GREMLIN Database
YOHK - Inner membrane protein YohK
UniProt: P0AD19 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12024
Length: 231 (220)
Sequences: 1920 (1346)
Seq/√Len: 90.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_I212_G5.8001.00
133_A151_V5.0741.00
135_A138_G4.2671.00
137_G147_S3.7581.00
125_P137_G3.3071.00
174_K197_D3.1691.00
162_G181_M3.1471.00
181_M193_C3.1061.00
12_T55_Y3.0661.00
158_G185_S2.8161.00
15_V40_V2.7141.00
190_T204_S2.5641.00
128_V136_V2.4701.00
167_N177_R2.4221.00
192_R195_E2.2961.00
110_A115_A2.2301.00
162_G166_L2.2191.00
110_A120_A2.0721.00
19_A36_V2.0401.00
15_V37_A2.0001.00
166_L181_M1.9341.00
177_R200_E1.8961.00
121_A140_I1.8691.00
21_K25_R1.8621.00
36_V40_V1.8471.00
197_D200_E1.8311.00
122_S142_G1.8011.00
19_A37_A1.7571.00
122_S143_I1.7561.00
97_I101_V1.7501.00
99_S211_C1.7311.00
56_F63_N1.7291.00
15_V41_I1.6951.00
43_P47_L1.6581.00
82_H86_A1.6501.00
18_A22_L1.6411.00
8_S50_I1.6211.00
43_P46_M1.6151.00
15_V44_F1.6061.00
110_A123_I1.6021.00
127_S154_V1.5941.00
87_R90_S1.5941.00
206_L212_G1.5891.00
179_L183_T1.5651.00
15_V19_A1.5641.00
106_G154_V1.5231.00
164_T168_A1.5141.00
117_P121_A1.4961.00
96_F214_I1.4701.00
108_S112_L1.4570.99
129_T132_I1.4450.99
107_T124_L1.4200.99
44_F48_T1.3980.99
18_A40_V1.3850.99
39_V43_P1.3840.99
56_F59_S1.3720.99
57_K60_E1.3600.99
14_I18_A1.3450.99
128_V132_I1.3410.99
179_L207_A1.3400.99
99_S103_M1.3180.99
81_L85_R1.3140.99
88_W92_I1.3040.99
125_P147_S1.3020.99
21_K26_Y1.2990.99
131_P135_A1.2930.99
179_L203_F1.2880.99
45_L52_Y1.2830.99
104_V108_S1.2800.99
70_V75_Y1.2660.99
126_K154_V1.2610.99
103_M219_A1.2580.99
87_R203_F1.2550.98
134_M148_A1.2520.98
56_F60_E1.2390.98
185_S204_S1.2380.98
136_V215_T1.2260.98
130_T152_I1.2000.98
67_Q131_P1.1830.98
144_P148_A1.1810.98
146_I150_C1.1630.97
116_S119_I1.1580.97
11_L41_I1.1520.97
18_A21_K1.1510.97
152_I156_I1.1410.97
108_S111_L1.1320.97
23_A31_L1.1090.97
70_V154_V1.0930.96
66_L187_A1.0690.96
76_P205_S1.0630.96
154_V185_S1.0560.96
42_I46_M1.0540.96
28_F31_L1.0430.95
103_M124_L1.0400.95
193_C197_D1.0360.95
166_L171_I1.0360.95
48_T51_S1.0330.95
26_Y31_L1.0290.95
119_I122_S1.0290.95
20_R24_A1.0230.95
54_S59_S1.0150.94
174_K200_E1.0150.94
79_E198_Y1.0130.94
22_L36_V1.0080.94
8_S58_G1.0030.94
193_C201_G1.0020.94
194_A202_A0.9950.94
205_S209_V0.9930.94
21_K24_A0.9770.93
159_A188_L0.9760.93
