GREMLIN Database
YEBS - Inner membrane protein YebS
UniProt: P0AD03 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14021
Length: 427 (394)
Sequences: 489 (329)
Seq/√Len: 16.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_R416_D7.1911.00
31_C34_C5.0251.00
272_A401_L4.3051.00
110_T118_G3.7691.00
38_F52_P3.2570.99
36_M53_R3.2100.99
258_R262_S3.1040.99
256_R260_R2.9500.98
310_N359_W2.9140.98
83_A193_S2.8520.98
102_V188_G2.7920.98
324_V371_I2.7850.98
267_W340_H2.7410.97
270_L329_V2.7170.97
240_G249_P2.7140.97
214_W250_R2.6870.97
278_L282_L2.6820.97
30_R35_D2.5890.96
315_G319_I2.5740.96
322_I371_I2.5640.96
73_A174_V2.5640.96
122_F127_G2.5600.96
120_M396_G2.5420.96
297_D301_S2.5160.95
304_M330_I2.5080.95
51_C54_C2.4570.95
267_W368_L2.4220.94
71_A75_T2.3990.94
313_V316_I2.3600.93
398_A402_T2.3330.93
91_I380_R2.3260.93
117_T388_M2.2790.92
180_Q391_A2.2580.92
91_I357_V2.2400.92
322_I356_M2.2230.91
170_V414_L2.2030.91
262_S416_D2.1230.89
262_S413_L2.1190.89
43_I49_A2.0670.88
355_R375_M2.0420.87
272_A276_L2.0240.87
174_V190_G1.9680.85
208_L393_F1.9530.85
191_L297_D1.9080.83
156_L200_L1.9010.83
288_I310_N1.8960.83
31_C35_D1.8820.82
135_S152_V1.8650.82
413_L416_D1.8530.81
286_S386_F1.8510.81
339_I409_L1.8500.81
316_I319_I1.8340.81
306_L319_I1.8310.80
209_N362_R1.8160.80
307_A314_A1.8030.79
258_R413_L1.8010.79
138_Y152_V1.7960.79
88_L172_I1.7950.79
331_V357_V1.7610.78
274_I304_M1.7370.77
38_F58_I1.7160.76
247_R337_L1.6920.75
30_R239_T1.6800.74
88_L109_M1.6780.74
390_P393_F1.6730.74
67_T71_A1.6690.74
86_E190_G1.6520.73
277_L368_L1.6480.73
35_D225_R1.6470.73
121_V372_S1.6460.73
313_V414_L1.6060.71
89_L285_I1.5800.69
381_D385_A1.5720.69
30_R37_L1.5690.69
403_I406_V1.5480.68
104_Q310_N1.5390.67
170_V317_V1.5250.67
88_L168_Y1.5240.67
229_K257_L1.5040.65
319_I414_L1.4820.64
36_M282_L1.4590.63
68_R139_L1.4500.63
177_I391_A1.4450.62
263_L405_A1.4430.62
306_L310_N1.4330.62
231_R255_L1.4320.62
238_F266_C1.4270.61
35_D229_K1.4110.60
248_C251_C1.4100.60
27_D330_I1.4040.60
100_A369_F1.4000.60
263_L404_L1.3990.60
26_G44_N1.3880.59
262_S285_I1.3710.58
168_Y317_V1.3670.58
191_L317_V1.3560.57
34_C51_C1.3550.57
102_V356_M1.3550.57
233_C248_C1.3480.57
233_C251_C1.3470.57
323_L391_A1.3330.56
269_A408_W1.3260.55
366_L373_L1.3240.55
173_G358_T1.3220.55
134_T228_E1.3180.55
270_L357_V1.3100.55
256_R376_S1.2990.54
44_N47_Q1.2980.54
277_L329_V1.2910.53
306_L317_V1.2860.53
225_R229_K1.2830.53
37_L360_I1.2770.53
35_D413_L1.2690.52
171_G277_L1.2640.52
