YFCA - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

YFCA - UPF0721 transmembrane protein YfcA

UniProt:	P0AD30	Sequences: METFNSLFMVSPLLLGVLFFVAMLAGFIDSIAGGGGLLTIPALMAAGMSPANALATNKLQACGGSISATIYFIRRKVVSLSDQKLNIAMTFVGSMSGALLVQYVQADVLRQILPILVICIGLYFLLMPKLGEEDRQRRMYGLPFALIAGGCVGFYDGFFGPAAGSFYALAFVTLCGFNLAKATAHAKLLNATSNIGGLLLFILGGKVIWATGFVMLVGQFLGARMGSRLVLSKGQKLIRPMIVIVSAVMSAKLLYDSHGQEILHWLGMN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11144
Length:	269 (242)
Sequences:	9711 (6753)
Seq/√Len:	434.1

ECOLI - YFCA
BACSU - YRKJ YUNE YJNA YTNM YDHB
HALSA - O54662
SULSO - Q97WF4 Q981D0 Q97UT0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
27_F	229_L	3.704	1.00
93_G	150_G	3.507	1.00
252_K	256_D	3.341	1.00
100_L	154_F	3.009	1.00
79_S	181_K	2.897	1.00
19_F	218_G	2.650	1.00
236_K	240_P	2.577	1.00
73_I	80_L	2.503	1.00
67_S	220_F	2.484	1.00
237_L	240_P	2.436	1.00
87_I	192_T	2.403	1.00
63_G	216_L	2.367	1.00
122_L	126_L	2.324	1.00
148_A	170_A	2.316	1.00
21_V	42_A	2.289	1.00
228_R	232_S	2.198	1.00
89_M	146_L	2.188	1.00
58_K	197_G	2.128	1.00
83_Q	188_L	2.125	1.00
178_N	181_K	2.100	1.00
67_S	224_R	2.054	1.00
251_A	255_Y	2.039	1.00
95_M	200_L	2.008	1.00
52_N	55_A	1.902	1.00
56_T	212_G	1.888	1.00
82_D	177_F	1.858	1.00
79_S	82_D	1.823	1.00
114_P	250_S	1.811	1.00
234_G	237_L	1.809	1.00
59_L	212_G	1.804	1.00
121_G	250_S	1.788	1.00
23_M	221_L	1.775	1.00
71_Y	227_S	1.751	1.00
72_F	77_V	1.728	1.00
81_S	84_K	1.720	1.00
23_M	222_G	1.687	1.00
99_L	103_Y	1.680	1.00
121_G	247_A	1.679	1.00
125_L	243_V	1.668	1.00
118_I	250_S	1.666	1.00
43_L	215_M	1.663	1.00
15_L	214_V	1.658	1.00
22_A	215_M	1.646	1.00
25_A	38_L	1.629	1.00
152_V	166_F	1.569	1.00
75_R	231_L	1.534	1.00
150_G	154_F	1.534	1.00
240_P	244_I	1.532	1.00
84_K	88_A	1.531	1.00
115_I	119_C	1.528	1.00
247_A	251_A	1.519	1.00
72_F	230_V	1.499	1.00
81_S	85_L	1.494	1.00
208_I	211_T	1.488	1.00
114_P	254_L	1.476	1.00
91_F	196_G	1.473	1.00
83_Q	185_H	1.464	1.00
27_F	225_M	1.459	1.00
121_G	243_V	1.425	1.00
96_S	150_G	1.412	1.00
69_T	188_L	1.411	1.00
84_K	87_I	1.411	1.00
20_F	24_L	1.400	1.00
108_V	112_I	1.393	1.00
213_F	217_V	1.381	1.00
202_I	209_W	1.348	1.00
22_A	218_G	1.348	1.00
80_L	84_K	1.348	1.00
68_A	187_K	1.344	1.00
167_Y	189_L	1.342	1.00
62_C	195_I	1.337	1.00
16_G	20_F	1.326	1.00
224_R	228_R	1.319	1.00
116_L	159_F	1.317	1.00
