GREMLIN Database
CUSR - Transcriptional regulatory protein CusR
UniProt: P0ACZ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13851
Length: 227 (206)
Sequences: 80843 (57659)
Seq/√Len: 4017.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_G29_L3.8471.00
13_G31_D3.4011.00
17_T29_L3.3451.00
6_V36_G2.8431.00
37_Y65_M2.8191.00
34_L56_D2.6131.00
28_D45_Y2.5581.00
33_G57_V2.4711.00
41_M69_A2.4671.00
57_V65_M2.4091.00
32_N56_D2.3611.00
19_G105_F2.1111.00
30_A39_L2.0921.00
23_A109_L2.0691.00
2_K26_V2.0601.00
17_T21_T2.0261.00
53_M81_L1.9781.00
31_D35_N1.9181.00
87_R107_E1.8601.00
63_V75_I1.8561.00
189_N192_D1.8551.00
50_L62_I1.8521.00
28_D39_L1.8181.00
77_L90_G1.8061.00
2_K28_D1.7871.00
39_L43_G1.7701.00
32_N35_N1.7691.00
65_M69_A1.7681.00
28_D43_G1.7311.00
4_L30_A1.7121.00
67_R96_D1.6861.00
77_L95_A1.6601.00
154_K157_T1.6441.00
84_I104_A1.6441.00
64_R93_L1.6391.00
57_V61_D1.6361.00
172_R192_D1.6231.00
33_G62_I1.5931.00
58_N61_D1.5781.00
97_D111_R1.5721.00
160_E164_R1.5681.00
39_L42_T1.5421.00
65_M68_S1.4971.00
20_L112_V1.4961.00
40_A66_L1.4871.00
81_L86_H1.4671.00
170_L178_Q1.4671.00
161_F178_Q1.4631.00
48_I73_M1.4521.00
171_P174_L1.4481.00
34_L57_V1.4331.00
194_A197_R1.4321.00
63_V77_L1.4301.00
61_D64_R1.3601.00
37_Y62_I1.3551.00
129_Q134_M1.3531.00
96_D118_R1.3411.00
47_L112_V1.3321.00
96_D115_L1.3291.00
39_L45_Y1.3121.00
76_L115_L1.3011.00
10_K31_D1.2991.00
132_D145_S1.2961.00
161_F165_H1.2941.00
7_E13_G1.2711.00
70_N73_M1.2621.00
38_H42_T1.2481.00
37_Y57_V1.2381.00
52_I60_W1.2361.00
6_V54_L1.2201.00
60_W90_G1.2181.00
156_F160_E1.2121.00
25_F113_R1.2061.00
8_D51_D1.2021.00
35_N39_L1.1941.00
35_N38_H1.1921.00
4_L45_Y1.1831.00
50_L63_V1.1761.00
89_K93_L1.1741.00
174_L178_Q1.1671.00
155_E201_K1.1671.00
109_L113_R1.1531.00
34_L38_H1.1501.00
30_A36_G1.1421.00
52_I77_L1.1291.00
60_W89_K1.1261.00
83_T86_H1.1201.00
190_A194_A1.1151.00
195_V199_R1.1131.00
2_K43_G1.1101.00
4_L36_G1.1051.00
23_A113_R1.0801.00
24_G113_R1.0791.00
4_L39_L1.0701.00
84_I88_V1.0701.00
157_T160_E1.0571.00
110_A114_T1.0571.00
204_N213_T1.0571.00
134_M143_T1.0501.00
189_N193_V1.0481.00
37_Y41_M1.0401.00
3_L25_F1.0391.00
64_R89_K1.0391.00
136_D139_S1.0351.00
107_E110_A1.0351.00
193_V196_K1.0331.00
40_A70_N1.0301.00
47_L116_L1.0301.00
88_V92_E1.0291.00
30_A35_N1.0271.00
36_G62_I1.0221.00
173_S188_T1.0191.00
141_K148_R1.0181.00
14_E29_L1.0131.00
158_L162_F1.0061.00
92_E113_R0.9971.00
85_E89_K0.9921.00
17_T27_V0.9681.00
48_I66_L0.9651.00
10_K14_E0.9591.00
161_F170_L0.9541.00
5_I16_L0.9541.00
170_L174_L0.9491.00
153_S157_T0.9471.00
4_L40_A0.9461.00
87_R100_V0.9451.00
11_K15_Y0.9401.00
135_V163_L0.9391.00
36_G40_A0.9391.00
6_V30_A0.9231.00
137_L160_E0.9201.00
50_L75_I0.9191.00
60_W93_L0.9171.00
52_I58_N0.9111.00
48_I75_I0.9071.00
16_L78_L0.9061.00
84_I87_R0.9031.00
74_P96_D0.9011.00
63_V93_L0.8991.00
38_H41_M0.8991.00
63_V95_A0.8941.00
154_K180_W0.8871.00
6_V48_I0.8841.00
61_D65_M0.8821.00
89_K92_E0.8801.00
50_L77_L0.8771.00
76_L111_R0.8771.00
14_E17_T0.8701.00
49_I108_L0.8641.00
127_Q134_M0.8631.00
135_V156_F0.8591.00
205_D208_P0.8521.00
143_T148_R0.8451.00
188_T192_D0.8421.00
5_I27_V0.8411.00
44_D70_N0.8411.00
52_I86_H0.8391.00
10_K13_G0.8361.00
115_L118_R0.8351.00
25_F109_L0.8271.00
82_G100_V0.8271.00
174_L177_S0.8171.00
107_E111_R0.8131.00