34_C54_C1.2600.52
264_Q285_I1.2570.51
31_C51_C1.2550.51
128_A404_L1.2510.51
172_I175_A1.2410.50
106_I396_G1.2360.50
196_A271_L1.2360.50
139_L264_Q1.2270.50
56_A362_R1.2270.50
236_C248_C1.2200.49
213_L331_V1.2200.49
145_L330_I1.2180.49
236_C251_C1.2140.49
233_C236_C1.2130.49
193_S335_L1.2100.49
389_G394_Y1.2080.49
160_K342_K1.2040.48
167_I394_Y1.1930.48
285_I381_D1.1870.47
199_I414_L1.1860.47
251_C410_D1.1850.47
28_Y39_S1.1830.47
175_A197_L1.1810.47
68_R360_I1.1810.47
151_P322_I1.1780.47
115_A283_L1.1760.47
35_D76_M1.1710.46
190_G216_R1.1680.46
41_P190_G1.1640.46
33_Q56_A1.1620.46
31_C54_C1.1610.46
412_R415_W1.1580.46
149_L197_L1.1540.45
335_L370_V1.1510.45
74_F237_H1.1500.45
73_A137_A1.1470.45
50_Y55_Q1.1380.44
123_F128_A1.1370.44
54_C58_I1.1360.44
168_Y175_A1.1360.44
248_C410_D1.1320.44
88_L373_L1.1290.44
274_I278_L1.1210.43
43_I224_T1.1200.43
43_I102_V1.1150.43
33_Q362_R1.1140.43
193_S373_L1.1110.43
287_I296_E1.1100.43
179_V183_A1.1040.42
49_A52_P1.1010.42
348_R352_L1.0990.42
348_R420_S1.0950.42
74_F400_I1.0940.42
316_I323_L1.0910.42
65_S212_E1.0890.42
105_G238_F1.0880.42
239_T322_I1.0880.42
393_F419_E1.0850.41
233_C410_D1.0850.41
35_D230_L1.0760.41
180_Q368_L1.0750.41
38_F369_F1.0680.40
38_F317_V1.0670.40
177_I204_T1.0650.40
75_T247_R1.0620.40
225_R230_L1.0550.40
190_G312_A1.0480.39
286_S307_A1.0450.39
109_M375_M1.0430.39
167_I231_R1.0400.39
296_E374_T1.0400.39
192_F288_I1.0390.39
140_W317_V1.0380.39
44_N70_A1.0330.38
103_M171_G1.0320.38
105_G310_N1.0270.38
292_G388_M1.0240.38
56_A357_V1.0240.38
44_N137_A1.0220.38
285_I391_A1.0190.38
168_Y285_I1.0130.37
332_M397_A1.0110.37
51_C58_I0.9990.37
71_A188_G0.9990.37
150_R276_L0.9960.36
329_V341_F0.9920.36
195_V208_L0.9910.36
135_S323_L0.9860.36
84_W140_W0.9840.36
178_K270_L0.9830.36
163_V166_D0.9810.36
166_D362_R0.9790.35
236_C410_D0.9740.35
113_G317_V0.9700.35
199_I372_S0.9690.35
44_N127_G0.9640.35
190_G384_L0.9630.35
277_L398_A0.9620.35
324_V405_A0.9600.34
53_R58_I0.9590.34
37_L42_E0.9590.34
50_Y274_I0.9570.34
76_M172_I0.9510.34
41_P59_R0.9410.33
259_R416_D0.9390.33
37_L229_K0.9360.33
410_D415_W0.9350.33
66_L405_A0.9300.33
88_L366_L0.9280.33
93_L359_W0.9220.32
76_M386_F0.9180.32
312_A316_I0.9160.32
172_I317_V0.9100.32
88_L388_M0.9080.32
218_Y221_R0.9080.32
333_F401_L0.9040.32
288_I307_A0.9030.31
254_P315_G0.9020.31
368_L381_D0.8960.31
368_L371_I0.8930.31
98_I396_G0.8880.31
35_D228_E0.8880.31
105_G121_V0.8850.31
178_K370_V0.8810.30
308_S386_F0.8800.30
185_I419_E0.8780.30
295_Q358_T0.8740.30
