L	420_V	0.907	0.94
101_G	106_V	0.905	0.94
397_L	437_A	0.905	0.94
113_F	142_V	0.896	0.94
68_K	177_D	0.896	0.94
230_F	266_K	0.895	0.94
20_L	53_V	0.894	0.94
68_K	173_K	0.893	0.94
227_L	247_L	0.891	0.94
77_L	91_F	0.891	0.94
106_V	152_L	0.889	0.94
44_G	180_F	0.889	0.94
186_V	215_I	0.888	0.94
41_A	45_Q	0.886	0.93
110_Y	116_D	0.886	0.93
88_G	145_K	0.884	0.93
234_L	270_A	0.883	0.93
26_A	325_V	0.877	0.93
77_L	152_L	0.876	0.93
322_L	326_S	0.875	0.93
131_G	289_R	0.873	0.93
231_D	234_L	0.869	0.93
231_D	270_A	0.861	0.92
234_L	267_C	0.860	0.92
265_E	269_R	0.858	0.92
94_T	99_V	0.857	0.92
224_Q	255_E	0.857	0.92
358_V	452_V	0.855	0.92
320_Y	324_A	0.854	0.92
99_V	105_M	0.854	0.92
159_N	250_E	0.844	0.92
108_V	158_V	0.843	0.92
93_F	144_C	0.843	0.92
53_V	56_K	0.843	0.92
93_F	123_V	0.842	0.92
188_F	218_I	0.841	0.92
281_L	324_A	0.841	0.92
40_Y	44_G	0.828	0.91
77_L	153_G	0.828	0.91
26_A	322_L	0.826	0.91
232_E	235_E	0.823	0.91
434_K	449_V	0.821	0.91
126_D	282_D	0.820	0.90
456_L	463_N	0.819	0.90
79_G	83_V	0.818	0.90
93_F	106_V	0.818	0.90
65_L	71_E	0.817	0.90
52_N	55_S	0.814	0.90
298_V	309_V	0.814	0.90
264_I	274_V	0.813	0.90
57_T	60_T	0.811	0.90
200_V	237_S	0.811	0.90
62_A	188_F	0.809	0.90
24_L	57_T	0.808	0.90
121_N	134_V	0.803	0.90
258_F	335_T	0.798	0.89
373_L	443_A	0.798	0.89
60_T	417_P	0.794	0.89
360_R	368_K	0.793	0.89
230_F	262_M	0.792	0.89
178_L	206_H	0.792	0.89
36_S	177_D	0.792	0.89
20_L	50_L	0.788	0.89
71_E	157_G	0.786	0.89
182_C	189_V	0.784	0.88
135_T	144_C	0.783	0.88
303_L	338_V	0.781	0.88
10_I	33_L	0.780	0.88
430_Y	451_M	0.778	0.88
14_T	315_S	0.776	0.88
20_L	49_N	0.775	0.88
119_V	136_A	0.774	0.88
117_L	123_V	0.772	0.88
384_A	398_A	0.771	0.88
60_T	406_A	0.771	0.88
180_F	184_Q	0.771	0.88
234_L	263_M	0.768	0.87
179_I	206_H	0.768	0.87
127_D	157_G	0.768	0.87
87_A	145_K	0.768	0.87
126_D	157_G	0.767	0.87
359_C	387_V	0.766	0.87
92_T	105_M	0.765	0.87
112_G	166_A	0.764	0.87
218_I	411_L	0.763	0.87
403_E	419_L	0.763	0.87
98_S	111_E	0.761	0.87
405_T	409_L	0.761	0.87
74_T	158_V	0.759	0.87
14_T	322_L	0.758	0.87
126_D	313_G	0.757	0.87
362_A	366_A	0.755	0.86
437_A	443_A	0.754	0.86
78_E	103_S	0.754	0.86
404_K	408_Q	0.752	0.86
400_T	419_L	0.752	0.86
118_S	137_I	0.750	0.86
204_R	208_K	0.750	0.86
54_M	61_A	0.748	0.86
7_V	28_M	0.745	0.86
364_E	368_K	0.745	0.86
108_V	112_G	0.741	0.85
385_R	408_Q	0.740	0.85
382_K	386_A	0.739	0.85
127_D	279_Q	0.738	0.85
230_F	267_C	0.737	0.85
30_V	62_A	0.735	0.85
119_V	135_T	0.735	0.85
252_P	256_V	0.734	0.85
90_T	104_E	0.733	0.85
179_I	182_C	0.733	0.85
