PGPC - ECOLI - GREMLIN Contacts

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PGPC - Phosphatidylglycerophosphatase C

UniProt:	P0AD42	Sequences: MATHERRVVFFDLDGTLHQQDMFGSFLRYLLRRQPLNALLVLPLLPIIAIALLIKGRAARWPMSLLLWGCTFGHSEARLQTLQADFVRWFRDNVTAFPLVQERLTTYLLSSDADIWLITGSPQPLVEAVYFDTPWLPRVNLIASQIQRGYGGWVLTMRCLGHEKVAQLERKIGTPLRLYSGYSDSNQDNPLLYFCQHRWRVTPRGELQQLE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11371
Length:	211 (186)
Sequences:	4077 (2539)
Seq/√Len:	186.2

ECOLI - PGPC SERB
HALSA - Q9HMR1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
123_Q	145_Q	3.471	1.00
7_R	112_D	2.875	1.00
114_D	140_N	2.737	1.00
123_Q	127_E	2.671	1.00
169_E	194_F	2.654	1.00
107_Y	112_D	2.502	1.00
106_T	110_S	2.414	1.00
108_L	115_I	2.270	1.00
162_H	166_A	2.256	1.00
119_T	126_V	2.228	1.00
108_L	139_V	2.211	1.00
65_L	153_W	2.170	1.00
75_S	149_G	2.138	1.00
47_I	66_L	2.134	1.00
75_S	78_R	2.105	1.00
163_E	166_A	2.028	1.00
46_P	50_I	2.017	1.00
117_L	138_R	1.953	1.00
101_Q	132_D	1.947	1.00
192_L	198_R	1.869	1.00
163_E	167_Q	1.863	1.00
18_H	22_M	1.837	1.00
9_V	107_Y	1.836	1.00
61_W	160_L	1.834	1.00
168_L	191_L	1.805	1.00
126_V	141_L	1.790	1.00
115_I	138_R	1.774	1.00
161_G	190_P	1.769	1.00
105_T	109_L	1.759	1.00
181_G	195_C	1.734	1.00
105_T	108_L	1.703	1.00
76_E	80_Q	1.688	1.00
101_Q	105_T	1.685	1.00
116_W	171_K	1.678	1.00
165_V	169_E	1.668	1.00
11_F	182_Y	1.657	1.00
172_I	176_L	1.642	1.00
118_I	168_L	1.615	1.00
127_E	131_F	1.605	1.00
117_L	130_Y	1.580	1.00
116_W	140_N	1.575	1.00
74_H	78_R	1.575	1.00
107_Y	182_Y	1.566	1.00
179_Y	195_C	1.565	1.00
142_I	167_Q	1.560	1.00
130_Y	141_L	1.544	1.00
142_I	159_C	1.517	1.00
59_A	62_P	1.503	1.00
20_Q	95_T	1.492	1.00
142_I	170_R	1.464	1.00
145_Q	155_L	1.406	1.00
76_E	148_R	1.374	1.00
180_S	197_H	1.359	1.00
176_L	179_Y	1.354	1.00
181_G	191_L	1.340	1.00
43_P	47_I	1.338	1.00
144_S	154_V	1.331	1.00
189_N	207_L	1.320	1.00
144_S	159_C	1.310	1.00
165_V	194_F	1.310	1.00
13_L	117_L	1.284	1.00
7_R	178_L	1.277	1.00
10_F	168_L	1.276	1.00
13_L	126_V	1.269	1.00
178_L	197_H	1.262	1.00
97_F	201_V	1.247	1.00
29_Y	85_D	1.225	1.00
10_F	116_W	1.213	1.00
200_R	203_P	1.205	1.00
13_L	129_V	1.204	1.00
186_N	206_E	1.198	1.00
19_Q	97_F	1.179	1.00
87_V	132_D	1.147	1.00
114_D	139_V	1.144	1.00
107_Y	180_S	1.143	1.00
79_L	124_P	1.129	1.00
104_L	138_R	1.126	1.00
44_L	47_I	1.125	1.00
83_Q	87_V	1.124	1.00
140_N	171_K	1.118	1.00
166_A	170_R	1.117	1.00
85_D	89_W	1.115	1.00
64_S	68_W	1.107	1.00
