MPAA - ECOLI - GREMLIN Contacts

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MPAA - Protein MpaA

UniProt:	P0ACV6	Sequences: MTVTRPRAERGAFPPGTEHYGRSLLGAPLIWFPAPAASRESGLILAGTHGDENSSVVTLSCALRTLTPSLRRHHVVLCVNPDGCQLGLRANANGVDLNRNFPAANWKEGETVYRWNSAAEERDVVLLTGDKPGSEPETQALCQLIHRIQPAWVVSFHDPLACIEDPRHSELGEWLAQAFELPLVTSVGYETPGSFGSWCADLNLHCITAEFPPISSDEASEKYLFAMANLLRWHPKDAIRPS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13906
Length:	242 (221)
Sequences:	3274 (2125)
Seq/√Len:	142.9

ECOLI - MPAA
BACSU - YQGT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
46_A	59_L	4.331	1.00
133_G	142_C	3.166	1.00
48_T	101_F	3.124	1.00
91_N	97_L	3.071	1.00
19_H	28_P	3.057	1.00
47_G	56_V	2.914	1.00
29_L	140_A	2.896	1.00
22_R	28_P	2.676	1.00
102_P	133_G	2.491	1.00
74_H	144_L	2.326	1.00
93_N	135_E	2.304	1.00
45_L	155_S	2.297	1.00
95_V	135_E	2.205	1.00
179_F	183_L	2.094	1.00
196_G	208_T	2.018	1.00
5_R	30_I	2.016	1.00
18_E	31_W	2.012	1.00
63_L	75_V	1.979	1.00
19_H	22_R	1.971	1.00
5_R	17_T	1.910	1.00
157_H	210_E	1.864	1.00
33_P	72_R	1.785	1.00
29_L	76_V	1.765	1.00
49_H	52_E	1.722	1.00
16_G	33_P	1.680	1.00
32_F	63_L	1.675	1.00
41_S	74_H	1.656	1.00
173_E	177_Q	1.653	1.00
136_P	140_A	1.652	1.00
185_T	188_G	1.636	1.00
168_H	172_G	1.625	1.00
107_K	128_T	1.607	1.00
100_N	135_E	1.590	1.00
146_H	198_W	1.571	1.00
36_A	39_R	1.538	1.00
7_R	15_P	1.526	1.00
226_A	229_N	1.515	1.00
104_A	108_E	1.512	1.00
139_Q	143_Q	1.506	1.00
142_C	146_H	1.501	1.00
31_W	76_V	1.489	1.00
43_L	76_V	1.486	1.00
102_P	142_C	1.476	1.00
23_S	136_P	1.476	1.00
98_N	210_E	1.468	1.00
15_P	32_F	1.467	1.00
48_T	155_S	1.456	1.00
59_L	156_F	1.454	1.00
153_V	195_F	1.421	1.00
31_W	74_H	1.407	1.00
172_G	183_L	1.406	1.00
133_G	138_T	1.405	1.00
24_L	136_P	1.403	1.00
145_I	202_L	1.396	1.00
145_I	199_C	1.368	1.00
34_A	63_L	1.363	1.00
25_L	92_A	1.363	1.00
19_H	30_I	1.359	1.00
127_L	130_D	1.356	1.00
8_A	15_P	1.340	1.00
169_S	173_E	1.326	1.00
89_R	157_H	1.325	1.00
44_I	59_L	1.320	1.00
56_V	84_C	1.319	1.00
171_L	175_L	1.316	1.00
156_F	209_A	1.310	1.00
100_N	134_S	1.309	1.00
146_H	202_L	1.291	1.00
21_G	140_A	1.290	1.00
48_T	79_V	1.288	1.00
20_Y	76_V	1.287	1.00
47_G	84_C	1.282	1.00
17_T	30_I	1.280	1.00
6_P	10_R	1.277	1.00
180_E	183_L	1.270	1.00
33_P	74_H	1.267	1.00
176_A	183_L	1.264	1.00
143_Q	147_R	1.262	1.00
54_S	158_D	1.249	1.00
171_L	179_F	1.227	1.00
44_I	75_V	1.226	1.00
35_P	39_R	1.213	1.00
199_C	206_C	1.210	1.00
168_H	171_L	1.201	1.00
24_L	91_N	1.198	1.00
46_A	55_S	1.188	1.00
168_H	200_A	1.172	1.00
224_L	228_A	1.169	1.00
20_Y	31_W	1.168	1.00
98_N	157_H	1.165	1.00
4_T	17_T	1.162	1.00
89_R	96_D	1.154	0.99
89_R	98_N	1.146	0.99
66_L	73_H	1.140	0.99
172_G	180_E	1.139	0.99
110_E	119_A	1.128	0.99
168_H	179_F	1.127	0.99
17_T	32_F	1.115	0.99
171_L	181_L	1.097	0.99
163_I	209_A	1.096	0.99
35_P	72_R	1.090	0.99
49_H	157_H	1.087	0.99