266_C319_I0.8740.30
163_V375_M0.8720.30
102_V307_A0.8690.30
299_I398_A0.8690.30
343_C346_G0.8670.30
179_V259_R0.8650.30
165_L307_A0.8630.29
118_G401_L0.8610.29
109_M356_M0.8600.29
75_T255_L0.8590.29
31_C36_M0.8560.29
306_L384_L0.8530.29
189_V295_Q0.8530.29
107_W397_A0.8520.29
303_I386_F0.8520.29
223_A283_L0.8480.29
206_S272_A0.8470.29
188_G300_L0.8470.29
276_L293_G0.8450.29
258_R371_I0.8440.29
339_I414_L0.8400.28
36_M406_V0.8370.28
286_S368_L0.8330.28
297_D318_F0.8320.28
100_A191_L0.8280.28
118_G309_S0.8280.28
316_I370_V0.8260.28
234_L379_N0.8240.28
141_F220_Q0.8230.28
167_I273_S0.8220.27
267_W337_L0.8210.27
192_F354_L0.8200.27
117_T383_I0.8150.27
156_L335_L0.8130.27
151_P273_S0.8130.27
53_R402_T0.8110.27
75_T200_L0.8110.27
254_P282_L0.8080.27
130_L189_V0.8070.27
332_M382_Q0.8060.27
270_L391_A0.8050.27
291_N368_L0.8010.27
232_V391_A0.8010.27
74_F263_L0.8010.27
205_L249_P0.7990.26
130_L270_L0.7980.26
128_A198_V0.7970.26
213_L407_E0.7960.26
168_Y371_I0.7950.26
360_I371_I0.7930.26
125_V197_L0.7870.26
296_E301_S0.7870.26
91_I166_D0.7850.26
209_N334_T0.7840.26
193_S319_I0.7830.26
73_A77_L0.7800.26
35_D266_C0.7770.25
56_A355_R0.7760.25
167_I194_F0.7760.25
183_A324_V0.7750.25
262_S411_S0.7720.25
217_F362_R0.7720.25
136_I139_L0.7710.25
267_W336_L0.7700.25
37_L134_T0.7700.25
227_D246_G0.7690.25
88_L173_G0.7690.25
349_T352_L0.7680.25
122_F403_I0.7650.25
185_I333_F0.7630.25
125_V185_I0.7600.25
175_A269_A0.7600.25
391_A411_S0.7580.25
91_I285_I0.7580.25
120_M393_F0.7570.25
297_D324_V0.7560.24
102_V323_L0.7550.24
150_R203_V0.7520.24
105_G307_A0.7510.24
227_D278_L0.7490.24
81_P168_Y0.7490.24
179_V327_T0.7460.24
269_A398_A0.7460.24
169_L193_S0.7410.24
213_L234_L0.7390.24
315_G344_Q0.7380.24
173_G286_S0.7350.24
32_P55_Q0.7330.24
69_L339_I0.7330.24
117_T329_V0.7310.23
224_T230_L0.7310.23
128_A324_V0.7310.23
52_P369_F0.7300.23
226_R257_L0.7300.23
179_V378_I0.7290.23
290_L383_I0.7270.23
67_T144_R0.7270.23
355_R362_R0.7270.23
89_L413_L0.7220.23
291_N409_L0.7220.23
76_M200_L0.7210.23
184_H191_L0.7190.23
74_F141_F0.7180.23
252_H322_I0.7160.23
177_I370_V0.7160.23
314_A389_G0.7160.23
49_A58_I0.7130.23
281_N392_A0.7120.23
78_L113_G0.7120.23
210_V297_D0.7100.23
84_W126_I0.7070.22
174_V316_I0.7070.22
283_L348_R0.7040.22
118_G345_Q0.7030.22
386_F389_G0.7020.22
177_I307_A0.7020.22
247_R344_Q0.7000.22
373_L390_P0.6990.22
412_R416_D0.6970.22
298_T332_M0.6970.22
357_V406_V0.6970.22
43_I61_G0.6960.22
134_T226_R0.6960.22
85_G170_V0.6940.22
258_R412_R0.6920.22
