GREMLIN Database
ISPB - Octaprenyl-diphosphate synthase
UniProt: P0AD57 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10017
Length: 323 (295)
Sequences: 9677 (6479)
Seq/√Len: 377.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_A66_H3.4281.00
180_Q197_Q3.0721.00
189_T192_E2.9901.00
91_D101_A2.9501.00
176_E197_Q2.7821.00
202_Y294_K2.5941.00
159_T162_N2.4871.00
246_H283_W2.4751.00
273_E277_A2.4681.00
180_Q193_E2.4631.00
134_V180_Q2.4421.00
168_Y201_R2.4241.00
202_Y291_E2.3791.00
254_M270_P2.3341.00
176_E201_R2.3121.00
287_R290_E2.2391.00
219_D222_Q2.2291.00
134_V184_I2.2281.00
92_M97_A2.2131.00
226_N229_D2.1371.00
242_H283_W2.1121.00
118_R121_Q2.0851.00
87_V146_E2.0221.00
55_A196_L2.0121.00
183_G196_L1.9841.00
131_V181_C1.9811.00
279_G282_E1.9541.00
130_K193_E1.9491.00
242_H280_S1.9361.00
55_A179_A1.8911.00
198_D298_A1.8661.00
293_D297_A1.8441.00
59_V192_E1.8431.00
179_A200_G1.8321.00
104_G107_A1.8171.00
165_R169_S1.8141.00
251_Q277_A1.8001.00
20_A71_A1.7871.00
194_K198_D1.7311.00
13_D57_R1.7311.00
213_L284_T1.7131.00
253_Q257_T1.7061.00
20_A68_T1.7031.00
252_A256_R1.6601.00
18_N21_I1.6301.00
20_A23_E1.6261.00
83_H113_D1.6061.00
282_E286_Q1.5971.00
254_M257_T1.5891.00
198_D202_Y1.5741.00
248_T251_Q1.5681.00
290_E294_K1.5581.00
121_Q137_E1.5551.00
297_A300_Q1.5461.00
83_H112_G1.5441.00
250_E253_Q1.5301.00
160_E242_H1.5301.00
68_T125_S1.5141.00
289_E293_D1.5131.00
124_T132_L1.5061.00
130_K190_P1.4951.00
37_Y41_S1.4851.00
183_G188_C1.4711.00
155_D162_N1.4681.00
276_N281_L1.4651.00
218_A223_L1.4591.00
188_C192_E1.4571.00
82_L99_A1.4511.00
130_K133_E1.4491.00
107_A147_V1.4491.00
22_L37_Y1.4451.00
282_E285_R1.4421.00
177_A181_C1.4281.00
56_A61_Y1.4241.00
270_P273_E1.4211.00
148_L165_R1.4001.00
90_S229_D1.3881.00
190_P194_K1.3781.00
286_Q290_E1.3701.00
55_A59_V1.3681.00
54_L57_R1.3661.00
229_D233_E1.3631.00
125_S133_E1.3521.00
182_S186_A1.3511.00
18_N46_R1.3471.00
146_E149_Q1.3451.00
176_E180_Q1.3381.00
80_T142_I1.3171.00
209_L284_T1.3161.00
287_R291_E1.2971.00
286_Q289_E1.2931.00
17_V21_I1.2881.00
242_H246_H1.2871.00
86_V105_N1.2761.00
163_Y167_I1.2491.00
19_A23_E1.2461.00
275_M280_S1.2331.00
15_A18_N1.2291.00
292_A296_I1.2271.00
298_A301_V1.2251.00
243_A275_M1.2221.00
133_E137_E1.2161.00
213_L281_L1.2141.00
220_G226_N1.2071.00
53_V70_A1.2051.00
213_L285_R1.2021.00
220_G227_V1.1981.00
