GREMLIN Database
YPHA - Inner membrane protein YphA
UniProt: P0AD47 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13462
Length: 140 (117)
Sequences: 1694 (1103)
Seq/√Len: 101.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_P113_N4.5971.00
98_H101_D3.2451.00
39_F59_I2.5981.00
29_I69_A2.5671.00
17_L130_T2.5041.00
27_I120_I2.4931.00
61_A65_E2.3521.00
83_V128_A2.1581.00
46_M58_A2.1471.00
68_A81_L2.0731.00
71_L81_L2.0411.00
25_V29_I2.0151.00
70_I74_L2.0021.00
99_Y114_F1.9011.00
25_V69_A1.9001.00
111_M115_W1.8821.00
38_G41_G1.8791.00
29_I73_V1.7861.00
126_L130_T1.7381.00
90_L94_V1.6201.00
20_A126_L1.5661.00
36_M62_V1.5601.00
72_I127_L1.5211.00
87_F91_G1.5201.00
18_L22_I1.5081.00
93_A114_F1.4971.00
93_A121_A1.4911.00
17_L126_L1.4831.00
30_I111_M1.4471.00
80_P84_L1.4391.00
43_V55_M1.4341.00
83_V87_F1.4311.00
63_V67_P1.4291.00
58_A62_V1.3821.00
93_A117_N1.3410.99
67_P71_L1.3250.99
25_V72_I1.2930.99
77_F80_P1.2800.99
20_A129_I1.2650.99
93_A100_W1.2620.99
56_L60_I1.2010.99
64_M84_L1.1690.98
97_H110_N1.1430.98
25_V119_S1.1410.98
16_L129_I1.1170.98
33_F37_M1.1070.98
81_L84_L1.1000.98
35_K65_E1.0990.98
86_I125_L1.0980.98
43_V47_A1.0850.97
99_Y102_M1.0750.97
30_I115_W1.0730.97
24_V123_A1.0610.97
113_N116_K1.0570.97
25_V73_V1.0510.97
33_F66_V1.0430.97
76_F131_G1.0400.97
108_G111_M1.0370.96
100_W114_F1.0260.96
90_L121_A1.0240.96
31_F115_W1.0220.96
32_G69_A1.0120.96
102_M110_N1.0120.96
24_V120_I0.9850.95
55_M59_I0.9740.95
120_I123_A0.9740.95
125_L129_I0.9560.94
85_F124_F0.9560.94
34_P111_M0.9430.94
69_A73_V0.9360.94
72_I124_F0.9320.94
61_A92_T0.9150.93
60_I64_M0.9100.93
89_T121_A0.9070.93
59_I62_V0.8970.92
65_E89_T0.8860.92
112_I115_W0.8710.91
39_F62_V0.8600.91
41_G63_V0.8560.91
76_F132_P0.8500.90
115_W118_V0.8430.90
46_M96_G0.8420.90
28_F89_T0.8380.90
47_A54_P0.8260.89
30_I34_P0.8220.89
42_T58_A0.8140.88
58_A96_G0.8090.88
61_A88_Y0.8080.88
61_A64_M0.8070.88
39_F58_A0.8070.88
94_V98_H0.8000.87
31_F88_Y0.7920.87
40_D55_M0.7820.86
92_T95_I0.7790.86
42_T45_Y0.7770.86
35_K88_Y0.7750.86
23_A125_L0.7710.85
83_V91_G0.7600.84
110_N113_N0.7470.83
62_V66_V0.7410.83
16_L128_A0.7360.83
23_A118_V0.7180.81
90_L118_V0.7150.81
50_G53_M0.7080.80
51_A95_I0.7000.79
119_S126_L0.6980.79
27_I31_F0.6950.79
42_T65_E0.6950.79
65_E88_Y0.6920.79
30_I33_F0.6860.78
31_F34_P0.6740.77
14_P134_A0.6740.77
14_P71_L0.6720.76
27_I30_I0.6690.76
100_W111_M0.6650.76
64_M68_A0.6610.75
44_Q47_A0.6600.75
78_T127_L0.6600.75
46_M57_A0.6580.75
72_I81_L0.6580.75
73_V77_F0.6570.75
20_A123_A0.6540.75
102_M107_V0.6450.74
77_F84_L0.6450.74
58_A61_A0.6400.73
81_L85_F0.6380.73
74_L84_L0.6260.71
40_D43_V0.6260.71
124_F127_L0.6240.71
27_I119_S0.6230.71
112_I116_K0.6200.71
53_M56_L0.6200.71
97_H117_N0.6170.70
46_M51_A0.6090.69
71_L76_F0.6040.69
46_M49_L0.6030.68
68_A85_F0.5990.68
72_I132_P0.5950.67
18_L131_G0.5940.67
86_I90_L0.5850.66
75_G89_T0.5830.66
54_P57_A0.5820.66
51_A57_A0.5810.66
24_V127_L0.5780.65
17_L127_L0.5750.65
72_I85_F0.5740.65
35_K61_A0.5720.64
35_K42_T0.5720.64
113_N120_I0.5690.64
45_Y48_S0.5660.64
72_I75_G0.5650.63
39_F43_V0.5650.63
31_F35_K0.5610.63
64_M91_G0.5550.62
39_F42_T0.5490.61
46_M62_V0.5480.61
52_P56_L0.5470.61
35_K117_N0.5450.61
34_P37_M0.5430.60
50_G60_I0.5360.59
88_Y92_T0.5350.59
20_A24_V0.5340.59
61_A96_G0.5260.58
24_V124_F0.5250.58
89_T93_A0.5250.58
20_A55_M0.5240.58
85_F119_S0.5230.58
41_G122_G0.5220.57
32_G67_P0.5210.57
72_I123_A0.5200.57
85_F122_G0.5180.57
14_P26_L0.5130.56
35_K62_V0.5120.56
78_T81_L0.5050.55
115_W119_S0.5010.54
49_L95_I0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.5071 4.4 0.944 Contact Map
1vkmA 5 0.7857 4 0.945 Contact Map
4ev6A 3 0.5214 3.6 0.946 Contact Map
4ymkA 1 0.7571 3.2 0.948 Contact Map
3ldzA 1 0.3571 3 0.949 Contact Map
4ex8A 3 0.7929 2.7 0.95 Contact Map
2l9uA 2 0.2286 2 0.953 Contact Map
1lnqA 6 0.6357 1.9 0.954 Contact Map
2ou3A 2 0.3571 1.9 0.954 Contact Map
4he8J 1 0.7571 1.8 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.006 seconds.