GREMLIN Database
YFCA - UPF0721 transmembrane protein YfcA
UniProt: P0AD30 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11144
Length: 269 (242)
Sequences: 9711 (6753)
Seq/√Len: 434.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_F229_L3.7041.00
93_G150_G3.5071.00
252_K256_D3.3411.00
100_L154_F3.0091.00
79_S181_K2.8971.00
19_F218_G2.6501.00
236_K240_P2.5771.00
73_I80_L2.5031.00
67_S220_F2.4841.00
237_L240_P2.4361.00
87_I192_T2.4031.00
63_G216_L2.3671.00
122_L126_L2.3241.00
148_A170_A2.3161.00
21_V42_A2.2891.00
228_R232_S2.1981.00
89_M146_L2.1881.00
58_K197_G2.1281.00
83_Q188_L2.1251.00
178_N181_K2.1001.00
67_S224_R2.0541.00
251_A255_Y2.0391.00
95_M200_L2.0081.00
52_N55_A1.9021.00
56_T212_G1.8881.00
82_D177_F1.8581.00
79_S82_D1.8231.00
114_P250_S1.8111.00
234_G237_L1.8091.00
59_L212_G1.8041.00
121_G250_S1.7881.00
23_M221_L1.7751.00
71_Y227_S1.7511.00
72_F77_V1.7281.00
81_S84_K1.7201.00
23_M222_G1.6871.00
99_L103_Y1.6801.00
121_G247_A1.6791.00
125_L243_V1.6681.00
118_I250_S1.6661.00
43_L215_M1.6631.00
15_L214_V1.6581.00
22_A215_M1.6461.00
25_A38_L1.6291.00
152_V166_F1.5691.00
75_R231_L1.5341.00
150_G154_F1.5341.00
240_P244_I1.5321.00
84_K88_A1.5311.00
115_I119_C1.5281.00
247_A251_A1.5191.00
72_F230_V1.4991.00
81_S85_L1.4941.00
208_I211_T1.4881.00
114_P254_L1.4761.00
91_F196_G1.4731.00
83_Q185_H1.4641.00
27_F225_M1.4591.00
121_G243_V1.4251.00
96_S150_G1.4121.00
69_T188_L1.4111.00
84_K87_I1.4111.00
20_F24_L1.4001.00
108_V112_I1.3931.00
213_F217_V1.3811.00
202_I209_W1.3481.00
22_A218_G1.3481.00
80_L84_K1.3481.00
68_A187_K1.3441.00
167_Y189_L1.3421.00
62_C195_I1.3371.00
16_G20_F1.3261.00
224_R228_R1.3191.00
116_L159_F1.3171.00
70_I74_R1.3001.00
217_V221_L1.2881.00
199_L203_L1.2861.00
114_P118_I1.2821.00
19_F214_V1.2771.00
210_A214_V1.2731.00
77_V231_L1.2681.00
48_M211_T1.2521.00
133_E137_R1.2431.00
52_N208_I1.2391.00
66_I191_A1.2391.00
95_M99_L1.2381.00
49_S52_N1.2291.00
143_P147_I1.2251.00
93_G97_G1.2161.00
90_T193_S1.2081.00
77_V184_A1.2031.00
69_T73_I1.2021.00
168_A182_A1.2001.00
94_S197_G1.1981.00
89_M149_G1.1881.00
89_M93_G1.1881.00
126_L129_K1.1661.00
244_I248_V1.1601.00
104_V158_F1.1581.00
222_G226_G1.1571.00
98_A200_L1.1531.00
190_N193_S1.1341.00
129_K132_E1.1301.00
222_G225_M1.1271.00
145_A175_C1.1211.00
68_A223_A1.1191.00
54_L201_F1.1091.00
124_F242_I1.0951.00
80_L83_Q1.0921.00
237_L241_M1.0861.00
88_A92_V1.0851.00
66_I70_I1.0781.00
55_A207_V1.0751.00
218_G222_G1.0741.00
180_A230_V1.0701.00
98_A197_G1.0641.00
69_T191_A1.0421.00
32_A241_M1.0411.00
143_P146_L1.0341.00
72_F227_S1.0331.00
163_A167_Y1.0171.00
86_N171_F1.0081.00
