GREMLIN Database
ETP - Low molecular weight protein-tyrosine-phosphatase etp
UniProt: P0ACZ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13727
Length: 148 (139)
Sequences: 4696 (3555)
Seq/√Len: 301.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_R140_Q3.3221.00
29_K33_G3.2431.00
24_E28_R2.9421.00
72_L94_V2.7671.00
85_A94_V2.3881.00
118_P134_M2.3471.00
8_S35_K2.3211.00
57_A64_L2.0921.00
22_I53_A2.0621.00
14_T90_H2.0491.00
88_S116_E2.0181.00
59_N129_E1.8981.00
123_K127_A1.7861.00
11_V27_L1.7511.00
10_L39_A1.7241.00
37_K70_R1.6861.00
56_V129_E1.6801.00
22_I57_A1.5871.00
91_I95_T1.5581.00
60_H136_E1.5381.00
108_F139_S1.5311.00
106_M111_W1.5091.00
75_E79_N1.5071.00
9_I27_L1.4951.00
14_T42_H1.4881.00
35_K79_N1.4841.00
85_A91_I1.4671.00
30_R136_E1.4661.00
31_L34_V1.4631.00
60_H132_Y1.4321.00
108_F135_L1.4321.00
49_A67_H1.4221.00
31_L36_V1.3961.00
37_K80_Y1.3841.00
56_V59_N1.3821.00
56_V132_Y1.3761.00
70_R76_M1.3721.00
45_V69_G1.3721.00
26_L132_Y1.3581.00
30_R139_S1.3511.00
109_G112_L1.3421.00
41_V93_Q1.3381.00
27_L36_V1.3351.00
88_S107_L1.3331.00
130_H134_M1.3191.00
60_H133_G1.3091.00
26_L135_L1.2971.00
26_L139_S1.2901.00
45_V71_K1.2831.00
48_P54_A1.2751.00
106_M110_Q1.2261.00
109_G134_M1.2121.00
55_D125_Q1.2101.00
49_A54_A1.1991.00
44_L47_H1.1911.00
25_R64_L1.1871.00
54_A64_L1.1851.00
62_V136_E1.1841.00
25_R62_V1.1721.00
49_A64_L1.1421.00
43_G71_K1.1161.00
107_L116_E1.0991.00
111_W142_W1.0851.00
91_I105_T1.0841.00
28_R36_V1.0621.00
29_K32_P1.0621.00
39_A70_R1.0601.00
23_G86_M1.0601.00
77_A83_I1.0571.00
56_V60_H1.0521.00
95_T105_T1.0511.00
8_S79_N1.0481.00
77_A101_V1.0391.00
54_A58_A1.0331.00
111_W145_R1.0171.00
124_S127_A1.0131.00
85_A107_L1.0111.00
112_L137_R1.0001.00
136_E140_Q0.9971.00
27_L139_S0.9971.00
53_A56_V0.9901.00
86_M108_F0.9791.00
87_E90_H0.9721.00
74_A97_I0.9571.00
89_E93_Q0.9551.00
55_D59_N0.9501.00
109_G138_A0.9441.00
125_Q129_E0.9361.00
141_E144_K0.9351.00
59_N125_Q0.9331.00
93_Q96_A0.9301.00
25_R67_H0.9211.00
42_H45_V0.9191.00
25_R28_R0.9161.00
82_L106_M0.9121.00
72_L77_A0.9081.00
82_L142_W0.8981.00
131_V135_L0.8971.00
84_L142_W0.8921.00
30_R143_A0.8911.00
110_Q114_Q0.8911.00
101_V104_K0.8911.00
108_F138_A0.8871.00
93_Q97_I0.8841.00
129_E133_G0.8841.00
94_V105_T0.8811.00
91_I107_L0.8771.00
14_T89_E0.8761.00
30_R33_G0.8741.00
22_I132_Y0.8731.00
51_A55_D0.8711.00
86_M117_I0.8651.00
11_V23_G0.8571.00
10_L80_Y0.8491.00
84_L106_M0.8491.00
84_L111_W0.8341.00
50_D128_F0.8301.00
25_R49_A0.8271.00
114_Q130_H0.8081.00
12_V94_V0.8081.00
12_V83_I0.8071.00
41_V94_V0.7951.00
62_V132_Y0.7880.99
75_E78_R0.7790.99
49_A57_A0.7770.99
98_A105_T0.7660.99
31_L143_A0.7580.99
52_T125_Q0.7580.99
95_T98_A0.7560.99
58_A64_L0.7530.99
26_L62_V0.7500.99
56_V125_Q0.7450.99
77_A98_A0.7440.99
39_A72_L0.7410.99
132_Y136_E0.7100.99
48_P68_A0.7040.99
106_M145_R0.6960.99
77_A94_V0.6940.99
22_I56_V0.6860.99
112_L141_E0.6830.99
8_S80_Y0.6820.99
54_A65_E0.6770.98
23_G108_F0.6650.98
73_T76_M0.6640.98
107_L110_Q0.6630.98
16_N20_S0.6630.98
48_P67_H0.6560.98
98_A101_V0.6550.98
52_T123_K0.6540.98
111_W141_E0.6510.98
127_A130_H0.6500.98
14_T87_E0.6480.98
28_R32_P0.6480.98
76_M80_Y0.6420.98
10_L83_I0.6390.98
27_L30_R0.6370.98
42_H71_K0.6280.97
112_L142_W0.6280.97
60_H129_E0.6280.97
83_I94_V0.6240.97
84_L108_F0.6230.97
42_H93_Q0.6220.97
98_A103_G0.6190.97
43_G47_H0.6170.97
10_L70_R0.6160.97
39_A76_M0.6150.97
8_S37_K0.6150.97
74_A78_R0.6120.97
101_V105_T0.6040.97
53_A57_A0.6040.97
23_G135_L0.6030.97
37_K79_N0.5960.97
117_I138_A0.5900.96
86_M90_H0.5880.96
131_V134_M0.5830.96
109_G116_E0.5760.96
63_S66_G0.5670.95
22_I131_V0.5640.95
78_R101_V0.5640.95
142_W146_L0.5640.95
57_A62_V0.5630.95
98_A104_K0.5600.95
73_T79_N0.5510.95
82_L111_W0.5480.95
25_R63_S0.5480.95
28_R66_G0.5440.94
142_W145_R0.5440.94
13_C16_N0.5430.94
50_D121_Y0.5420.94
117_I134_M0.5410.94
70_R80_Y0.5380.94
26_L136_E0.5380.94
14_T93_Q0.5380.94
109_G117_I0.5370.94
77_A99_P0.5360.94
122_R127_A0.5360.94
47_H69_G0.5350.94
135_L139_S0.5260.93
26_L30_R0.5240.93
17_I128_F0.5230.93
11_V142_W0.5220.93
11_V139_S0.5160.93
127_A131_V0.5150.93
44_L121_Y0.5150.93
43_G122_R0.5140.92
24_E67_H0.5070.92
108_F142_W0.5030.92
52_T124_S0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wmyA 3 0.9797 100 0.133 Contact Map
2wjaA 1 0.973 100 0.133 Contact Map
2fekA 1 0.9662 100 0.145 Contact Map
4egsA 2 0.9527 100 0.161 Contact Map
4etnA 1 0.9595 100 0.163 Contact Map
1d1qA 1 0.973 100 0.163 Contact Map
2cwdA 1 0.973 100 0.165 Contact Map
4picA 2 0.9595 100 0.167 Contact Map
4lrqA 2 0.9595 100 0.168 Contact Map
3jviA 1 0.9459 100 0.168 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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