83_V	106_V	0.730	0.85
181_G	189_V	0.729	0.85
356_E	386_A	0.727	0.84
371_A	467_V	0.727	0.84
120_G	133_E	0.726	0.84
358_V	465_A	0.726	0.84
161_P	250_E	0.723	0.84
67_T	223_N	0.712	0.83
280_M	328_M	0.712	0.83
130_I	146_V	0.711	0.83
362_A	450_V	0.710	0.83
71_E	226_G	0.707	0.83
85_L	130_I	0.706	0.83
165_I	168_P	0.705	0.83
114_T	140_N	0.705	0.83
77_L	106_V	0.705	0.83
162_G	224_Q	0.704	0.82
35_F	177_D	0.700	0.82
430_Y	466_S	0.698	0.82
39_D	155_N	0.698	0.82
239_G	273_V	0.697	0.82
40_Y	176_Q	0.696	0.82
74_T	77_L	0.694	0.82
54_M	57_T	0.694	0.82
268_I	307_D	0.693	0.81
89_Q	104_E	0.692	0.81
50_L	54_M	0.690	0.81
24_L	54_M	0.689	0.81
21_A	52_N	0.687	0.81
334_R	338_V	0.686	0.81
231_D	262_M	0.685	0.81
24_L	50_L	0.684	0.81
403_E	407_H	0.684	0.81
355_T	382_K	0.684	0.81
366_A	374_I	0.684	0.81
378_T	384_A	0.683	0.80
33_L	43_H	0.682	0.80
182_C	213_E	0.680	0.80
375_V	443_A	0.679	0.80
376_V	383_S	0.679	0.80
62_A	407_H	0.678	0.80
280_M	309_V	0.678	0.80
258_F	338_V	0.678	0.80
248_G	289_R	0.678	0.80
379_Q	401_T	0.677	0.80
300_N	304_D	0.677	0.80
130_I	152_L	0.677	0.80
16_S	23_M	0.676	0.80
92_T	95_T	0.676	0.80
167_L	171_A	0.676	0.80
379_Q	402_N	0.674	0.80
10_I	31_M	0.673	0.80
153_G	317_K	0.670	0.79
273_V	411_L	0.667	0.79
369_L	448_V	0.666	0.79
221_I	227_L	0.665	0.79
15_E	20_L	0.664	0.79
402_N	405_T	0.663	0.78
235_E	272_K	0.661	0.78
89_Q	132_M	0.661	0.78
438_L	443_A	0.661	0.78
329_A	332_C	0.660	0.78
129_L	287_N	0.660	0.78
188_F	411_L	0.659	0.78
77_L	101_G	0.659	0.78
19_M	49_N	0.658	0.78
67_T	191_A	0.658	0.78
362_A	452_V	0.655	0.78
410_V	417_P	0.655	0.78
302_I	309_V	0.654	0.78
435_E	438_L	0.653	0.77
241_M	312_S	0.652	0.77
169_A	194_I	0.652	0.77
196_K	229_N	0.651	0.77
22_K	26_A	0.650	0.77
6_I	325_V	0.648	0.77
434_K	468_H	0.647	0.77
396_I	415_V	0.647	0.77
68_K	313_G	0.647	0.77
259_A	262_M	0.647	0.77
406_A	417_P	0.646	0.77
75_M	109_T	0.644	0.76
188_F	412_S	0.643	0.76
376_V	384_A	0.643	0.76
47_I	50_L	0.642	0.76
365_T	369_L	0.642	0.76
110_Y	195_R	0.639	0.76
203_I	217_I	0.639	0.76
35_F	43_H	0.638	0.76
451_M	468_H	0.637	0.76
110_Y	113_F	0.636	0.76
399_L	437_A	0.635	0.75
10_I	49_N	0.634	0.75
221_I	230_F	0.632	0.75
77_L	130_I	0.631	0.75
230_F	240_I	0.630	0.75
302_I	335_T	0.630	0.75
130_I	150_G	0.630	0.75
303_L	335_T	0.629	0.75
423_I	428_D	0.627	0.75
25_D	59_K	0.627	0.75
15_E	42_E	0.626	0.74
38_G	42_E	0.626	0.74
37_H	246_D	0.625	0.74
315_S	328_M	0.625	0.74
379_Q	422_E	0.625	0.74
317_K	324_A	0.624	0.74
91_F	102_N	0.624	0.74
452_V	462_T	0.624	0.74
362_A	374_I	0.622	0.74
117_L	134_V	0.622	0.74