75_F122_M1.1941.00
174_L178_A1.1871.00
242_H245_H1.1851.00
42_G96_K1.1821.00
59_V186_A1.1751.00
168_Y205_T1.1721.00
59_V182_S1.1641.00
195_G301_V1.1631.00
130_K184_I1.1581.00
165_R168_Y1.1531.00
245_H283_W1.1351.00
173_R176_E1.1341.00
270_P274_A1.1311.00
38_Y102_A1.1301.00
214_L223_L1.1301.00
148_L169_S1.1301.00
14_M18_N1.1251.00
152_N166_V1.1221.00
183_G193_E1.1201.00
272_L276_N1.1161.00
134_V177_A1.1051.00
31_L104_G1.1031.00
205_T291_E1.0941.00
148_L166_V1.0931.00
160_E287_R1.0911.00
283_W286_Q1.0911.00
138_A177_A1.0881.00
72_L123_M1.0761.00
31_L151_M1.0741.00
69_I131_V1.0721.00
191_E195_G1.0661.00
131_V185_L1.0641.00
192_E195_G1.0631.00
167_I205_T1.0591.00
199_Y299_L1.0561.00
30_Q34_Q1.0531.00
246_H249_P1.0491.00
52_A73_I1.0491.00
249_P252_A1.0471.00
35_L99_A1.0401.00
217_N248_T1.0401.00
179_A196_L1.0391.00
152_N158_I1.0381.00
69_I181_C1.0371.00
11_A15_A1.0351.00
53_V67_V1.0331.00
33_N37_Y1.0321.00
202_Y298_A1.0291.00
141_V169_S1.0241.00
51_I179_A1.0221.00
247_G278_C1.0201.00
19_A22_L1.0151.00
243_A280_S1.0121.00
213_L217_N1.0101.00
12_Q15_A1.0011.00
269_E273_E0.9901.00
97_A101_A0.9761.00
39_I99_A0.9741.00
69_I123_M0.9741.00
280_S283_W0.9731.00
123_M131_V0.9711.00
160_E245_H0.9681.00
160_E164_M0.9641.00
22_L41_S0.9581.00
43_G46_R0.9571.00
291_E294_K0.9551.00
31_L34_Q0.9541.00
16_G67_V0.9541.00
56_A186_A0.9531.00
164_M205_T0.9471.00
87_V110_L0.9441.00
121_Q140_N0.9411.00
89_E105_N0.9401.00
20_A24_Q0.9381.00
163_Y241_L0.9361.00
232_N265_R0.9301.00
179_A199_Y0.9301.00
160_E283_W0.9281.00
210_I288_A0.9281.00
59_V188_C0.9221.00
53_V66_H0.9201.00
180_Q184_I0.9201.00
293_D296_I0.9141.00
100_N105_N0.9141.00
195_G298_A0.9131.00
16_G19_A0.9111.00
216_Y239_P0.9071.00
158_I162_N0.9071.00
129_L133_E0.9061.00
18_N22_L0.9011.00
62_E65_A0.8981.00
178_A182_S0.8971.00
98_T101_A0.8941.00
266_H269_E0.8921.00
36_G114_F0.8891.00
12_Q16_G0.8881.00
238_L284_T0.8881.00
251_Q278_C0.8871.00
261_Q267_L0.8871.00
17_V71_A0.8861.00
24_Q68_T0.8751.00
69_I185_L0.8721.00
243_A278_C0.8711.00
92_M220_G0.8681.00
52_A66_H0.8651.00
164_M168_Y0.8631.00
216_Y231_L0.8621.00
249_P253_Q0.8621.00
210_I285_R0.8601.00
217_N281_L0.8601.00
269_E272_L0.8521.00
273_E276_N0.8511.00
180_Q194_K0.8471.00
149_Q235_K0.8451.00
238_L287_R0.8421.00
120_F136_S0.8411.00
257_T261_Q0.8401.00
268_L272_L0.8331.00
199_Y298_A0.8311.00
256_R260_E0.8281.00