331_V334_T0.6900.22
168_Y318_F0.6890.22
248_C415_W0.6870.22
91_I132_L0.6860.22
166_D360_I0.6850.22
142_G413_L0.6850.22
373_L382_Q0.6830.21
48_S141_F0.6800.21
101_N256_R0.6800.21
150_R253_I0.6780.21
35_D272_A0.6780.21
89_L292_G0.6780.21
191_L197_L0.6770.21
93_L304_M0.6770.21
106_I122_F0.6760.21
285_I313_V0.6760.21
227_D254_P0.6740.21
357_V380_R0.6720.21
351_I371_I0.6720.21
30_R391_A0.6710.21
307_A310_N0.6690.21
141_F223_A0.6680.21
212_E317_V0.6670.21
197_L312_A0.6670.21
74_F316_I0.6660.21
307_A311_I0.6650.21
35_D258_R0.6640.21
66_L74_F0.6630.21
50_Y57_K0.6630.21
145_L184_H0.6600.21
186_Q196_A0.6570.20
179_V334_T0.6560.20
123_F322_I0.6560.20
110_T330_I0.6550.20
386_F418_H0.6550.20
119_S295_Q0.6520.20
287_I294_R0.6500.20
181_D317_V0.6500.20
207_H324_V0.6470.20
68_R118_G0.6470.20
207_H273_S0.6460.20
301_S360_I0.6450.20
265_K408_W0.6440.20
200_L372_S0.6420.20
49_A120_M0.6400.20
154_L386_F0.6380.20
303_I360_I0.6380.20
76_M133_V0.6370.20
339_I368_L0.6370.20
74_F224_T0.6340.20
126_I268_A0.6340.20
38_F56_A0.6310.19
41_P65_S0.6310.19
88_L357_V0.6310.19
267_W392_A0.6300.19
52_P77_L0.6300.19
330_I356_M0.6290.19
55_Q293_G0.6290.19
291_N379_N0.6280.19
354_L409_L0.6260.19
283_L366_L0.6260.19
248_C412_R0.6250.19
80_M197_L0.6240.19
193_S351_I0.6240.19
91_I190_G0.6230.19
178_K365_M0.6220.19
60_D259_R0.6210.19
251_C415_W0.6210.19
117_T379_N0.6200.19
156_L183_A0.6190.19
323_L366_L0.6190.19
260_R404_L0.6180.19
199_I419_E0.6180.19
117_T140_W0.6180.19
182_Y305_S0.6170.19
89_L357_V0.6170.19
173_G291_N0.6160.19
104_Q329_V0.6150.19
189_V282_L0.6150.19
118_G319_I0.6130.19
127_G349_T0.6130.19
75_T137_A0.6090.19
211_E403_I0.6080.19
121_V324_V0.6060.19
210_V386_F0.6030.18
159_L319_I0.6030.18
117_T354_L0.6020.18
254_P330_I0.6010.18
55_Q342_K0.6000.18
219_P372_S0.6000.18
271_L322_I0.5980.18
280_A298_T0.5980.18
179_V393_F0.5970.18
77_L274_I0.5960.18
196_A316_I0.5960.18
182_Y313_V0.5930.18
310_N386_F0.5930.18
155_M344_Q0.5930.18
140_W313_V0.5930.18
205_L370_V0.5920.18
233_C415_W0.5920.18
338_S342_K0.5910.18
33_Q355_R0.5900.18
65_S69_L0.5890.18
221_R337_L0.5890.18
238_F375_M0.5880.18
289_Y294_R0.5880.18
135_S184_H0.5880.18
109_M120_M0.5870.18
310_N370_V0.5870.18
76_M204_T0.5860.18
309_S401_L0.5860.18
233_C412_R0.5840.18
222_P255_L0.5840.18
166_D170_V0.5830.18
125_V190_G0.5820.18
251_C412_R0.5810.18
93_L368_L0.5810.18
177_I335_L0.5810.18
104_Q313_V0.5810.18
335_L365_M0.5810.18
188_G306_L0.5810.18
73_A206_S0.5800.18
362_R402_T0.5780.18
192_F216_R0.5780.18