134_M144_P0.9720.93
103_M218_I0.9680.93
78_Y81_L0.9640.93
99_S215_T0.9520.92
82_H85_R0.9480.92
134_M137_G0.9410.92
107_T120_A0.9320.92
190_T201_G0.9320.92
66_L131_P0.9310.92
32_N36_V0.9270.91
183_T211_C0.9210.91
98_G183_T0.9180.91
95_C211_C0.9050.90
187_A205_S0.9030.90
147_S151_V0.8980.90
186_H189_G0.8950.90
26_Y29_P0.8820.89
122_S147_S0.8780.89
156_I188_L0.8740.89
173_T176_A0.8670.88
32_N35_L0.8670.88
89_K92_I0.8620.88
177_R196_L0.8600.88
154_V157_L0.8590.88
34_L188_L0.8590.88
111_L120_A0.8580.88
88_W152_I0.8570.88
175_A203_F0.8570.88
148_A151_V0.8390.87
17_F21_K0.8390.87
106_G126_K0.8380.87
91_I179_L0.8370.87
31_L36_V0.8360.86
161_F164_T0.8340.86
194_A201_G0.8310.86
40_V43_P0.8310.86
8_S59_S0.8300.86
37_A40_V0.8300.86
204_S207_A0.8290.86
72_A148_A0.8280.86
119_I143_I0.8250.86
158_G204_S0.8200.85
217_L221_F0.8200.85
155_G158_G0.8190.85
95_C183_T0.8140.85
135_A139_S0.8090.85
87_R175_A0.8000.84
31_L162_G0.8000.84
51_S54_S0.7990.84
180_A184_A0.7990.84
46_M49_G0.7980.84
77_L220_P0.7900.83
16_F20_R0.7890.83
32_N203_F0.7880.83
93_T97_I0.7850.83
203_F208_L0.7840.83
199_Q213_I0.7820.83
94_I203_F0.7720.82
158_G186_H0.7720.82
52_Y71_V0.7620.81
106_G109_V0.7570.80
58_G125_P0.7530.80
136_V219_A0.7510.80
140_I219_A0.7490.80
37_A41_I0.7490.80
71_V146_I0.7440.79
103_M208_L0.7390.79
23_A28_F0.7380.79
113_M213_I0.7360.79
129_T212_G0.7330.78
102_A105_T0.7320.78
137_G142_G0.7310.78
126_K216_S0.7300.78
183_T205_S0.7300.78
121_A223_F0.7250.78
82_H97_I0.7240.77
131_P144_P0.7210.77
121_A142_G0.7180.77
23_A26_Y0.7130.76
73_L126_K0.7120.76
122_S137_G0.7080.76
130_T151_V0.7070.76
24_A27_K0.7060.76
49_G167_N0.7040.75
83_Q175_A0.7040.75
157_L161_F0.7030.75
124_L223_F0.7000.75
128_V215_T0.6970.75
124_L219_A0.6950.75
221_F225_I0.6940.74
54_S57_K0.6940.74
56_F61_V0.6910.74
197_D203_F0.6900.74
123_I150_C0.6860.74
80_Q199_Q0.6800.73
100_V109_V0.6790.73
161_F165_L0.6790.73
109_V113_M0.6770.73
186_H190_T0.6770.73
11_L44_F0.6700.72
23_A131_P0.6690.72
136_V223_F0.6690.72
31_L91_I0.6680.72
108_S225_I0.6680.72
99_S214_I0.6650.71
62_L65_L0.6630.71
71_V76_P0.6630.71
117_P225_I0.6600.71
100_V168_A0.6560.70
155_G186_H0.6560.70
46_M118_E0.6520.70
94_I102_A0.6520.70
212_G216_S0.6460.69
75_Y102_A0.6460.69
52_Y149_V0.6380.68
12_T187_A0.6360.68
221_F224_P0.6360.68
70_V215_T0.6360.68
163_H192_R0.6350.68
14_I49_G0.6340.68
80_Q134_M0.6330.68
139_S209_V0.6310.67
