GREMLIN Database
DCUR - Transcriptional regulatory protein DcuR
UniProt: P0AD01 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12464
Length: 239 (198)
Sequences: 78322 (55995)
Seq/√Len: 3979.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_A32_T3.7201.00
14_A34_S3.2911.00
18_R32_T3.2021.00
7_I39_A2.7411.00
40_K70_V2.6551.00
37_E61_K2.5811.00
36_L62_E2.4591.00
44_F74_A2.4121.00
35_T61_K2.3241.00
62_E70_V2.3201.00
3_N28_Q2.0951.00
20_Y110_A2.0391.00
33_A42_I2.0011.00
24_I114_E1.9561.00
18_R22_A1.9451.00
92_I112_R1.9211.00
34_S38_K1.8731.00
193_V196_R1.8631.00
58_Y86_A1.8281.00
68_L80_V1.8111.00
55_L67_L1.8021.00
31_G42_I1.7961.00
181_T196_R1.7551.00
89_A109_Q1.7311.00
35_T38_K1.7251.00
82_V95_S1.7071.00
70_V74_A1.7001.00
5_L33_A1.6631.00
169_Q173_A1.6591.00
31_G50_I1.6381.00
82_V100_V1.6381.00
72_H101_V1.6081.00
42_I48_T1.5971.00
31_G48_T1.5841.00
63_N66_D1.5801.00
62_E66_D1.5791.00
36_L67_L1.5691.00
198_Y201_W1.5261.00
69_P98_Y1.5211.00
102_D116_A1.4841.00
42_I45_N1.4821.00
43_I71_L1.4811.00
180_S183_E1.4741.00
21_V117_L1.4691.00
140_Q153_R1.4591.00
70_V73_N1.4531.00
170_W187_E1.4381.00
137_E142_I1.4111.00
68_L82_V1.4111.00
179_F187_E1.3901.00
86_A91_T1.3881.00
3_N31_G1.3861.00
101_V123_K1.3781.00
53_I78_S1.3751.00
66_D69_P1.3561.00
40_K67_L1.3531.00
37_E62_E1.3441.00
81_I120_W1.3311.00
52_L117_L1.3121.00
75_R78_S1.2811.00
8_D14_A1.2751.00
11_A34_S1.2731.00
42_I50_I1.2691.00
149_E156_P1.2531.00
55_L68_L1.2501.00
7_I59_M1.2441.00
27_F118_T1.2431.00
57_I65_L1.2421.00
101_V120_W1.2381.00
9_D56_D1.2301.00
41_E45_N1.2191.00
162_Q165_R1.2151.00
40_K62_E1.2081.00
163_T205_C1.1991.00
3_N48_T1.1991.00
45_N48_T1.1951.00
210_T213_H1.1921.00
57_I82_V1.1871.00
142_I151_D1.1791.00
33_A39_A1.1711.00
38_K41_E1.1621.00
24_I118_T1.1511.00
37_E41_E1.1481.00
38_K42_I1.1471.00
5_L50_I1.1331.00
183_E187_E1.1311.00
114_E118_T1.1261.00
88_D91_T1.1151.00
65_L95_S1.1151.00
65_L94_D1.1071.00
5_L39_A1.0991.00
182_D192_R1.0881.00
69_P94_D1.0771.00
4_V27_F1.0751.00
94_D98_Y1.0751.00
52_L121_R1.0721.00
97_H118_T1.0701.00
5_L42_I1.0501.00
209_F213_H1.0351.00
193_V197_K1.0351.00
197_K200_I1.0311.00
115_E119_G1.0271.00
144_G147_S1.0191.00
138_L141_L1.0191.00
112_R115_E1.0171.00
170_W179_F1.0161.00
165_R169_Q1.0151.00
143_H172_D1.0121.00
40_K44_F1.0021.00
194_S198_Y1.0011.00
39_A67_L0.9851.00
39_A43_I0.9591.00
53_I71_L0.9571.00
89_A93_K0.9561.00
15_E32_T0.9541.00
65_L98_Y0.9521.00
11_A15_E0.9511.00
179_F183_E0.9471.00
26_G118_T0.9461.00
7_I53_I0.9441.00
33_A38_K0.9391.00
90_A94_D0.9381.00
6_I17_N0.9251.00
92_I105_I0.9221.00
5_L31_G0.9191.00
57_I63_N0.9151.00
17_N83_I0.9131.00
5_L43_I0.9001.00
93_K97_H0.8961.00
41_E44_F0.8961.00
53_I80_V0.8951.00
3_N50_I0.8801.00
55_L82_V0.8791.00
89_A92_I0.8731.00
94_D97_H0.8731.00
66_D70_V0.8721.00
55_L80_V0.8721.00
54_L113_F0.8701.00
7_I33_A0.8691.00
12_M16_L0.8691.00
68_L98_Y0.8671.00
148_N165_R0.8631.00
151_D156_P0.8611.00
18_R29_C0.8601.00
68_L100_V0.8551.00
182_D186_N0.8461.00
170_W184_L0.8451.00
27_F114_E0.8441.00
183_E186_N0.8361.00
81_I116_A0.8351.00
79_D101_V0.8301.00
15_E18_R0.8291.00
192_R196_R0.8261.00
120_W123_K0.8251.00
11_A14_A0.8231.00
57_I91_T0.8221.00
87_A105_I0.8211.00
