GREMLIN Database
YEAL - UPF0756 membrane protein YeaL
UniProt: P0ACY6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13498
Length: 148 (141)
Sequences: 405 (224)
Seq/√Len: 18.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_V135_L3.4911.00
123_G137_A2.9940.99
120_T124_V2.9760.99
9_L67_A2.8480.99
10_L14_A2.6170.98
7_L11_G2.5380.97
101_R143_L2.5160.97
39_L44_P2.3730.96
21_N96_S2.3670.96
87_V144_I2.3330.95
21_N124_V2.2600.94
66_I122_L2.2560.94
93_V122_L2.2520.94
98_L107_G2.0330.90
96_S120_T1.8850.86
86_L90_A1.7950.84
14_A18_I1.7840.83
101_R142_S1.7770.83
13_A29_L1.7250.81
99_G136_I1.7020.80
95_V136_I1.6760.79
6_L32_I1.5830.75
81_L145_V1.5810.75
96_S124_V1.5780.75
124_V136_I1.5770.75
39_L42_F1.5730.74
82_N93_V1.5030.71
89_I123_G1.4980.71
131_P142_S1.4960.70
13_A104_T1.4750.69
31_L68_S1.3960.65
83_W128_R1.3840.64
64_A68_S1.3750.64
33_I37_T1.3700.63
45_W53_I1.3660.63
97_W100_G1.3490.62
43_F64_A1.3410.62
55_I95_V1.3340.61
95_V124_V1.3240.61
99_G130_V1.3170.60
13_A112_L1.3000.59
27_S72_P1.2790.58
21_N120_T1.2590.57
19_S41_T1.2570.57
58_L113_V1.2400.56
95_V120_T1.2380.55
125_A130_V1.2300.55
21_N55_I1.2040.53
120_T136_I1.2040.53
28_I63_M1.2040.53
117_L121_V1.1890.52
80_F89_I1.1620.51
100_G112_L1.1430.50
52_S142_S1.1390.49
21_N136_I1.1380.49
92_G137_A1.1310.49
31_L62_V1.1260.48
24_V59_T1.1250.48
23_T66_I1.1240.48
34_V43_F1.1210.48
6_L128_R1.1130.48
29_L60_I1.1120.48
35_R67_A1.1030.47
62_V138_A1.0980.47
46_I60_I1.0880.46
19_S24_V1.0610.44
10_L17_F1.0590.44
34_V46_I1.0570.44
39_L135_L1.0510.44
32_I38_P1.0510.44
20_H117_L1.0500.44
92_G110_P1.0310.43
25_A33_I1.0240.42
18_I45_W1.0190.42
43_F80_F1.0160.42
10_L32_I1.0030.41
89_I130_V1.0030.41
30_V60_I0.9980.41
13_A32_I0.9950.40
16_G24_V0.9890.40
21_N95_V0.9880.40
31_L99_G0.9640.38
101_R137_A0.9600.38
46_I64_A0.9530.38
62_V135_L0.9480.38
29_L33_I0.9330.37
122_L126_L0.9290.36
90_A94_I0.9270.36
29_L112_L0.9220.36
46_I118_V0.9220.36
30_V46_I0.9080.35
76_L144_I0.8990.35
12_L138_A0.8960.34
16_G51_L0.8840.34
50_G88_A0.8760.33
18_I90_A0.8690.33
66_I126_L0.8680.33
36_V67_A0.8650.33
98_L123_G0.8610.33
100_G107_G0.8550.32
95_V99_G0.8490.32
86_L131_P0.8460.32
29_L46_I0.8390.31
9_L100_G0.8280.31
35_R50_G0.8230.30
93_V103_V0.8220.30
43_F118_V0.8190.30
14_A33_I0.8180.30
13_A28_I0.8180.30
42_F46_I0.8100.30
34_V145_V0.8030.29
117_L131_P0.7970.29