92_T	140_N	0.621	0.74
303_L	339_M	0.620	0.74
450_V	467_V	0.620	0.74
6_I	328_M	0.619	0.74
226_G	234_L	0.618	0.73
258_F	334_R	0.618	0.73
261_K	300_N	0.616	0.73
216_H	385_R	0.615	0.73
391_F	413_K	0.614	0.73
116_D	195_R	0.614	0.73
203_I	206_H	0.614	0.73
43_H	181_G	0.614	0.73
34_N	37_H	0.613	0.73
10_I	15_E	0.612	0.73
87_A	320_Y	0.609	0.72
181_G	185_G	0.608	0.72
262_M	338_V	0.608	0.72
2_K	29_N	0.608	0.72
268_I	276_T	0.606	0.72
68_K	223_N	0.606	0.72
115_T	166_A	0.604	0.72
206_H	209_A	0.604	0.72
280_M	312_S	0.603	0.72
221_I	263_M	0.603	0.72
130_I	149_N	0.602	0.72
54_M	59_K	0.601	0.71
256_V	295_A	0.601	0.71
271_R	389_K	0.600	0.71
54_M	60_T	0.600	0.71
189_V	207_L	0.598	0.71
23_M	322_L	0.598	0.71
355_T	386_A	0.598	0.71
271_R	392_P	0.596	0.71
92_T	138_E	0.595	0.71
93_F	125_V	0.595	0.71
115_T	140_N	0.594	0.71
20_L	23_M	0.594	0.71
266_K	269_R	0.593	0.70
354_I	376_V	0.593	0.70
363_V	392_P	0.591	0.70
281_L	327_I	0.590	0.70
185_G	215_I	0.587	0.70
327_I	331_I	0.587	0.70
91_F	107_A	0.587	0.70
454_G	462_T	0.586	0.70
353_R	356_E	0.586	0.70
444_H	447_D	0.583	0.69
85_L	89_Q	0.581	0.69
91_F	146_V	0.581	0.69
30_V	410_V	0.578	0.68
71_E	167_L	0.578	0.68
25_D	56_K	0.577	0.68
366_A	371_A	0.577	0.68
383_S	454_G	0.576	0.68
373_L	395_T	0.575	0.68
152_L	155_N	0.575	0.68
344_E	347_N	0.574	0.68
377_A	429_F	0.574	0.68
367_E	393_D	0.573	0.68
91_F	101_G	0.571	0.68
241_M	310_M	0.571	0.68
339_M	344_E	0.570	0.67
208_K	214_N	0.570	0.67
10_I	28_M	0.570	0.67
50_L	61_A	0.570	0.67
46_R	49_N	0.569	0.67
23_M	31_M	0.566	0.67
384_A	417_P	0.566	0.67
423_I	429_F	0.566	0.67
416_V	442_L	0.565	0.67
2_K	6_I	0.565	0.67
241_M	277_A	0.565	0.67
369_L	450_V	0.565	0.67
193_F	250_E	0.564	0.67
74_T	93_F	0.563	0.66
341_S	345_F	0.563	0.66
423_I	432_L	0.562	0.66
33_L	38_G	0.562	0.66
6_I	329_A	0.562	0.66
206_H	210_H	0.561	0.66
353_R	386_A	0.560	0.66
170_L	206_H	0.560	0.66
169_A	195_R	0.560	0.66
207_L	216_H	0.560	0.66
2_K	296_G	0.559	0.66
167_L	194_I	0.558	0.66
10_I	16_S	0.558	0.66
434_K	443_A	0.558	0.66
387_V	452_V	0.556	0.66
196_K	232_E	0.556	0.66
273_V	307_D	0.556	0.66
308_A	411_L	0.555	0.65
72_I	173_K	0.555	0.65
193_F	246_D	0.555	0.65
454_G	460_G	0.554	0.65
151_D	286_K	0.553	0.65
94_T	114_T	0.552	0.65
197_R	221_I	0.552	0.65
238_D	272_K	0.552	0.65
275_I	310_M	0.551	0.65
253_V	296_G	0.551	0.65
315_S	324_A	0.550	0.65
205_E	208_K	0.550	0.65
280_M	306_T	0.549	0.65
65_L	180_F	0.548	0.64
72_I	158_V	0.548	0.64
194_I	219_S	0.547	0.64
257_I	413_K	0.547	0.64
362_A	371_A	0.547	0.64
188_F	216_H	0.547	0.64
