GREMLIN Database
YEEZ - Protein YeeZ
UniProt: P0AD12 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13393
Length: 274 (253)
Sequences: 63057 (44287)
Seq/√Len: 2784.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_L29_G3.0881.00
19_S195_G2.6341.00
3_K26_Q2.5991.00
196_A212_I2.5951.00
86_E90_Q2.5281.00
110_T197_I2.4581.00
71_A201_L2.4241.00
208_H254_R2.4131.00
19_S198_T2.3521.00
210_Y258_E2.2501.00
30_S50_L2.1821.00
19_S23_R2.0921.00
106_R153_S2.0901.00
74_I109_F2.0791.00
3_K28_T2.0461.00
124_K127_T1.9811.00
221_N225_P1.9811.00
73_V201_L1.9801.00
159_L197_I1.9651.00
28_T69_A1.9011.00
28_T46_D1.8921.00
23_R198_T1.8831.00
50_L57_V1.8551.00
219_A222_V1.8441.00
5_A69_A1.8431.00
157_L200_L1.8421.00
93_Q145_W1.8401.00
7_V74_I1.8371.00
146_L154_V1.8041.00
28_T48_Y1.7991.00
253_S257_N1.7781.00
140_E144_D1.7231.00
23_R202_Q1.7161.00
6_I17_A1.7151.00
195_G199_L1.7131.00
16_L194_I1.7111.00
26_Q46_D1.6921.00
198_T202_Q1.6761.00
85_D141_E1.6371.00
93_Q97_D1.6371.00
226_Q229_R1.6331.00
54_P57_V1.6161.00
4_V25_W1.5961.00
226_Q230_L1.5611.00
199_L203_A1.5591.00
90_Q93_Q1.5481.00
92_V142_L1.5401.00
16_L73_V1.5321.00
55_E97_D1.4941.00
170_G173_F1.4931.00
106_R155_D1.4921.00
255_I259_L1.4901.00
16_L75_T1.4871.00
61_D65_A1.4731.00
53_E86_E1.4711.00
19_S194_I1.4621.00
19_S22_A1.4561.00
63_L101_A1.4561.00
159_L193_V1.4511.00
111_S115_V1.4501.00
75_T110_T1.4351.00
70_D105_P1.4301.00
55_E94_E1.4051.00
184_G217_H1.3981.00
160_A250_I1.3831.00
125_E254_R1.3781.00
135_S139_L1.3771.00
12_L162_L1.3751.00
33_T36_G1.3731.00
96_V149_L1.3591.00
72_L99_A1.3581.00
110_T159_L1.3541.00
157_L197_I1.3521.00
33_T47_S1.3241.00
150_P154_V1.3231.00
25_W202_Q1.3211.00
188_V193_V1.3151.00
144_D147_H1.3111.00
73_V197_I1.3051.00
18_M166_G1.3021.00
17_A29_G1.2991.00
137_R141_E1.2891.00
147_H156_I1.2821.00
129_R140_E1.2711.00
222_V225_P1.2671.00
9_L17_A1.2551.00
190_L194_I1.2331.00
208_H258_E1.2181.00
20_L198_T1.2131.00
116_Y211_N1.2131.00
15_P191_E1.2011.00
123_V127_T1.1991.00
109_F142_L1.1941.00
254_R258_E1.1931.00
15_P190_L1.1811.00
252_G263_Y1.1721.00
52_M91_A1.1691.00
106_R204_P1.1661.00
97_D100_L1.1611.00
158_R209_I1.1531.00
5_A30_S1.1531.00
4_V20_L1.1461.00
145_W148_N1.1451.00
19_S191_E1.1421.00
163_V189_H1.1311.00
79_R82_G1.1291.00
74_I92_V1.1281.00
186_N215_P1.1261.00
147_H154_V1.1241.00
109_F156_I1.1241.00
29_G45_I1.1111.00
143_E158_R1.1101.00
182_E219_A1.1081.00
124_K251_D1.1041.00
182_E221_N1.1031.00
147_H209_I1.1001.00
108_I157_L1.1001.00
195_G261_F1.0931.00
21_S45_I1.0921.00
21_S44_G1.0831.00
57_V61_D1.0831.00
88_Y138_V1.0801.00
126_T254_R1.0711.00
192_D214_A1.0701.00
52_M76_L1.0671.00
99_A107_I1.0621.00
78_A87_F1.0621.00
199_L259_L1.0551.00