8_A	17_T	1.086	0.99
52_E	157_H	1.080	0.99
153_V	199_C	1.076	0.99
212_P	226_A	1.075	0.99
199_C	204_L	1.073	0.99
41_S	72_R	1.073	0.99
22_R	26_G	1.069	0.99
143_Q	146_H	1.066	0.99
191_T	194_S	1.066	0.99
11_G	67_T	1.065	0.99
135_E	138_T	1.059	0.99
89_R	210_E	1.058	0.99
74_H	148_I	1.036	0.99
20_Y	140_A	1.035	0.99
40_E	151_A	1.030	0.99
174_W	178_A	1.019	0.99
20_Y	29_L	1.013	0.99
11_G	68_P	1.013	0.99
175_L	178_A	1.012	0.99
146_H	201_D	1.007	0.99
52_E	210_E	1.003	0.99
15_P	63_L	1.002	0.99
191_T	196_G	1.002	0.99
89_R	99_R	0.999	0.99
102_P	201_D	0.999	0.99
168_H	176_A	0.997	0.98
130_D	134_S	0.982	0.98
103_A	167_R	0.978	0.98
145_I	198_W	0.975	0.98
45_L	153_V	0.973	0.98
79_V	141_L	0.969	0.98
34_A	75_V	0.966	0.98
144_L	148_I	0.965	0.98
4_T	63_L	0.964	0.98
78_C	84_C	0.963	0.98
65_T	69_S	0.963	0.98
64_R	68_P	0.959	0.98
23_S	81_P	0.943	0.98
172_G	179_F	0.940	0.98
167_R	197_S	0.934	0.98
168_H	183_L	0.932	0.98
139_Q	142_C	0.924	0.98
14_P	70_L	0.921	0.97
53_N	84_C	0.917	0.97
88_L	92_A	0.905	0.97
7_R	11_G	0.904	0.97
101_F	138_T	0.902	0.97
47_G	78_C	0.897	0.97
43_L	145_I	0.897	0.97
170_E	174_W	0.890	0.97
9_E	12_A	0.878	0.97
108_E	111_T	0.877	0.97
164_E	188_G	0.869	0.96
93_N	136_P	0.868	0.96
18_E	74_H	0.861	0.96
99_R	210_E	0.858	0.96
51_D	88_L	0.855	0.96
209_A	233_W	0.853	0.96
7_R	63_L	0.849	0.96
169_S	172_G	0.849	0.96
138_T	142_C	0.844	0.96
49_H	210_E	0.843	0.96
76_V	79_V	0.839	0.96
163_I	180_E	0.827	0.95
156_F	230_L	0.827	0.95
58_T	211_F	0.826	0.95
189_Y	210_E	0.823	0.95
4_T	32_F	0.823	0.95
178_A	182_P	0.819	0.95
95_V	134_S	0.818	0.95
227_M	231_L	0.817	0.95
168_H	180_E	0.815	0.95
59_L	75_V	0.815	0.95
168_H	182_P	0.805	0.95
21_G	29_L	0.799	0.94
96_D	99_R	0.798	0.94
91_N	137_E	0.788	0.94
5_R	8_A	0.781	0.94
41_S	148_I	0.777	0.93
14_P	67_T	0.777	0.93
101_F	141_L	0.770	0.93
171_L	180_E	0.769	0.93
168_H	205_H	0.768	0.93
23_S	91_N	0.763	0.93
199_C	202_L	0.762	0.93
161_A	213_P	0.759	0.93
58_T	227_M	0.759	0.93
225_F	229_N	0.758	0.93
15_P	34_A	0.756	0.93
166_P	200_A	0.756	0.93
97_L	138_T	0.755	0.92
23_S	82_D	0.754	0.92
194_S	198_W	0.751	0.92
80_N	83_G	0.750	0.92
6_P	9_E	0.749	0.92
43_L	199_C	0.746	0.92
89_R	189_Y	0.746	0.92
91_N	95_V	0.746	0.92
65_T	231_L	0.743	0.92
176_A	207_I	0.742	0.92
168_H	175_L	0.741	0.92
106_W	132_P	0.741	0.92
175_L	183_L	0.739	0.92
142_C	198_W	0.737	0.92
131_K	134_S	0.737	0.92
150_P	204_L	0.734	0.91
76_V	141_L	0.734	0.91
99_R	189_Y	0.733	0.91
187_V	190_E	0.731	0.91
100_N	138_T	0.727	0.91
218_E	226_A	0.722	0.91
171_L	182_P	0.721	0.91
222_K	226_A	0.718	0.90
145_I	195_F	0.717	0.90
188_G	191_T	0.717	0.90
159_P	166_P	0.716	0.90
180_E	184_V	0.716	0.90
133_G	146_H	0.713	0.90
54_S	226_A	0.707	0.90
165_D	200_A	0.707	0.90
55_S	211_F	0.706	0.90
224_L	227_M	0.701	0.89
218_E	222_K	0.700	0.89
183_L	230_L	0.699	0.89
177_Q	181_L	0.698	0.89
43_L	141_L	0.695	0.89
90_A	94_G	0.694	0.89
