GREMLIN Database
MPAA - Protein MpaA
UniProt: P0ACV6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13906
Length: 242 (221)
Sequences: 3274 (2125)
Seq/√Len: 142.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_A59_L4.3311.00
133_G142_C3.1661.00
48_T101_F3.1241.00
91_N97_L3.0711.00
19_H28_P3.0571.00
47_G56_V2.9141.00
29_L140_A2.8961.00
22_R28_P2.6761.00
102_P133_G2.4911.00
74_H144_L2.3261.00
93_N135_E2.3041.00
45_L155_S2.2971.00
95_V135_E2.2051.00
179_F183_L2.0941.00
196_G208_T2.0181.00
5_R30_I2.0161.00
18_E31_W2.0121.00
63_L75_V1.9791.00
19_H22_R1.9711.00
5_R17_T1.9101.00
157_H210_E1.8641.00
33_P72_R1.7851.00
29_L76_V1.7651.00
49_H52_E1.7221.00
16_G33_P1.6801.00
32_F63_L1.6751.00
41_S74_H1.6561.00
173_E177_Q1.6531.00
136_P140_A1.6521.00
185_T188_G1.6361.00
168_H172_G1.6251.00
107_K128_T1.6071.00
100_N135_E1.5901.00
146_H198_W1.5711.00
36_A39_R1.5381.00
7_R15_P1.5261.00
226_A229_N1.5151.00
104_A108_E1.5121.00
139_Q143_Q1.5061.00
142_C146_H1.5011.00
31_W76_V1.4891.00
43_L76_V1.4861.00
102_P142_C1.4761.00
23_S136_P1.4761.00
98_N210_E1.4681.00
15_P32_F1.4671.00
48_T155_S1.4561.00
59_L156_F1.4541.00
153_V195_F1.4211.00
31_W74_H1.4071.00
172_G183_L1.4061.00
133_G138_T1.4051.00
24_L136_P1.4031.00
145_I202_L1.3961.00
145_I199_C1.3681.00
34_A63_L1.3631.00
25_L92_A1.3631.00
19_H30_I1.3591.00
127_L130_D1.3561.00
8_A15_P1.3401.00
169_S173_E1.3261.00
89_R157_H1.3251.00
44_I59_L1.3201.00
56_V84_C1.3191.00
171_L175_L1.3161.00
156_F209_A1.3101.00
100_N134_S1.3091.00
146_H202_L1.2911.00
21_G140_A1.2901.00
48_T79_V1.2881.00
20_Y76_V1.2871.00
47_G84_C1.2821.00
17_T30_I1.2801.00
6_P10_R1.2771.00
180_E183_L1.2701.00
33_P74_H1.2671.00
176_A183_L1.2641.00
143_Q147_R1.2621.00
54_S158_D1.2491.00
171_L179_F1.2271.00
44_I75_V1.2261.00
35_P39_R1.2131.00
199_C206_C1.2101.00
168_H171_L1.2011.00
24_L91_N1.1981.00
46_A55_S1.1881.00
168_H200_A1.1721.00
224_L228_A1.1691.00
20_Y31_W1.1681.00
98_N157_H1.1651.00
4_T17_T1.1621.00
89_R96_D1.1540.99
89_R98_N1.1460.99
66_L73_H1.1400.99
172_G180_E1.1390.99
110_E119_A1.1280.99
168_H179_F1.1270.99
17_T32_F1.1150.99
171_L181_L1.0970.99
163_I209_A1.0960.99
35_P72_R1.0900.99
49_H157_H1.0870.99
8_A17_T1.0860.99
52_E157_H1.0800.99
153_V199_C1.0760.99
212_P226_A1.0750.99
199_C204_L1.0730.99
41_S72_R1.0730.99
22_R26_G1.0690.99
143_Q146_H1.0660.99
191_T194_S1.0660.99
11_G67_T1.0650.99
