GREMLIN Database
RAIA - Ribosome-associated inhibitor A
UniProt: P0AD49 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11151
Length: 113 (101)
Sequences: 1648 (947)
Seq/√Len: 94.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_H73_A5.2781.00
20_V41_L2.9971.00
7_S12_I2.6311.00
30_W82_E2.6161.00
49_V66_K2.5481.00
14_P18_Q2.5091.00
16_I70_M2.4891.00
52_A77_L2.3121.00
18_Q22_D2.2561.00
43_K48_F2.1311.00
41_L50_A2.0251.00
86_N90_H1.9801.00
13_T71_Y1.9161.00
65_G76_E1.7801.00
2_T36_N1.7431.00
53_T62_V1.6861.00
47_G66_K1.5411.00
63_A77_L1.5391.00
15_A71_Y1.5361.00
17_R21_A1.5041.00
15_A19_H1.4831.00
41_L70_M1.4331.00
43_K71_Y1.4280.99
16_I41_L1.4020.99
20_V39_I1.3440.99
5_I41_L1.2590.99
48_F70_M1.2590.99
12_I17_R1.2540.99
7_S13_T1.2490.99
24_L52_A1.2420.99
52_A81_L1.2210.98
13_T16_I1.1990.98
27_L85_L1.1970.98
55_N60_V1.1900.98
4_N38_H1.1890.98
44_E49_V1.1700.98
22_D25_A1.1560.98
43_K70_M1.1460.98
19_H72_T1.1320.97
60_V64_S1.1290.97
10_M16_I1.1190.97
83_R87_K1.1160.97
90_H94_A1.0620.96
94_A98_A1.0000.95
63_A84_Q1.0000.95
56_T59_G0.9770.94
51_D62_V0.9700.94
83_R86_N0.9660.94
56_T85_L0.9650.94
70_M74_I0.9530.93
76_E80_K0.9510.93
56_T88_L0.9510.93
34_L37_P0.9410.93
6_T40_I0.9370.93
29_K82_E0.9350.92
50_A77_L0.9190.92
48_F73_A0.9000.91
58_N88_L0.8980.91
23_R61_L0.8840.90
26_K45_P0.8810.90
14_P21_A0.8790.90
11_E17_R0.8650.89
65_G77_L0.8640.89
53_T60_V0.8630.89
20_V50_A0.8610.89
68_E80_K0.8590.89
10_M71_Y0.8580.89
11_E71_Y0.8520.88
75_N89_Q0.8450.88
40_I91_K0.8370.88
3_M39_I0.8340.87
4_N36_N0.8310.87
3_M80_K0.8270.87
50_A81_L0.8240.87
31_Q92_G0.8200.86
51_D87_K0.8170.86
14_P17_R0.8080.86
33_H57_P0.8070.86
50_A70_M0.7980.85
31_Q85_L0.7980.85
25_A28_E0.7910.84
40_I70_M0.7900.84
65_G80_K0.7890.84
6_T38_H0.7870.84
19_H74_I0.7830.84
22_D94_A0.7820.84
40_I51_D0.7820.84
28_E37_P0.7740.83
72_T76_E0.7700.83
23_R89_Q0.7630.82
49_V64_S0.7580.82
8_K42_S0.7520.81
75_N79_N0.7510.81
44_E85_L0.7500.81
5_I20_V0.7470.81
53_T64_S0.7450.81
32_T66_K0.7380.80
19_H50_A0.7290.79
30_W86_N0.7270.79
81_L96_R0.7250.79
5_I12_I0.7130.78
67_H72_T0.7090.77
7_S10_M0.7080.77
59_G94_A0.7060.77
13_T74_I0.6980.76
1_M58_N0.6960.76
85_L94_A0.6940.76
88_L92_G0.6800.74
76_E79_N0.6600.72
40_I53_T0.6520.71
5_I21_A0.6440.70
16_I74_I0.6370.69
24_L28_E0.6270.68
9_Q14_P0.6230.68
97_A100_S0.6200.67
90_H93_E0.6190.67
46_Q62_V0.6180.67
15_A80_K0.6130.67
38_H44_E0.6100.66
37_P54_I0.6100.66
52_A61_L0.6030.65
21_A25_A0.5990.65
3_M28_E0.5970.65
38_H68_E0.5940.64
96_R99_T0.5930.64
18_Q21_A0.5910.64
31_Q51_D0.5910.64
38_H53_T0.5900.64
13_T48_F0.5880.63
1_M84_Q0.5870.63
93_E97_A0.5810.62
31_Q89_Q0.5700.61
34_L95_R0.5570.59
35_I57_P0.5560.59
67_H76_E0.5350.56
2_T40_I0.5340.56
23_R31_Q0.5320.56
61_L81_L0.5250.55
38_H46_Q0.5230.55
27_L35_I0.5210.54
9_Q88_L0.5210.54
52_A55_N0.5160.54
24_L78_I0.5140.53
46_Q51_D0.5120.53
62_V85_L0.5080.52
44_E58_N0.5070.52
84_Q91_K0.5050.52
93_E101_V0.5010.51
42_S58_N0.5010.51
1_M48_F0.5010.51
57_P60_V0.5000.51
38_H76_E0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v2cY 1 0.8407 100 0.178 Contact Map
1imuA 1 0.9469 100 0.232 Contact Map
3tqmA 1 0.823 100 0.245 Contact Map
3v26X 1 0.8407 100 0.249 Contact Map
4heiA 1 0.8142 100 0.252 Contact Map
2ywqA 1 0.7699 100 0.26 Contact Map
4iwxA 3 0.6991 19.7 0.919 Contact Map
1i7nA 4 0.7168 17.3 0.922 Contact Map
1miuA 4 0.8673 12.1 0.927 Contact Map
1pu1A 1 0.6637 10.6 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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