GREMLIN Database
YDHR - Putative monooxygenase YdhR
UniProt: P0ACX3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13952
Length: 101 (99)
Sequences: 201 (149)
Seq/√Len: 15.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_S98_A6.3721.00
31_N96_N4.6841.00
58_D61_S3.3030.99
31_N36_F2.9050.97
57_T61_S2.6860.96
49_E84_K2.5430.94
29_S68_K2.3610.91
66_L83_A2.3220.91
74_K79_E2.2240.89
20_A91_P2.1250.86
8_H82_V1.8940.79
59_E63_L1.8590.78
44_S86_F1.8090.76
3_T87_D1.7630.74
25_P28_E1.7190.72
24_K28_E1.7170.72
55_L88_V1.6620.69
19_M38_W1.6580.69
44_S47_N1.6360.68
11_F23_L1.6340.68
74_K81_V1.5860.65
3_T59_E1.5640.64
13_G73_L1.4140.56
37_L55_L1.3920.55
7_L68_K1.3600.53
21_E48_H1.3050.50
5_L66_L1.2990.50
7_L83_A1.2330.46
49_E86_F1.1840.43
34_P64_A1.1780.43
6_Q53_I1.1770.43
15_F97_Q1.1400.41
8_H66_L1.1250.40
36_F50_A1.0910.38
8_H83_A1.0680.37
74_K80_E1.0640.37
29_S36_F1.0550.37
13_G38_W1.0420.36
50_A84_K1.0390.36
45_E87_D1.0390.36
8_H44_S1.0000.34
4_L15_F0.9780.33
66_L86_F0.9500.31
20_A24_K0.9450.31
7_L85_V0.9360.31
44_S49_E0.9260.30
49_E82_V0.9200.30
60_K94_Q0.9190.30
60_K64_A0.9160.30
28_E32_Q0.9140.30
91_P94_Q0.9030.29
4_L87_D0.8970.29
38_W73_L0.8830.28
8_H86_F0.8780.28
49_E76_L0.8760.28
57_T75_N0.8740.28
36_F96_N0.8630.27
15_F18_A0.8490.27
40_V53_I0.8480.27
8_H99_K0.8380.26
40_V85_V0.8350.26
6_Q44_S0.8350.26
30_I68_K0.8310.26
32_Q48_H0.8250.26
44_S75_N0.8120.25
4_L85_V0.8040.25
73_L78_V0.8020.25
23_L96_N0.7970.24
37_L46_K0.7910.24
19_M23_L0.7910.24
22_Q36_F0.7890.24
9_F16_G0.7750.23
14_P78_V0.7610.23
29_S33_E0.7570.23
87_D91_P0.7560.23
9_F52_G0.7540.23
23_L34_P0.7520.23
21_E45_E0.7500.22
17_D79_E0.7490.22
13_G78_V0.7400.22
14_P38_W0.7290.22
3_T61_S0.7290.22
20_A25_P0.7280.22
6_Q9_F0.7210.21
40_V68_K0.7160.21
2_A67_E0.7160.21
2_A24_K0.7120.21
14_P73_L0.7090.21
52_G89_N0.7060.21
90_E94_Q0.7040.21
43_E89_N0.6990.21
58_D99_K0.6980.21
10_A23_L0.6970.20
38_W99_K0.6750.20
22_Q47_N0.6670.19
4_L48_H0.6650.19
34_P74_K0.6620.19
5_L9_F0.6610.19
35_G56_F0.6610.19
6_Q86_F0.6570.19
21_E32_Q0.6530.19
37_L83_A0.6360.18
63_L84_K0.6330.18
20_A43_E0.6290.18
19_M29_S0.6230.18
37_L80_E0.6140.18
17_D21_E0.6090.17
33_E65_Y0.6090.17
3_T78_V0.6060.17
24_K94_Q0.6060.17
30_I33_E0.6040.17
29_S32_Q0.6020.17
59_E71_A0.6010.17
67_E94_Q0.5910.17
11_F78_V0.5900.17
14_P99_K0.5880.17
15_F95_I0.5810.17
41_W92_L0.5770.16
12_N60_K0.5750.16
12_N28_E0.5750.16
23_L78_V0.5710.16
71_A78_V0.5650.16
67_E96_N0.5620.16
70_T83_A0.5590.16
85_V94_Q0.5580.16
44_S91_P0.5580.16
1_M62_A0.5560.16
21_E24_K0.5480.16
22_Q76_L0.5450.15
63_L67_E0.5440.15
48_H75_N0.5440.15
55_L58_D0.5430.15
12_N48_H0.5370.15
43_E52_G0.5340.15
30_I69_H0.5290.15
55_L61_S0.5280.15
19_M73_L0.5270.15
29_S64_A0.5260.15
47_N86_F0.5200.15
17_D32_Q0.5180.15
71_A74_K0.5130.15
24_K93_S0.5130.15
80_E94_Q0.5110.15
46_K67_E0.5100.14
91_P98_A0.5090.14
9_F50_A0.5040.14
16_G52_G0.5010.14
60_K76_L0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2asyA 2 0.9901 100 0.192 Contact Map
2hiqA 2 0.9505 100 0.206 Contact Map
3fgvA 2 0.8515 81.1 0.912 Contact Map
3kg0A 2 0.8911 66.6 0.922 Contact Map
2zdoA 2 0.9208 65.9 0.922 Contact Map
2bbeA 3 0.9307 65.2 0.922 Contact Map
3hx9A 2 0.9307 59.7 0.925 Contact Map
1y0hA 2 0.9208 58.3 0.925 Contact Map
1iujA 4 0.9208 53.4 0.928 Contact Map
4zosA 2 0.901 51.9 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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