GREMLIN Database
YOHC - Inner membrane protein YohC
UniProt: P0AD17 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12016
Length: 195 (188)
Sequences: 377 (243)
Seq/√Len: 17.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_C125_L5.9431.00
90_I110_A4.4271.00
98_P161_E3.8431.00
87_G107_M3.5041.00
109_F154_F3.4011.00
45_F65_W2.7500.98
33_V111_G2.5930.97
32_H115_T2.3940.95
6_G14_E2.2640.93
97_Y165_F2.1400.91
29_Y80_L2.1390.91
155_L166_S2.1250.91
87_G110_A2.0210.88
80_L84_A1.9720.87
41_V80_L1.9570.87
45_F50_Q1.9290.86
131_L154_F1.8900.85
155_L165_F1.8860.85
89_V172_I1.8730.84
135_V139_A1.8650.84
16_Q122_L1.8360.83
110_A169_T1.8350.83
134_L138_V1.8220.82
97_Y164_S1.7500.80
94_A115_T1.7190.78
43_C121_G1.7160.78
3_H14_E1.6560.76
15_M150_G1.6530.76
71_L181_L1.6200.74
128_L160_E1.5970.73
36_M42_I1.5700.72
174_V178_E1.5700.72
86_M122_L1.5510.71
44_A124_A1.5350.70
148_Y167_S1.5120.69
136_G140_L1.4990.68
82_G117_L1.4790.67
75_F165_F1.4520.66
79_M118_F1.4500.65
93_M161_E1.4200.64
19_N156_N1.3950.62
136_G182_A1.3870.62
123_V135_V1.3690.61
87_G90_I1.3650.61
56_G64_S1.3570.60
87_G111_G1.3550.60
72_A103_L1.3460.59
28_H170_L1.3330.59
62_K122_L1.3070.57
144_G161_E1.2990.57
96_N174_V1.2980.57
72_A85_V1.2970.57
90_I169_T1.2880.56
109_F171_A1.2870.56
45_F151_I1.2840.56
93_M179_V1.2750.55
125_L143_T1.2620.54
172_I175_L1.2590.54
20_R129_V1.2570.54
113_V158_N1.2560.54
75_F111_G1.2540.54
162_G167_S1.2520.54
35_L43_C1.2440.53
59_T71_L1.2300.52
18_I142_Y1.2270.52
96_N175_L1.2150.52
141_F181_L1.2010.51
42_I137_T1.1940.50
21_E46_I1.1740.49
109_F132_C1.1670.49
125_L140_L1.1660.49
125_L149_L1.1570.48
123_V131_L1.1530.48
180_L187_L1.1470.47
29_Y162_G1.1330.47
133_A137_T1.1140.45
4_V24_T1.1120.45
53_W188_W1.1090.45
18_I148_Y1.1080.45
43_C47_G1.0940.44
19_N74_L1.0910.44
98_P143_T1.0770.43
52_G76_Y1.0710.43
75_F181_L1.0520.42
145_Y148_Y1.0450.41
100_R160_E1.0450.41
48_T83_V1.0430.41
162_G173_G1.0410.41
6_G110_A1.0400.41
136_G139_A1.0320.41
183_L187_L1.0240.40
59_T116_P1.0210.40
93_M167_S1.0160.40
24_T187_L1.0120.39
133_A139_A1.0110.39
74_L143_T1.0070.39
5_W9_S1.0040.39
87_G106_C1.0030.39
116_P188_W1.0010.39
39_I187_L1.0000.39
58_G159_K0.9970.38
21_E106_C0.9940.38
51_I179_V0.9930.38
122_L135_V0.9740.37
37_A112_Y0.9660.37
7_L129_V0.9470.36
62_K121_G0.9450.36
142_Y145_Y0.9390.35
11_P152_P0.9360.35
78_V179_V0.9330.35
77_G159_K0.9250.34
96_N178_E0.9220.34
134_L160_E0.9150.34
33_V118_F0.9140.34
94_A133_A0.9140.34
67_T174_V0.9030.33
163_L167_S0.9020.33
35_L138_V0.9000.33
79_M165_F0.9000.33
75_F180_L0.8980.33
32_H101_P0.8940.33
24_T85_V0.8900.32
22_N31_H0.8780.32
109_F170_L0.8780.32
42_I69_L0.8770.32
64_S67_T0.8720.32
138_V167_S0.8690.31
97_Y161_E0.8690.31
73_V133_A0.8680.31
7_L111_G0.8670.31
120_S133_A0.8550.31
101_P175_L0.8530.31
82_G177_L0.8510.30
55_F159_K0.8500.30
105_H147_L0.8460.30
91_W175_L0.8440.30
115_T145_Y0.8430.30
138_V141_F0.8400.30
46_I187_L0.8400.30
66_F70_A0.8310.29
185_V189_G0.8250.29
134_L141_F0.8250.29
102_S105_H0.8230.29
24_T186_I0.8150.29
64_S153_S0.8120.28
13_R133_A0.8110.28
11_P37_A0.8070.28