294_K297_A0.8261.00
152_N162_N0.8251.00
61_Y66_H0.8231.00
253_Q256_R0.8231.00
223_L227_V0.8181.00
247_G251_Q0.8171.00
11_A14_M0.8161.00
166_V235_K0.8151.00
228_G268_L0.8121.00
198_D201_R0.8111.00
153_V236_P0.8111.00
99_A103_F0.8091.00
254_M258_A0.8091.00
194_K197_Q0.8091.00
124_T133_E0.8061.00
243_A274_A0.8051.00
13_D16_G0.7981.00
176_E200_G0.7971.00
15_A19_A0.7931.00
41_S96_K0.7931.00
24_Q125_S0.7911.00
86_V109_V0.7901.00
76_I135_M0.7851.00
285_R289_E0.7841.00
265_R269_E0.7821.00
267_L270_P0.7811.00
51_I203_L0.7801.00
57_R63_G0.7781.00
68_T126_L0.7761.00
250_E254_M0.7751.00
211_D214_L0.7711.00
193_E197_Q0.7711.00
49_P78_T0.7711.00
38_Y103_F0.7691.00
91_D100_N0.7681.00
97_A102_A0.7681.00
201_R205_T0.7671.00
228_G272_L0.7651.00
58_A302_L0.7621.00
214_L218_A0.7621.00
71_A122_M0.7601.00
213_L244_M0.7591.00
16_G63_G0.7551.00
75_F118_R0.7541.00
148_L152_N0.7541.00
14_M50_M0.7531.00
197_Q201_R0.7471.00
121_Q133_E0.7461.00
121_Q125_S0.7451.00
17_V53_V0.7451.00
99_A102_A0.7451.00
36_G115_I0.7421.00
48_R207_F0.7411.00
135_M181_C0.7401.00
46_R49_P0.7371.00
184_I193_E0.7341.00
52_A178_A0.7331.00
254_M259_I0.7331.00
22_L26_N0.7331.00
24_Q122_M0.7331.00
164_M291_E0.7301.00
52_A70_A0.7291.00
82_L108_S0.7271.00
16_G64_N0.7241.00
34_Q38_Y0.7221.00
218_A222_Q0.7201.00
58_A196_L0.7181.00
79_A116_Y0.7181.00
80_T174_L0.7111.00
223_L226_N0.7081.00
281_L285_R0.7081.00
181_C185_L0.7071.00
160_E238_L0.7071.00
96_K102_A0.7071.00
151_M155_D0.7050.99
39_I82_L0.7050.99
65_A126_L0.7020.99
13_D53_V0.6990.99
169_S173_R0.6970.99
134_V138_A0.6960.99
202_Y257_T0.6960.99
154_N234_G0.6890.99
195_G199_Y0.6870.99
207_F211_D0.6870.99
134_V197_Q0.6850.99
198_D294_K0.6830.99
283_W287_R0.6790.99
280_S284_T0.6750.99
255_I259_I0.6730.99
26_N33_N0.6720.99
168_Y173_R0.6720.99
290_E293_D0.6710.99
116_Y143_A0.6680.99
175_F203_L0.6680.99
160_E241_L0.6670.99
66_H185_L0.6650.99
242_H287_R0.6620.99
77_H80_T0.6610.99
190_P193_E0.6510.99
155_D158_I0.6490.99
87_V143_A0.6480.99
134_V137_E0.6470.99
161_E164_M0.6440.99
17_V67_V0.6410.99
129_L132_L0.6410.99
67_V71_A0.6400.99
69_I126_L0.6390.99
144_E169_S0.6380.99
35_L111_V0.6370.99
258_A267_L0.6370.99
48_R77_H0.6350.99
38_Y96_K0.6340.99
210_I213_L0.6340.99
297_A301_V0.6330.99
52_A182_S0.6330.99
16_G20_A0.6320.99
213_L288_A0.6310.99
68_T122_M0.6310.99
73_I178_A0.6300.99
164_M287_R0.6290.99
247_G274_A0.6250.99