70_I	74_R	1.300	1.00
217_V	221_L	1.288	1.00
199_L	203_L	1.286	1.00
114_P	118_I	1.282	1.00
19_F	214_V	1.277	1.00
210_A	214_V	1.273	1.00
77_V	231_L	1.268	1.00
48_M	211_T	1.252	1.00
133_E	137_R	1.243	1.00
52_N	208_I	1.239	1.00
66_I	191_A	1.239	1.00
95_M	99_L	1.238	1.00
49_S	52_N	1.229	1.00
143_P	147_I	1.225	1.00
93_G	97_G	1.216	1.00
90_T	193_S	1.208	1.00
77_V	184_A	1.203	1.00
69_T	73_I	1.202	1.00
168_A	182_A	1.200	1.00
94_S	197_G	1.198	1.00
89_M	149_G	1.188	1.00
89_M	93_G	1.188	1.00
126_L	129_K	1.166	1.00
244_I	248_V	1.160	1.00
104_V	158_F	1.158	1.00
222_G	226_G	1.157	1.00
98_A	200_L	1.153	1.00
190_N	193_S	1.134	1.00
129_K	132_E	1.130	1.00
222_G	225_M	1.127	1.00
145_A	175_C	1.121	1.00
68_A	223_A	1.119	1.00
54_L	201_F	1.109	1.00
124_F	242_I	1.095	1.00
80_L	83_Q	1.092	1.00
237_L	241_M	1.086	1.00
88_A	92_V	1.085	1.00
66_I	70_I	1.078	1.00
55_A	207_V	1.075	1.00
218_G	222_G	1.074	1.00
180_A	230_V	1.070	1.00
98_A	197_G	1.064	1.00
69_T	191_A	1.042	1.00
32_A	241_M	1.041	1.00
143_P	146_L	1.034	1.00
72_F	227_S	1.033	1.00
163_A	167_Y	1.017	1.00
86_N	171_F	1.008	1.00
228_R	231_L	0.997	1.00
71_Y	224_R	0.996	1.00
39_T	215_M	0.994	1.00
64_G	219_Q	0.987	1.00
147_I	151_C	0.986	1.00
71_Y	75_R	0.981	1.00
19_F	217_V	0.980	1.00
57_N	61_A	0.968	1.00
93_G	154_F	0.968	1.00
172_V	182_A	0.965	1.00
96_S	99_L	0.962	1.00
69_T	80_L	0.962	1.00
108_V	111_Q	0.959	1.00
161_P	165_S	0.957	1.00
72_F	184_A	0.951	1.00
172_V	179_L	0.946	1.00
17_V	20_F	0.945	1.00
206_K	210_A	0.933	1.00
163_A	169_L	0.932	1.00
18_L	211_T	0.929	1.00
47_G	53_A	0.929	1.00
56_T	207_V	0.929	1.00
168_A	186_A	0.928	1.00
86_N	189_L	0.922	1.00
252_K	255_Y	0.917	1.00
78_V	185_H	0.916	1.00
230_V	238_I	0.915	1.00
250_S	254_L	0.912	1.00
221_L	224_R	0.907	1.00
18_L	214_V	0.906	1.00
99_L	102_Q	0.906	1.00
73_I	78_V	0.903	1.00
62_C	198_L	0.902	1.00
118_I	122_L	0.898	1.00
111_Q	115_I	0.889	1.00
67_S	223_A	0.889	1.00
213_F	216_L	0.884	1.00
248_V	251_A	0.873	1.00
248_V	252_K	0.868	1.00
94_S	98_A	0.868	1.00
97_G	154_F	0.868	1.00
107_D	111_Q	0.866	1.00
149_G	167_Y	0.864	1.00
144_F	147_I	0.860	1.00
98_A	196_G	0.860	1.00
90_T	189_L	0.860	1.00
179_L	183_T	0.860	1.00
52_N	56_T	0.855	1.00
19_F	23_M	0.854	1.00
119_C	123_Y	0.853	1.00
25_A	39_T	0.845	1.00
156_D	193_S	0.842	1.00
170_A	174_L	0.840	1.00
73_I	76_K	0.838	1.00
106_A	110_R	0.831	1.00