18_K22_E0.8071.00
64_R68_S0.8061.00
62_I66_L0.8021.00
204_N209_K0.7991.00
189_N196_K0.7921.00
74_P118_R0.7811.00
105_F109_L0.7761.00
40_A45_Y0.7761.00
161_F175_I0.7741.00
54_L62_I0.7711.00
57_V62_I0.7681.00
114_T117_R0.7671.00
173_S177_S0.7601.00
104_A107_E0.7541.00
52_I81_L0.7541.00
86_H89_K0.7531.00
49_I112_V0.7531.00
33_G37_Y0.7531.00
12_T103_F0.7461.00
129_Q132_D0.7441.00
40_A73_M0.7401.00
41_M70_N0.7391.00
88_V106_A0.7341.00
193_V197_R0.7331.00
74_P122_V0.7321.00
205_D209_K0.7301.00
66_L71_K0.7291.00
161_F164_R0.7281.00
197_R200_G0.7251.00
16_L108_L0.7251.00
78_L103_F0.7251.00
66_L75_I0.7251.00
49_I78_L0.7231.00
172_R188_T0.7211.00
203_D209_K0.7191.00
103_F108_L0.7181.00
6_V62_I0.7161.00
53_M80_A0.7131.00
14_E18_K0.7131.00
143_T146_G0.7111.00
33_G56_D0.7101.00
85_E106_A0.7091.00
97_D114_T0.7051.00
116_L119_G0.7051.00
119_G123_I0.6981.00
186_S191_I0.6971.00
114_T119_G0.6901.00
41_M65_M0.6781.00
106_A110_A0.6741.00
157_T161_F0.6701.00
5_I17_T0.6691.00
196_K200_G0.6671.00
72_G122_V0.6651.00
128_F131_A0.6641.00
140_R157_T0.6631.00
37_Y40_A0.6631.00
33_G54_L0.6561.00
2_K46_D0.6491.00
15_Y19_G0.6491.00
111_R115_L0.6481.00
40_A48_I0.6461.00
67_R74_P0.6461.00
13_G17_T0.6411.00
152_T201_K0.6411.00
19_G109_L0.6401.00
49_I76_L0.6401.00
51_D101_K0.6391.00
5_I29_L0.6351.00
126_S129_Q0.6311.00
91_L111_R0.6301.00
76_L97_D0.6281.00
177_S180_W0.6271.00
152_T155_E0.6231.00
9_E80_A0.6151.00
90_G95_A0.6151.00
92_E110_A0.6121.00
79_T101_K0.6101.00
140_R156_F0.6101.00
7_E54_L0.6071.00
74_P116_L0.6071.00
37_Y69_A0.6051.00
9_E12_T0.6051.00
164_R178_Q0.5991.00
85_E88_V0.5941.00
203_D208_P0.5941.00
199_R204_N0.5931.00
135_V160_E0.5921.00
87_R104_A0.5881.00
21_T27_V0.5881.00
209_K212_Q0.5881.00
208_P211_I0.5871.00
63_V67_R0.5871.00
67_R73_M0.5861.00
60_W86_H0.5861.00
162_F165_H0.5831.00
126_S138_V0.5831.00
192_D195_V0.5821.00
103_F107_E0.5761.00
110_A113_R0.5751.00
20_L25_F0.5691.00
176_A180_W0.5661.00
164_R170_L0.5651.00
113_R117_R0.5651.00
190_A195_V0.5631.00
84_I106_A0.5611.00
154_K194_A0.5581.00
165_H178_Q0.5561.00
133_L144_R0.5561.00
12_T15_Y0.5551.00
50_L54_L0.5541.00
3_L20_L0.5501.00
74_P119_G0.5491.00
187_D190_A0.5481.00
151_L155_E0.5471.00
66_L73_M0.5461.00
191_I195_V0.5461.00
72_G121_A0.5441.00
135_V142_V0.5431.00
208_P212_Q0.5401.00
52_I90_G0.5381.00
8_D79_T0.5341.00
88_V91_L0.5321.00
80_A102_P0.5281.00
144_R205_D0.5271.00
19_G23_A0.5251.00
79_T87_R0.5231.00
79_T98_Y0.5201.00
208_P216_G0.5191.00
35_N56_D0.5161.00
15_Y18_K0.5131.00
195_V207_E0.5101.00
162_F195_V0.5101.00
192_D196_K0.5081.00
155_E158_L0.5071.00
3_L47_L0.5071.00
111_R114_T0.5051.00
132_D144_R0.5051.00
130_V134_M0.5051.00
152_T162_F0.5041.00
50_L66_L0.5041.00
144_R147_T0.5031.00
144_R203_D0.5031.00
5_I13_G0.5021.00
159_L162_F0.5021.00
155_E162_F0.5021.00
25_F116_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ys7A 2 0.9824 100 0.188 Contact Map
3r0jA 2 0.9648 100 0.192 Contact Map
2gwrA 1 0.9692 100 0.2 Contact Map
1kgsA 1 0.9604 100 0.203 Contact Map
2oqrA 2 0.9736 100 0.22 Contact Map
2hqrA 2 0.9648 100 0.221 Contact Map
4b09A 2 0.9295 100 0.223 Contact Map
4kfcA 2 0.9736 100 0.226 Contact Map
1p2fA 1 0.9427 100 0.244 Contact Map
3q9sA 1 0.9207 100 0.247 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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