ISPB - ECOLI - GREMLIN Contacts

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ISPB - Octaprenyl-diphosphate synthase

UniProt:	P0AD57	Sequences: MNLEKINELTAQDMAGVNAAILEQLNSDVQLINQLGYYIVSGGGKRIRPMIAVLAARAVGYEGNAHVTIAALIEFIHTATLLHDDVVDESDMRRGKATANAAFGNAASVLVGDFIYTRAFQMMTSLGSLKVLEVMSEAVNVIAEGEVLQLMNVNDPDITEENYMRVIYSKTARLFEAAAQCSGILAGCTPEEEKGLQDYGRYLGTAFQLIDDLLDYNADGEQLGKNVGDDLNEGKPTLPLLHAMHHGTPEQAQMIRTAIEQGNGRHLLEPVLEAMNACGSLEWTRQRAEEEADKAIAALQVLPDTPWREALIGLAHIAVQRDR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10017
Length:	323 (295)
Sequences:	9677 (6479)
Seq/√Len:	377.2

ECOLI - ISPB ISPA
BACSU - HEPS2 ISPA COMQ
HALSA - Q9HQI3 Q9HND0
SULSO - GGPS HEXPP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
56_A	66_H	3.428	1.00
180_Q	197_Q	3.072	1.00
189_T	192_E	2.990	1.00
91_D	101_A	2.950	1.00
176_E	197_Q	2.782	1.00
202_Y	294_K	2.594	1.00
159_T	162_N	2.487	1.00
246_H	283_W	2.475	1.00
273_E	277_A	2.468	1.00
180_Q	193_E	2.463	1.00
134_V	180_Q	2.442	1.00
168_Y	201_R	2.424	1.00
202_Y	291_E	2.379	1.00
254_M	270_P	2.334	1.00
176_E	201_R	2.312	1.00
287_R	290_E	2.239	1.00
219_D	222_Q	2.229	1.00
134_V	184_I	2.228	1.00
92_M	97_A	2.213	1.00
226_N	229_D	2.137	1.00
242_H	283_W	2.112	1.00
118_R	121_Q	2.085	1.00
87_V	146_E	2.022	1.00
55_A	196_L	2.012	1.00
183_G	196_L	1.984	1.00
131_V	181_C	1.981	1.00
279_G	282_E	1.954	1.00
130_K	193_E	1.949	1.00
242_H	280_S	1.936	1.00
55_A	179_A	1.891	1.00
198_D	298_A	1.866	1.00
293_D	297_A	1.844	1.00
59_V	192_E	1.843	1.00
179_A	200_G	1.832	1.00
104_G	107_A	1.817	1.00
165_R	169_S	1.814	1.00
251_Q	277_A	1.800	1.00
20_A	71_A	1.787	1.00
194_K	198_D	1.731	1.00
13_D	57_R	1.731	1.00
213_L	284_T	1.713	1.00
253_Q	257_T	1.706	1.00
20_A	68_T	1.703	1.00
252_A	256_R	1.660	1.00
18_N	21_I	1.630	1.00
20_A	23_E	1.626	1.00
83_H	113_D	1.606	1.00
282_E	286_Q	1.597	1.00
254_M	257_T	1.589	1.00
198_D	202_Y	1.574	1.00
248_T	251_Q	1.568	1.00
290_E	294_K	1.558	1.00
121_Q	137_E	1.555	1.00
297_A	300_Q	1.546	1.00
83_H	112_G	1.544	1.00
250_E	253_Q	1.530	1.00
160_E	242_H	1.530	1.00
68_T	125_S	1.514	1.00
289_E	293_D	1.513	1.00
124_T	132_L	1.506	1.00
130_K	190_P	1.495	1.00
37_Y	41_S	1.485	1.00
183_G	188_C	1.471	1.00
155_D	162_N	1.468	1.00
276_N	281_L	1.465	1.00
218_A	223_L	1.459	1.00
