GREMLIN Database
KPYK1 - Pyruvate kinase I
UniProt: P0AD61 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10804
Length: 470 (464)
Sequences: 4162 (2383)
Seq/√Len: 110.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_T145_K4.3541.00
21_A56_K4.3221.00
219_S237_S4.3211.00
231_D266_K4.0871.00
44_G48_Q3.4111.00
17_E52_N3.3931.00
230_F263_M3.3811.00
133_E145_K3.1711.00
201_I236_A3.1651.00
8_C28_M3.0861.00
65_L181_G2.9851.00
78_E102_N2.9641.00
227_L259_A2.8851.00
200_V219_S2.8281.00
276_T306_T2.8011.00
255_E334_R2.8001.00
28_M31_M2.7611.00
204_R217_I2.7221.00
133_E147_L2.7141.00
62_A410_V2.7031.00
136_A143_I2.6191.00
19_M22_K2.5771.00
16_S19_M2.5421.00
90_T143_I2.5261.00
44_G184_Q2.4731.00
86_K89_Q2.4191.00
76_K155_N2.4191.00
90_T135_T2.3531.00
42_E46_R2.2911.00
91_F106_V2.2821.00
200_V217_I2.2781.00
254_E330_T2.2681.00
235_E270_A2.2261.00
15_E46_R2.2201.00
24_L61_A2.1841.00
400_T406_A2.1811.00
198_S202_E2.1401.00
286_K319_K2.1331.00
25_D57_T2.1261.00
372_P447_D2.1141.00
178_L189_V2.0861.00
78_E100_I2.0861.00
47_I184_Q2.0781.00
251_I259_A2.0361.00
218_I239_G2.0341.00
261_K304_D2.0191.00
112_G115_T2.0071.00
125_V152_L1.9971.00
89_Q103_S1.9561.00
309_V332_C1.9541.00
17_E49_N1.9461.00
329_A333_E1.9381.00
205_E209_A1.8931.00
96_D140_N1.8791.00
185_G404_K1.8601.00
90_T145_K1.8551.00
19_M322_L1.8511.00
179_I210_H1.8441.00
80_G154_E1.8321.00
82_D151_D1.8221.00
182_C215_I1.8081.00
85_L146_V1.8051.00
216_H408_Q1.7981.00
105_M141_K1.7751.00
264_I276_T1.7621.00
119_V137_I1.7581.00
47_I63_I1.7521.00
230_F234_L1.7471.00
122_T131_G1.7371.00
51_R54_M1.7321.00
175_K179_I1.7301.00
375_V449_V1.7261.00
21_A25_D1.7241.00
172_E176_Q1.7151.00
33_L47_I1.7121.00
93_F132_M1.7111.00
435_E439_Q1.7101.00
198_S201_I1.7081.00
132_M144_C1.6991.00
84_S151_D1.6961.00
92_T143_I1.6811.00
365_T465_A1.6791.00
116_D166_A1.6781.00
197_R232_E1.6751.00
91_F144_C1.6551.00
406_A419_L1.6541.00
17_E56_K1.6511.00
191_A203_I1.6441.00
10_I20_L1.6361.00
173_K177_D1.6321.00
67_T71_E1.6191.00
224_Q228_N1.6101.00
138_E141_K1.6061.00
29_N59_K1.6021.00
7_V275_I1.6021.00
41_A44_G1.6001.00
240_I263_M1.5961.00
164_S225_E1.5861.00
89_Q146_V1.5851.00
262_M266_K1.5821.00
52_N56_K1.5701.00
22_K25_D1.5641.00
83_V103_S1.5591.00
96_D105_M1.5431.00
24_L53_V1.5401.00
323_E326_S1.5401.00
30_V64_L1.5311.00
92_T141_K1.5221.00
175_K202_E1.5001.00
7_V30_V1.4941.00
118_S121_N1.4931.00
31_M50_L1.4851.00