126_D	156_K	0.546	0.64
125_V	130_I	0.545	0.64
74_T	152_L	0.545	0.64
99_V	107_A	0.544	0.64
202_E	206_H	0.543	0.64
47_I	51_R	0.541	0.63
114_T	139_G	0.541	0.63
170_L	178_L	0.540	0.63
198_S	232_E	0.539	0.63
121_N	162_G	0.538	0.63
455_A	466_S	0.537	0.63
175_K	209_A	0.537	0.63
23_M	28_M	0.535	0.63
82_D	154_E	0.535	0.63
246_D	277_A	0.535	0.63
29_N	410_V	0.534	0.62
208_K	217_I	0.533	0.62
54_M	407_H	0.532	0.62
93_F	113_F	0.532	0.62
191_A	194_I	0.531	0.62
392_P	396_I	0.531	0.62
375_V	399_L	0.531	0.62
398_A	417_P	0.530	0.62
90_T	133_E	0.528	0.62
405_T	454_G	0.527	0.61
221_I	239_G	0.527	0.61
44_G	47_I	0.527	0.61
170_L	203_I	0.526	0.61
89_Q	149_N	0.526	0.61
198_S	205_E	0.525	0.61
127_D	316_A	0.524	0.61
426_T	464_T	0.524	0.61
258_F	295_A	0.523	0.61
36_S	65_L	0.523	0.61
85_L	125_V	0.523	0.61
14_T	317_K	0.522	0.61
159_N	171_A	0.522	0.61
101_G	107_A	0.522	0.61
323_E	327_I	0.521	0.61
124_L	190_A	0.521	0.61
399_L	418_Q	0.520	0.60
189_V	213_E	0.520	0.60
67_T	157_G	0.520	0.60
137_I	140_N	0.520	0.60
397_L	442_L	0.519	0.60
74_T	156_K	0.519	0.60
450_V	465_A	0.519	0.60
91_F	103_S	0.518	0.60
299_A	303_L	0.518	0.60
460_G	463_N	0.517	0.60
16_S	20_L	0.516	0.60
262_M	265_E	0.516	0.60
91_F	153_G	0.515	0.60
188_F	308_A	0.515	0.60
193_F	241_M	0.514	0.60
64_L	188_F	0.514	0.60
327_I	330_T	0.514	0.60
309_V	329_A	0.514	0.60
157_G	249_V	0.514	0.60
95_T	139_G	0.514	0.60
386_A	430_Y	0.513	0.59
79_G	82_D	0.513	0.59
126_D	195_R	0.512	0.59
257_I	296_G	0.512	0.59
35_F	186_V	0.510	0.59
127_D	246_D	0.510	0.59
201_I	208_K	0.509	0.59
110_Y	114_T	0.509	0.59
18_E	22_K	0.508	0.59
168_P	202_E	0.507	0.58
381_G	398_A	0.505	0.58
85_L	152_L	0.505	0.58
204_R	236_A	0.505	0.58
219_S	240_I	0.505	0.58
287_N	319_K	0.505	0.58
210_H	215_I	0.505	0.58
122_T	162_G	0.504	0.58
157_G	250_E	0.504	0.58
318_G	321_P	0.503	0.58
53_V	58_G	0.503	0.58
255_E	330_T	0.503	0.58
240_I	270_A	0.503	0.58
39_D	76_K	0.503	0.58
239_G	411_L	0.502	0.58
101_G	105_M	0.502	0.58
15_E	18_E	0.501	0.58
131_G	148_N	0.501	0.58
23_M	315_S	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3gr4A	4	0.9979	100	0.132	Contact Map
2e28A	3	0.9957	100	0.134	Contact Map
1a3wA	3	0.9936	100	0.135	Contact Map
3t05A	3	0.9915	100	0.136	Contact Map
1e0tA	3	0.9489	100	0.138	Contact Map
3gg8A	3	0.9936	100	0.139	Contact Map
3khdA	3	0.9957	100	0.142	Contact Map
4kctB	3	0.9957	100	0.159	Contact Map
4drsA	3	0.9809	100	0.172	Contact Map
3qtgA	3	0.9447	100	0.182	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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