28_H80_L0.8020.28
54_N129_V0.7990.28
37_A115_T0.7930.28
113_V147_L0.7920.27
53_W121_G0.7900.27
40_P52_G0.7890.27
14_E18_I0.7890.27
24_T102_S0.7830.27
80_L86_M0.7820.27
67_T78_V0.7760.27
93_M115_T0.7740.27
75_F140_L0.7670.26
113_V124_A0.7650.26
109_F150_G0.7650.26
146_L170_L0.7550.26
37_A142_Y0.7520.26
90_I106_C0.7510.26
48_T80_L0.7460.25
94_A169_T0.7390.25
18_I39_I0.7380.25
40_P130_W0.7370.25
18_I145_Y0.7350.25
8_F137_T0.7250.24
93_M98_P0.7240.24
128_L179_V0.7230.24
147_L158_N0.7190.24
87_G151_I0.7160.24
41_V49_T0.7150.24
113_V118_F0.7120.24
63_L68_G0.7120.24
120_S175_L0.7050.23
143_T154_F0.7010.23
86_M154_F0.7000.23
46_I121_G0.6990.23
75_F120_S0.6970.23
32_H94_A0.6930.23
39_I122_L0.6930.23
23_E134_L0.6910.23
39_I42_I0.6900.23
4_V149_L0.6860.23
78_V106_C0.6850.23
57_D60_I0.6820.22
137_T161_E0.6820.22
90_I154_F0.6800.22
116_P157_I0.6760.22
33_V113_V0.6760.22
87_G176_V0.6750.22
145_Y158_N0.6740.22
137_T141_F0.6650.22
115_T142_Y0.6640.22
69_L172_I0.6640.22
76_Y142_Y0.6630.22
55_F173_G0.6610.22
15_M78_V0.6590.21
25_I134_L0.6520.21
79_M85_V0.6460.21
68_G76_Y0.6440.21
48_T170_L0.6430.21
122_L138_V0.6390.21
55_F66_F0.6380.21
112_Y142_Y0.6360.21
169_T179_V0.6320.20
123_V130_W0.6310.20
14_E44_A0.6310.20
32_H86_M0.6250.20
23_E34_L0.6220.20
41_V176_V0.6210.20
145_Y152_P0.6210.20
157_I162_G0.6130.20
48_T114_A0.6110.20
102_S113_V0.6090.20
4_V36_M0.6070.19
45_F68_G0.6060.19
89_V176_V0.6000.19
72_A87_G0.6000.19
46_I50_Q0.5980.19
87_G144_G0.5970.19
63_L174_V0.5920.19
131_L135_V0.5890.19
44_A82_G0.5860.19
153_S174_V0.5810.18
125_L150_G0.5810.18
31_H122_L0.5800.18
77_G88_R0.5780.18
23_E114_A0.5780.18
11_P112_Y0.5770.18
62_K85_V0.5750.18
73_V83_V0.5730.18
64_S72_A0.5730.18
11_P145_Y0.5720.18
88_R93_M0.5710.18
12_D25_I0.5680.18
109_F175_L0.5680.18
93_M96_N0.5680.18
53_W130_W0.5660.18
33_V54_N0.5620.18
53_W147_L0.5610.18
62_K166_S0.5530.17
31_H129_V0.5510.17
7_L179_V0.5510.17
8_F39_I0.5490.17
8_F119_L0.5480.17
177_L188_W0.5470.17
66_F125_L0.5420.17
155_L158_N0.5410.17
64_S175_L0.5390.17
39_I43_C0.5390.17
86_M109_F0.5380.17
42_I70_A0.5380.17
97_Y132_C0.5360.17
38_A148_Y0.5340.17
67_T155_L0.5340.17
157_I177_L0.5320.17
145_Y155_L0.5320.17
82_G118_F0.5300.17
45_F168_S0.5280.17
137_T168_S0.5270.17
74_L87_G0.5250.16
25_I80_L0.5220.16
17_V138_V0.5180.16
9_S133_A0.5170.16
47_G119_L0.5160.16
65_W74_L0.5150.16
69_L72_A0.5150.16
61_L186_I0.5140.16
9_S122_L0.5100.16
3_H6_G0.5100.16
114_A147_L0.5090.16
55_F58_G0.5060.16
117_L177_L0.5040.16
92_W161_E0.5040.16
18_I94_A0.5030.16
19_N87_G0.5010.16
21_E112_Y0.5000.16
91_W129_V0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.8872 24.6 0.95 Contact Map
4j05A 3 0.7949 18.6 0.952 Contact Map
3wdoA 1 0.8103 11.9 0.956 Contact Map
4xnjA 1 0.9231 10.6 0.957 Contact Map
4pypA 1 0.8308 9 0.959 Contact Map
3o7qA 1 0.8205 7 0.961 Contact Map
2ltlA 1 0.2051 6.8 0.961 Contact Map
4he8N 1 0.6462 5.5 0.962 Contact Map
4ldsA 2 0.7692 5.4 0.963 Contact Map
2gfpA 2 0.7692 5 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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