122_T133_E1.4831.00
218_I275_I1.4741.00
17_E53_V1.4661.00
65_L186_V1.4611.00
320_Y323_E1.4521.00
436_L439_Q1.4431.00
95_T114_T1.4381.00
2_K329_A1.4331.00
77_L154_E1.4191.00
21_A57_T1.4151.00
45_Q48_Q1.3991.00
96_D141_K1.3981.00
229_N232_E1.3881.00
94_T105_M1.3831.00
38_G43_H1.3831.00
409_L412_S1.3831.00
285_I313_G1.3741.00
176_Q179_I1.3691.00
114_T142_V1.3671.00
44_G183_E1.3571.00
256_V296_G1.3521.00
63_I186_V1.3501.00
371_A450_V1.3481.00
40_Y180_F1.3431.00
253_V327_I1.3401.00
436_L440_S1.3301.00
26_A326_S1.3180.99
137_I142_V1.3180.99
45_Q49_N1.3180.99
53_V57_T1.3160.99
182_C210_H1.3140.99
39_D42_E1.3110.99
214_N404_K1.2960.99
121_N163_V1.2940.99
33_L50_L1.2930.99
126_D129_L1.2840.99
378_T398_A1.2790.99
74_T130_I1.2790.99
19_M23_M1.2760.99
8_C31_M1.2760.99
175_K206_H1.2720.99
438_L445_K1.2670.99
326_S330_T1.2600.99
138_E143_I1.2590.99
74_T106_V1.2570.99
48_Q52_N1.2460.99
181_G186_V1.2450.99
96_D99_V1.2440.99
125_V132_M1.2410.99
302_I332_C1.2370.99
75_M107_A1.2350.99
197_R236_A1.2340.99
266_K270_A1.2330.99
18_E21_A1.2230.99
10_I46_R1.2210.99
16_S49_N1.2150.99
282_D286_K1.2120.99
223_N226_G1.2110.99
117_L142_V1.2000.99
14_T19_M1.1960.99
87_A149_N1.1920.99
182_C207_L1.1820.99
334_R337_R1.1800.99
354_I448_V1.1780.99
43_H46_R1.1770.99
33_L186_V1.1710.99
201_I205_E1.1640.99
86_K149_N1.1580.99
259_A263_M1.1580.99
94_T141_K1.1540.99
23_M325_V1.1470.99
21_A53_V1.1430.99
425_S428_D1.1360.98
365_T467_V1.1340.98
179_I183_E1.1310.98
234_L266_K1.1290.98
49_N52_N1.1280.98
357_A365_T1.1260.98
22_K326_S1.1240.98
4_T332_C1.1230.98
398_A409_L1.1230.98
15_E45_Q1.1210.98
197_R201_I1.1190.98
183_E210_H1.1190.98
111_E114_T1.1180.98
83_V152_L1.1160.98
264_I306_T1.1040.98
47_I180_F1.1010.98
24_L59_K1.0920.98
40_Y177_D1.0880.98
15_E49_N1.0740.98
76_K100_I1.0730.98
112_G116_D1.0720.98
398_A415_V1.0700.98
160_L163_V1.0700.98
10_I14_T1.0630.98
208_K213_E1.0620.98
68_K71_E1.0610.98
131_G147_L1.0600.98
356_E389_K1.0580.98
35_F65_L1.0520.98
33_L63_I1.0500.97
22_K322_L1.0500.97
280_M298_V1.0470.97
82_D153_G1.0470.97
373_L397_L1.0440.97
258_F303_L1.0410.97
17_E21_A1.0400.97
453_S464_T1.0360.97
49_N53_V1.0340.97
282_D285_I1.0320.97
93_F108_V1.0270.97
288_P320_Y1.0260.97
55_S403_E1.0260.97
50_L63_I1.0230.97
14_T23_M1.0210.97
207_L213_E1.0170.97
146_V149_N1.0150.97
179_I209_A1.0120.97
385_R412_S1.0110.97
376_V387_V1.0080.97
132_M146_V0.9990.97
202_E205_E0.9990.97