18_L	215_M	0.829	1.00
105_Q	108_V	0.827	1.00
67_S	71_Y	0.826	1.00
118_I	247_A	0.823	1.00
96_S	154_F	0.821	1.00
223_A	227_S	0.818	1.00
75_R	228_R	0.817	1.00
40_I	57_N	0.815	1.00
233_K	237_L	0.814	1.00
71_Y	228_R	0.811	1.00
127_M	239_R	0.802	1.00
141_G	144_F	0.800	1.00
100_L	103_Y	0.798	1.00
188_L	192_T	0.797	1.00
48_M	208_I	0.795	1.00
89_M	92_V	0.795	1.00
111_Q	114_P	0.795	1.00
214_V	218_G	0.793	1.00
122_L	247_A	0.792	1.00
78_V	83_Q	0.789	1.00
127_M	130_L	0.788	1.00
168_A	183_T	0.786	1.00
31_I	226_G	0.769	1.00
36_G	157_G	0.765	1.00
210_A	213_F	0.764	1.00
132_E	135_R	0.764	1.00
23_M	218_G	0.762	1.00
25_A	42_A	0.761	1.00
80_L	188_L	0.760	1.00
44_M	53_A	0.760	1.00
23_M	225_M	0.760	1.00
27_F	222_G	0.759	1.00
133_E	136_Q	0.759	1.00
101_V	201_F	0.759	1.00
30_S	227_S	0.746	1.00
29_D	36_G	0.743	1.00
200_L	204_G	0.742	1.00
85_L	142_L	0.742	1.00
242_I	246_S	0.738	1.00
30_S	68_A	0.729	1.00
26_G	35_G	0.728	1.00
225_M	228_R	0.728	1.00
156_D	163_A	0.728	1.00
65_S	160_G	0.727	1.00
55_A	198_L	0.726	1.00
17_V	21_V	0.724	1.00
56_T	208_I	0.723	1.00
107_D	110_R	0.723	1.00
201_F	206_K	0.720	1.00
167_Y	171_F	0.719	1.00
152_V	163_A	0.716	1.00
63_G	220_F	0.716	1.00
144_F	170_A	0.714	1.00
22_A	39_T	0.713	1.00
96_S	100_L	0.711	1.00
48_M	52_N	0.711	1.00
71_Y	74_R	0.710	1.00
36_G	61_A	0.709	1.00
70_I	73_I	0.708	1.00
90_T	167_Y	0.703	1.00
23_M	27_F	0.701	1.00
59_L	198_L	0.700	1.00
83_Q	189_L	0.700	1.00
98_A	201_F	0.698	1.00
39_T	43_L	0.696	1.00
163_A	190_N	0.694	1.00
85_L	88_A	0.688	1.00
61_A	163_A	0.687	1.00
181_K	184_A	0.683	1.00
22_A	26_G	0.682	1.00
92_V	96_S	0.679	1.00
182_A	186_A	0.678	1.00
31_I	238_I	0.678	1.00
61_A	194_N	0.677	1.00
86_N	149_G	0.674	1.00
129_K	133_E	0.672	1.00
179_L	242_I	0.672	1.00
138_R	141_G	0.670	1.00
110_R	256_D	0.665	1.00
198_L	212_G	0.662	1.00
60_Q	219_Q	0.661	1.00
117_V	246_S	0.657	1.00
166_F	169_L	0.655	0.99
120_I	165_S	0.655	0.99
160_G	186_A	0.650	0.99
65_S	190_N	0.650	0.99
19_F	22_A	0.649	0.99
149_G	153_G	0.646	0.99
31_I	233_K	0.645	0.99
99_L	200_L	0.645	0.99
187_K	190_N	0.642	0.99
29_D	156_D	0.641	0.99
235_Q	239_R	0.640	0.99
147_I	150_G	0.638	0.99
58_K	160_G	0.638	0.99
220_F	224_R	0.638	0.99
51_A	55_A	0.631	0.99
177_F	181_K	0.627	0.99
51_A	109_L	0.625	0.99
37_L	117_V	0.625	0.99
121_G	246_S	0.620	0.99
45_A	253_L	0.617	0.99
65_S	191_A	0.612	0.99
229_L	233_K	0.612	0.99