130_T134_M0.6280.67
100_V104_V0.6270.67
29_P32_N0.6230.66
83_Q199_Q0.6200.66
154_V186_H0.6200.66
21_K161_F0.6200.66
32_N38_M0.6140.65
94_I141_G0.6140.65
166_L180_A0.6140.65
96_F210_L0.6130.65
35_L160_V0.6110.65
163_H167_N0.6090.65
18_A225_I0.6090.65
166_L170_R0.6080.64
83_Q203_F0.6080.64
84_I202_A0.6070.64
97_I108_S0.6060.64
16_F173_T0.6050.64
75_Y206_L0.6020.64
74_A128_V0.6020.64
49_G153_F0.6010.64
95_C207_A0.6010.64
216_S219_A0.5990.63
21_K27_K0.5990.63
87_R173_T0.5940.63
158_G190_T0.5910.62
82_H172_R0.5870.62
67_Q126_K0.5860.62
194_A205_S0.5860.62
185_S189_G0.5800.61
38_M130_T0.5780.61
13_L17_F0.5750.60
73_L194_A0.5740.60
6_W17_F0.5730.60
187_A190_T0.5730.60
208_L212_G0.5730.60
192_R196_L0.5720.60
105_T109_V0.5720.60
129_T163_H0.5720.60
111_L225_I0.5700.59
45_L50_I0.5700.59
101_V105_T0.5670.59
109_V115_A0.5600.58
175_A207_A0.5590.58
7_W48_T0.5580.58
188_L191_A0.5570.58
187_A195_E0.5550.57
20_R126_K0.5530.57
132_I136_V0.5520.57
163_H212_G0.5510.57
13_L22_L0.5500.57
26_Y188_L0.5470.56
192_R198_Y0.5470.56
32_N185_S0.5460.56
148_A201_G0.5450.56
61_V100_V0.5440.56
11_L14_I0.5430.56
11_L40_V0.5390.55
8_S94_I0.5380.55
128_V151_V0.5360.55
95_C122_S0.5350.55
85_R184_A0.5350.55
6_W10_P0.5340.55
152_I188_L0.5340.55
73_L190_T0.5310.54
77_L110_A0.5310.54
18_A44_F0.5300.54
6_W58_G0.5280.54
49_G53_D0.5250.53
16_F23_A0.5250.53
108_S167_N0.5250.53
49_G138_G0.5220.53
108_S118_E0.5210.53
38_M65_L0.5210.53
110_A146_I0.5210.53
84_I93_T0.5180.52
185_S218_I0.5180.52
204_S211_C0.5170.52
37_A207_A0.5150.52
136_V216_S0.5130.52
84_I203_F0.5130.52
104_V107_T0.5130.52
137_G144_P0.5120.52
98_G105_T0.5120.52
178_G190_T0.5110.51
130_T147_S0.5110.51
90_S209_V0.5100.51
23_A195_E0.5100.51
107_T223_F0.5080.51
207_A216_S0.5070.51
99_S184_A0.5060.51
96_F218_I0.5050.51
159_A205_S0.5050.51
18_A26_Y0.5040.50
102_A180_A0.5040.50
123_I191_A0.5030.50
54_S168_A0.5000.50
159_A191_A0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.7446 94.1 0.918 Contact Map
4n7wA 2 0.7229 91.9 0.924 Contact Map
4cz8A 2 0.9437 44.3 0.95 Contact Map
4bwzA 2 0.9134 37.6 0.952 Contact Map
2zy9A 2 0.7316 26.5 0.956 Contact Map
4czbA 2 0.9481 23.8 0.957 Contact Map
2a65A 2 0.3766 14.6 0.961 Contact Map
3nd0A 2 0.9048 12.8 0.962 Contact Map
4humA 1 0.697 7.2 0.966 Contact Map
2gfpA 2 0.8052 6.7 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0086 seconds.