135_E138_T1.0590.99
89_R210_E1.0580.99
74_H148_I1.0360.99
20_Y140_A1.0350.99
40_E151_A1.0300.99
174_W178_A1.0190.99
20_Y29_L1.0130.99
11_G68_P1.0130.99
175_L178_A1.0120.99
146_H201_D1.0070.99
52_E210_E1.0030.99
15_P63_L1.0020.99
191_T196_G1.0020.99
89_R99_R0.9990.99
102_P201_D0.9990.99
168_H176_A0.9970.98
130_D134_S0.9820.98
103_A167_R0.9780.98
145_I198_W0.9750.98
45_L153_V0.9730.98
79_V141_L0.9690.98
34_A75_V0.9660.98
144_L148_I0.9650.98
4_T63_L0.9640.98
78_C84_C0.9630.98
65_T69_S0.9630.98
64_R68_P0.9590.98
23_S81_P0.9430.98
172_G179_F0.9400.98
167_R197_S0.9340.98
168_H183_L0.9320.98
139_Q142_C0.9240.98
14_P70_L0.9210.97
53_N84_C0.9170.97
88_L92_A0.9050.97
7_R11_G0.9040.97
101_F138_T0.9020.97
47_G78_C0.8970.97
43_L145_I0.8970.97
170_E174_W0.8900.97
9_E12_A0.8780.97
108_E111_T0.8770.97
164_E188_G0.8690.96
93_N136_P0.8680.96
18_E74_H0.8610.96
99_R210_E0.8580.96
51_D88_L0.8550.96
209_A233_W0.8530.96
7_R63_L0.8490.96
169_S172_G0.8490.96
138_T142_C0.8440.96
49_H210_E0.8430.96
76_V79_V0.8390.96
163_I180_E0.8270.95
156_F230_L0.8270.95
58_T211_F0.8260.95
189_Y210_E0.8230.95
4_T32_F0.8230.95
178_A182_P0.8190.95
95_V134_S0.8180.95
227_M231_L0.8170.95
168_H180_E0.8150.95
59_L75_V0.8150.95
168_H182_P0.8050.95
21_G29_L0.7990.94
96_D99_R0.7980.94
91_N137_E0.7880.94
5_R8_A0.7810.94
41_S148_I0.7770.93
14_P67_T0.7770.93
101_F141_L0.7700.93
171_L180_E0.7690.93
168_H205_H0.7680.93
23_S91_N0.7630.93
199_C202_L0.7620.93
161_A213_P0.7590.93
58_T227_M0.7590.93
225_F229_N0.7580.93
15_P34_A0.7560.93
166_P200_A0.7560.93
97_L138_T0.7550.92
23_S82_D0.7540.92
194_S198_W0.7510.92
80_N83_G0.7500.92
6_P9_E0.7490.92
43_L199_C0.7460.92
89_R189_Y0.7460.92
91_N95_V0.7460.92
65_T231_L0.7430.92
176_A207_I0.7420.92
168_H175_L0.7410.92
106_W132_P0.7410.92
175_L183_L0.7390.92
142_C198_W0.7370.92
131_K134_S0.7370.92
150_P204_L0.7340.91
76_V141_L0.7340.91
99_R189_Y0.7330.91
187_V190_E0.7310.91
100_N138_T0.7270.91
218_E226_A0.7220.91
171_L182_P0.7210.91
222_K226_A0.7180.90
145_I195_F0.7170.90
188_G191_T0.7170.90
159_P166_P0.7160.90
180_E184_V0.7160.90
133_G146_H0.7130.90
54_S226_A0.7070.90
165_D200_A0.7070.90
55_S211_F0.7060.90
224_L227_M0.7010.89
218_E222_K0.7000.89
183_L230_L0.6990.89
177_Q181_L0.6980.89
43_L141_L0.6950.89
90_A94_G0.6940.89
219_A223_Y0.6940.89
186_S190_E0.6940.89
11_G71_R0.6930.89
213_P217_D0.6910.89
151_A204_L0.6890.89
