GREMLIN Database
YFEC - Uncharacterized protein YfeC
UniProt: P0AD37 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11431
Length: 114 (112)
Sequences: 104 (63)
Seq/√Len: 5.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_V81_A3.9460.93
42_V80_L3.0950.80
19_K38_K2.7200.70
14_R40_R2.4930.63
61_Q66_A2.3650.58
32_P51_Y2.2350.54
13_S35_Q1.8920.42
84_M101_I1.8900.42
27_T82_K1.8550.40
51_Y91_Q1.8330.40
8_R73_L1.8210.39
3_P12_Y1.7380.37
19_K56_E1.7330.36
46_E73_L1.7120.36
45_N80_L1.6790.35
13_S19_K1.6550.34
32_P101_I1.6090.32
13_S38_K1.5910.32
86_P112_D1.5880.32
44_V82_K1.5860.32
31_K35_Q1.5700.31
85_T102_I1.5170.30
35_Q76_L1.4860.29
95_L99_E1.4760.28
74_E82_K1.4590.28
47_Q71_A1.4430.28
23_K49_R1.4010.26
53_R59_E1.3960.26
18_N28_T1.3830.26
17_I52_I1.3740.26
31_K56_E1.3340.25
105_L110_I1.3340.25
10_T19_K1.2660.23
1_M22_R1.2540.23
28_T98_R1.2540.23
35_Q38_K1.2490.22
28_T34_V1.2390.22
31_K73_L1.2210.22
19_K35_Q1.2210.22
55_A111_R1.1970.21
29_S104_L1.1920.21
24_E43_H1.1850.21
38_K104_L1.1850.21
56_E77_L1.1720.21
44_V74_E1.1720.21
4_D43_H1.1630.20
3_P19_K1.1380.20
9_L92_F1.1310.20
28_T40_R1.1020.19
76_L79_T1.0880.19
47_Q87_V1.0870.19
27_T92_F1.0860.19
27_T64_A1.0710.18
64_A87_V1.0670.18
30_P51_Y1.0510.18
63_E72_P1.0430.18
31_K76_L1.0360.18
44_V55_A1.0280.17
3_P13_S1.0240.17
19_K77_L1.0120.17
55_A82_K1.0120.17
9_L104_L0.9950.17
27_T112_D0.9910.17
9_L42_V0.9760.16
25_G47_Q0.9740.16
54_N80_L0.9610.16
2_T110_I0.9570.16
68_S72_P0.9540.16
10_T13_S0.9310.16
11_G39_A0.9280.16
42_V45_N0.9240.15
47_Q64_A0.9200.15
23_K38_K0.9180.15
38_K56_E0.9170.15
50_E67_L0.9160.15
24_E77_L0.9100.15
1_M25_G0.8940.15
10_T76_L0.8900.15
23_K29_S0.8850.15
47_Q109_G0.8770.15
22_R41_L0.8730.15
96_L99_E0.8710.14
32_P91_Q0.8640.14
50_E112_D0.8440.14
10_T35_Q0.8420.14
89_Q105_L0.8380.14
29_S56_E0.8330.14
12_Y19_K0.8300.14
61_Q92_F0.8180.14
32_P40_R0.8140.14
36_G39_A0.8070.13
66_A80_L0.8040.13
18_N34_V0.8040.13
22_R38_K0.7840.13
79_T92_F0.7810.13
63_E106_Q0.7790.13
13_S31_K0.7650.13
3_P83_E0.7650.13
19_K29_S0.7610.13
8_R54_N0.7610.13
87_V112_D0.7540.13
18_N98_R0.7510.13
89_Q110_I0.7510.13
12_Y70_D0.7500.13
12_Y93_T0.7500.13
52_I57_R0.7490.12
101_I106_Q0.7470.12
34_V98_R0.7450.12
88_E96_L0.7290.12
1_M27_T0.7260.12
76_L91_Q0.7240.12
54_N75_V0.7170.12
10_T38_K0.7150.12
27_T68_S0.7150.12
42_V83_E0.6980.12
53_R60_G0.6960.12
7_A18_N0.6960.12
34_V96_L0.6930.12
45_N55_A0.6840.12
63_E86_P0.6790.11
43_H49_R0.6760.11
63_E112_D0.6740.11
8_R42_V0.6620.11
93_T104_L0.6620.11
42_V102_I0.6560.11
42_V50_E0.6550.11
88_E99_E0.6540.11
102_I112_D0.6530.11
47_Q62_G0.6500.11
21_V49_R0.6440.11
9_L25_G0.6390.11
49_R109_G0.6360.11
58_P84_M0.6310.11
46_E58_P0.6290.11
75_V81_A0.6270.11
5_E107_R0.6260.11
88_E108_L0.6240.11
66_A91_Q0.6220.11
8_R64_A0.6180.11
60_G109_G0.6140.11
29_S38_K0.6120.11
67_L78_V0.6120.11
11_G37_G0.6030.10
11_G36_G0.6030.10
10_T17_I0.5870.10
18_N40_R0.5820.10
53_R65_P0.5810.10
44_V87_V0.5750.10
13_S97_L0.5750.10
9_L50_E0.5740.10
51_Y105_L0.5720.10
45_N81_A0.5670.10
42_V55_A0.5640.10
4_D14_R0.5610.10
6_L31_K0.5560.10
88_E98_R0.5530.10
24_E46_E0.5470.10
95_L102_I0.5450.10
83_E94_S0.5450.10
12_Y77_L0.5350.10
28_T39_A0.5350.10
17_I83_E0.5300.09
76_L97_L0.5290.09
96_L108_L0.5100.09
3_P21_V0.5060.09
21_V57_R0.5030.09
68_S73_L0.5000.09
9_L45_N0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g4dA 1 0.5263 98.6 0.805 Contact Map
1tnsA 1 0.5877 98.5 0.812 Contact Map
4j2nA 4 0.4298 97.4 0.858 Contact Map
1z4hA 1 0.4825 97.3 0.86 Contact Map
1j9iA 2 0.5789 97 0.866 Contact Map
3kp7A 2 0.7544 96.6 0.872 Contact Map
1y6uA 1 0.4474 96.5 0.874 Contact Map
2ao9A 7 0.6754 96.2 0.877 Contact Map
4yifA 2 0.807 95.8 0.881 Contact Map
3s2wA 3 0.7895 95.8 0.881 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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