187_D407_H0.9980.97
135_T143_I0.9970.97
197_R229_N0.9950.97
282_D313_G0.9940.96
298_V331_I0.9930.96
195_R225_E0.9900.96
295_A331_I0.9890.96
114_T137_I0.9870.96
10_I50_L0.9860.96
253_V295_A0.9790.96
86_K103_S0.9780.96
90_T136_A0.9770.96
170_L175_K0.9740.96
4_T302_I0.9710.96
360_R364_E0.9650.96
388_R412_S0.9590.96
102_N105_M0.9540.96
125_V144_C0.9510.95
76_K154_E0.9510.95
178_L203_I0.9470.95
237_S240_I0.9460.95
453_S456_L0.9430.95
64_L190_A0.9410.95
122_T147_L0.9410.95
30_V308_A0.9380.95
204_R238_D0.9370.95
48_Q184_Q0.9360.95
71_E223_N0.9330.95
372_P444_H0.9310.95
207_L215_I0.9300.95
47_I186_V0.9300.95
172_E175_K0.9280.95
7_V308_A0.9240.95
175_K205_E0.9210.95
87_A319_K0.9210.95
160_L165_I0.9190.95
42_E45_Q0.9140.94
74_T153_G0.9110.94
126_D153_G0.9110.94
84_S149_N0.9080.94
196_K199_D0.9070.94
399_L420_V0.9070.94
101_G106_V0.9050.94
397_L437_A0.9050.94
113_F142_V0.8960.94
68_K177_D0.8960.94
230_F266_K0.8950.94
20_L53_V0.8940.94
68_K173_K0.8930.94
227_L247_L0.8910.94
77_L91_F0.8910.94
106_V152_L0.8890.94
44_G180_F0.8890.94
186_V215_I0.8880.94
41_A45_Q0.8860.93
110_Y116_D0.8860.93
88_G145_K0.8840.93
234_L270_A0.8830.93
26_A325_V0.8770.93
77_L152_L0.8760.93
322_L326_S0.8750.93
131_G289_R0.8730.93
231_D234_L0.8690.93
231_D270_A0.8610.92
234_L267_C0.8600.92
265_E269_R0.8580.92
94_T99_V0.8570.92
224_Q255_E0.8570.92
358_V452_V0.8550.92
320_Y324_A0.8540.92
99_V105_M0.8540.92
159_N250_E0.8440.92
108_V158_V0.8430.92
93_F144_C0.8430.92
53_V56_K0.8430.92
93_F123_V0.8420.92
188_F218_I0.8410.92
281_L324_A0.8410.92
40_Y44_G0.8280.91
77_L153_G0.8280.91
26_A322_L0.8260.91
232_E235_E0.8230.91
434_K449_V0.8210.91
126_D282_D0.8200.90
456_L463_N0.8190.90
79_G83_V0.8180.90
93_F106_V0.8180.90
65_L71_E0.8170.90
52_N55_S0.8140.90
298_V309_V0.8140.90
264_I274_V0.8130.90
57_T60_T0.8110.90
200_V237_S0.8110.90
62_A188_F0.8090.90
24_L57_T0.8080.90
121_N134_V0.8030.90
258_F335_T0.7980.89
373_L443_A0.7980.89
60_T417_P0.7940.89
360_R368_K0.7930.89
230_F262_M0.7920.89
178_L206_H0.7920.89
36_S177_D0.7920.89
20_L50_L0.7880.89
71_E157_G0.7860.89
182_C189_V0.7840.88
135_T144_C0.7830.88
303_L338_V0.7810.88
10_I33_L0.7800.88
430_Y451_M0.7780.88
14_T315_S0.7760.88
20_L49_N0.7750.88
119_V136_A0.7740.88
117_L123_V0.7720.88
384_A398_A0.7710.88
60_T406_A0.7710.88
180_F184_Q0.7710.88
234_L263_M0.7680.87
179_I206_H0.7680.87
127_D157_G0.7680.87
87_A145_K0.7680.87
126_D157_G0.7670.87