56_V78_C0.6840.88
175_L179_F0.6820.88
179_F184_V0.6790.88
179_F182_P0.6770.88
120_E128_T0.6770.88
103_A194_S0.6710.87
170_E173_E0.6690.87
159_P164_E0.6670.87
42_G73_H0.6560.86
24_L93_N0.6560.86
7_R14_P0.6550.86
48_T97_L0.6530.86
23_S27_A0.6520.86
165_D173_E0.6480.85
61_C227_M0.6430.85
172_G176_A0.6300.84
133_G139_Q0.6290.84
169_S183_L0.6250.83
18_E33_P0.6190.83
4_T30_I0.6180.83
52_E98_N0.6150.82
128_T192_P0.6140.82
164_E196_G0.6130.82
212_P217_D0.6110.82
122_R127_L0.6060.81
99_R157_H0.6060.81
177_Q180_E0.6020.81
41_S150_P0.6000.81
103_A106_W0.5950.80
119_A128_T0.5940.80
162_C188_G0.5920.80
181_L184_V0.5910.80
226_A230_L0.5900.80
202_L205_H0.5900.80
43_L144_L0.5890.79
161_A229_N0.5890.79
169_S179_F0.5850.79
163_I179_F0.5840.79
18_E76_V0.5830.79
196_G206_C0.5830.79
45_L48_T0.5790.78
227_M230_L0.5780.78
150_P199_C0.5780.78
172_G175_L0.5780.78
44_I156_F0.5760.78
87_G90_A0.5750.78
171_L183_L0.5740.78
82_D92_A0.5730.78
172_G181_L0.5730.78
200_A206_C0.5730.78
81_P137_E0.5720.78
54_S223_Y0.5710.77
106_W110_E0.5710.77
49_H98_N0.5710.77
106_W133_G0.5690.77
175_L182_P0.5670.77
170_E181_L0.5650.77
121_E124_V0.5650.77
39_R72_R0.5620.76
44_I62_A0.5620.76
161_A212_P0.5620.76
23_S29_L0.5590.76
42_G152_W0.5560.76
18_E144_L0.5560.76
22_R131_K0.5540.75
169_S175_L0.5540.75
171_L205_H0.5540.75
178_A181_L0.5520.75
51_D125_V0.5510.75
165_D169_S0.5510.75
29_L81_P0.5460.74
43_L153_V0.5440.74
168_H181_L0.5380.73
27_A82_D0.5350.73
222_K225_F0.5340.73
7_R67_T0.5330.72
176_A180_E0.5320.72
185_T191_T0.5320.72
152_W179_F0.5300.72
97_L137_E0.5300.72
107_K111_T0.5290.72
53_N88_L0.5240.71
41_S144_L0.5240.71
91_N99_R0.5220.71
93_N134_S0.5210.71
29_L79_V0.5170.70
212_P229_N0.5170.70
86_L92_A0.5170.70
133_G143_Q0.5170.70
212_P222_K0.5160.70
9_E13_F0.5150.70
211_F230_L0.5130.70
185_T190_E0.5120.69
45_L141_L0.5110.69
198_W214_I0.5110.69
84_C216_S0.5070.69
100_N129_G0.5060.69
158_D218_E0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pcaA 1 0.9669 100 0.233 Contact Map
4ihmA 1 0.9669 100 0.233 Contact Map
2boaA 1 0.9669 100 0.234 Contact Map
4p10A 1 0.9669 100 0.237 Contact Map
1jqgA 1 0.9628 100 0.24 Contact Map
1ayeA 1 0.9669 100 0.24 Contact Map
1kwmA 1 0.9669 100 0.245 Contact Map
2bo9A 2 0.9669 100 0.252 Contact Map
1dtdA 1 0.9669 100 0.257 Contact Map
1z5rA 1 0.9669 100 0.257 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.