228_R231_L0.9971.00
71_Y224_R0.9961.00
39_T215_M0.9941.00
64_G219_Q0.9871.00
147_I151_C0.9861.00
71_Y75_R0.9811.00
19_F217_V0.9801.00
57_N61_A0.9681.00
93_G154_F0.9681.00
172_V182_A0.9651.00
96_S99_L0.9621.00
69_T80_L0.9621.00
108_V111_Q0.9591.00
161_P165_S0.9571.00
72_F184_A0.9511.00
172_V179_L0.9461.00
17_V20_F0.9451.00
206_K210_A0.9331.00
163_A169_L0.9321.00
18_L211_T0.9291.00
47_G53_A0.9291.00
56_T207_V0.9291.00
168_A186_A0.9281.00
86_N189_L0.9221.00
252_K255_Y0.9171.00
78_V185_H0.9161.00
230_V238_I0.9151.00
250_S254_L0.9121.00
221_L224_R0.9071.00
18_L214_V0.9061.00
99_L102_Q0.9061.00
73_I78_V0.9031.00
62_C198_L0.9021.00
118_I122_L0.8981.00
111_Q115_I0.8891.00
67_S223_A0.8891.00
213_F216_L0.8841.00
248_V251_A0.8731.00
248_V252_K0.8681.00
94_S98_A0.8681.00
97_G154_F0.8681.00
107_D111_Q0.8661.00
149_G167_Y0.8641.00
144_F147_I0.8601.00
98_A196_G0.8601.00
90_T189_L0.8601.00
179_L183_T0.8601.00
52_N56_T0.8551.00
19_F23_M0.8541.00
119_C123_Y0.8531.00
25_A39_T0.8451.00
156_D193_S0.8421.00
170_A174_L0.8401.00
73_I76_K0.8381.00
106_A110_R0.8311.00
18_L215_M0.8291.00
105_Q108_V0.8271.00
67_S71_Y0.8261.00
118_I247_A0.8231.00
96_S154_F0.8211.00
223_A227_S0.8181.00
75_R228_R0.8171.00
40_I57_N0.8151.00
233_K237_L0.8141.00
71_Y228_R0.8111.00
127_M239_R0.8021.00
141_G144_F0.8001.00
100_L103_Y0.7981.00
188_L192_T0.7971.00
48_M208_I0.7951.00
89_M92_V0.7951.00
111_Q114_P0.7951.00
214_V218_G0.7931.00
122_L247_A0.7921.00
78_V83_Q0.7891.00
127_M130_L0.7881.00
168_A183_T0.7861.00
31_I226_G0.7691.00
36_G157_G0.7651.00
210_A213_F0.7641.00
132_E135_R0.7641.00
23_M218_G0.7621.00
25_A42_A0.7611.00
80_L188_L0.7601.00
44_M53_A0.7601.00
23_M225_M0.7601.00
27_F222_G0.7591.00
133_E136_Q0.7591.00
101_V201_F0.7591.00
30_S227_S0.7461.00
29_D36_G0.7431.00
200_L204_G0.7421.00
85_L142_L0.7421.00
242_I246_S0.7381.00
30_S68_A0.7291.00
26_G35_G0.7281.00
225_M228_R0.7281.00
156_D163_A0.7281.00
65_S160_G0.7271.00
55_A198_L0.7261.00
17_V21_V0.7241.00
56_T208_I0.7231.00
107_D110_R0.7231.00
201_F206_K0.7201.00
167_Y171_F0.7191.00
152_V163_A0.7161.00
63_G220_F0.7161.00
144_F170_A0.7141.00
22_A39_T0.7131.00
96_S100_L0.7111.00
48_M52_N0.7111.00
71_Y74_R0.7101.00
36_G61_A0.7091.00
70_I73_I0.7081.00
90_T167_Y0.7031.00
23_M27_F0.7011.00
59_L198_L0.7001.00
83_Q189_L0.7001.00
98_A201_F0.6981.00
39_T43_L0.6961.00
163_A190_N0.6941.00
85_L88_A0.6881.00
61_A163_A0.6871.00
181_K184_A0.6831.00
22_A26_G0.6821.00
92_V96_S0.6791.00
182_A186_A0.6781.00
31_I238_I0.6781.00
61_A194_N0.6771.00
86_N149_G0.6741.00
129_K133_E0.6721.00
179_L242_I0.6721.00
138_R141_G0.6701.00
110_R256_D0.6651.00