359_C387_V0.7660.87
92_T105_M0.7650.87
112_G166_A0.7640.87
218_I411_L0.7630.87
403_E419_L0.7630.87
98_S111_E0.7610.87
405_T409_L0.7610.87
74_T158_V0.7590.87
14_T322_L0.7580.87
126_D313_G0.7570.87
362_A366_A0.7550.86
437_A443_A0.7540.86
78_E103_S0.7540.86
404_K408_Q0.7520.86
400_T419_L0.7520.86
118_S137_I0.7500.86
204_R208_K0.7500.86
54_M61_A0.7480.86
7_V28_M0.7450.86
364_E368_K0.7450.86
108_V112_G0.7410.85
385_R408_Q0.7400.85
382_K386_A0.7390.85
127_D279_Q0.7380.85
230_F267_C0.7370.85
30_V62_A0.7350.85
119_V135_T0.7350.85
252_P256_V0.7340.85
90_T104_E0.7330.85
179_I182_C0.7330.85
83_V106_V0.7300.85
181_G189_V0.7290.85
356_E386_A0.7270.84
371_A467_V0.7270.84
120_G133_E0.7260.84
358_V465_A0.7260.84
161_P250_E0.7230.84
67_T223_N0.7120.83
280_M328_M0.7120.83
130_I146_V0.7110.83
362_A450_V0.7100.83
71_E226_G0.7070.83
85_L130_I0.7060.83
165_I168_P0.7050.83
114_T140_N0.7050.83
77_L106_V0.7050.83
162_G224_Q0.7040.82
35_F177_D0.7000.82
430_Y466_S0.6980.82
39_D155_N0.6980.82
239_G273_V0.6970.82
40_Y176_Q0.6960.82
74_T77_L0.6940.82
54_M57_T0.6940.82
268_I307_D0.6930.81
89_Q104_E0.6920.81
50_L54_M0.6900.81
24_L54_M0.6890.81
21_A52_N0.6870.81
334_R338_V0.6860.81
231_D262_M0.6850.81
24_L50_L0.6840.81
403_E407_H0.6840.81
355_T382_K0.6840.81
366_A374_I0.6840.81
378_T384_A0.6830.80
33_L43_H0.6820.80
182_C213_E0.6800.80
375_V443_A0.6790.80
376_V383_S0.6790.80
62_A407_H0.6780.80
280_M309_V0.6780.80
258_F338_V0.6780.80
248_G289_R0.6780.80
379_Q401_T0.6770.80
300_N304_D0.6770.80
130_I152_L0.6770.80
16_S23_M0.6760.80
92_T95_T0.6760.80
167_L171_A0.6760.80
379_Q402_N0.6740.80
10_I31_M0.6730.80
153_G317_K0.6700.79
273_V411_L0.6670.79
369_L448_V0.6660.79
221_I227_L0.6650.79
15_E20_L0.6640.79
402_N405_T0.6630.78
235_E272_K0.6610.78
89_Q132_M0.6610.78
438_L443_A0.6610.78
329_A332_C0.6600.78
129_L287_N0.6600.78
188_F411_L0.6590.78
77_L101_G0.6590.78
19_M49_N0.6580.78
67_T191_A0.6580.78
362_A452_V0.6550.78
410_V417_P0.6550.78
302_I309_V0.6540.78
435_E438_L0.6530.77
241_M312_S0.6520.77
169_A194_I0.6520.77
196_K229_N0.6510.77
22_K26_A0.6500.77
6_I325_V0.6480.77
434_K468_H0.6470.77
396_I415_V0.6470.77
68_K313_G0.6470.77
259_A262_M0.6470.77
406_A417_P0.6460.77
75_M109_T0.6440.76
188_F412_S0.6430.76
376_V384_A0.6430.76
47_I50_L0.6420.76
365_T369_L0.6420.76
110_Y195_R0.6390.76
203_I217_I0.6390.76
35_F43_H0.6380.76
451_M468_H0.6370.76
110_Y113_F0.6360.76
399_L437_A0.6350.75