39_I78_T0.6240.99
161_E165_R0.6200.99
31_L107_A0.6190.99
163_Y238_L0.6180.99
114_F143_A0.6170.99
276_N282_E0.6150.99
142_I175_F0.6140.99
130_K134_V0.6140.99
82_L86_V0.6110.99
20_A67_V0.6100.99
36_G111_V0.6050.98
240_L259_I0.6030.98
289_E292_A0.6020.98
246_H279_G0.5930.98
90_S215_D0.5910.98
105_N109_V0.5910.98
61_Y182_S0.5890.98
73_I181_C0.5890.98
257_T267_L0.5880.98
117_T143_A0.5880.98
106_A150_L0.5870.98
274_A277_A0.5860.98
122_M125_S0.5810.98
87_V150_L0.5800.98
125_S137_E0.5800.98
275_M278_C0.5790.98
84_D88_D0.5760.98
30_Q33_N0.5750.98
59_V196_L0.5750.98
82_L115_I0.5740.98
239_P242_H0.5730.98
265_R268_L0.5690.98
195_G198_D0.5690.98
286_Q293_D0.5660.98
210_I251_Q0.5620.98
271_V275_M0.5620.98
171_T207_F0.5600.97
217_N285_R0.5600.97
64_N68_T0.5600.97
86_V106_A0.5590.97
45_K211_D0.5590.97
266_H270_P0.5580.97
199_Y202_Y0.5580.97
14_M21_I0.5560.97
215_D223_L0.5540.97
158_I236_P0.5500.97
220_G223_L0.5500.97
173_R201_R0.5500.97
120_F123_M0.5490.97
166_V169_S0.5490.97
170_K208_Q0.5470.97
246_H250_E0.5470.97
36_G39_I0.5470.97
215_D229_D0.5440.97
131_V184_I0.5440.97
35_L107_A0.5430.97
68_T71_A0.5430.97
79_A117_T0.5430.97
153_V233_E0.5360.97
56_A185_L0.5350.97
40_V75_F0.5340.97
82_L111_V0.5340.97
55_A182_S0.5330.97
138_A173_R0.5320.97
164_M209_L0.5310.97
44_G48_R0.5280.96
117_T120_F0.5270.96
243_A271_V0.5260.96
166_V236_P0.5260.96
229_D232_N0.5250.96
117_T139_V0.5250.96
206_A292_A0.5230.96
118_R122_M0.5220.96
28_D165_R0.5210.96
219_D223_L0.5210.96
72_L135_M0.5200.96
238_L242_H0.5200.96
42_G78_T0.5180.96
35_L103_F0.5170.96
79_A87_V0.5160.96
14_M17_V0.5160.96
188_C193_E0.5150.96
137_E180_Q0.5150.96
206_A295_A0.5140.96
287_R294_K0.5080.96
53_V57_R0.5080.96
281_L284_T0.5070.96
124_T136_S0.5060.95
202_Y205_T0.5060.95
26_N37_Y0.5050.95
75_F115_I0.5040.95
296_I300_Q0.5020.95
148_L151_M0.5020.95
171_T175_F0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jxyA 5 0.9412 100 0.046 Contact Map
3oyrA 2 1 100 0.052 Contact Map
3wjkA 2 0.9721 100 0.058 Contact Map
3aqbB 1 0.9969 100 0.064 Contact Map
3mzvA 2 1 100 0.064 Contact Map
4lobA 2 0.9474 100 0.068 Contact Map
1wy0A 2 0.9938 100 0.081 Contact Map
3rmgA 2 0.9412 100 0.081 Contact Map
3lmdA 2 0.9319 100 0.09 Contact Map
3pkoA 2 0.9876 100 0.093 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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