GREMLIN Database
YFHG - Uncharacterized protein YfhG
UniProt: P0AD44 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12139
Length: 237 (212)
Sequences: 120 (85)
Seq/√Len: 5.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_K144_Q3.4370.86
31_N51_Y2.9960.77
163_Y166_L2.9110.75
27_V35_I2.8780.74
31_N190_L2.8630.73
114_A197_N2.7410.70
50_D70_N2.6640.68
131_L135_I2.6250.66
71_P180_Q2.5630.64
124_L152_L2.4700.61
134_E182_H2.4310.60
22_A75_L2.3180.56
83_R140_R2.2390.53
43_I134_E2.2210.53
48_L131_L2.2030.52
132_S213_N2.1480.50
27_V117_T1.9740.44
155_Q159_E1.9550.43
105_F175_D1.9020.42
73_Y142_L1.8940.41
88_Q95_Q1.8860.41
131_L207_T1.7920.38
96_Y124_L1.7770.37
86_P180_Q1.7330.36
139_V160_R1.7290.36
39_A82_D1.7190.36
166_L178_R1.7140.35
158_E212_G1.7020.35
55_E108_G1.6940.35
167_Q171_D1.6920.35
77_A100_S1.6750.34
40_E82_D1.6700.34
117_T153_Q1.6580.34
139_V168_Q1.6230.33
177_L225_P1.6230.33
112_A139_V1.6020.32
84_L166_L1.5790.31
135_I143_Y1.5480.30
77_A185_Q1.5330.30
187_Q192_T1.5200.29
45_V100_S1.5200.29
51_Y155_Q1.5120.29
66_S132_S1.5120.29
68_E138_Q1.4980.29
104_T157_A1.4940.29
90_R156_L1.4890.29
44_P79_D1.4830.28
22_A78_M1.4760.28
149_G210_P1.4600.28
25_G197_N1.4530.28
149_G164_S1.4470.27
112_A153_Q1.4470.27
96_Y185_Q1.4260.27
19_P35_I1.4100.26
163_Y177_L1.3910.26
61_A91_Q1.3620.25
108_G139_V1.3600.25
30_H99_G1.3560.25
41_E216_P1.3440.25
98_D127_R1.3370.24
83_R121_R1.3170.24
88_Q170_S1.3170.24
25_G43_I1.3150.24
79_D167_Q1.2990.23
64_G216_P1.2860.23
166_L171_D1.2840.23
16_A158_E1.2700.23
93_A166_L1.2650.23
132_S158_E1.2610.23
104_T117_T1.2610.23
116_I154_L1.2600.23
158_E172_S1.2410.22
197_N216_P1.2310.22
192_T209_K1.2000.21
114_A209_K1.1990.21
125_V158_E1.1790.21
108_G113_D1.1770.21
128_I177_L1.1760.21
85_M224_K1.1760.21
116_I197_N1.1680.20
59_I71_P1.1660.20
102_Q149_G1.1650.20
24_L186_Q1.1630.20
67_T142_L1.1450.20
52_L210_P1.1350.20
47_Q131_L1.1340.20
73_Y134_E1.1300.19
37_T215_S1.1280.19
162_R191_T1.1230.19
71_P154_L1.1170.19
188_L199_T1.1170.19
73_Y190_L1.1120.19
15_L190_L1.0990.19
143_Y182_H1.0990.19
161_Q185_Q1.0970.19
47_Q116_I1.0960.19
90_R200_D1.0910.19
124_L164_S1.0860.19
95_Q224_K1.0840.18
140_R147_R1.0800.18
163_Y178_R1.0770.18
173_E185_Q1.0730.18
118_P154_L1.0660.18
20_C210_P1.0640.18
173_E178_R1.0580.18
120_E150_Q1.0570.18
47_Q68_E1.0540.18
48_L161_Q1.0530.18
129_E154_L1.0530.18
113_D171_D1.0520.18
18_L145_L1.0510.18
67_T73_Y1.0420.18
140_R175_D1.0350.17
97_D124_L1.0310.17
31_N35_I1.0290.17
75_L78_M1.0290.17
40_E183_V1.0270.17
28_Q172_S1.0260.17
121_R200_D1.0260.17
151_A213_N1.0190.17
163_Y171_D1.0100.17
148_D192_T1.0100.17
78_M142_L1.0000.17
60_W200_D1.0000.17
45_V69_T0.9960.17
58_D220_H0.9950.17
123_Q173_E0.9940.17
21_L41_E0.9910.17
92_Q108_G0.9850.16
121_R150_Q0.9840.16
38_P213_N0.9820.16
150_Q200_D0.9800.16
214_F217_D0.9800.16
83_R92_Q0.9750.16
77_A103_N0.9740.16
135_I192_T0.9740.16
60_W167_Q0.9730.16
50_D72_L0.9720.16
43_I94_R0.9700.16
17_G20_C0.9610.16
111_L171_D0.9610.16
19_P29_N0.9520.16
105_F207_T0.9520.16
217_D221_E0.9490.16
193_R200_D0.9480.16
30_H127_R0.9460.16
24_L45_V0.9450.16
133_T182_H0.9430.16
176_T187_Q0.9360.16
68_E164_S0.9330.16
96_Y152_L0.9250.15
102_Q155_Q0.9190.15
117_T166_L0.9110.15
59_I168_Q0.9100.15
167_Q196_E0.9040.15
25_G62_L0.8910.15
48_L82_D0.8900.15
90_R193_R0.8900.15
75_L114_A0.8890.15
21_L182_H0.8850.15
47_Q165_K0.8800.15
43_I113_D0.8740.14
34_A173_E0.8710.14
104_T191_T0.8650.14
128_I219_P0.8630.14
30_H138_Q0.8580.14