10_I49_N0.6340.75
221_I230_F0.6320.75
77_L130_I0.6310.75
230_F240_I0.6300.75
302_I335_T0.6300.75
130_I150_G0.6300.75
303_L335_T0.6290.75
423_I428_D0.6270.75
25_D59_K0.6270.75
15_E42_E0.6260.74
38_G42_E0.6260.74
37_H246_D0.6250.74
315_S328_M0.6250.74
379_Q422_E0.6250.74
317_K324_A0.6240.74
91_F102_N0.6240.74
452_V462_T0.6240.74
362_A374_I0.6220.74
117_L134_V0.6220.74
92_T140_N0.6210.74
303_L339_M0.6200.74
450_V467_V0.6200.74
6_I328_M0.6190.74
226_G234_L0.6180.73
258_F334_R0.6180.73
261_K300_N0.6160.73
216_H385_R0.6150.73
391_F413_K0.6140.73
116_D195_R0.6140.73
203_I206_H0.6140.73
43_H181_G0.6140.73
34_N37_H0.6130.73
10_I15_E0.6120.73
87_A320_Y0.6090.72
181_G185_G0.6080.72
262_M338_V0.6080.72
2_K29_N0.6080.72
268_I276_T0.6060.72
68_K223_N0.6060.72
115_T166_A0.6040.72
206_H209_A0.6040.72
280_M312_S0.6030.72
221_I263_M0.6030.72
130_I149_N0.6020.72
54_M59_K0.6010.71
256_V295_A0.6010.71
271_R389_K0.6000.71
54_M60_T0.6000.71
189_V207_L0.5980.71
23_M322_L0.5980.71
355_T386_A0.5980.71
271_R392_P0.5960.71
92_T138_E0.5950.71
93_F125_V0.5950.71
115_T140_N0.5940.71
20_L23_M0.5940.71
266_K269_R0.5930.70
354_I376_V0.5930.70
363_V392_P0.5910.70
281_L327_I0.5900.70
185_G215_I0.5870.70
327_I331_I0.5870.70
91_F107_A0.5870.70
454_G462_T0.5860.70
353_R356_E0.5860.70
444_H447_D0.5830.69
85_L89_Q0.5810.69
91_F146_V0.5810.69
30_V410_V0.5780.68
71_E167_L0.5780.68
25_D56_K0.5770.68
366_A371_A0.5770.68
383_S454_G0.5760.68
373_L395_T0.5750.68
152_L155_N0.5750.68
344_E347_N0.5740.68
377_A429_F0.5740.68
367_E393_D0.5730.68
91_F101_G0.5710.68
241_M310_M0.5710.68
339_M344_E0.5700.67
208_K214_N0.5700.67
10_I28_M0.5700.67
50_L61_A0.5700.67
46_R49_N0.5690.67
23_M31_M0.5660.67
384_A417_P0.5660.67
423_I429_F0.5660.67
416_V442_L0.5650.67
2_K6_I0.5650.67
241_M277_A0.5650.67
369_L450_V0.5650.67
193_F250_E0.5640.67
74_T93_F0.5630.66
341_S345_F0.5630.66
423_I432_L0.5620.66
33_L38_G0.5620.66
6_I329_A0.5620.66
206_H210_H0.5610.66
353_R386_A0.5600.66
170_L206_H0.5600.66
169_A195_R0.5600.66
207_L216_H0.5600.66
2_K296_G0.5590.66
167_L194_I0.5580.66
10_I16_S0.5580.66
434_K443_A0.5580.66
387_V452_V0.5560.66
196_K232_E0.5560.66
273_V307_D0.5560.66
308_A411_L0.5550.65
72_I173_K0.5550.65
193_F246_D0.5550.65
454_G460_G0.5540.65
151_D286_K0.5530.65
94_T114_T0.5520.65
197_R221_I0.5520.65
238_D272_K0.5520.65
275_I310_M0.5510.65
253_V296_G0.5510.65
315_S324_A0.5500.65
205_E208_K0.5500.65
