GREMLIN Database
PGPC - Phosphatidylglycerophosphatase C
UniProt: P0AD42 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11371
Length: 211 (186)
Sequences: 4077 (2539)
Seq/√Len: 186.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_Q145_Q3.4711.00
7_R112_D2.8751.00
114_D140_N2.7371.00
123_Q127_E2.6711.00
169_E194_F2.6541.00
107_Y112_D2.5021.00
106_T110_S2.4141.00
108_L115_I2.2701.00
162_H166_A2.2561.00
119_T126_V2.2281.00
108_L139_V2.2111.00
65_L153_W2.1701.00
75_S149_G2.1381.00
47_I66_L2.1341.00
75_S78_R2.1051.00
163_E166_A2.0281.00
46_P50_I2.0171.00
117_L138_R1.9531.00
101_Q132_D1.9471.00
192_L198_R1.8691.00
163_E167_Q1.8631.00
18_H22_M1.8371.00
9_V107_Y1.8361.00
61_W160_L1.8341.00
168_L191_L1.8051.00
126_V141_L1.7901.00
115_I138_R1.7741.00
161_G190_P1.7691.00
105_T109_L1.7591.00
181_G195_C1.7341.00
105_T108_L1.7031.00
76_E80_Q1.6881.00
101_Q105_T1.6851.00
116_W171_K1.6781.00
165_V169_E1.6681.00
11_F182_Y1.6571.00
172_I176_L1.6421.00
118_I168_L1.6151.00
127_E131_F1.6051.00
117_L130_Y1.5801.00
116_W140_N1.5751.00
74_H78_R1.5751.00
107_Y182_Y1.5661.00
179_Y195_C1.5651.00
142_I167_Q1.5601.00
130_Y141_L1.5441.00
142_I159_C1.5171.00
59_A62_P1.5031.00
20_Q95_T1.4921.00
142_I170_R1.4641.00
145_Q155_L1.4061.00
76_E148_R1.3741.00
180_S197_H1.3591.00
176_L179_Y1.3541.00
181_G191_L1.3401.00
43_P47_I1.3381.00
144_S154_V1.3311.00
189_N207_L1.3201.00
144_S159_C1.3101.00
165_V194_F1.3101.00
13_L117_L1.2841.00
7_R178_L1.2771.00
10_F168_L1.2761.00
13_L126_V1.2691.00
178_L197_H1.2621.00
97_F201_V1.2471.00
29_Y85_D1.2251.00
10_F116_W1.2131.00
200_R203_P1.2051.00
13_L129_V1.2041.00
186_N206_E1.1981.00
19_Q97_F1.1791.00
87_V132_D1.1471.00
114_D139_V1.1441.00
107_Y180_S1.1431.00
79_L124_P1.1291.00
104_L138_R1.1261.00
44_L47_I1.1251.00
83_Q87_V1.1241.00
140_N171_K1.1181.00
166_A170_R1.1171.00
85_D89_W1.1151.00
64_S68_W1.1071.00
27_L41_V1.0991.00
192_L207_L1.0931.00
10_F195_C1.0921.00
32_R90_F1.0861.00
127_E141_L1.0841.00
28_R38_A1.0781.00
159_C163_E1.0721.00
17_L104_L1.0551.00
103_R106_T1.0541.00
72_F153_W1.0491.00
189_N193_Y1.0461.00
17_L100_V1.0441.00
175_P178_L1.0341.00
167_Q170_R1.0161.00
20_Q25_S1.0100.99
179_Y196_Q1.0080.99
180_S199_W1.0070.99
9_V180_S1.0000.99
22_M125_L0.9960.99
118_I191_L0.9950.99
162_H190_P0.9940.99
174_T196_Q0.9920.99
183_S190_P0.9920.99
112_D180_S0.9890.99
77_A81_T0.9870.99
38_A42_L0.9860.99
159_C167_Q0.9800.99
157_M166_A0.9800.99
142_I171_K0.9570.99
78_R81_T0.9330.99
64_S158_R0.9300.99
195_C198_R0.9290.99
80_Q88_R0.9220.99
28_R42_L0.9150.99
165_V190_P0.9140.99
168_L179_Y0.9130.99
181_G192_L0.9100.99
84_A131_F0.9060.99
61_W65_L0.9040.99
15_G20_Q0.8930.99
11_F107_Y0.8930.99
88_R132_D0.8860.99
11_F115_I0.8860.99
29_Y89_W0.8750.99
29_Y82_L0.8730.99
81_T85_D0.8710.99
65_L156_T0.8670.98
123_Q143_A0.8650.98
178_L196_Q0.8550.98
19_Q95_T0.8530.98
102_E106_T0.8360.98
8_V174_T0.8320.98
25_S95_T0.8290.98
96_A101_Q0.8290.98
176_L196_Q0.8280.98
104_L115_I0.8250.98
108_L137_P0.8140.98
123_Q141_L0.8130.98
106_T109_L0.8090.98
25_S28_R0.8050.97
47_I57_R0.8030.97
172_I179_Y0.8020.97
21_D121_S0.8000.97