85_D89_L1.0551.00
98_S102_H1.0541.00
196_A255_I1.0511.00
11_W164_G1.0471.00
97_D101_A1.0431.00
225_P228_A1.0421.00
218_P222_V1.0401.00
153_S206_G1.0391.00
228_A235_P1.0391.00
96_V107_I1.0381.00
61_D64_D1.0361.00
217_H247_G1.0361.00
109_F146_L1.0341.00
95_L107_I1.0311.00
94_E97_D1.0281.00
90_Q94_E1.0261.00
4_V71_A1.0231.00
228_A234_E1.0221.00
97_D149_L1.0221.00
11_W190_L1.0221.00
213_C250_I1.0221.00
18_M22_A1.0221.00
158_R211_N1.0141.00
217_H249_I1.0131.00
221_N239_R1.0091.00
7_V95_L1.0051.00
189_H192_D0.9991.00
87_F91_A0.9911.00
155_D200_L0.9861.00
184_G219_A0.9781.00
3_K69_A0.9781.00
63_L69_A0.9771.00
162_L193_V0.9701.00
199_L202_Q0.9671.00
63_L102_H0.9631.00
241_S244_S0.9621.00
75_T197_I0.9591.00
14_M166_G0.9591.00
89_L141_E0.9541.00
34_Q49_L0.9411.00
84_G138_V0.9371.00
107_I146_L0.9311.00
215_P252_G0.9271.00
78_A83_P0.9261.00
85_D90_Q0.9251.00
99_A104_I0.9231.00
71_A106_R0.9181.00
195_G198_T0.9181.00
15_P18_M0.9161.00
100_L149_L0.9091.00
96_V146_L0.9061.00
210_Y254_R0.9061.00
7_V76_L0.9001.00
46_D67_M0.8971.00
48_Y65_A0.8951.00
3_K70_D0.8921.00
31_K47_S0.8911.00
98_S101_A0.8911.00
141_E144_D0.8901.00
121_G127_T0.8891.00
240_N243_D0.8791.00
121_G124_K0.8781.00
113_T160_A0.8771.00
63_L98_S0.8771.00
100_L152_T0.8741.00
94_E98_S0.8731.00
157_L212_I0.8711.00
213_C252_G0.8681.00
16_L20_L0.8611.00
80_R83_P0.8581.00
72_L95_L0.8521.00
4_V73_V0.8511.00
156_I209_I0.8461.00
3_K25_W0.8421.00
21_S27_V0.8401.00
160_A213_C0.8351.00
78_A84_G0.8331.00
15_P19_S0.8271.00
155_D204_P0.8261.00
222_V226_Q0.8251.00
184_G247_G0.8201.00
30_S57_V0.8201.00
228_A233_L0.8171.00
133_T136_G0.8141.00
113_T250_I0.8101.00
149_L152_T0.8091.00
17_A27_V0.8071.00
92_V146_L0.8051.00
92_V96_V0.8031.00
32_T51_R0.8031.00
33_T49_L0.8001.00
144_D148_N0.7981.00
165_P189_H0.7911.00
111_S143_E0.7851.00
4_V201_L0.7841.00
181_G221_N0.7811.00
83_P87_F0.7791.00
105_P153_S0.7751.00
199_L260_G0.7701.00
134_N137_R0.7701.00
96_V145_W0.7681.00
15_P194_I0.7661.00
162_L188_V0.7641.00
239_R243_D0.7631.00
58_C98_S0.7621.00
196_A261_F0.7541.00
200_L255_I0.7531.00
122_T127_T0.7511.00
74_I95_L0.7511.00
12_L193_V0.7481.00
16_L197_I0.7441.00
218_P223_F0.7411.00
235_P238_F0.7381.00
83_P86_E0.7341.00
141_E145_W0.7331.00
28_T68_D0.7281.00
100_L151_G0.7231.00
24_G27_V0.7211.00
72_L107_I0.7191.00
154_V207_G0.7161.00
115_V143_E0.7141.00
212_I255_I0.7121.00
53_E87_F0.7121.00
200_L259_L0.7101.00
55_E101_A0.7091.00
170_G174_A0.7091.00
194_I198_T0.7071.00
145_W149_L0.7061.00
161_G185_V0.6971.00
184_G249_I0.6951.00
51_R54_P0.6921.00
199_L261_F0.6881.00
33_T37_V0.6851.00
23_R199_L0.6841.00
137_R144_D0.6811.00
28_T67_M0.6811.00
119_A123_V0.6811.00
25_W70_D0.6811.00
85_D138_V0.6781.00