126_A186_Q0.8550.14
105_F109_I0.8450.14
69_T148_D0.8440.14
33_P73_Y0.8420.14
149_G154_L0.8290.14
60_W90_R0.8230.14
22_A164_S0.8150.13
107_Q145_L0.8150.13
99_G176_T0.8110.13
24_L39_A0.8070.13
100_S170_S0.8070.13
31_N57_S0.8060.13
84_L167_Q0.8040.13
15_L66_S0.7990.13
44_P60_W0.7980.13
43_I46_Y0.7930.13
46_Y88_Q0.7880.13
71_P77_A0.7880.13
199_T206_S0.7870.13
51_Y173_E0.7860.13
40_E125_V0.7860.13
73_Y106_K0.7850.13
82_D204_Q0.7840.13
187_Q217_D0.7810.13
174_L189_E0.7790.13
121_R206_S0.7780.13
62_L217_D0.7730.13
15_L36_D0.7620.13
200_D206_S0.7580.13
94_R151_A0.7580.13
43_I77_A0.7560.13
75_L165_K0.7410.12
171_D175_D0.7370.12
115_K165_K0.7350.12
78_M214_F0.7340.12
41_E152_L0.7290.12
76_R162_R0.7290.12
140_R166_L0.7280.12
45_V158_E0.7250.12
136_P152_L0.7200.12
114_A212_G0.7070.12
119_Y155_Q0.7050.12
78_M103_N0.7040.12
116_I143_Y0.6960.12
114_A192_T0.6940.12
45_V207_T0.6900.12
148_D190_L0.6870.12
78_M117_T0.6860.11
126_A209_K0.6830.11
83_R175_D0.6810.11
94_R223_E0.6770.11
27_V59_I0.6710.11
45_V179_Q0.6660.11
49_A192_T0.6610.11
109_I127_R0.6570.11
79_D84_L0.6560.11
42_K100_S0.6490.11
79_D83_R0.6460.11
122_R162_R0.6390.11
86_P120_E0.6370.11
118_P149_G0.6360.11
120_E199_T0.6250.11
172_S183_V0.6250.11
135_I173_E0.6230.11
106_K219_P0.6220.11
81_A90_R0.6190.11
60_W193_R0.6190.11
65_K176_T0.6130.10
45_V185_Q0.6120.10
114_A152_L0.6090.10
27_V219_P0.6060.10
81_A100_S0.6040.10
64_G148_D0.6040.10
81_A156_L0.6020.10
89_S199_T0.6020.10
15_L119_Y0.5950.10
152_L197_N0.5910.10
111_L163_Y0.5910.10
25_G209_K0.5870.10
88_Q128_I0.5840.10
35_I40_E0.5820.10
47_Q84_L0.5790.10
144_Q200_D0.5780.10
104_T160_R0.5770.10
107_Q116_I0.5770.10
53_S210_P0.5740.10
101_W162_R0.5690.10
52_L71_P0.5670.10
24_L89_S0.5670.10
170_S225_P0.5660.10
93_A140_R0.5600.10
160_R178_R0.5570.10
109_I129_E0.5560.10
164_S212_G0.5550.10
50_D76_R0.5540.10
71_P164_S0.5520.10
108_G148_D0.5500.10
66_S215_S0.5480.10
92_Q133_T0.5470.10
108_G112_A0.5430.10
21_L191_T0.5420.10
60_W132_S0.5410.10
68_E107_Q0.5400.10
25_G70_N0.5370.10
84_L108_G0.5370.10
85_M212_G0.5330.09
19_P155_Q0.5320.09
155_Q168_Q0.5310.09
118_P153_Q0.5300.09
64_G204_Q0.5250.09
117_T163_Y0.5250.09
108_G210_P0.5240.09
51_Y149_G0.5230.09
34_A174_L0.5220.09
76_R83_R0.5150.09
138_Q165_K0.5120.09
81_A191_T0.5110.09
27_V216_P0.5100.09
88_Q219_P0.5100.09
75_L137_A0.5070.09
59_I139_V0.5050.09
29_N36_D0.5010.09
74_W195_L0.5000.09
74_W208_R0.5000.09
195_L198_L0.5000.09
195_L201_I0.5000.09
74_W146_W0.5000.09
74_W80_C0.5000.09
80_C195_L0.5000.09
80_C198_L0.5000.09
80_C201_I0.5000.09
80_C203_R0.5000.09
80_C205_L0.5000.09
80_C202_E0.5000.09
195_L202_E0.5000.09
195_L203_R0.5000.09
195_L205_L0.5000.09
74_W201_I0.5000.09
205_L208_R0.5000.09
203_R208_R0.5000.09
202_E208_R0.5000.09
202_E205_L0.5000.09
201_I208_R0.5000.09
201_I205_L0.5000.09
74_W202_E0.5000.09
74_W203_R0.5000.09
198_L208_R0.5000.09
198_L205_L0.5000.09
198_L203_R0.5000.09
198_L202_E0.5000.09
198_L201_I0.5000.09
74_W205_L0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbiC 1 0.0928 53.9 0.962 Contact Map
2xdjA 3 0.2152 46 0.963 Contact Map
3utkA 1 0.3418 41.3 0.964 Contact Map
3swfA 3 0.2447 19.9 0.97 Contact Map
4q4gX 1 0.0422 18.8 0.97 Contact Map
1yr2A 1 0.5949 14.4 0.971 Contact Map
3j3wX 1 0.1772 13.1 0.972 Contact Map
1jocA 2 0.2785 10.3 0.973 Contact Map
3fx7A 2 0.3333 9.4 0.974 Contact Map
2wt7B 1 0.3418 7.7 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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