29_Y86_F0.7990.97
40_L43_P0.7990.97
26_F74_H0.7980.97
58_A62_P0.7970.97
42_L46_P0.7950.97
9_V112_D0.7890.97
11_F17_L0.7800.97
97_F202_T0.7750.97
124_P150_Y0.7710.97
177_R196_Q0.7610.96
10_F179_Y0.7590.96
87_V128_A0.7590.96
15_G183_S0.7510.96
84_A128_A0.7500.96
80_Q84_A0.7460.96
10_F118_I0.7450.96
107_Y198_R0.7440.96
180_S198_R0.7350.96
45_L49_A0.7340.96
21_D185_S0.7280.95
127_E130_Y0.7280.95
64_S154_V0.7200.95
39_L43_P0.7190.95
80_Q127_E0.7180.95
76_E150_Y0.7170.95
45_L48_I0.7160.95
128_A131_F0.7090.95
115_I118_I0.7060.95
170_R173_G0.7030.95
79_L150_Y0.7030.95
40_L44_L0.6970.94
47_I50_I0.6960.94
17_L117_L0.6860.94
182_Y201_V0.6840.94
69_G72_F0.6840.94
120_G160_L0.6730.93
10_F191_L0.6720.93
130_Y137_P0.6700.93
27_L31_L0.6660.93
58_A66_L0.6650.93
169_E173_G0.6640.93
102_E105_T0.6630.93
142_I163_E0.6630.93
104_L136_L0.6610.93
81_T84_A0.6540.92
120_G144_S0.6530.92
15_G185_S0.6520.92
98_P102_E0.6520.92
186_N204_R0.6510.92
61_W158_R0.6500.92
25_S86_F0.6480.92
14_D121_S0.6430.92
121_S125_L0.6430.92
21_D120_G0.6380.91
169_E176_L0.6380.91
100_V104_L0.6380.91
50_I57_R0.6370.91
17_L136_L0.6370.91
60_R144_S0.6330.91
15_G119_T0.6290.91
124_P145_Q0.6250.90
119_T141_L0.6240.90
73_G149_G0.6220.90
78_R82_L0.6190.90
176_L194_F0.6180.90
90_F94_V0.6150.90
203_P207_L0.6110.89
61_W157_M0.6050.89
60_R120_G0.6030.89
80_Q83_Q0.5980.88
118_I183_S0.5970.88
30_L82_L0.5960.88
130_Y138_R0.5880.88
77_A148_R0.5870.87
10_F161_G0.5860.87
148_R151_G0.5830.87
87_V90_F0.5810.87
114_D174_T0.5790.87
16_T119_T0.5770.87
60_R63_M0.5770.87
29_Y81_T0.5760.86
166_A169_E0.5750.86
60_R187_Q0.5750.86
68_W71_T0.5750.86
8_V179_Y0.5730.86
46_P201_V0.5730.86
8_V172_I0.5650.85
129_V136_L0.5640.85
60_R68_W0.5630.85
128_A132_D0.5630.85
13_L18_H0.5600.85
13_L115_I0.5600.85
80_Q128_A0.5590.85
38_A50_I0.5580.85
9_V182_Y0.5570.85
15_G187_Q0.5500.84
37_N40_L0.5500.84
21_D187_Q0.5490.84
190_P207_L0.5490.84
190_P193_Y0.5490.84
68_W154_V0.5480.84
175_P196_Q0.5460.83
10_F178_L0.5420.83
117_L141_L0.5410.83
182_Y199_W0.5360.82
72_F152_G0.5350.82
25_S90_F0.5340.82
186_N189_N0.5330.82
46_P49_A0.5330.82
157_M170_R0.5320.82
97_F100_V0.5310.82
103_R107_Y0.5290.81
103_R112_D0.5270.81
32_R39_L0.5270.81
14_D21_D0.5240.81
73_G148_R0.5230.81
12_D16_T0.5230.81
56_G60_R0.5200.80
122_P143_A0.5150.80
118_I171_K0.5130.79
157_M163_E0.5120.79
7_R180_S0.5120.79
107_Y110_S0.5070.79
74_H119_T0.5060.79
13_L124_P0.5050.78
160_L187_Q0.5050.78
69_G73_G0.5040.78
160_L163_E0.5040.78
107_Y115_I0.5030.78
120_G158_R0.5020.78
11_F112_D0.5010.78
127_E145_Q0.5010.78
65_L154_V0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fvvA 2 0.9573 100 0.463 Contact Map
4as2A 4 0.9858 100 0.463 Contact Map
4gxtA 1 0.981 100 0.505 Contact Map
4ovyA 2 0.9668 99.9 0.569 Contact Map
1l7mA 1 0.8863 99.9 0.595 Contact Map
4ezeA 1 0.8957 99.9 0.601 Contact Map
1y8aA 1 0.9005 99.9 0.602 Contact Map
3m1yA 2 0.8815 99.8 0.61 Contact Map
1rkuA 2 0.8246 99.8 0.614 Contact Map
3p96A 2 0.8957 99.8 0.642 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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