56_L61_D0.6781.00
30_S58_C0.6751.00
150_P207_G0.6721.00
14_M18_M0.6711.00
237_Q241_S0.6711.00
5_A50_L0.6711.00
159_L162_L0.6691.00
240_N244_S0.6681.00
137_R148_N0.6671.00
74_I107_I0.6631.00
186_N214_A0.6621.00
67_M102_H0.6611.00
91_A94_E0.6561.00
254_R257_N0.6551.00
57_V62_D0.6551.00
255_I258_E0.6541.00
245_G248_K0.6501.00
93_Q149_L0.6501.00
205_K258_E0.6481.00
131_P136_G0.6471.00
64_D67_M0.6461.00
225_P229_R0.6441.00
218_P226_Q0.6431.00
82_G86_E0.6421.00
147_H150_P0.6391.00
89_L93_Q0.6391.00
85_D137_R0.6371.00
125_E255_I0.6371.00
23_R195_G0.6361.00
29_G47_S0.6361.00
114_S136_G0.6351.00
186_N217_H0.6331.00
5_A72_L0.6301.00
117_G130_N0.6281.00
192_D195_G0.6281.00
120_Q127_T0.6271.00
142_L146_L0.6261.00
65_A69_A0.6261.00
71_A108_I0.6241.00
25_W71_A0.6221.00
224_Y228_A0.6221.00
174_A177_T0.6201.00
183_H220_R0.6171.00
124_K253_S0.6171.00
108_I200_L0.6151.00
138_V142_L0.6131.00
20_L201_L0.6131.00
99_A103_R0.6111.00
71_A105_P0.6111.00
157_L196_A0.6081.00
26_Q44_G0.6061.00
15_P166_G0.6051.00
3_K68_D0.6001.00
108_I197_I0.5991.00
48_Y62_D0.5981.00
228_A231_L0.5961.00
108_I201_L0.5951.00
134_N138_V0.5921.00
48_Y67_M0.5911.00
153_S205_K0.5901.00
62_D65_A0.5861.00
122_T247_G0.5841.00
72_L104_I0.5791.00
237_Q240_N0.5791.00
54_P58_C0.5761.00
115_V129_R0.5721.00
228_A237_Q0.5701.00
16_L198_T0.5691.00
252_G261_F0.5661.00
18_M191_E0.5651.00
3_K67_M0.5621.00
99_A102_H0.5581.00
64_D102_H0.5541.00
185_V220_R0.5531.00
38_E43_S0.5471.00
17_A21_S0.5461.00
112_S139_L0.5451.00
193_V212_I0.5441.00
58_C62_D0.5431.00
135_S138_V0.5431.00
6_I20_L0.5411.00
17_A45_I0.5411.00
92_V109_F0.5401.00
54_P61_D0.5391.00
160_A186_N0.5381.00
235_P239_R0.5381.00
78_A88_Y0.5371.00
153_S204_P0.5361.00
46_D65_A0.5361.00
115_V158_R0.5351.00
119_A122_T0.5321.00
63_L72_L0.5321.00
146_L156_I0.5291.00
65_A68_D0.5291.00
234_E237_Q0.5281.00
232_G236_P0.5261.00
63_L67_M0.5261.00
24_G44_G0.5241.00
161_G187_L0.5231.00
156_I207_G0.5211.00
11_W15_P0.5171.00
15_P165_P0.5161.00
163_V214_A0.5131.00
25_W198_T0.5121.00
75_T159_L0.5111.00
163_V187_L0.5091.00
142_L145_W0.5071.00
20_L25_W0.5061.00
155_D210_Y0.5051.00
232_G235_P0.5041.00
255_I263_Y0.5041.00
236_P239_R0.5011.00
233_L236_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rkxA 3 0.9854 100 0.238 Contact Map
3m2pA 2 0.9562 100 0.243 Contact Map
1sb8A 2 0.9854 100 0.244 Contact Map
1orrA 3 0.9891 100 0.246 Contact Map
2c20A 2 0.9854 100 0.248 Contact Map
2pzmA 2 0.9891 100 0.249 Contact Map
1n7hA 4 0.9891 100 0.251 Contact Map
2c5aA 2 0.9818 100 0.251 Contact Map
3rufA 2 0.9745 100 0.251 Contact Map
2yy7A 2 0.9781 100 0.251 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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