280_M306_T0.5490.65
65_L180_F0.5480.64
72_I158_V0.5480.64
194_I219_S0.5470.64
257_I413_K0.5470.64
362_A371_A0.5470.64
188_F216_H0.5470.64
126_D156_K0.5460.64
125_V130_I0.5450.64
74_T152_L0.5450.64
99_V107_A0.5440.64
202_E206_H0.5430.64
47_I51_R0.5410.63
114_T139_G0.5410.63
170_L178_L0.5400.63
198_S232_E0.5390.63
121_N162_G0.5380.63
455_A466_S0.5370.63
175_K209_A0.5370.63
23_M28_M0.5350.63
82_D154_E0.5350.63
246_D277_A0.5350.63
29_N410_V0.5340.62
208_K217_I0.5330.62
54_M407_H0.5320.62
93_F113_F0.5320.62
191_A194_I0.5310.62
392_P396_I0.5310.62
375_V399_L0.5310.62
398_A417_P0.5300.62
90_T133_E0.5280.62
405_T454_G0.5270.61
221_I239_G0.5270.61
44_G47_I0.5270.61
170_L203_I0.5260.61
89_Q149_N0.5260.61
198_S205_E0.5250.61
127_D316_A0.5240.61
426_T464_T0.5240.61
258_F295_A0.5230.61
36_S65_L0.5230.61
85_L125_V0.5230.61
14_T317_K0.5220.61
159_N171_A0.5220.61
101_G107_A0.5220.61
323_E327_I0.5210.61
124_L190_A0.5210.61
399_L418_Q0.5200.60
189_V213_E0.5200.60
67_T157_G0.5200.60
137_I140_N0.5200.60
397_L442_L0.5190.60
74_T156_K0.5190.60
450_V465_A0.5190.60
91_F103_S0.5180.60
299_A303_L0.5180.60
460_G463_N0.5170.60
16_S20_L0.5160.60
262_M265_E0.5160.60
91_F153_G0.5150.60
188_F308_A0.5150.60
193_F241_M0.5140.60
64_L188_F0.5140.60
327_I330_T0.5140.60
309_V329_A0.5140.60
157_G249_V0.5140.60
95_T139_G0.5140.60
386_A430_Y0.5130.59
79_G82_D0.5130.59
126_D195_R0.5120.59
257_I296_G0.5120.59
35_F186_V0.5100.59
127_D246_D0.5100.59
201_I208_K0.5090.59
110_Y114_T0.5090.59
18_E22_K0.5080.59
168_P202_E0.5070.58
381_G398_A0.5050.58
85_L152_L0.5050.58
204_R236_A0.5050.58
219_S240_I0.5050.58
287_N319_K0.5050.58
210_H215_I0.5050.58
122_T162_G0.5040.58
157_G250_E0.5040.58
318_G321_P0.5030.58
53_V58_G0.5030.58
255_E330_T0.5030.58
240_I270_A0.5030.58
39_D76_K0.5030.58
239_G411_L0.5020.58
101_G105_M0.5020.58
15_E18_E0.5010.58
131_G148_N0.5010.58
23_M315_S0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gr4A 4 0.9979 100 0.132 Contact Map
2e28A 3 0.9957 100 0.134 Contact Map
1a3wA 3 0.9936 100 0.135 Contact Map
3t05A 3 0.9915 100 0.136 Contact Map
1e0tA 3 0.9489 100 0.138 Contact Map
3gg8A 3 0.9936 100 0.139 Contact Map
3khdA 3 0.9957 100 0.142 Contact Map
4kctB 3 0.9957 100 0.159 Contact Map
4drsA 3 0.9809 100 0.172 Contact Map
3qtgA 3 0.9447 100 0.182 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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