27_L	41_V	1.099	1.00
192_L	207_L	1.093	1.00
10_F	195_C	1.092	1.00
32_R	90_F	1.086	1.00
127_E	141_L	1.084	1.00
28_R	38_A	1.078	1.00
159_C	163_E	1.072	1.00
17_L	104_L	1.055	1.00
103_R	106_T	1.054	1.00
72_F	153_W	1.049	1.00
189_N	193_Y	1.046	1.00
17_L	100_V	1.044	1.00
175_P	178_L	1.034	1.00
167_Q	170_R	1.016	1.00
20_Q	25_S	1.010	0.99
179_Y	196_Q	1.008	0.99
180_S	199_W	1.007	0.99
9_V	180_S	1.000	0.99
22_M	125_L	0.996	0.99
118_I	191_L	0.995	0.99
162_H	190_P	0.994	0.99
174_T	196_Q	0.992	0.99
183_S	190_P	0.992	0.99
112_D	180_S	0.989	0.99
77_A	81_T	0.987	0.99
38_A	42_L	0.986	0.99
159_C	167_Q	0.980	0.99
157_M	166_A	0.980	0.99
142_I	171_K	0.957	0.99
78_R	81_T	0.933	0.99
64_S	158_R	0.930	0.99
195_C	198_R	0.929	0.99
80_Q	88_R	0.922	0.99
28_R	42_L	0.915	0.99
165_V	190_P	0.914	0.99
168_L	179_Y	0.913	0.99
181_G	192_L	0.910	0.99
84_A	131_F	0.906	0.99
61_W	65_L	0.904	0.99
15_G	20_Q	0.893	0.99
11_F	107_Y	0.893	0.99
88_R	132_D	0.886	0.99
11_F	115_I	0.886	0.99
29_Y	89_W	0.875	0.99
29_Y	82_L	0.873	0.99
81_T	85_D	0.871	0.99
65_L	156_T	0.867	0.98
123_Q	143_A	0.865	0.98
178_L	196_Q	0.855	0.98
19_Q	95_T	0.853	0.98
102_E	106_T	0.836	0.98
8_V	174_T	0.832	0.98
25_S	95_T	0.829	0.98
96_A	101_Q	0.829	0.98
176_L	196_Q	0.828	0.98
104_L	115_I	0.825	0.98
108_L	137_P	0.814	0.98
123_Q	141_L	0.813	0.98
106_T	109_L	0.809	0.98
25_S	28_R	0.805	0.97
47_I	57_R	0.803	0.97
172_I	179_Y	0.802	0.97
21_D	121_S	0.800	0.97
29_Y	86_F	0.799	0.97
40_L	43_P	0.799	0.97
26_F	74_H	0.798	0.97
58_A	62_P	0.797	0.97
42_L	46_P	0.795	0.97
9_V	112_D	0.789	0.97
11_F	17_L	0.780	0.97
97_F	202_T	0.775	0.97
124_P	150_Y	0.771	0.97
177_R	196_Q	0.761	0.96
10_F	179_Y	0.759	0.96
87_V	128_A	0.759	0.96
15_G	183_S	0.751	0.96
84_A	128_A	0.750	0.96
80_Q	84_A	0.746	0.96
10_F	118_I	0.745	0.96
107_Y	198_R	0.744	0.96
180_S	198_R	0.735	0.96
45_L	49_A	0.734	0.96
21_D	185_S	0.728	0.95
127_E	130_Y	0.728	0.95
64_S	154_V	0.720	0.95
39_L	43_P	0.719	0.95
80_Q	127_E	0.718	0.95
76_E	150_Y	0.717	0.95
45_L	48_I	0.716	0.95
128_A	131_F	0.709	0.95
115_I	118_I	0.706	0.95
170_R	173_G	0.703	0.95
79_L	150_Y	0.703	0.95
40_L	44_L	0.697	0.94
47_I	50_I	0.696	0.94
17_L	117_L	0.686	0.94
182_Y	201_V	0.684	0.94
69_G	72_F	0.684	0.94
120_G	160_L	0.673	0.93
10_F	191_L	0.672	0.93
130_Y	137_P	0.670	0.93
27_L	31_L	0.666	0.93
58_A	66_L	0.665	0.93
169_E	173_G	0.664	0.93
102_E	105_T	0.663	0.93
142_I	163_E	0.663	0.93
104_L	136_L	0.661	0.93
81_T	84_A	0.654	0.92
120_G	144_S	0.653	0.92
15_G	185_S	0.652	0.92