188_C	192_E	1.457	1.00
82_L	99_A	1.451	1.00
130_K	133_E	1.449	1.00
107_A	147_V	1.449	1.00
22_L	37_Y	1.445	1.00
282_E	285_R	1.442	1.00
177_A	181_C	1.428	1.00
56_A	61_Y	1.424	1.00
270_P	273_E	1.421	1.00
148_L	165_R	1.400	1.00
90_S	229_D	1.388	1.00
190_P	194_K	1.378	1.00
286_Q	290_E	1.370	1.00
55_A	59_V	1.368	1.00
54_L	57_R	1.366	1.00
229_D	233_E	1.363	1.00
125_S	133_E	1.352	1.00
182_S	186_A	1.351	1.00
18_N	46_R	1.347	1.00
146_E	149_Q	1.345	1.00
176_E	180_Q	1.338	1.00
80_T	142_I	1.317	1.00
209_L	284_T	1.316	1.00
287_R	291_E	1.297	1.00
286_Q	289_E	1.293	1.00
17_V	21_I	1.288	1.00
242_H	246_H	1.287	1.00
86_V	105_N	1.276	1.00
163_Y	167_I	1.249	1.00
19_A	23_E	1.246	1.00
275_M	280_S	1.233	1.00
15_A	18_N	1.229	1.00
292_A	296_I	1.227	1.00
298_A	301_V	1.225	1.00
243_A	275_M	1.222	1.00
133_E	137_E	1.216	1.00
213_L	281_L	1.214	1.00
220_G	226_N	1.207	1.00
53_V	70_A	1.205	1.00
213_L	285_R	1.202	1.00
220_G	227_V	1.198	1.00
75_F	122_M	1.194	1.00
174_L	178_A	1.187	1.00
242_H	245_H	1.185	1.00
42_G	96_K	1.182	1.00
59_V	186_A	1.175	1.00
168_Y	205_T	1.172	1.00
59_V	182_S	1.164	1.00
195_G	301_V	1.163	1.00
130_K	184_I	1.158	1.00
165_R	168_Y	1.153	1.00
245_H	283_W	1.135	1.00
173_R	176_E	1.134	1.00
270_P	274_A	1.131	1.00
38_Y	102_A	1.130	1.00
214_L	223_L	1.130	1.00
148_L	169_S	1.130	1.00
14_M	18_N	1.125	1.00
152_N	166_V	1.122	1.00
183_G	193_E	1.120	1.00
272_L	276_N	1.116	1.00
134_V	177_A	1.105	1.00
31_L	104_G	1.103	1.00
205_T	291_E	1.094	1.00
148_L	166_V	1.093	1.00
160_E	287_R	1.091	1.00
283_W	286_Q	1.091	1.00
138_A	177_A	1.088	1.00
72_L	123_M	1.076	1.00
31_L	151_M	1.074	1.00
69_I	131_V	1.072	1.00
191_E	195_G	1.066	1.00
131_V	185_L	1.064	1.00
192_E	195_G	1.063	1.00
167_I	205_T	1.059	1.00
199_Y	299_L	1.056	1.00
30_Q	34_Q	1.053	1.00
246_H	249_P	1.049	1.00
52_A	73_I	1.049	1.00
249_P	252_A	1.047	1.00
35_L	99_A	1.040	1.00
217_N	248_T	1.040	1.00
179_A	196_L	1.039	1.00
152_N	158_I	1.038	1.00
69_I	181_C	1.037	1.00
11_A	15_A	1.035	1.00
53_V	67_V	1.033	1.00
33_N	37_Y	1.032	1.00
202_Y	298_A	1.029	1.00
141_V	169_S	1.024	1.00
51_I	179_A	1.022	1.00
247_G	278_C	1.020	1.00
19_A	22_L	1.015	1.00
243_A	280_S	1.012	1.00
213_L	217_N	1.010	1.00
12_Q	15_A	1.001	1.00
269_E	273_E	0.990	1.00
97_A	101_A	0.976	1.00
39_I	99_A	0.974	1.00
69_I	123_M	0.974	1.00
