GREMLIN Database
YCIS - Inner membrane protein YciS
UniProt: P0ACV4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13904
Length: 102 (91)
Sequences: 191 (100)
Seq/√Len: 10.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_L74_A4.1890.99
84_Q89_T2.6310.88
15_V39_Y2.6220.88
30_F61_G2.3680.82
19_T48_L2.3270.80
19_T46_A2.3120.80
43_T79_K2.3060.80
5_L66_R2.2470.78
14_F53_F2.1240.74
23_Q53_F1.8250.61
51_A84_Q1.6870.55
33_L42_S1.6520.54
32_Y36_Q1.6290.52
27_Q55_I1.6260.52
46_A67_V1.5770.50
55_I64_W1.5650.49
13_I80_R1.5400.48
34_L51_A1.5130.47
39_Y47_V1.5110.47
74_A81_L1.5090.47
61_G65_L1.5010.47
31_N65_L1.4460.44
50_A56_G1.4310.43
85_L88_A1.4010.42
20_L33_L1.3820.41
25_D74_A1.3800.41
39_Y46_A1.2890.37
74_A78_I1.2780.36
26_Q80_R1.2570.35
37_G57_W1.2550.35
20_L53_F1.2340.35
68_R71_L1.2050.33
33_L44_L1.1850.32
70_S75_E1.1420.31
41_I64_W1.1310.30
85_L89_T1.1250.30
58_L91_V1.1190.30
15_V74_A1.1190.30
31_N76_R1.1150.30
37_G45_L1.1010.29
69_V72_A1.1000.29
4_L23_Q1.0470.27
4_L34_L1.0470.27
19_T63_F1.0320.27
34_L40_R1.0190.26
26_Q62_L1.0100.26
74_A82_E1.0040.26
13_I41_I0.9800.25
57_W61_G0.9710.24
54_A75_E0.9700.24
81_L88_A0.9630.24
73_R82_E0.9630.24
5_L8_L0.9350.23
11_L64_W0.9340.23
18_V49_F0.9300.23
25_D76_R0.9250.23
13_I30_F0.9230.23
27_Q38_E0.9110.22
54_A82_E0.9090.22
16_I28_V0.9000.22
78_I83_N0.8920.22
23_Q28_V0.8900.22
12_A41_I0.8850.22
1_M33_L0.8830.21
58_L75_E0.8790.21
17_S50_A0.8640.21
83_N86_S0.8480.20
45_L51_A0.8470.20
41_I70_S0.8360.20
58_L69_V0.8220.20
19_T50_A0.8160.19
34_L50_A0.8130.19
38_E72_A0.8040.19
45_L57_W0.7970.19
69_V89_T0.7940.19
58_L85_L0.7740.18
11_L42_S0.7740.18
4_L46_A0.7650.18
67_V71_L0.7560.18
31_N87_P0.7490.18
19_T30_F0.7450.17
4_L70_S0.7240.17
3_Y22_A0.7180.17
86_S89_T0.7140.17
69_V85_L0.7080.16
15_V55_I0.6990.16
34_L90_D0.6960.16
66_R73_R0.6950.16
37_G47_V0.6920.16
48_L56_G0.6910.16
17_S41_I0.6900.16
3_Y19_T0.6850.16
4_L75_E0.6790.16
34_L79_K0.6730.16
14_F51_A0.6710.16
12_A16_I0.6680.15
40_R56_G0.6650.15
42_S64_W0.6470.15
11_L75_E0.6470.15
10_V81_L0.6460.15
22_A77_K0.6420.15
11_L38_E0.6400.15
16_I87_P0.6360.15
23_Q30_F0.6310.15
48_L76_R0.6300.15
36_Q91_V0.6230.14
26_Q38_E0.6210.14
48_L63_F0.6130.14
87_P91_V0.6080.14
7_F67_V0.6050.14
56_G61_G0.6050.14
1_M83_N0.5950.14
17_S48_L0.5840.13
5_L80_R0.5840.13
64_W67_V0.5830.13
12_A82_E0.5750.13
39_Y57_W0.5740.13
30_F44_L0.5680.13
6_I22_A0.5600.13
30_F50_A0.5570.13
47_V87_P0.5490.13
51_A67_V0.5480.13
25_D35_A0.5420.13
17_S60_C0.5410.13
17_S81_L0.5380.13
56_G60_C0.5370.13
5_L54_A0.5280.12
9_L87_P0.5270.12
15_V28_V0.5260.12
7_F36_Q0.5250.12
4_L60_C0.5170.12
68_R72_A0.5100.12
22_A72_A0.5080.12
9_L88_A0.5020.12
9_L84_Q0.5000.12
5_L9_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z73A 2 0.9804 59.7 0.901 Contact Map
4mbsA 1 0.9804 14.1 0.929 Contact Map
3ra3B 1 0.2647 10.1 0.933 Contact Map
3vw7A 1 0.9804 10.1 0.934 Contact Map
3oduA 2 0.9706 9.9 0.934 Contact Map
2r4rA 1 0.6078 9.8 0.934 Contact Map
2m7gA 1 0.5882 8.9 0.935 Contact Map
2k3cA 1 0.3039 8.9 0.935 Contact Map
4c91A 2 0.6373 8.2 0.936 Contact Map
3emlA 1 0.9608 7.9 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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