198_L212_G0.6621.00
60_Q219_Q0.6611.00
117_V246_S0.6571.00
166_F169_L0.6550.99
120_I165_S0.6550.99
160_G186_A0.6500.99
65_S190_N0.6500.99
19_F22_A0.6490.99
149_G153_G0.6460.99
31_I233_K0.6450.99
99_L200_L0.6450.99
187_K190_N0.6420.99
29_D156_D0.6410.99
235_Q239_R0.6400.99
147_I150_G0.6380.99
58_K160_G0.6380.99
220_F224_R0.6380.99
51_A55_A0.6310.99
177_F181_K0.6270.99
51_A109_L0.6250.99
37_L117_V0.6250.99
121_G246_S0.6200.99
45_A253_L0.6170.99
65_S191_A0.6120.99
229_L233_K0.6120.99
102_Q204_G0.6110.99
28_I38_L0.6090.99
180_A235_Q0.6070.99
26_G219_Q0.6070.99
207_V212_G0.6060.99
134_D137_R0.6040.99
163_A186_A0.6020.99
112_I159_F0.6020.99
29_D38_L0.6010.99
66_I69_T0.6000.99
104_V108_V0.5990.99
77_V181_K0.5960.99
61_A65_S0.5960.99
114_P253_L0.5810.99
234_G238_I0.5800.99
23_M26_G0.5800.99
31_I229_L0.5800.99
152_V167_Y0.5760.99
32_A245_V0.5750.99
92_V150_G0.5710.99
132_E136_Q0.5690.99
197_G200_L0.5680.99
54_L109_L0.5680.99
202_I207_V0.5680.99
29_D64_G0.5680.99
58_K61_A0.5680.99
22_A211_T0.5670.99
54_L58_K0.5640.98
42_A46_A0.5640.98
137_R141_G0.5640.98
198_L202_I0.5620.98
229_L232_S0.5610.98
81_S142_L0.5610.98
121_G125_L0.5610.98
209_W213_F0.5580.98
156_D161_P0.5580.98
59_L209_W0.5570.98
50_P53_A0.5570.98
186_A190_N0.5550.98
118_I251_A0.5550.98
59_L216_L0.5540.98
54_L101_V0.5520.98
212_G216_L0.5500.98
239_R243_V0.5490.98
29_D190_N0.5480.98
214_V217_V0.5480.98
85_L146_L0.5450.98
106_A158_F0.5430.98
123_Y128_P0.5430.98
32_A223_A0.5430.98
44_M50_P0.5420.98
225_M229_L0.5410.98
195_I199_L0.5400.98
39_T61_A0.5390.98
238_I243_V0.5390.98
61_A156_D0.5380.98
33_G162_A0.5350.98
79_S84_K0.5320.98
145_A171_F0.5320.98
58_K156_D0.5310.98
95_M203_L0.5310.98
164_G186_A0.5310.98
171_F189_L0.5300.98
30_S183_T0.5290.98
30_S223_A0.5260.98
243_V247_A0.5200.97
51_A54_L0.5190.97
118_I254_L0.5180.97
135_R139_M0.5180.97
100_L104_V0.5150.97
236_K239_R0.5130.97
22_A56_T0.5120.97
194_N197_G0.5110.97
160_G163_A0.5090.97
92_V95_M0.5060.97
102_Q206_K0.5050.97
167_Y190_N0.5040.97
82_D181_K0.5040.97
113_L253_L0.5020.97
61_A190_N0.5020.97
15_L19_F0.5000.97
94_S196_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3llqA 3 0.7361 55.9 0.929 Contact Map
2f2bA 4 0.7323 33.3 0.938 Contact Map
2gfpA 2 0.8773 30.2 0.94 Contact Map
2nwlA 3 0.2751 28.2 0.94 Contact Map
2a65A 2 0.4796 26.8 0.941 Contact Map
3cn5A 3 0.7398 26.4 0.941 Contact Map
1pw4A 1 0.8625 24.7 0.942 Contact Map
1j4nA 4 0.7695 19.9 0.945 Contact Map
4rp9A 2 0.4944 19.7 0.945 Contact Map
2zy9A 2 0.632 16 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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