280_S	283_W	0.973	1.00
123_M	131_V	0.971	1.00
160_E	245_H	0.968	1.00
160_E	164_M	0.964	1.00
22_L	41_S	0.958	1.00
43_G	46_R	0.957	1.00
291_E	294_K	0.955	1.00
31_L	34_Q	0.954	1.00
16_G	67_V	0.954	1.00
56_A	186_A	0.953	1.00
164_M	205_T	0.947	1.00
87_V	110_L	0.944	1.00
121_Q	140_N	0.941	1.00
89_E	105_N	0.940	1.00
20_A	24_Q	0.938	1.00
163_Y	241_L	0.936	1.00
232_N	265_R	0.930	1.00
179_A	199_Y	0.930	1.00
160_E	283_W	0.928	1.00
210_I	288_A	0.928	1.00
59_V	188_C	0.922	1.00
53_V	66_H	0.920	1.00
180_Q	184_I	0.920	1.00
293_D	296_I	0.914	1.00
100_N	105_N	0.914	1.00
195_G	298_A	0.913	1.00
16_G	19_A	0.911	1.00
216_Y	239_P	0.907	1.00
158_I	162_N	0.907	1.00
129_L	133_E	0.906	1.00
18_N	22_L	0.901	1.00
62_E	65_A	0.898	1.00
178_A	182_S	0.897	1.00
98_T	101_A	0.894	1.00
266_H	269_E	0.892	1.00
36_G	114_F	0.889	1.00
12_Q	16_G	0.888	1.00
238_L	284_T	0.888	1.00
251_Q	278_C	0.887	1.00
261_Q	267_L	0.887	1.00
17_V	71_A	0.886	1.00
24_Q	68_T	0.875	1.00
69_I	185_L	0.872	1.00
243_A	278_C	0.871	1.00
92_M	220_G	0.868	1.00
52_A	66_H	0.865	1.00
164_M	168_Y	0.863	1.00
216_Y	231_L	0.862	1.00
249_P	253_Q	0.862	1.00
210_I	285_R	0.860	1.00
217_N	281_L	0.860	1.00
269_E	272_L	0.852	1.00
273_E	276_N	0.851	1.00
180_Q	194_K	0.847	1.00
149_Q	235_K	0.845	1.00
238_L	287_R	0.842	1.00
120_F	136_S	0.841	1.00
257_T	261_Q	0.840	1.00
268_L	272_L	0.833	1.00
199_Y	298_A	0.831	1.00
256_R	260_E	0.828	1.00
294_K	297_A	0.826	1.00
152_N	162_N	0.825	1.00
61_Y	66_H	0.823	1.00
253_Q	256_R	0.823	1.00
223_L	227_V	0.818	1.00
247_G	251_Q	0.817	1.00
11_A	14_M	0.816	1.00
166_V	235_K	0.815	1.00
228_G	268_L	0.812	1.00
198_D	201_R	0.811	1.00
153_V	236_P	0.811	1.00
99_A	103_F	0.809	1.00
254_M	258_A	0.809	1.00
194_K	197_Q	0.809	1.00
124_T	133_E	0.806	1.00
243_A	274_A	0.805	1.00
13_D	16_G	0.798	1.00
176_E	200_G	0.797	1.00
15_A	19_A	0.793	1.00
41_S	96_K	0.793	1.00
24_Q	125_S	0.791	1.00
86_V	109_V	0.790	1.00
76_I	135_M	0.785	1.00
285_R	289_E	0.784	1.00
265_R	269_E	0.782	1.00
267_L	270_P	0.781	1.00
51_I	203_L	0.780	1.00
57_R	63_G	0.778	1.00
68_T	126_L	0.776	1.00
250_E	254_M	0.775	1.00
211_D	214_L	0.771	1.00
193_E	197_Q	0.771	1.00
49_P	78_T	0.771	1.00
38_Y	103_F	0.769	1.00
91_D	100_N	0.768	1.00
97_A	102_A	0.768	1.00
201_R	205_T	0.767	1.00
228_G	272_L	0.765	1.00