102_Q	204_G	0.611	0.99
28_I	38_L	0.609	0.99
180_A	235_Q	0.607	0.99
26_G	219_Q	0.607	0.99
207_V	212_G	0.606	0.99
134_D	137_R	0.604	0.99
163_A	186_A	0.602	0.99
112_I	159_F	0.602	0.99
29_D	38_L	0.601	0.99
66_I	69_T	0.600	0.99
104_V	108_V	0.599	0.99
77_V	181_K	0.596	0.99
61_A	65_S	0.596	0.99
114_P	253_L	0.581	0.99
234_G	238_I	0.580	0.99
23_M	26_G	0.580	0.99
31_I	229_L	0.580	0.99
152_V	167_Y	0.576	0.99
32_A	245_V	0.575	0.99
92_V	150_G	0.571	0.99
132_E	136_Q	0.569	0.99
197_G	200_L	0.568	0.99
54_L	109_L	0.568	0.99
202_I	207_V	0.568	0.99
29_D	64_G	0.568	0.99
58_K	61_A	0.568	0.99
22_A	211_T	0.567	0.99
54_L	58_K	0.564	0.98
42_A	46_A	0.564	0.98
137_R	141_G	0.564	0.98
198_L	202_I	0.562	0.98
229_L	232_S	0.561	0.98
81_S	142_L	0.561	0.98
121_G	125_L	0.561	0.98
209_W	213_F	0.558	0.98
156_D	161_P	0.558	0.98
59_L	209_W	0.557	0.98
50_P	53_A	0.557	0.98
186_A	190_N	0.555	0.98
118_I	251_A	0.555	0.98
59_L	216_L	0.554	0.98
54_L	101_V	0.552	0.98
212_G	216_L	0.550	0.98
239_R	243_V	0.549	0.98
29_D	190_N	0.548	0.98
214_V	217_V	0.548	0.98
85_L	146_L	0.545	0.98
106_A	158_F	0.543	0.98
123_Y	128_P	0.543	0.98
32_A	223_A	0.543	0.98
44_M	50_P	0.542	0.98
225_M	229_L	0.541	0.98
195_I	199_L	0.540	0.98
39_T	61_A	0.539	0.98
238_I	243_V	0.539	0.98
61_A	156_D	0.538	0.98
33_G	162_A	0.535	0.98
79_S	84_K	0.532	0.98
145_A	171_F	0.532	0.98
58_K	156_D	0.531	0.98
95_M	203_L	0.531	0.98
164_G	186_A	0.531	0.98
171_F	189_L	0.530	0.98
30_S	183_T	0.529	0.98
30_S	223_A	0.526	0.98
243_V	247_A	0.520	0.97
51_A	54_L	0.519	0.97
118_I	254_L	0.518	0.97
135_R	139_M	0.518	0.97
100_L	104_V	0.515	0.97
236_K	239_R	0.513	0.97
22_A	56_T	0.512	0.97
194_N	197_G	0.511	0.97
160_G	163_A	0.509	0.97
92_V	95_M	0.506	0.97
102_Q	206_K	0.505	0.97
167_Y	190_N	0.504	0.97
82_D	181_K	0.504	0.97
113_L	253_L	0.502	0.97
61_A	190_N	0.502	0.97
15_L	19_F	0.500	0.97
94_S	196_G	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3llqA	3	0.7361	55.9	0.929	Contact Map
2f2bA	4	0.7323	33.3	0.938	Contact Map
2gfpA	2	0.8773	30.2	0.94	Contact Map
2nwlA	3	0.2751	28.2	0.94	Contact Map
2a65A	2	0.4796	26.8	0.941	Contact Map
3cn5A	3	0.7398	26.4	0.941	Contact Map
1pw4A	1	0.8625	24.7	0.942	Contact Map
1j4nA	4	0.7695	19.9	0.945	Contact Map
4rp9A	2	0.4944	19.7	0.945	Contact Map
2zy9A	2	0.632	16	0.947	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0097 seconds.