219_A	223_Y	0.694	0.89
186_S	190_E	0.694	0.89
11_G	71_R	0.693	0.89
213_P	217_D	0.691	0.89
151_A	204_L	0.689	0.89
56_V	78_C	0.684	0.88
175_L	179_F	0.682	0.88
179_F	184_V	0.679	0.88
179_F	182_P	0.677	0.88
120_E	128_T	0.677	0.88
103_A	194_S	0.671	0.87
170_E	173_E	0.669	0.87
159_P	164_E	0.667	0.87
42_G	73_H	0.656	0.86
24_L	93_N	0.656	0.86
7_R	14_P	0.655	0.86
48_T	97_L	0.653	0.86
23_S	27_A	0.652	0.86
165_D	173_E	0.648	0.85
61_C	227_M	0.643	0.85
172_G	176_A	0.630	0.84
133_G	139_Q	0.629	0.84
169_S	183_L	0.625	0.83
18_E	33_P	0.619	0.83
4_T	30_I	0.618	0.83
52_E	98_N	0.615	0.82
128_T	192_P	0.614	0.82
164_E	196_G	0.613	0.82
212_P	217_D	0.611	0.82
122_R	127_L	0.606	0.81
99_R	157_H	0.606	0.81
177_Q	180_E	0.602	0.81
41_S	150_P	0.600	0.81
103_A	106_W	0.595	0.80
119_A	128_T	0.594	0.80
162_C	188_G	0.592	0.80
181_L	184_V	0.591	0.80
226_A	230_L	0.590	0.80
202_L	205_H	0.590	0.80
43_L	144_L	0.589	0.79
161_A	229_N	0.589	0.79
169_S	179_F	0.585	0.79
163_I	179_F	0.584	0.79
18_E	76_V	0.583	0.79
196_G	206_C	0.583	0.79
45_L	48_T	0.579	0.78
227_M	230_L	0.578	0.78
150_P	199_C	0.578	0.78
172_G	175_L	0.578	0.78
44_I	156_F	0.576	0.78
87_G	90_A	0.575	0.78
171_L	183_L	0.574	0.78
82_D	92_A	0.573	0.78
172_G	181_L	0.573	0.78
200_A	206_C	0.573	0.78
81_P	137_E	0.572	0.78
54_S	223_Y	0.571	0.77
106_W	110_E	0.571	0.77
49_H	98_N	0.571	0.77
106_W	133_G	0.569	0.77
175_L	182_P	0.567	0.77
170_E	181_L	0.565	0.77
121_E	124_V	0.565	0.77
39_R	72_R	0.562	0.76
44_I	62_A	0.562	0.76
161_A	212_P	0.562	0.76
23_S	29_L	0.559	0.76
42_G	152_W	0.556	0.76
18_E	144_L	0.556	0.76
22_R	131_K	0.554	0.75
169_S	175_L	0.554	0.75
171_L	205_H	0.554	0.75
178_A	181_L	0.552	0.75
51_D	125_V	0.551	0.75
165_D	169_S	0.551	0.75
29_L	81_P	0.546	0.74
43_L	153_V	0.544	0.74
168_H	181_L	0.538	0.73
27_A	82_D	0.535	0.73
222_K	225_F	0.534	0.73
7_R	67_T	0.533	0.72
176_A	180_E	0.532	0.72
185_T	191_T	0.532	0.72
152_W	179_F	0.530	0.72
97_L	137_E	0.530	0.72
107_K	111_T	0.529	0.72
53_N	88_L	0.524	0.71
41_S	144_L	0.524	0.71
91_N	99_R	0.522	0.71
93_N	134_S	0.521	0.71
29_L	79_V	0.517	0.70
212_P	229_N	0.517	0.70
86_L	92_A	0.517	0.70
133_G	143_Q	0.517	0.70
212_P	222_K	0.516	0.70
9_E	13_F	0.515	0.70
211_F	230_L	0.513	0.70
185_T	190_E	0.512	0.69
45_L	141_L	0.511	0.69
198_W	214_I	0.511	0.69
84_C	216_S	0.507	0.69
100_N	129_G	0.506	0.69
158_D	218_E	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pcaA	1	0.9669	100	0.233	Contact Map
4ihmA	1	0.9669	100	0.233	Contact Map
2boaA	1	0.9669	100	0.234	Contact Map
4p10A	1	0.9669	100	0.237	Contact Map
1jqgA	1	0.9628	100	0.24	Contact Map
1ayeA	1	0.9669	100	0.24	Contact Map
1kwmA	1	0.9669	100	0.245	Contact Map
2bo9A	2	0.9669	100	0.252	Contact Map
1dtdA	1	0.9669	100	0.257	Contact Map
1z5rA	1	0.9669	100	0.257	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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