58_A	302_L	0.762	1.00
214_L	218_A	0.762	1.00
71_A	122_M	0.760	1.00
213_L	244_M	0.759	1.00
16_G	63_G	0.755	1.00
75_F	118_R	0.754	1.00
148_L	152_N	0.754	1.00
14_M	50_M	0.753	1.00
197_Q	201_R	0.747	1.00
121_Q	133_E	0.746	1.00
121_Q	125_S	0.745	1.00
17_V	53_V	0.745	1.00
99_A	102_A	0.745	1.00
36_G	115_I	0.742	1.00
48_R	207_F	0.741	1.00
135_M	181_C	0.740	1.00
46_R	49_P	0.737	1.00
184_I	193_E	0.734	1.00
52_A	178_A	0.733	1.00
254_M	259_I	0.733	1.00
22_L	26_N	0.733	1.00
24_Q	122_M	0.733	1.00
164_M	291_E	0.730	1.00
52_A	70_A	0.729	1.00
82_L	108_S	0.727	1.00
16_G	64_N	0.724	1.00
34_Q	38_Y	0.722	1.00
218_A	222_Q	0.720	1.00
58_A	196_L	0.718	1.00
79_A	116_Y	0.718	1.00
80_T	174_L	0.711	1.00
223_L	226_N	0.708	1.00
281_L	285_R	0.708	1.00
181_C	185_L	0.707	1.00
160_E	238_L	0.707	1.00
96_K	102_A	0.707	1.00
151_M	155_D	0.705	0.99
39_I	82_L	0.705	0.99
65_A	126_L	0.702	0.99
13_D	53_V	0.699	0.99
169_S	173_R	0.697	0.99
134_V	138_A	0.696	0.99
202_Y	257_T	0.696	0.99
154_N	234_G	0.689	0.99
195_G	199_Y	0.687	0.99
207_F	211_D	0.687	0.99
134_V	197_Q	0.685	0.99
198_D	294_K	0.683	0.99
283_W	287_R	0.679	0.99
280_S	284_T	0.675	0.99
255_I	259_I	0.673	0.99
26_N	33_N	0.672	0.99
168_Y	173_R	0.672	0.99
290_E	293_D	0.671	0.99
116_Y	143_A	0.668	0.99
175_F	203_L	0.668	0.99
160_E	241_L	0.667	0.99
66_H	185_L	0.665	0.99
242_H	287_R	0.662	0.99
77_H	80_T	0.661	0.99
190_P	193_E	0.651	0.99
155_D	158_I	0.649	0.99
87_V	143_A	0.648	0.99
134_V	137_E	0.647	0.99
161_E	164_M	0.644	0.99
17_V	67_V	0.641	0.99
129_L	132_L	0.641	0.99
67_V	71_A	0.640	0.99
69_I	126_L	0.639	0.99
144_E	169_S	0.638	0.99
35_L	111_V	0.637	0.99
258_A	267_L	0.637	0.99
48_R	77_H	0.635	0.99
38_Y	96_K	0.634	0.99
210_I	213_L	0.634	0.99
297_A	301_V	0.633	0.99
52_A	182_S	0.633	0.99
16_G	20_A	0.632	0.99
213_L	288_A	0.631	0.99
68_T	122_M	0.631	0.99
73_I	178_A	0.630	0.99
164_M	287_R	0.629	0.99
247_G	274_A	0.625	0.99
39_I	78_T	0.624	0.99
161_E	165_R	0.620	0.99
31_L	107_A	0.619	0.99
163_Y	238_L	0.618	0.99
114_F	143_A	0.617	0.99
276_N	282_E	0.615	0.99
142_I	175_F	0.614	0.99
130_K	134_V	0.614	0.99
82_L	86_V	0.611	0.99
20_A	67_V	0.610	0.99
36_G	111_V	0.605	0.98
240_L	259_I	0.603	0.98
289_E	292_A	0.602	0.98
246_H	279_G	0.593	0.98
90_S	215_D	0.591	0.98
105_N	109_V	0.591	0.98
61_Y	182_S	0.589	0.98