69_P73_N0.8191.00
19_R23_Q0.8191.00
197_K201_W0.8141.00
67_L71_L0.8101.00
59_M67_L0.8071.00
110_A114_E0.8071.00
6_I29_C0.8041.00
119_G122_Q0.7841.00
199_L203_V0.7761.00
43_I75_R0.7751.00
93_K111_S0.7721.00
79_D127_L0.7711.00
17_N113_F0.7701.00
209_F212_I0.7671.00
13_V108_F0.7591.00
201_W204_N0.7591.00
137_E140_Q0.7531.00
207_I213_H0.7501.00
54_L117_L0.7441.00
43_I78_S0.7421.00
36_L40_K0.7401.00
112_R116_A0.7381.00
15_E19_R0.7381.00
108_F113_F0.7371.00
205_C213_H0.7351.00
148_N164_L0.7311.00
43_I50_I0.7311.00
54_L83_I0.7311.00
58_Y85_S0.7311.00
3_N51_D0.7301.00
7_I67_L0.7281.00
121_R124_K0.7271.00
207_I210_T0.7251.00
109_Q112_R0.7241.00
91_T94_D0.7231.00
77_K127_L0.7211.00
62_E67_L0.7201.00
6_I18_R0.7101.00
102_D119_G0.7081.00
29_C32_T0.7061.00
124_K128_E0.7051.00
119_G124_K0.7041.00
207_I211_S0.7031.00
169_Q172_D0.7031.00
151_D154_R0.7031.00
57_I86_A0.7031.00
71_L76_C0.6981.00
36_L61_K0.6971.00
90_A111_S0.6941.00
143_H164_L0.6941.00
44_F70_V0.6941.00
81_I102_D0.6941.00
161_P165_R0.6931.00
83_I108_F0.6921.00
177_Y183_E0.6891.00
160_T163_T0.6831.00
200_I204_N0.6831.00
71_L80_V0.6781.00
193_V200_I0.6761.00
72_H79_D0.6751.00
143_H150_Q0.6721.00
181_T192_R0.6701.00
111_S115_E0.6701.00
196_R199_L0.6681.00
96_L116_A0.6681.00
97_H115_E0.6651.00
40_K43_I0.6651.00
177_Y187_E0.6651.00
23_Q26_G0.6591.00
89_A111_S0.6581.00
79_D123_K0.6581.00
14_A18_R0.6511.00
199_L211_S0.6501.00
8_D59_M0.6481.00
168_C172_D0.6471.00
6_I32_T0.6441.00
84_S92_I0.6391.00
54_L81_I0.6371.00
160_T205_C0.6361.00
140_Q152_P0.6351.00
20_Y114_E0.6331.00
49_P75_R0.6311.00
139_D143_H0.6271.00
43_I53_I0.6211.00
116_A120_W0.6201.00
203_V208_L0.6181.00
44_F75_R0.6121.00
90_A93_K0.6091.00
92_I109_Q0.6091.00
140_Q143_H0.6061.00
24_I27_F0.6041.00
28_Q31_G0.6041.00
21_V27_F0.6031.00
55_L59_M0.6011.00
173_A187_E0.6011.00
118_T122_Q0.6001.00
79_D121_R0.5991.00
36_L59_M0.5981.00
190_I195_C0.5921.00
16_L20_Y0.5921.00
22_A29_C0.5861.00
40_K74_A0.5861.00
10_D85_S0.5831.00
95_S100_V0.5771.00
167_L170_W0.5741.00
152_P155_L0.5641.00
171_I199_L0.5631.00
181_T185_A0.5601.00
208_L213_H0.5581.00
136_A139_D0.5571.00
68_L72_H0.5541.00
85_S107_P0.5521.00
162_Q198_Y0.5521.00
194_S197_K0.5511.00
77_K126_A0.5501.00
143_H169_Q0.5501.00
108_F112_R0.5491.00
72_H78_S0.5461.00
27_F121_R0.5331.00
65_L91_T0.5331.00
71_L78_S0.5311.00
43_I67_L0.5281.00
10_D13_V0.5221.00
167_L171_I0.5221.00
115_E118_T0.5221.00
136_A143_H0.5211.00
152_P207_I0.5211.00
22_A28_Q0.5201.00
79_D124_K0.5151.00
93_K96_L0.5111.00
164_L169_Q0.5111.00
9_D84_S0.5081.00
13_V16_L0.5081.00
159_L163_T0.5071.00
150_Q157_K0.5071.00
119_G123_K0.5071.00
184_L187_E0.5051.00
4_V52_L0.5051.00
49_P76_C0.5031.00
144_G149_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gvpA 1 0.8703 100 0.279 Contact Map
3c3wA 2 0.8828 100 0.286 Contact Map
4b09A 2 0.8787 100 0.299 Contact Map
1a04A 1 0.8536 100 0.3 Contact Map
4ldzA 2 0.8117 100 0.304 Contact Map
3r0jA 2 0.8954 100 0.306 Contact Map
1yioA 1 0.8243 100 0.31 Contact Map
2oqrA 2 0.9247 100 0.315 Contact Map
1ys7A 2 0.9247 100 0.316 Contact Map
4kfcA 2 0.9163 100 0.318 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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