98_P	102_E	0.652	0.92
186_N	204_R	0.651	0.92
61_W	158_R	0.650	0.92
25_S	86_F	0.648	0.92
14_D	121_S	0.643	0.92
121_S	125_L	0.643	0.92
21_D	120_G	0.638	0.91
169_E	176_L	0.638	0.91
100_V	104_L	0.638	0.91
50_I	57_R	0.637	0.91
17_L	136_L	0.637	0.91
60_R	144_S	0.633	0.91
15_G	119_T	0.629	0.91
124_P	145_Q	0.625	0.90
119_T	141_L	0.624	0.90
73_G	149_G	0.622	0.90
78_R	82_L	0.619	0.90
176_L	194_F	0.618	0.90
90_F	94_V	0.615	0.90
203_P	207_L	0.611	0.89
61_W	157_M	0.605	0.89
60_R	120_G	0.603	0.89
80_Q	83_Q	0.598	0.88
118_I	183_S	0.597	0.88
30_L	82_L	0.596	0.88
130_Y	138_R	0.588	0.88
77_A	148_R	0.587	0.87
10_F	161_G	0.586	0.87
148_R	151_G	0.583	0.87
87_V	90_F	0.581	0.87
114_D	174_T	0.579	0.87
16_T	119_T	0.577	0.87
60_R	63_M	0.577	0.87
29_Y	81_T	0.576	0.86
166_A	169_E	0.575	0.86
60_R	187_Q	0.575	0.86
68_W	71_T	0.575	0.86
8_V	179_Y	0.573	0.86
46_P	201_V	0.573	0.86
8_V	172_I	0.565	0.85
129_V	136_L	0.564	0.85
60_R	68_W	0.563	0.85
128_A	132_D	0.563	0.85
13_L	18_H	0.560	0.85
13_L	115_I	0.560	0.85
80_Q	128_A	0.559	0.85
38_A	50_I	0.558	0.85
9_V	182_Y	0.557	0.85
15_G	187_Q	0.550	0.84
37_N	40_L	0.550	0.84
21_D	187_Q	0.549	0.84
190_P	207_L	0.549	0.84
190_P	193_Y	0.549	0.84
68_W	154_V	0.548	0.84
175_P	196_Q	0.546	0.83
10_F	178_L	0.542	0.83
117_L	141_L	0.541	0.83
182_Y	199_W	0.536	0.82
72_F	152_G	0.535	0.82
25_S	90_F	0.534	0.82
186_N	189_N	0.533	0.82
46_P	49_A	0.533	0.82
157_M	170_R	0.532	0.82
97_F	100_V	0.531	0.82
103_R	107_Y	0.529	0.81
103_R	112_D	0.527	0.81
32_R	39_L	0.527	0.81
14_D	21_D	0.524	0.81
73_G	148_R	0.523	0.81
12_D	16_T	0.523	0.81
56_G	60_R	0.520	0.80
122_P	143_A	0.515	0.80
118_I	171_K	0.513	0.79
157_M	163_E	0.512	0.79
7_R	180_S	0.512	0.79
107_Y	110_S	0.507	0.79
74_H	119_T	0.506	0.79
13_L	124_P	0.505	0.78
160_L	187_Q	0.505	0.78
69_G	73_G	0.504	0.78
160_L	163_E	0.504	0.78
107_Y	115_I	0.503	0.78
120_G	158_R	0.502	0.78
11_F	112_D	0.501	0.78
127_E	145_Q	0.501	0.78
65_L	154_V	0.500	0.78

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3fvvA	2	0.9573	100	0.463	Contact Map
4as2A	4	0.9858	100	0.463	Contact Map
4gxtA	1	0.981	100	0.505	Contact Map
4ovyA	2	0.9668	99.9	0.569	Contact Map
1l7mA	1	0.8863	99.9	0.595	Contact Map
4ezeA	1	0.8957	99.9	0.601	Contact Map
1y8aA	1	0.9005	99.9	0.602	Contact Map
3m1yA	2	0.8815	99.8	0.61	Contact Map
1rkuA	2	0.8246	99.8	0.614	Contact Map
3p96A	2	0.8957	99.8	0.642	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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