73_I	181_C	0.589	0.98
257_T	267_L	0.588	0.98
117_T	143_A	0.588	0.98
106_A	150_L	0.587	0.98
274_A	277_A	0.586	0.98
122_M	125_S	0.581	0.98
87_V	150_L	0.580	0.98
125_S	137_E	0.580	0.98
275_M	278_C	0.579	0.98
84_D	88_D	0.576	0.98
30_Q	33_N	0.575	0.98
59_V	196_L	0.575	0.98
82_L	115_I	0.574	0.98
239_P	242_H	0.573	0.98
265_R	268_L	0.569	0.98
195_G	198_D	0.569	0.98
286_Q	293_D	0.566	0.98
210_I	251_Q	0.562	0.98
271_V	275_M	0.562	0.98
171_T	207_F	0.560	0.97
217_N	285_R	0.560	0.97
64_N	68_T	0.560	0.97
86_V	106_A	0.559	0.97
45_K	211_D	0.559	0.97
266_H	270_P	0.558	0.97
199_Y	202_Y	0.558	0.97
14_M	21_I	0.556	0.97
215_D	223_L	0.554	0.97
158_I	236_P	0.550	0.97
220_G	223_L	0.550	0.97
173_R	201_R	0.550	0.97
120_F	123_M	0.549	0.97
166_V	169_S	0.549	0.97
170_K	208_Q	0.547	0.97
246_H	250_E	0.547	0.97
36_G	39_I	0.547	0.97
215_D	229_D	0.544	0.97
131_V	184_I	0.544	0.97
35_L	107_A	0.543	0.97
68_T	71_A	0.543	0.97
79_A	117_T	0.543	0.97
153_V	233_E	0.536	0.97
56_A	185_L	0.535	0.97
40_V	75_F	0.534	0.97
82_L	111_V	0.534	0.97
55_A	182_S	0.533	0.97
138_A	173_R	0.532	0.97
164_M	209_L	0.531	0.97
44_G	48_R	0.528	0.96
117_T	120_F	0.527	0.96
243_A	271_V	0.526	0.96
166_V	236_P	0.526	0.96
229_D	232_N	0.525	0.96
117_T	139_V	0.525	0.96
206_A	292_A	0.523	0.96
118_R	122_M	0.522	0.96
28_D	165_R	0.521	0.96
219_D	223_L	0.521	0.96
72_L	135_M	0.520	0.96
238_L	242_H	0.520	0.96
42_G	78_T	0.518	0.96
35_L	103_F	0.517	0.96
79_A	87_V	0.516	0.96
14_M	17_V	0.516	0.96
188_C	193_E	0.515	0.96
137_E	180_Q	0.515	0.96
206_A	295_A	0.514	0.96
287_R	294_K	0.508	0.96
53_V	57_R	0.508	0.96
281_L	284_T	0.507	0.96
124_T	136_S	0.506	0.95
202_Y	205_T	0.506	0.95
26_N	37_Y	0.505	0.95
75_F	115_I	0.504	0.95
296_I	300_Q	0.502	0.95
148_L	151_M	0.502	0.95
171_T	175_F	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4jxyA	5	0.9412	100	0.046	Contact Map
3oyrA	2	1	100	0.052	Contact Map
3wjkA	2	0.9721	100	0.058	Contact Map
3aqbB	1	0.9969	100	0.064	Contact Map
3mzvA	2	1	100	0.064	Contact Map
4lobA	2	0.9474	100	0.068	Contact Map
1wy0A	2	0.9938	100	0.081	Contact Map
3rmgA	2	0.9412	100	0.081	Contact Map
3lmdA	2	0.9319	100	0.09	Contact Map
3pkoA	2	0.9876	100	0.093	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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