79_L93_L0.5780.18
154_L398_A0.5770.18
105_G181_D0.5710.17
139_L291_N0.5670.17
132_L166_D0.5670.17
72_M76_M0.5660.17
164_M167_I0.5660.17
103_M146_G0.5650.17
384_L409_L0.5640.17
166_D355_R0.5640.17
269_A387_T0.5630.17
28_Y265_K0.5620.17
333_F339_I0.5620.17
316_I414_L0.5610.17
93_L310_N0.5600.17
231_R324_V0.5580.17
139_L213_L0.5580.17
327_T379_N0.5570.17
55_Q244_Q0.5560.17
173_G409_L0.5550.17
255_L326_F0.5550.17
36_M45_S0.5540.17
126_I141_F0.5540.17
163_V194_F0.5530.17
293_G366_L0.5520.17
152_V243_D0.5510.17
32_P405_A0.5480.17
256_R340_H0.5470.17
214_W248_C0.5460.17
68_R207_H0.5460.17
210_V372_S0.5460.17
79_L216_R0.5460.17
336_L368_L0.5440.16
43_I266_C0.5430.16
147_M344_Q0.5430.16
43_I48_S0.5420.16
56_A166_D0.5410.16
278_L290_L0.5400.16
196_A311_I0.5400.16
316_I400_I0.5390.16
43_I47_Q0.5380.16
372_S417_A0.5380.16
175_A373_L0.5380.16
80_M332_M0.5370.16
105_G380_R0.5360.16
210_V271_L0.5350.16
134_T404_L0.5340.16
76_M197_L0.5340.16
85_G391_A0.5310.16
108_Q379_N0.5300.16
286_S358_T0.5300.16
169_L324_V0.5300.16
38_F50_Y0.5290.16
127_G330_I0.5280.16
49_A391_A0.5280.16
41_P62_R0.5280.16
305_S317_V0.5270.16
179_V200_L0.5270.16
163_V357_V0.5270.16
44_N222_P0.5260.16
287_I330_I0.5260.16
346_G417_A0.5250.16
186_Q274_I0.5250.16
90_H290_L0.5250.16
83_A169_L0.5240.16
214_W251_C0.5200.16
144_R271_L0.5200.16
368_L392_A0.5190.16
165_L285_I0.5180.16
114_D375_M0.5180.16
82_F193_S0.5180.16
70_A143_N0.5180.16
149_L303_I0.5170.16
170_V316_I0.5170.16
106_I179_V0.5150.16
259_R304_M0.5140.15
335_L354_L0.5140.15
166_D307_A0.5130.15
101_N109_M0.5130.15
329_V398_A0.5120.15
322_I346_G0.5110.15
40_L121_V0.5100.15
286_S409_L0.5100.15
49_A308_S0.5090.15
199_I235_G0.5090.15
183_A193_S0.5090.15
156_L330_I0.5090.15
69_L362_R0.5080.15
43_I353_L0.5070.15
78_L356_M0.5050.15
161_E183_A0.5050.15
80_M84_W0.5040.15
191_L202_T0.5030.15
143_N403_I0.5030.15
227_D418_H0.5020.15
169_L377_L0.5010.15
299_I355_R0.5010.15
171_G209_N0.5000.15
236_C412_R0.5000.15
299_I402_T0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lcqA 1 0.1429 87.3 0.97 Contact Map
4aybP 1 0.103 86.5 0.971 Contact Map
1ryqA 1 0.1475 82.7 0.972 Contact Map
3wwlA 1 0.1265 81.5 0.972 Contact Map
4qiwP 1 0.096 80.7 0.973 Contact Map
3h0gL 1 0.103 78 0.973 Contact Map
1twfL 1 0.1054 70.9 0.975 Contact Map
1h7bA 2 0.1101 68.2 0.975 Contact Map
3j20Y 1 0.1124 65.5 0.976 Contact Map
3w0fA 1 0.1335 63.6 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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