66_I114_A0.7930.29
81_L112_L0.7880.29
51_L55_I0.7840.28
43_F88_A0.7830.28
22_T80_F0.7820.28
13_A48_K0.7750.28
55_I99_G0.7730.28
19_S108_S0.7650.27
27_S71_L0.7630.27
20_H33_I0.7610.27
21_N99_G0.7560.27
80_F143_L0.7540.27
56_I128_R0.7540.27
23_T136_I0.7530.27
19_S109_Q0.7490.27
19_S121_V0.7430.26
99_G120_T0.7380.26
135_L138_A0.7310.26
99_G125_A0.7240.25
11_G69_G0.7210.25
38_P98_L0.7210.25
42_F118_V0.7200.25
80_F130_V0.7190.25
23_T41_T0.7040.25
59_T139_G0.7020.24
141_V145_V0.7010.24
42_F82_N0.7010.24
118_V125_A0.6990.24
96_S103_V0.6950.24
122_L127_F0.6910.24
27_S36_V0.6880.24
123_G134_P0.6850.24
130_V136_I0.6830.24
44_P122_L0.6810.23
34_V56_I0.6700.23
15_L18_I0.6670.23
25_A58_L0.6660.23
98_L104_T0.6660.23
36_V56_I0.6650.23
46_I70_T0.6640.23
19_S45_W0.6620.23
12_L140_L0.6590.22
18_I37_T0.6590.22
68_S78_H0.6570.22
6_L38_P0.6520.22
24_V83_W0.6510.22
47_E52_S0.6490.22
99_G124_V0.6450.22
96_S99_G0.6450.22
129_G133_G0.6420.22
53_I62_V0.6390.22
115_G131_P0.6390.22
34_V122_L0.6390.22
37_T42_F0.6340.21
92_G123_G0.6340.21
49_Q75_T0.6250.21
50_G116_L0.6180.21
81_L84_K0.6130.21
49_Q52_S0.6110.20
18_I60_I0.6080.20
87_V141_V0.6060.20
17_F20_H0.6040.20
7_L64_A0.5900.20
35_R81_L0.5890.20
62_V98_L0.5890.20
33_I80_F0.5870.19
6_L20_H0.5850.19
28_I48_K0.5700.19
51_L73_P0.5680.19
136_I139_G0.5640.19
101_R130_V0.5610.18
118_V126_L0.5580.18
26_V118_V0.5580.18
105_L108_S0.5550.18
34_V72_P0.5530.18
8_I49_Q0.5480.18
29_L48_K0.5470.18
17_F25_A0.5420.18
18_I128_R0.5410.18
13_A45_W0.5390.18
49_Q91_V0.5380.18
55_I96_S0.5380.18
63_M117_L0.5340.17
30_V47_E0.5330.17
43_F145_V0.5330.17
137_A141_V0.5320.17
23_T95_V0.5300.17
8_I63_M0.5280.17
16_G105_L0.5260.17
20_H103_V0.5250.17
61_G80_F0.5240.17
84_K90_A0.5230.17
40_S103_V0.5200.17
102_G119_G0.5180.17
46_I78_H0.5110.17
72_P76_L0.5090.17
123_G141_V0.5060.16
55_I136_I0.5040.16
77_I94_I0.5000.16
58_L117_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qi9A 2 0.7568 5.8 0.955 Contact Map
4o93B 1 0.7905 4.2 0.958 Contact Map
4o9uB 2 0.7905 4.1 0.958 Contact Map
2jlnA 1 0.8784 3.7 0.959 Contact Map
1i5pA 1 0.527 3.5 0.959 Contact Map
4u9nA 2 0.9054 3.5 0.959 Contact Map
1wu0A 1 0.4865 3.4 0.959 Contact Map
1a91A 1 0.4932 2.6 0.962 Contact Map
3orgA 2 0.9122 2.5 0.962 Contact Map
2nq2A 2 0.6554 2 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0058 seconds.